- active not recruitingPHASE2
Chemotherapy-free Trastuzumab and Pertuzumab in HER2-positive Breast Cancer: FDG-PET Response-adapted Strategy.
This study looks at new ways to treat a type of breast cancer called HER2-positive. We're testing if using special drugs (Herceptin and Perjeta) without chemotherapy first can shrink tumours effectively. We're also checking if scans can predict how well treatments work.
Belgium · France · Germany - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - completed
Availability of free door-to-door transport to increase the attendance of breast screening appointments in Yorkshire
This study in Yorkshire looks at whether offering free transport to breast screening appointments helps more women attend. The goal is to catch breast cancer earlier and improve chances of recovery. It involves women aged 50-70 and compares those offered transport to those who aren’t.
United Kingdom · England - active not recruitingPHASE1
To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer
This study looks at a new drug, Inavolisib, for people with solid tumours or breast cancer, focusing on safety and how the body handles it. It's an early-stage study, checking if the drug works alone or with other common cancer treatments.
United States · Canada · France - recruitingPHASE1, PHASE2
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
This study is testing a new medicine called AZD8205, by itself or with other cancer drugs. It's for people with advanced cancers like breast, ovarian, or lung cancer, to see if it's safe and helps shrink tumours.
United States · Australia · Belgium - active not recruiting
Cancer Surveillance and Support
This study helps people who have had breast or bowel cancer after their treatment. It looks at using an online system for survivors to report health changes from home and get quick advice. The goal is better support and faster help when needed.
United Kingdom - recruiting
Can we safely reduce the number of days of radiotherapy needed to treat people with breast cancer who need boost treatment?
This study looks at whether we can safely give breast cancer patients who need an extra 'boost' of radiotherapy a shorter 5-day treatment instead of the usual 15 days. It compares two different 5-day boost doses with the standard 15-day boost.
United Kingdom · England · Northern Ireland - recruitingPHASE3
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
This study is testing a new drug, Elacestrant, against standard hormone treatments for early breast cancer. It's for men and women whose cancer is ER-positive and HER2-negative, and has a high chance of coming back. The aim is to see if Elacestrant works better.
United States · Argentina · Australia - not yet recruitingNA
EQUITA - A Feasibility Trial of a Faith-placed Intervention to Increase Screening Uptake in Black Adults
This study looks at how faith groups can help Black adults get important cancer and aneurysm screenings. It's a small trial in the North East, Leeds, and Scotland to see if this approach works and is well-received before a larger study.
United Kingdom - active not recruitingPHASE1, PHASE2
Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer
This study looks at new drug combinations for advanced ER+ breast cancer in women aged 18-100. It tests LEE011 and BYL719 with letrozole to find safe and effective doses, hoping to improve treatment for this type of cancer.
United States · Australia · France - active not recruitingPHASE1
DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer
This study looks at a new combination treatment for advanced breast cancer or a type of lung cancer. It combines two drugs, Trastuzumab deruxtecan and Pembrolizumab, to see if they are safe and effective together.
United States · France · Spain - active not recruitingPHASE1, PHASE2
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.
United States · Australia · Canada - recruiting
Prospective Evaluation of AI R&D Tool for Patient Stratification - MoA Evaluation in Triple Negative Breast Cancer (PEAR-MET)
This study is testing a new tool for people with advanced triple-negative breast cancer. It uses a small sample of your tumour to see how it might react to different treatments. This helps researchers understand how to better choose treatments in the future, aiming to improve care for patients.
United Kingdom - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom - authorisedTherapeutic use (Phase IV)
ENDO-67 project: Investigating ENDOcrine therapy-related questions using Ki67 changes in the window-of-opportunity before breast surgery
This study is looking at how a common breast cancer drug, tamoxifen, works in the body. Researchers want to understand if different levels of a substance called endoxifen affect a patient's response to tamoxifen treatment before surgery, using a marker called Ki67.
Netherlands - active not recruitingPHASE2
Study of Neoadjuvant Olaparib Monotherapy and Olaparib and Durvalumab Combination in HER2 Negative BRCAm Breast Cancer
This study looks at new treatments for a specific type of breast cancer with a BRCA gene change. It tests olaparib, alone or with durvalumab, before surgery. The aim is to find better ways to treat this cancer and reduce the need for strong chemotherapy.
United States · Australia · Austria - recruitingPHASE2
To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer
This study is looking at a new combination of medicines, Inavolisib and Fulvestrant, for people with a specific type of advanced breast cancer. It aims to see how well this combination works and if it's safe after other treatments haven't worked.
United States · Argentina · Australia - authorisedPhase I and Phase II (Integrated)- First administration to humans
SPRAYDYE-Trial - A phase I/II study to assess the efficacy, safety and tolerability of topically applied 6qc-ICG, a cathepsin-activatable fluorescent probe, for real-time intraoperative resection margin assessment in breast conserving surgery
This study looks at a special dye for breast cancer surgery. It's designed to help surgeons see cancer cells more clearly during an operation, aiming to ensure all cancer is removed and reduce the need for more surgery later.
Netherlands - recruitingPHASE2
KORTUC Phase II - Intra-tumoural Radiation Sensitizer in Patients With Locally Advanced/Recurrent Breast Cancer
This study is testing if a very diluted version of a common chemical, hydrogen peroxide, can make radiotherapy work better for large breast cancer lumps. It involves injecting this special gel into the cancer twice a week during a standard course of radiotherapy. Early results from Japan have been promising.
India · United Kingdom - authorisedTherapeutic exploratory (Phase II)
A multicentre, prospective, open-label study with [68Ga]Ga-ABY-025 PET-imaging to characterize HER2-expression and explore the therapy-predictive value for HER2-antibody drug conjugates in patients with metastatic breast cancer (HER2-Ex PET)
This study looks at a new special scan for breast cancer to see how HER2 protein levels affect treatment. It uses a new drug called Enhertu to treat metastatic breast cancer and aims to find out if the scan can predict how well the treatment will work.
Sweden - active not recruitingPHASE3
A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer
This study looks at a new combination of medicines for postmenopausal women with a certain type of breast cancer. It tests if abemaciclib with standard hormone therapy works better than hormone therapy alone.
United States · Australia · Austria - recruitingPHASE1, PHASE2
A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.
This study is for people with advanced breast cancer that has grown despite previous treatments. It tests a new combination of targeted radiation therapy and chemotherapy to see if it can stop cancer growth and if it's safe. We're looking at different doses to find the best way to use these treatments.
United States · Australia · Canada - recruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
This study is looking at new combinations of medicines for advanced lung or breast cancer. We want to see if they are safe, how much medicine gets into the body, and if they show early signs of working. It's for adults with certain types of advanced cancer.
United States · Australia · Canada - ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1b/2 Open-Label Study of Samuraciclib in Combination with Elacestrant in Participants with Metastatic or Locally Advanced Hormone-Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer
This study looks at combining two drugs, samuraciclib and elacestrant, for people with advanced breast cancer. It aims to find the best dose and see how well the combination works and if it's safe.
France · Spain - recruitingNA
Biological Matrices Versus Synthetic Meshes
This study looks at two types of mesh used in breast reconstruction after cancer surgery: natural (biological) and man-made (synthetic). It aims to see if patients and doctors are comfortable with not choosing which mesh they get, and to check their long-term safety and how happy people are with the results.
United Kingdom - recruitingPHASE4
A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies
This study looks into why some breast cancers stop responding to treatment. We will examine tissue and blood samples from patients with specific types of breast cancer to understand how the cancer becomes resistant and find new ways to help them.
Belgium · Denmark · Finland - authorisedTherapeutic confirmatory (Phase III)
Assessing Oxytocin's Role in Mitigating Psychosocial Stress in Breast Cancer Survivors
This study looks at whether a nasal spray with a natural hormone called oxytocin can help women who have had breast cancer feel less stressed, anxious, and sad. Researchers will compare it to a dummy spray.
Belgium - active not recruitingPHASE1
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
This early-stage study is testing a new drug, MOMA-313, for advanced solid tumours, including prostate, breast, and pancreatic cancers. It aims to find a safe dose and see how it works, either alone or with another drug called Olaparib, in patients whose tumours have a specific genetic weakness.
United States · Spain · United Kingdom - active not recruiting
The OPBC-07/microNAC Study
This study looks at whether it's safe to skip a full lymph node removal surgery in breast cancer patients who have only tiny traces of cancer left in their armpit lymph nodes after chemotherapy. It checks how these patients have fared over time.
United States · Argentina · Australia - authorisedPhase I and Phase II (Integrated)- Other
Tumour heterogeneity studies based on dedicated breast PET using proliferation radiotracers: early detection of the treatment response.
This study is looking for better ways to spot early signs if breast cancer treatment is working. It uses a special advanced scan called a PET scan, specifically designed for the breast, to see how fast cancer cells are growing.
Spain - ongoing, recruitingTherapeutic confirmatory (Phase III)
A–BRAVE-Trial. ADJUVANT TREATMENT FOR HIGH-RISK TRIPLE NEGATIVE BREAST CANCER PATIENTS WITH THE ANTI-PD-L1 ANTIBODY AVELUMAB: A PHASE III RANDOMIZED TRIAL
This study is looking at a new treatment called Bavencio for a specific type of breast cancer (triple negative). It's a large study to see if adding Bavencio after initial treatment can help people live longer without their cancer coming back.
Italy - active not recruitingPHASE1, PHASE2
Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer
This study is testing a new drug called elacestrant with other breast cancer medicines. It's for people with a specific type of advanced breast cancer that has spread. The main goals are to see if these drug combinations are safe and if they can help shrink the cancer.
United States · Argentina · Australia - active not recruitingPHASE1
A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors
This study is looking into a new medicine, LOXO-783, for breast cancer and other solid tumours with a specific gene change (PIK3CA). It aims to understand if the medicine is safe, what side effects it has, and how well it works.
United States · Australia · Belgium - ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase I/II study to determine the safety and efficacy of Ribociclib in combination with hormone therapy and hypofractionated radiotherapy in breast cancer, with positive hormone receptors and negative HER2 status, in newly diagnosed, not immediately operable (or wishing to avoid surgery), elderly patient
This study looks at a new way to treat specific breast cancers in older women. It combines a drug called Kisqali with hormone therapy and focused radiotherapy. We want to see if this treatment is safe and effective, especially for patients who can't have or prefer to avoid surgery.
France - active not recruitingPHASE2, PHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer
This study looks at a new drug, Inavolisib, combined with standard treatments (Palbociclib and Fulvestrant) for a specific type of advanced breast cancer. It compares this new combination to the standard treatments alone, checking how well it works and if it's safe.
United States · Argentina · Australia - active not recruitingPHASE2
Study of Zelenectide Pevedotin in Participants With Advanced Breast Cancer
This study looks at a new drug, zelenectide pevedotin, for advanced breast cancer. It's for people whose cancer has a specific marker called NECTIN4. The study aims to see how well it works and if it's safe for different types of breast cancer.
United States · Australia · Belgium - recruitingNA
Laser Speckle Imaging During Breast Reconstruction
This study looks at a new way to check blood flow during breast reconstruction surgery. It aims to see if a special camera, which doesn’t touch the skin, can help surgeons make better choices and reduce healing problems for women after breast cancer surgery.
United Kingdom - active not recruitingPHASE2
Artificial Intelligence Supporting CAncer Patients Across Europe - the ASCAPE Project
This study uses AI to improve life quality for breast and prostate cancer patients across Europe. It aims to create personalised predictions about challenges patients might face and suggest ways doctors can help, using smart technology and data.
Greece · Spain · Sweden - authorisedTherapeutic confirmatory (Phase III)
A randomized phase III study comparing trastuzumab, pertuzumab plus docetaxel (TPD) followed by 3 cycles of chemotherapy to the current standard regimen as the treatments of early HER2-positive breast cancer
This study looks at a new way to treat early breast cancer that is HER2-positive. It compares a combination of medicines (trastuzumab, pertuzumab, and docetaxel) to the usual treatment to see which is better at preventing the cancer from coming back.
Sweden · Finland - ongoing, recruitingTherapeutic use (Phase IV)
FUnctional selection of advanced breast cancer patients for Talazoparib treatment Using the REpair Capacity (RECAP) test: The FUTURE trial
This study looks at a new test, RECAP, to see if it can predict how well a breast cancer treatment called Talzenna (talazoparib) will work. It focuses on people with advanced breast cancer to find out if the treatment can keep the cancer from growing for at least four months.
Netherlands - recruitingNA
Physical Exercise During Preoperative Chemotherapy for Breast Cancer
This study looks at whether regular exercise during chemotherapy for breast cancer can help the treatment work better. It aims to see if exercise helps clear the cancer completely and if it improves patients' well-being during treatment and recovery.
Australia · Finland · Sweden - active not recruitingPHASE3
Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease
This study is looking at a new drug, PF-07220060, combined with letrozole for advanced breast cancer. It compares this new treatment to existing approved therapies to see if it's safe and works well for people whose cancer needs hormones to grow.
United States · Argentina · Australia - active not recruiting
The EMBRACE Study The EMBRACE Study
This study looks at how breast cancer chemotherapy affects the heart. Some treatments can weaken the heart. Researchers want to find out if changes in the heart's energy happen before any damage, so they can find ways to protect it early.
United Kingdom - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - active not recruitingPHASE3
Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer
This study looks at a drug called Olaparib for people in the UK with a specific type of breast cancer linked to a BRCA gene change. It aims to see if Olaparib, given after standard treatments, can help prevent the cancer from coming back.
United States · Argentina · Australia - not yet recruiting
Breast Tumour Size Measurement by Field Cycling Imaging
This study looks at a new type of MRI scan called Field-Cycling Imaging (FCI) to see if it can accurately measure the size of a specific type of breast cancer (DCIS). We want to know if FCI is better than standard methods for sizing these tumours before surgery.
United Kingdom - recruiting
Oncologic, Cosmetic and Patient Reported Outcomes in Value-Based Breast Surgery (OnCoPRO Value)
This study looks at breast cancer surgery to improve results for patients. It focuses on how different surgical methods affect cancer outcomes, appearance, and quality of life for women needing breast preservation, aiming for better, more personalised care.
Australia · Sweden · United Kingdom - active not recruitingPHASE2
Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions)
This study looks at a drug called entrectinib for different types of advanced cancer. It focuses on cancers with specific genetic changes (NTRK, ROS1, or ALK gene fusions). Researchers want to see if entrectinib can help treat these cancers.
United States · Australia · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study with ABBV-155 Alone and in Combination with Taxane Therapy in Adults with Relapsed and/or Refractory Solid Tumors
This study is testing a new medicine, ABBV-155, by itself and with other cancer drugs called taxanes. It's for adults with certain cancers like lung or breast cancer that have come back or not responded to previous treatments.
Netherlands