- ongoing, recruitingHuman Pharmacology (Phase I)- Other
An open-label, crossover trial in otherwise healthy volunteers with allergic rhinitis to evaluate the relative bioavailability and hemodynamic effects of OX640 nasal epinephrine powder to a marketed epinephrine intramuscular injection
This study is testing a new nose spray for allergic reactions, comparing how well it puts medicine into the body compared to a standard injection. It's an early safety check in healthy people with hay fever to see how their bodies react.
Sweden - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Exploratory study to assess the pharmacokinetic interaction of doxepin with adrenaline after a concomitant co-administration using the Anapen® device and to compare the adrenaline comparative bioavailability with Anapen®500 commercial form in healthy normal weight male subjects
This study looks at how adrenaline, given through an Anapen device, works in the body when taken at the same time as another medicine called doxepin. Researchers want to compare a new Anapen device with one already available.
France - recruiting
Acquisition and Long-term Observation of Patients With Severe Allergic Reactions
This study is gathering information from people who have had severe allergic reactions (anaphylaxis). Researchers hope to learn more about what causes these reactions and how best to manage them, with the goal of improving diagnosis and care for patients in the future.
Germany - enrolling by invitationPHASE1, PHASE2
Comparative PK/PD of FMXIN002 and EpiPen, in Healthy Adults With Allergic Rhinitis
This study compares a new nasal powder (FMXIN002) to the EpiPen for treating severe allergic reactions. We're testing how the body handles the new medicine and how well it works in healthy adults with hay fever, checking different doses and nasal conditions.
Canada - active not recruiting
Canadian Anaphylaxis Network- Predicting Recurrence After Emergency Presentation for Allergic REaction
This study looks at how to predict if children who have a severe allergic reaction (anaphylaxis) need to stay in the hospital for a long time. It aims to develop a tool to help doctors decide who might have a second reaction, to improve care.
Canada - recruitingPHASE1
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral Challenges
This study looks at how an inhaled form of adrenaline (epinephrine) works to treat serious allergic reactions during allergy tests or treatments. It aims to help people who might not be able to join another ongoing study. We want to see if it's a helpful option.
Canada