Progression Of Gerds to Cancer?
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Hi all. My name is Curtis. Im 42 and I live in the U.S.,South Carolina. My first post so wanted to say hello before I bring up my issues and questions.
I have had reflux probably about 18 years. First signs of it were lpr symptoms pretty much outside a stomach burn when I was first put on gerds meds back then. Was put on protonix 20 mg and worked like a charm. Probably took it about a year and for the longest time didnt need it and was symptom free for years outside occasional regurgitation or very mild heartburn which an over the counter antacid took care of. My issues however started to get chronic after needing to take nsaids for degenerative cervical disk pain. My gerds got bad while taking them to the point I switched to tylenol instead. But by that time the gerds was here to stay. Was put back on ppi which has been changed up several times the last two years because they help for a while but then stop. Well in the last month I developed the classic lpr symptoms again along with what has now become daily heartburn. Actually it seems to alternate. Some days its the lpr and some its the chest pain of heartburn. Never had a scope for gerds. But have been set up appointment with GI doc to discuss if one is needed. Emergency told me I had esophagitis. My doc now has me taking 40 mg protinix and 150 mg ranitadine at night before bed. Just started that last week. Stopped coffee,cut way back on colas until I can boot them also. Scared of scope findings. Not really the scoping it self. My question is this. What has been studied to determine length of time from gerds to cancer in the general population? Im seeing many people who have had gerds for 30 plus years and no cancer even though they may have esophagus issues. Hoping I fall in to that catergory of people.
1 like, 32 replies
Curtis1973
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JFWski Curtis1973
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Curtis1973 JFWski
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rex_44766 Curtis1973
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Curtis1973 rex_44766
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Barretts Curtis1973
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1. GERD
2. Probably about 1 in 10 with GERD get Barrett's Oeosphagus. About 1 in 500 with non-dysplastic Barrett's per year will get cancer.
3. Next stage, if progression occurs, is Low Grade Dysplasia. Risk of progression about 1% p.a. If diagnosed with Barrett's with dysplasia have it ablated to minimise any risk of preogression.
4. Next would come High Grade Dysplasia with risk progression of 6% per year.
HGD used to be known as "carcinoma is situ" and may be graded on the cancer scale as Tis - which is below T1, neoplasia - the earliest stage of cancer
Anything upto and including T1 can usually be removed by ablation therapy.
Risks of progression over lifetime from Non-Dysplastic Barrett's gives reasonable chance over 20 years so if non Barrett's, just GERD, risk is about 200 years.
Your chances of getting cancer are, in other words, not worth worrying about. You're more likely to harm yourself through worry.
I know I've had reflux problems all my life and can trace particular symptoms of GORD and extra-oesophageal reflux for over 60 years.
For the last 21 years, Ive known I have Non-Dysplastic Barrett's and it hasn't changed in all that time and I am confident it will never change. (We're learning more about this every year and it seems, although I have the genetic potential to develop Barrett's, I probably don't have that gene combination to permit progression or it would probably have shown changes by now,)
So discover your own particular triggers - the foods that cause you problems (and it may not be coffee). Make lifestyle changes to reduce reflux because it takes reflux + acid + bile to make the cellular changes to your oesophagus. And your acid suppressants will reduce the acid. Not a lot you can do about the bile except for reducing fatty foods and processed meats.
(Figures quoted above provided by statistics unt of Cancer Research UK)
Curtis1973 Barretts
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jan21306 Barretts
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Barretts jan21306
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Curtis1973 jan21306
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jan21306 Barretts
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Barretts Curtis1973
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You don't have to take the medication in 2 doses. It just makes it easier to assimilate. Best time to take PPIs is 30 minutes before breakfast but that's only to get into a habit and for the food to help ensure the tablet has reached the duodenum before dissolving.
Barretts jan21306
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If you actually do find you react to PPIs, have you tried H" blockers, eg Ranitidine instead? They're not as effective as PPIs and you'd probably need 300mg dose.
Curtis1973 Barretts
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Curtis1973 jan21306
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rex_44766 Curtis1973
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jan21306 Barretts
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I like your idea of low dairy ice cream. I could do with a treat, so will try a small amount first. At the moment I am going to stick to vegetables for a few days i think.
jan21306 Curtis1973
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jan21306
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Curtis1973 rex_44766
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Curtis1973 jan21306
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rex_44766 Curtis1973
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rex_44766 Curtis1973
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rex_44766 jan21306
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Curtis1973 rex_44766
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jan21306 rex_44766
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