which brand of mirtazapine works best

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I’ve been on Mirtazapine for about a year, take 45mg. It doesn’t seem to work as well as it first did. I also have epilepsy and take two med for it and had break through seizures recently. I can only afford the generics, the name brands cost $1300/mo. I looked through the web and found people complain about which generic manufactures people complained about and which ones they liked or non of the above compared to the real stuff. I’m going to my Dr. today and ask him to wrote down which generic manufacture I want me to take my prescription refill. Apparently all generics are not the same.

So the question is has anyone experienced or noticed the same thing with Mirtazapine manufactures. I haven’t kept track with which generic I’ve been taking. Currently the manufacture I am using is made by Aurobindo which I found out is made in India. People in the anti-seizure forums complained about India manufactures. I assume each generic also has to be different form other generics and India seems to be at the bottom of the list. Has anyone noticed who makes the generics you take and any difference?

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9 Replies

  • Posted

    Hi Steve,

    i take the generic on the mirt and have never taken the brand name so I can't compare the two. Since being on the generic I notice that I sometimes get a round redish pill and sometimes an oblongish one, and I have never noticed a difference but that's just me. It did kinda make me a little bit angry that my pharm would switch them up so often tho.

    i really hope you get this resolved as it could make a difference in your treatment.

     

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  • Posted

    Hi there.  I dont take Mirtazapine any more, but i do tale Zopiclone for sleeping.  I have noticed recently that chemists are dishing out generic brands as opposed to the original Sanofi brand i have had for many years and which were good.  The generics brands definitely do not work the same as i have recently discovered.  I think that probably goes for the Mirts as well. It all comes down to cost.
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  • Posted

    Im a chemist. I see these all the time. Generic or name brand ....ITS THE SAME ACTIVE INGREDIENT. THERE IS NO DIFFERENCE AT ALL. CHEMICALLY IT IS NOT POSSIBLE. Buy generic.
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    • Posted

      Well, how can it be that certain brands induce sleep (Mirtazapine) and others don't?  My first prescription worked wonders but subsequent scripts  were no good for sleep.  Unfortunately I didn't note the brand of the first prescription and have tried one after the other since but none make me sleepy 
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    • Posted

      Since posting this comment a year ago, I’ve looked up the main difference between generics and brand name meds. on the web. The main difference I found were the time release binders that hold and dispense the active med into the body. Although the patent on a drug runs out and generic makers are allowed make them, the patent on the time release binders never expires. Each generic maker has to develop their own time release binders. So even each generic drug manufacture have to develop time release binders that can’t be copied by another generic maker. Most of the time release binders made by generic manufactures seem to be inferior to the name brand. So one generic drug may release the active drug faster or slower vs another generic vs the brand name med. I also found out, that in the U.S., generic drug manufactures are given a latitude of containing +/- 20% of the active ingredient! Meaning the generic may contain a low of 80% to a high of 120% of the med.

      For my seizure drugs, the drug store would not honor the request of ordering the generic manufacture I requested. I found a drug store that carries the generic brand I wanted after doing a lot of research on the web of other people taking different generic anti-seizure meds. I switched ordering my meds to this drug store. I haven’t had any more auras since then.

      I live in the U.S. and our government FDA (Food and Drug Agency) started testing the quality of generic made drugs last year due to a high volume of complaints on meds. Generic seizure meds are near the top of the list to be tested. Most Dr’s, mine included, believe that there is no difference of any generic vs the name brand. They don’t take these drugs.

      I just got a new prescription refill of mirtazapine, 45 mg. The drug store switched generic makers. In the past, all of the pills were small. These pills are the size of a button. Only taken them for a few days but I’m falling asleep. Just to make sure these button size pills were actually mirtazapine, not a mistake by the pharmacy, I went to google and typed the in the name of the: manufacture (space) mirtazapine (space) 45mg (space) picture. The image and imprinted number showed up and matched. Seem to have a lot of fillers in this generic.

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    • Posted

      Thanks Steve for taking the trouble to come back.  Very interested in what you have said.  Indeed, the doctors don't take the drugs, therefore have no idea when it comes to the variable reactions regarding different brands.  I'm still at a loss as to what to do because I've now had three different brands since my first prescription, none of them induce sleep like the first brand, and as a consequence I'm struggling to rest at night.  Called the doctor and he said he was sorry to hear I was having this problem, and his solution was for me to take sleeping tablets as well!!!   I could kick myself for not keeping the box and making a note of the manufacturer.  Foolishly assumed I would automatically be given the same brand.  
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    • Posted

      Christine

      One more option you can try if you can recognize the picture of the box, you can also try googling mirtazapine (space) number of mg (15, 30, 45) (space) mg (space) package (space) pictures:

      Mirtazapine 30(whatever you take) mg package pictures.

      Maybe the package will be displayed and jar your memory. Hope that helps

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  • Posted

    Yes they all have the exact same ingredients .....the difference between the brand and generic comes down to quality control only...which means generics can be a little different ...hence the reduced price...
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    • Posted

      One med which doesn't matter the brand. I don't know why but with Lithium this does matter. I used to take Priadel and went to a different pharmacist where I was given a new brand. I had to return and ask for Priadel as previous. This is a reason for going to the same pharmacist. They will keep a record of your previous prescrips. If the GP makes a mistake or there is a query they will contact the surgery, or they will discuss it with you to ask you if there is a specific reason for the change.
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