PPI "cold turkey"

Stay strong. What are your symptoms for now?

My side effects when I was on the PPI were; dizziness, diarrhea a few days, lightheaded, depressed, nauseous but extremely, vomiting, double vision.

Now 3 weeks without; heartburn, depressed and nausea.

I don't take anything for now. Just a healthy diet and DGL supplement. I want my body to fight against that heartburn/nauseous feeling. Difficult but I will fight against it.

I never had stomach issues before when I discovered my ulcers, gastritis,... I think it was all acute.

I ate poisoned meat on the bbq. The bbq was difficult to get on and many fuel cubes were used. When the toxic smoke was still coming out, the meat was put on the bbq and I ate it. A few days later I became very ill.

The specialist told me my ulcers were ulcers like the ones from medication, but I never toke any medication in my life before.

So how long could it take to recover from heartburn, nauseous feeling? Tomorrow week 3 will start without PPI.

I'm a bit scared that the heartburn can hurt my stomach, duodenal again.

I have no reflux symptoms. Sorry for my bad english, I'm from Belgium.

I wish you luck. It sounds as if you might succeed. I wouldn't think the heartburn would hurt your stomach with what you are trying to do.

BBQ food is bad. What symptoms did you have to discover the ulcers in the first place?

Yes, bbq is terrible, never again!

Symptoms like their was gas (reflux) in my mouth, extremely nauseous, lost 10 KG in 5 days, vomiting, exhausted,..

I did another endoscopy 7 weeks later because I was still nauseous. Night before the endoscopy I was vomiting again, body was shaking, extremely nauseous. Afterwards it showed that everything was cured. So it was the PPI.

were you tested for h pylori? Also have you had a full set of bloods taken including vitamin and mineral levels, inflammation and celiac disease? If not I would recommend getting these tested. The food poisoning may have aggravated an underlying problem. Not taking any medication could bring back the problems you had before.

Hi,

Yes, h. Pylori was neg.

I did a few blood tests, no inflammations. I did yesterday a new blood test on my demand. I know I'm low in Vit. D and B. Some days are better then others, but I feel that I'm still not the old one.

Also some days a feeling that something is stuck in my throat, never had it before. My right eye is weaker. I have creates a double vision, never hwd it before. But the reason could that I'm to much time spending on my phone. So the eye muscles can be weaker and staying 24/7 in bed for 2 months and a half.

Are you taking vitamin and mineral supplements? Vitamin and mineral deficiencies can lead to problems with your stomach as well as serious other problems.

Certain food allergies or intolerances can lead to problems with your stomach too. If you are so ill you find it hard to get out of bed, there maybe something else you need testing for.

Considering the amount of ulcers you had and the fact you had acute gastritis, I would strongly suggest something to protect your stomach. You know, you only tried one type of ppi, there are many others that you may get on with better. But if you are adamant you don't want to try another type, you should seriously consider high dose ranitidine. You can also take those double action indigestion relief chewable tablets or that peppermint double action liquid stuff they are always advertising on these pages!

You really need to take care of your stomach, I am on long term ppis because for some reason I have always had stomach problems. Every time I stop using them I get ill. I tried 3 different types before finding one that suited me. I first was given lanzoprazole which I didn't like, it wasn't that effective for me and gave me the most side effects. I now take esomeprazole, which works much better for me, I still get side effects but to a much lesser degree. The reason I was convinced to take them long term was because they protect against stomach cancer.

An article about hyper acid secretion;

This is an effect of acid suppression recognized for many years by basic investigators but largely ignored by clinicians. [24 ••, 25 ••] Sustained hypergastrinemia due to daily PPI therapy leads to increased gastric acid-secretory capacity that is not apparent during PPI therapy, but that appears promptly when the drug is stopped. In normal volunteers, treated for 8 weeks with esomeprazole 40 mg per day, stopping the drug was followed by de-novo development of dyspeptic symptoms in more than 40% or previously symptomless patients. Other smaller studies, published as abstracts, had previously reported similar increases in acid-related symptoms after stopping PPI therapy, both in normal volunteers and in symptomatic patients, and are discussed elsewhere. Depending on the dose and duration of exposure, it can take 2-3 months for rebound acid hypersecretion (RAHS) to return to pre-PPI basal levels. [24 ••] Like nocturnal acid breakthrough, RAHS is not prominent in H. pylori -infected patients.

  This phenomenon implies that a post-PPI therapy period or difficulty should be anticipated. Symptoms can be managed with antacids or H2RA drugs (which cause negligible RAHS and can be discontinued later with little difficulty), or perhaps the PPI dose could be tapered down over a period rather than suddenly discontinued: to date, too few studies or tapering drug cessation have been reported for any conclusion to be drawn. Furthermore, as gastrin acts by releasing histamine, the ultimate mediator of acid secretion, tolerance to histamine and to the effects of H2RAs occurring during PPI therapy, decreasing H2RA efficacy; thus, PPIs should not be used in advance or H2RAs, an argument against 'step-down' therapy and other popular practices.

Like I showed before; It is the rebound effect, because I was healed completely and never had issues before. Only symptoms of LPR.

I did yesterday a blood test, I'll know the results today. I already know my Vit. D is to low, 16.

I guess my B12 will also be very low.

Studies have shown that you can get stomach cancer with the use of PPIs, so take care. Zantaq was on the news, it contains a carcinogenic substance.

There are studies looking into the link, but no proof ppis cause stomach cancer. A study was done on h pylori patients taking ppis, h pylori can cause stomach cancer so it isn't really evidence. The press jump all over scare stories without understanding the medical knowledge or how scientific trials work. They just want the headlines.

I wasn't aware of zantac but I will definitely read up on it.

Anyway I hope you feel better soon and maybe try a low acid diet if you don't want medication.

Hi, are you healed now?

It came out of nowhere. I was nauseous, gas in the mouth, bad breath, vomiting.

After 3 days of suffering I went to the hospital.

I toke some PPIs and juiced a lot of cabbage. After 7 weeks I was still nauseous, so went again to the hospital and again an endoscopy. Showed everything was healed, so I was sick of the PPI.

Tomorrow is week 3 of stop taking the PPI. First week was okay, mild symptoms, same for the second week, now the third week I'am nauseous again, now i feel the burning sensation in the stomach.

no, i not healed. i had an endoscopy and colonoscopy on april and everything was normal no ulcers, gastritis or inflamation but i wasn't feeling this bad when i had the endoscopy my main symptom was sour taste in my mouth after eating and stomach cramping. now it is been two months since i stopped ppi and still having problems. now it is worse i can't skip a meal without having stomach pain. i get hunger pains, do you get this as well? doctor saud it is dyspesia and to take ppi again but i dont' want to start again those gave me all my symptoms. i did have stomach pain before starting them it was just a lump in mu throat feeling and sore throat but no stomach pain.

How long did you take the PPI?

This is some text from an article that I will show you;

This is an effect of acid suppression recognized for many years by basic investigators but largely ignored by clinicians.[24••,25••] Sustained hypergastrinemia due to daily PPI therapy leads to increased gastric acid-secretory capacity that is not apparent during PPI therapy, but that appears promptly when the drug is stopped. In normal volunteers, treated for 8 weeks with esomeprazole 40 mg per day, stopping the drug was followed by the de-novo development of dyspeptic symptoms in more than 40% of previously symptomless patients. Other smaller studies, published as abstracts, had previously reported similar increases in acid-related symptoms after stopping PPI therapy, both in normal volunteers and in symptomatic patients, and are discussed elsewhere. Depending on the dose and duration of exposure, it can take 2–3 months for rebound acid hypersecretion (RAHS) to return to pre-PPI basal levels.[24••] Like nocturnal acid breakthrough, RAHS is not prominent in H. pylori -infected patients.

So yea, the symptoms you can give are (maybe) from the withdrawal.

Dyspepsia is a withdrawal symptom. So wait with taking PPIs again.

Indigestion or Dyspepsia (30%)

Data from a study by Reimer et al. (2009) indicate that indigestion (medically referred to as “dyspepsia”) is the second most frequently-reported symptom that emerges following discontinuation of proton-pump inhibitors. Reflecting upon available data from the aforementioned Reimer et al. study, indigestion was reported to have occurred in approximately 30% of former proton-pump inhibitor users within 4 weeks of cessation.

The cause of indigestion (impaired or irregular digestion) during withdrawal is understood to be rebound stomach acid hypersecretion – or excessive production of stomach acid following proton-pump inhibitor cessation. The severity of indigestion reported in the Reimer et al. study was documented as being “mild-to-moderate” based on self-reports.

i took ppi for 4 months, i wean off slow. it is been 5 months since i stopped ppi and still having issues. have you had this feeing of hunger pain like gnawing feeling in the stomach? i burp alot too and get this sour taste in my mouth.

No I don't have these symptoms for now, I can't help you. How is your diet?

i was in a low acid, low fatty food diet and pretty much eat alot vegetables, fruits, rice , and bland diet. but i was loosing too much weight and was soo thin, so went back to eat normal food. i guess i need to go back to my diet. what are ur symptoms now? did u had stomach pain with stomach empty when u had the ulcer?

Yes a little pain but not that hard. Yes, a diet is very important!

My main symptom now is being nauseous. Does it go away? It drives me crazy!

Sorry for the late reply.