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gillybee gillybee

Stomach Problems and Steroids

Hi all.

I think I have read somewhere that taking regular steroids can give stomach problems as a possible side effect.

Can any of you ladies who have had stomach problems as a side effect tell me what to expect?

Not blaming the steroids particularly, but I have been feeling a little bit 'stomachy' in recent weeks, so just curious.. :huh:


40 Replies

  • Nefret Nefret

    Oh dear, Gillybee - have just added to my own thread about possible stomach issues with the uncoated Preds!

    I'm not really a typical enough case to help, as I have a hiatus hernia and gastritis anyway, so already on a stomach protector (Lansoprazole), but I do know that several on here were automatically prescribed or offered either that or Omezaprole on commencing steroids.

    I know Mrs O will be along shortly to ask if you are eating your yoghourts - live ones are very helpful first thing as a stomach liner, might be worth a try? I recently found a really scrummy coconut flavour one!


  • EileenH EileenH

    Steroids - irritated stomach lining, very likely! I only need a dose of about 4mg for it to pinch.

    The enteric coated version pass through the stomach to be absorbed lower down thus avoiding that problem. Longer term some people still develop stomach problems with extended periods of higher doses. But every little helps as some company keeps telling us! :lol:


  • MrsO-UK Surrey MrsO-UK Surrey


    I'm awkward....... from the outset I had stomach/bowel problems from both Omeprazole and Lansoprazole prescribed by my GP, the very drugs that are given to protect the stomach from the steroids! My rheumy told me not to take them and he reassured me that he'd never come across a 'burnt out stomach' from the steroids. Therefore in view of the very high steroid dose that I was taking I decided to take a small pot of live yoghurt daily with my muesli as a natural stomach liner before taking the steroids - four years later everything is fine (at least as far as I can see!).

    So here I am, Nefret, recommending live yoghurt once again! :wink:

    I think BettyE is another poster who believes in the yoghurt, too. Plus we both have a spoonful of Manuka Honey 10+ - great for the immune system especially whilst on steroids and that will help with the stomach too.

    I don't know whether you are taking all uncoated pills, Gillybee, as that seems to be the latest direction being taken by GPs but, if you are and are having stomach problems, then it would probably be advisable for you to ask for enteric coated ones in future.


  • BettyE BettyE

    [quote:9e6e297935]I think BettyE is another poster who believes in the yoghurt, too.[/quote:9e6e297935]

    Yes, I am. Cannot prove anything but some time before my first round of PMR over 11 years ago, I was referred for endoscopy because my middle portion was so miserable. No sign of anything untoward but I think it was then that I took to yoghurt ( full fat plain Yeo valley ) Even when I was taking 30 mgs of Pred there were no digestive upsets and I have never had any more trouble ( Well, not in my gut, anyway ).Well worth a try I would say. BettyE

  • Mrs G Mrs G

    Yes Im another yoghurt fan !!

    I used to take probiotic tablets at one time but changed to Yoghurt as I have been on non enteric tablets for probably about a year now and everything is fine

    Best wishes

    Mrs G

  • gillybee gillybee

    Hi all.

    Although feeling remarkably well in general, and now with the added bonus of being almost pain free, I am still getting these annoying 'tummy niggles'.

    To be honest it is more bowel problems than stomach, and I am sometimes rather 'windy' and get stomach cramps as well.

    I have taken the advice given on this post and I am now taking yogurts, and fingers crossed, I think that I may be improving. smile I try to have a yogurt a day and actually really love the Yeo Valley natural one and could eat any amount of it!

    I first noticed that my my tummy problems seemed to increase when I started taking the 1mg tablets. I am now taking one 5mg and four 1mg tablets in one sitting (total of 9mgs) with a drop to 8mgs next week.

    Just wondering if taking all these tabs in one go could be the root of my tummy problems, or is it just coincidence? :?

    I am seeing my GP next week and I will mention this to him.

    Once again ladies, your thoughts and advice would be appreciated.


  • EileenH EileenH

    Gillybee - that is exactly what happens to me. I have 5, 2.5 and 1mg pills and combine them appropriately, using my husband's pill cutter to get 0.5mg-ish. I can manage up to 2mg of the white ones providing I can take them with meal (which is, after all, what we are meant to do) no bother but when I tried doing what you are doing with 5+(4x1) to get to 9mg within a couple of days I had mild stabbing discomfort in my gastric area :cry: Nothing else had changed so I am confident it was just too much of the white stuff! I'm not even sure, to be honest, that it is the quantity of steroid in the stomach - it could be the carrier in the tablets that doesn't agree with me. I did - in a fit of \"don't waste money\" - decide I really ought to use up the packet of 5mg white tablets but as soon as I took a couple of them I had twinges so abandoned thoughts of economy :roll:

    The first trial of a steroid taper when the PMR was first diagnosed didn't have that effect as far as I remember even though that was the white tablets - of course the enormous sense of relief that nothing else hurt may have distracted me! On the other hand, the enteric coated ones have not the slightest bad effect - I could take 20mg in one go using 2.5mg pills (double dose on alternate days) with my early morning cup of tea if I was quite stiff on the second morning so they were starting to have an effect by the time I went out! Not a problem now as although there is a bitof stiffness in the late afternoon and evening it has improved next morning.

    The other thing that might cause a problem is the calcium/vit D tabs - some people find they cause wind and rumbles. Again I like mine :roll: - I know, I'm strange - and the ones I just got from the GP here are lovely lemon flavoured sweeties! They weren't the cheapest, I had to pay a bit extra over and above the prescription charge (usually 4 euros!), but nice flavour and texture - no rocks in the mix.


  • fiftiesgirl fiftiesgirl

    Interesting......... my 5mg used to be coated but the ones I picked up today are not.... watch this space...

    My 1mg have never been coated but I have always eaten 'live' yogurts and since listening to Mrs O switched these to when I take my steroids at breakfast time and have had no problems....something might change now all steroids un-coated...will let you know!

    Now, the Calceos a different kettle of fish!!!! They do give me wind and tummyache and I know it is them sad

    But a small price to pay..... being mainly vegetarian have this problem anyway!!!

    The Calceos have def added to the mix smile

  • EileenH EileenH

    Fifties girl - it has to be specified on the prescription if you want the enteric coated, otherwise the pharmacy will just dish out the white stuff. MrsK posted about the fact that the guidance was to be only enteric coated if needed a bit back - but although the official line was that there is no difference, many docs are now finding patients coming back to say they get indigestion with the non-coated variety. It was said that plain plus a PPI (the cheapest available) was a better (i.e. cheaper) solution - I ask why, as the PPI interferes with calcium absorption and puts you at increased risk of osteoporosis, some people can't take them and, frankly, why should I need to take extra medications I didn't need before. The more medications, the worse the compliance. And the Americans are bothered enough for the FDA to say PPIs should not be used more than 2 weeks at a go and not prescribed longterm (more than 6 months).


  • fiftiesgirl fiftiesgirl

    Eileen, what are PPI's? Stomach protectors I presume.... which I do not take......but I have also read that steroids without theenteric coating are far more readily absorbed and therefore much better at reducing inflammation?

    Seeing rheumy in a week and a half for all the results of all my tests/scans and doc a week later so will certainly raise this with both of them.

    But having my PMR 'L'plates up I know nothing :roll: :roll:

  • MrsO-UK Surrey MrsO-UK Surrey

    Hi gillybee

    I wonder if you have tried taking Manuka honey? Although I have always had the live yoghurt with my breakfast and before taking the steroids, I have also always had Manuka honey at the same time. Abandoned the Proton Pump Inhibitors (both Omeprazole and Lansoprazole) after a couple of weeks as they upset my stomach leading to bowel problems like you (weird because they're supposed to do the opposite! :?) whereas taking a mix of coated and uncoated tablets from 9mgs and only uncoated tablets from 5mgs have not had any bad effects at all.

    I also start the day with lemon juice squeezed into warm water, so any one of these three things, or a combination of all three, could have been protection

    The Manuka honey must bear the UMF mark (unique Manuka factor) as this guarantees the strength, and I have factor 10.

    So pleased to hear that your PMR pain is behaving! :D


  • BettyE BettyE

    [quote:535d258c7a]The Manuka honey must bear the UMF mark (unique Manuka factor) as this guarantees the strength, and I have factor 10.


    So do I and have done for several years. Like Mrs.O Icould not tolerate the PP inhibitors. When I returned them to the dispensary at our surgery, saying they made me feel worse, the pharmacist replied without batting an eyelid, \"Yes, they do some people\".!! :roll:

    Cannot remember who recommended Manuka honey but it certainly works for me. Ditto the yoghurt.This was long before PMR struck for the first time eleven years ago.

    If you don't have a handy Holland and Barrett ( not sure if full name is allowed ) their website is very good and their delivery charges very reasonable.

    Have a good Sunday, everyone. BettyE

  • EileenH EileenH

    Question answered - PPIs are Proton Pump Inhibitors and they stop the mechanism for the production of acid in your stomach which is what is often blamed for indigestion and is what does the damage if you have reflux - heartburn. The acid in your stomach doesn't damage the stomach lining as it is designed to resist it but the cells lining your gullet are not. However, indigestion can also be due to too little acid and presumably if that the case for you, you will feel even worse with the PPIs. Their forerunners were H2 antagonists - also interfere with the production of the acid but in a different way. And then there are the \"coating\" mechanisms like gaviscon and friends and the neutralisers like rennie and co.

    I'm sure I've mentioned it before - PPIs are associated with developing osteoporosis because the reduction of acid in the stomach also interferes with absorbing calcium and the FDA in the USA have warned against long term use of them. I can't get my head round the idea of handing over prescriptions for multiple drugs that have the same side-effect - it has to compound the problem.

    The enteric coated pills pass through the stomach and are broken down and absorbed further down the gut. This avoids the irritation of the stomach lining. There has been some concern about the enteric coated pills and the way they are absorbed. It seems to be a bit more uneven and in some cases the blood level may vary from day to day and so, in some cases, the anti-inflammatory effect seems poorer because effectively the dose received is lower than expected. The blood level certainly goes up much sooner with the white ones because they are absorbed directly from the stomach whilst the coated ones take a couple of hours to be broken down and absorbed. I use the enteric coated -because the GP did that automatically as she has had patients with problems with the others. I take my double dose every second day and the effect lasts well over 36 hours - I'm very satisfied with how it works and hve no desire to change.

    This problem does seem to be more associated with the gut diseases such as Crohn's where the gut lining is damaged anyway. They are also more expensive - and the combination of the two factors has led to the idea of using just the non-coated tablets as they were claimed to demonstrate no more side-effects and be more reliably absorbed. Until the idea was put into practice and enough people who take them long term are having problems and are now willing to go back and say so. So we can have them if we want to and tell the doctor. Some people have no bother at all with the white ones - as you've seen from the other replies. I'd use them if I didn't, but I do seem to.


    • michele96336 michele96336 EileenH

      HI Eileen, was going to try the yoghurt and honey combonation i have no signs of tummy problems but just think it cant do any harm. what yoghurt is best, and the honey, manuka honey i think. have gone back to 20mg as was not managing on 16 gp suggested it ,said to stay on that dose for 3 weeks and then reduce by 1 mg every  3 weeks or try the reducing program sent to me . its been great knowing i am one of many its a great support.

    • MrsO-UK Surrey MrsO-UK Surrey michele96336

      Michele, I was unable to tolerate the usual tummy protection pills (PPIs) prescribed alongside the steroids as they had an adverse effect on my bowel.  Instead I ate a 'live' (probiotic) yoghurt on my muesli each morning plus a teaspoonful of Manuka honey either UMF10 or 15 (must have UMF on the jar - this guarantees its quality/unique antibacterial factor found in some Manuka honey).  The 'live' yoghurt I eat is Yeo Valley organic fat-free.  Although I had a high starting dose of 40mg of Pred, I didn't suffer any tummy problems throughout my time on steroids.

      I'm sorry to hear you've had to increase back to 20mg but your GP is wise to recommend just a 1mg reduction next time - some patients do have more success in reducing slowly by this tiny amount even at the high doses.  Good luck next time around.

    • michele96336 michele96336 EileenH

      Hi Eileen can you get hreartburn with  pred on holiday in Cornwall lots of lovely food wich I have never had heartburn with in the past but have had it is it ok to take Rennies this gets rid of it until I can get back from hols and see gp 

    • EileenH EileenH michele96336

      If you are eating more or richer food than you are used to it can often cause indigestion and if rennies or gaviscon deal with it I would think it is probably OK to wait until you get back to see the GP. The amount on your plate when eating out is always more than on your plate at home and if you finish it - that's enough to cause a problem.

      However - if  you get any pain or discomfort that doesn't improve with simple remedies don't necessarily dismiss it as heartburn. It is called heartburn because it resembles heart pain! And Zantac might be a better option - it is available OTC.

  • Lizzie Ellen Lizzie Ellen

    [color=darkred:46d167896f]Hi Gillybee.[/color:46d167896f] I've never had a problem with PPI's but decided a couple of months ago to try to ditch some of my armoury of medicines! I stopped taking Omeprazole and took the advice of lots of people on this site regarding eating a yogurt before taking the Pred. Works a treat. Couldn't lay my hands on a yogurt at the Hospital one day last week and by mid morning it felt as though a little rodent was nibbling at my insides :dragon: (couldn't find a rodent!!). Then I stopped taking the Alendronic Acid - bliss! I'm sticking with 3mgs just now and I haven't had any stomach problems apart from the yogurtless day. Hope everyone is enjoying the lovely weather.

    Love from [color=darkred:46d167896f]Lizzie Ellen [/color:46d167896f]xx

  • fiftiesgirl fiftiesgirl

    Have been using Manuka Honey 10+ for some years now and usually put a large spoonful in my porridge...... because of my OLP have not been able to do lemon and warm water first thing in the morning but now that I am on a high dose of steroids and my OLP is under control I could contemplate trying this alongside the honey and bio yogurt!

  • MrsO-UK Surrey MrsO-UK Surrey

    Hi fiftiesgirl

    I do hope you wont have any side effects from the uncoated 5mg tablets you have just been prescribed. I was always given the coated 5mg tablets and, being unable to take the stomach protectors, I would have protested if they had prescribed the uncoated ones anyway! :wink:

  • gwyn57 gwyn57 gillybee

    Hi im new here diagnosed with pmr few months ago,gosh im having terrible tummy problems,been sick had the runs and cramp in tummy.It started last week i have been eating a light diet but not helping much,olso i cant sleep still awake 5 am.

    Pred has helped the pain but i dont know how i can cope with the side affect,feel so

    rotten.I take omeprasole for tummy 40 mg a day,have tried taking one in morning and one at night not been much help.

    I am going to go see my Dr in hope he can help.I hope things settle down for you,

    Thinking of you.

    • MrsO-UK Surrey MrsO-UK Surrey gwyn57

      Gwyn, are you taking enteric coated Prednisolone?  If so, you may not need the Omeprazole unless you already had gastric problems before diagnosis.  I was prescribed Omeprazole alongside the steroids and had horrendous stomach problems almost immediately.  As soon as I stopped taking it, my tummy returned to normal.  I was tried on another PPI (Lansoprazole) but that also caused problems and was also stopped within a few days.  To protect my stomach from any possible steroid side effects, I decided to eat a 'live' (probiotic) yoghurt with my breakfast each morning, before taking the steroids.  It obviously acted as a good stomach liner because I never had any more problems throughout my years on steroids.

      Most of us find sleep difficult but once you are down to the lower steroid doses you should find sleep easier.  Meanwhile, ensure that you take the steroids early in the morning, and try and have catnaps during the day.

      I do hope you feel better soon.

    • EileenH EileenH gwyn57

      The most likely cause of the stomach problems is the omeprazole. Other PPIs can also cause similar problems so if you definitely need "stomach protection" as they call it ask your doctor for ranitidine (Zantac) which is a completely different drug and many gastroenterologists wonder why PPIs are so popular with GPs!

      I have never taken a PPI and have had no problems. Like MrsO I used yoghurt when I was on ordinary pred and the rest of the time I have had an enteric coated version - not broken down in the stomach so less need for antacid medication.

      Is it the diarrhoea or the pred that's keeping you awake? If it is the pred that will improve as the dose falls. In the meantime just try to rest when you can. Lots of people get up and read or do computer things and settle down for a sleep any time it fits.

    • Flutterbie57 Flutterbie57 gwyn57

      Hi Gwyn57, just wondering how you and your tummy problems are 1 year down the track ? After about 1 year on prednisone  I have now developed really unpleasant digestive problems I have severe reflux,stomach/intestinal cramping and runs and endless burping,  Like Mrs O I am worse on PPi's. I have yoghurt daily. I cannot have honeybecause of (lichen planus another auto immune disease). I have cut out so many foods trying to find the culprit. I do not know if my pred is coated or not - must find out. Have you found a solution to your gastric problems ?

    • EileenH EileenH Flutterbie57

      Don't be disappointed if you don't get a reply. Although all this thread says is "over a year ago" it must be more like nearly 4 years or more ago judging by the names who contributed to the discussion and me talking about mixing enteric coated and ordinary pred tablets, I haven't taken them for 5 years!

    • Mrs CJ Mrs CJ Flutterbie57

      Hi Flutterbie

      i too have acid reflux so it sounds like it's not as bad as yours. There have been quite a few posts offering ideas about this. If you look back on the topics there is one on silent acid reflux with lots of posts in the link within that topic and one today I think called stomach problems.....not sure how to look at topics and also not lose what I have written!

      i finally had improvement when I started putting my plain white Pred into gel capsules (my pharmacy sells them) and I've recently been experimenting with making green juice. I've read others are putting their Pred into enteric coated gel capsules and I plan to start that next - have to get some family visits completed before I try something new with my Pred. 

  • Yvonneau07 Yvonneau07 gillybee

    Hi I have been taking Steroids (Predlestone) for over two years, am now on 2 or three mg per day have been taking Zantac  before taking them, and up till now all OK but now I have indigeston and a queasy stomach, this morning I had yogurt instead of Zantac but still have the same symtoms. Any ideas....  Yvonne

    • EileenH EileenH Yvonneau07

      Has your supplier changed? Sometimes the fillers in the tablets are different - they can be implicated in upset stomachs too. And I'd combine all available options if I had problems, not one or the other.

    • EileenH EileenH Flutterbie57

      Yes - all tablets are made up of the active substance plus a load of other things to be able to form a tablet including colourings and stabilisers. Each company uses something a bit different and that can make quite a bit of difference to some people. 

      So if you have a tablet from a particular company that you find works well with few side effects but another isn't so good then it is worth trying to get your pharmacy to get the one that suits you. You have to get your doctor to write that on the prescription though - the name of the brand if that applies and that only this version should be dispensed. Sometimes if it is a generic you have to shop around to find a pharmacy that will get the one you need.

    • Flutterbie57 Flutterbie57 EileenH

      Thanks Eileen. The generic version of Losec did not work for me in the past, so I did check about them, but it never occurred to me that Prednisone could come from different places as well. I will discuss it with the Dr and Chemist. I have been through a horrible few months with entire digestive system, which has improved at the moment. No obvious reasons have been found as yet for the problems which did begin suddenly. I want to be prepared in case they ever return.

    • EileenH EileenH Flutterbie57

      Losec is a common cause of gastric problems all the way through - and it doesn't always start immediately. The same applies to other drugs with the potential - side effects can appear later on. It's one of the things keeping a diary can be helpful for - changes of medications/doses and changes in symptoms in a diary may show up a relationship.

      What other medications are you on?

    • Flutterbie57 Flutterbie57 EileenH

      I have got a bit lax with my diary over the last few months - big mistake ! I am taking Loxamine, Prednisone and Ranitidine (another ppi). I was taking a few other things like vit b, magnesium, vit d, but stopped all for a few weeks, including wine. I have reintroduced red this week and think it has passed the test. a good start.

    • EileenH EileenH Flutterbie57

      Ranitidine isn't a PPI, it's an H2 histamine receptor antagonist - it is a different mechanism although it produces the same effect as a PPI and has different, generally fewer side effects. That's just me being picky...

      So did you recently change from omeprazole to ranitidine?

    • Flutterbie57 Flutterbie57 EileenH

      I knew thatredface​ - I was going to say i suffer from pred brain as well, but you have an excellent memory, so maybe I shouldn't blame my vagueness on pred.biggrin  I had a second ppi inbetween, which upset me badly within half hour of taking it. I took it 6 times and had an immediate bad  reaction every time. I have been on Ranitidine for a few weeks. I got no relief for the first 2 weeks. I now have relief from an unexpected source (a French Osteo). I just couldn't understand why omeprazole had worked well for me for a long time, then major problems flared up.

    • EileenH EileenH Flutterbie57

      I did have horrible concentration and memory problems at the start of PMR and pred made it worse for a while. It has improved dramatically since being on Lodotra - whether it is just the prednisone rather than prednosolone or methylprednisolone or whether Lodotra really is associated with far fewer side effects I have no idea! It is good to be back to "normal" - or what passes as normal for me...

  • chrisforever chrisforever gillybee

    I don't really experience bowel problems while I'm taking Prednisilone, but I do, about a week after I stop.  I sometimes take 25mg a day for a five day course, and a few days after I cease, I get sudden stomach pain and diarrea.  Usually lasts a couple of hours and then I'm fine.  But it's very inconvenient.  It's preceded by extreme fatigue, headaches and poor concentration.  I've mentioned it to my doctor, but he says it can't be the cortisone.  I asked if I should wean off but he said there is no need to do that any more.  So, basically, my doctor doesn't believe it's related to the medication and yet it's very coincidental. 

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