- recruitingPHASE2
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
This study looks at a medicine called atezolizumab for different cancers. We want to see if a special test of your cancer cells can predict if the medicine will work well for you. This helps us learn more about tailoring treatments.
Canada - active not recruiting
NOSTRA-Feasibility Study: A Study Looking at Ultrasound Guided Biopsies for Breast Cancer
This study looks into whether we can use special ultrasound-guided biopsies to check for breast cancer cells after treatment. The aim is to see if some patients might be able to avoid surgery if their cancer has responded well to chemotherapy and targeted drugs.
United Kingdom - active not recruitingPHASE1, PHASE2
A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.
This study is testing two new medicines, vepdegestrant and PF-07220060, for advanced breast cancer that has spread and isn't responding to previous treatments. Researchers want to see if the combination is safe and effective.
United States · Belgium · Canada - recruiting
LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study
This study looks at how new cancer treatments affect daily life for people with long-term cancer. It aims to understand how to best support them while they are on these treatments, often for many months or years.
Canada - active not recruitingNA
POSNOC - A Trial Looking at Axillary Treatment in Early Breast Cancer
This study, called POSNOC, looks at whether women with early breast cancer and a small number of affected lymph nodes can skip extra armpit surgery or radiotherapy, and just have standard drug treatment. We want to see if this is just as effective.
Australia · New Zealand · United Kingdom - recruitingNA
Predictive Toxicity Test Linked to Radiotherapy After Mastectomy and Immediate Implant Reconstruction
This study looks at a new test called NovaGray RILA Breast®. It aims to predict how radiotherapy after breast removal surgery might affect women who have an immediate implant reconstruction. This could help doctors plan treatment better.
France - recruitingNA
Prevention of Postoperative Complications by Negative Pressure Therapy After Complex Breast Cancer Surgery
This study looks into whether a special type of dressing, called negative pressure therapy, can help prevent problems after breast cancer surgery. It's especially for women having complex surgery, like reconstruction. The aim is to see if this dressing reduces complications and helps with healing.
France - recruitingPHASE3
A Study of Dato-DXd in Inoperable or Metastatic Hormone Receptor-positive, HER2 IHC 0 Breast Cancer
This study looks at a new drug, Dato-DXd, for advanced breast cancer that's hormone-sensitive but doesn't respond to usual treatments. It aims to see how well it works and if it's safe for patients before they start chemotherapy.
United States · China · France - active not recruitingNA
Functional Evaluation After Breast Reconstruction With a Minimally Invasive Latissimus Dorsi Flap Following Radical Surgery for Breast Cancer.
This study looks at how well a specific back muscle works after breast reconstruction surgery in women who've had breast cancer. We want to see how movement in the arm and shoulder changes over time after the operation.
France - recruiting
Chemotherapy Induced Cognitive Impairment
This study looks into 'chemo fog' (memory/thinking problems after chemotherapy for breast cancer). Researchers want to understand why it happens, possibly due to brain inflammation, so they can find ways to help patients in the future.
United Kingdom - recruiting
Predicting Breast Cancer With the BRAVE System
This study is testing a new, gentler way to find breast cancer called the BRAVE method. It uses a special bra to check breast stiffness, which might show if cancer is present, without X-rays or squashing the breast. It aims to be better for women, especially those with dense breasts.
Canada - active not recruitingPHASE2
CFI-400945 in Patients With Advanced/Metastatic Breast Cancer
This study is testing a new drug, CFI-400945, for advanced breast cancer in women. It's for patients who have already had chemotherapy, and researchers want to see if this new drug can help slow down cancer growth or shrink tumours.
Canada - recruitingNA
Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts
This study looks at new ways to check for breast cancer in women with dense breasts. We're comparing two types of scans, CESM and DBT, to see which one finds more cancers with fewer false alarms.
United States · Canada - recruitingPHASE3
Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer
This study compares two drug combinations, RLY-2608 with fulvestrant, and capivasertib with fulvestrant, for advanced breast cancer that has a specific gene change (PIK3CA mutation) and has grown after previous treatment. It's for HR+/HER2- breast cancer.
United States · Argentina · Australia - not yet recruiting
Three-Dimensional Ultrasound Imaging and Spectroscopy for Characterizing Breast Masses
This study uses special ultrasound scans to get a clearer picture of breast lumps. Researchers want to see if this new ultrasound method can accurately tell the difference between cancerous and non-cancerous lumps without needing invasive procedures. It's about finding better ways to understand breast changes.
Canada - recruitingNA
Positron Emission Mammography and Liquid Biopsy in Women With High-risk Breast Screenings
This study looks at new ways to check for breast cancer in women at higher risk. It uses a special blood test (Liquid Biopsy) and a detailed scan (PEM) to see if they can help doctors find changes in the breast more clearly and potentially reduce the need for unnecessary biopsies.
Canada - active not recruitingPHASE3
Trastuzumab Deruxtecan (DS-8201a) Versus Investigator's Choice for HER2-low Breast Cancer That Has Spread or Cannot be Surgically Removed [DESTINY-Breast04]
This study compares a new breast cancer drug, trastuzumab deruxtecan, with standard treatments. It's for people with HER2-low breast cancer that has spread or can't be removed by surgery and who have already had other treatments.
United States · Austria · Belgium - active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)
This study looks at a new drug, pembrolizumab, for early-stage breast cancer. It's for people with a specific type of breast cancer (ER+/HER2-). Researchers want to see if adding pembrolizumab to standard chemotherapy and hormone therapy works better than standard treatment alone.
United States · Australia · Belgium - recruitingPHASE2
A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer
This study is looking at a new combination of medicines for advanced breast cancer that has stopped responding to hormone therapy. It aims to see if combining inavolisib with ribociclib and fulvestrant works better than the current treatment.
United States · Argentina · Brazil - active not recruiting
Contrast-Free Magnetic Resonance Imaging for Breast Disease
This study is exploring a new MRI scan for breast problems that doesn't need a special dye. It aims to find breast changes in women, especially those with dense breasts, without using traditional contrast agents.
United Kingdom - recruiting
An Investigation Into Dielectric Assessment of Permittivity and Conductivity in Human Using a Novel Electrical Capacitance Tomography Scanner
This study uses a new Z-scanner to check for breast cancer and other breast conditions. It aims to see if the scanner can tell the difference between healthy, harmless, and cancerous breast tissue by measuring electrical properties. This might help improve early detection methods.
United Kingdom - not yet recruitingNA
Breast Cancer Plasma Adjuvant Intra-operative Treatment (Breast Cancer PAINT)
This study looks at a new treatment for breast cancer called non-thermal plasma (NTP). Doctors want to see if applying NTP to the area where a tumour was removed is safe, how much to use, and if it helps prevent the cancer from coming back or affects how the breast looks.
Canada - recruiting
Clinical Database of Safe Personalized Adjuvant Breast Radiotherapy Based on Individual Radiosensitivity
This study is looking at how to give breast cancer radiotherapy in a more personal way. It uses a special test to predict side effects, aiming to reduce problems like skin changes, while still treating the cancer effectively, especially for older women with certain types of breast cancer.
France - recruiting
Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!)
This study, called 'NIP IT!', aims to find tiny traces of cancer in patients who have finished their main treatment. We hope to use new technology and AI to spot cancer coming back very early, even before scans can see it. The goal is to help more people stay cancer-free for longer.
Canada - active not recruiting
Identification and Evaluation of Patients at Risk of Developing Cardiotoxicity After Receiving Chemotherapy for Breast Cancer, Lymphoma or Leukemia
This study looks at how chemotherapy for breast cancer, lymphoma, or leukaemia can sometimes affect the heart. Researchers want to find out who might be at risk and why, by checking heart health before, during, and after treatment.
Canada - recruitingPHASE1
MRI-Guided Ultrasound Stimulated Microbubbles Radiation Treatment for Patients with Chest-Wall and Locally Advanced Breast Cancer
This study is exploring a new way to treat breast cancer using special ultrasound technology and microbubbles alongside standard radiation. It focuses on chest-wall and advanced breast cancer to see if this combined approach can make radiation work even better.
Canada - recruiting
Feasibility Study to Evaluate the Use of Patient Reported Complications After Digital Consent
This study looks at how well breast cancer patients report their recovery and any problems after surgery, using an online form. It aims to see if this information can help improve how we talk about surgery risks and future patient care.
United Kingdom - active not recruitingPHASE3
A Study of Dato-DXd Versus Investigator's Choice Chemotherapy in Patients With Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer, Who Are Not Candidates for PD-1/PD-L1 Inhibitor Therapy (TROPION-Breast02)
This study is looking at a new medicine called Dato-DXd for advanced triple-negative breast cancer. It compares Dato-DXd with standard chemotherapy in patients who cannot have a specific type of immunotherapy. The aim is to see if Dato-DXd is better at shrinking tumours and helping people live longer.
United States · Argentina · Belgium - active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
This study looks at two drug combinations, inavolisib with fulvestrant, and alpelisib with fulvestrant, for advanced breast cancer that has specific genetic changes and has already been treated with certain therapies. It aims to see which combination works better and is safer.
United States · Argentina · Australia - recruiting
Audit of Targeted Sentinel Node Biopsy (TSNB) in Patients With Limited Nodal Disease Undergoing Primary Surgery
This study looks at a new way to remove lymph nodes in breast cancer surgery, called Targeted Sentinel Node Biopsy (TSNB). It helps doctors decide if extra treatment like more surgery or radiotherapy is needed, aiming to reduce side effects.
United Kingdom - not yet recruitingNA
JUdicious Surveillance for Trastuzumab Induced Cardiotoxicity in the First Year
This study looks at new ways to check the heart health of breast cancer patients. It aims to reduce how often patients need heart tests while making sure they still get safe and effective cancer treatment, helping them feel better and avoid unnecessary worry.
Canada - active not recruitingPHASE3
A Study of T-DXd in Participants With or Without Brain Metastasis Who Have Previously Treated Advanced or Metastatic HER2 Positive Breast Cancer
This study looks at a new treatment, Trastuzumab Deruxtecan (T-DXd), for advanced or metastatic HER2-positive breast cancer that has already been treated. It includes patients with or without brain metastases to see how safe and effective the treatment is.
United States · Australia · Belgium - recruitingNA
Development of Clinical and Biological Database
This study creates a vital collection of patient information and tissue samples from people with certain cancers. It helps scientists understand cancer better, find new ways to prevent and treat it, and improve care by making this information available for important research.
France - enrolling by invitation
Pharmacogenomic and Circulating Biomarkers for CDK4/6 Inhibitors
This study aims to understand why anti-cancer drugs called kinase inhibitors have different side effects in people. By looking at genes and blood markers, researchers hope to predict who might have unwanted reactions or not respond well to treatment, especially for breast cancer.
Canada - recruiting
FREDO-ODX Study: FREnch Data on Outcomes in HR+/HER2- Early Breast Cancer Patients With oncotypeDX Recurrence Score-guided Therapy
This study looks at how well a test called Oncotype DX helps guide treatment for early breast cancer in women in France. It focuses on a specific type of breast cancer to see how patients respond to treatments chosen using the test.
France - recruitingNA
Evaluation of the Impact of Taking American Ginseng for 8 Weeks on Fatigue in Patients Treated for Localized Breast or Gynecological Cancer
This study looks at whether a supplement called Qiseng, made from American ginseng and vitamin C, can help reduce tiredness in women who have had treatment for breast or gynaecological cancer. It's a randomised trial comparing Qiseng to a dummy pill.
France - recruitingPHASE1, PHASE2
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
This study is looking at new treatments for advanced breast cancer. It tests a new drug called GDC-4198, alone or with giredestrant, and compares it to another combination (abemaciclib + giredestrant). The aim is to find safer and more effective ways to treat this type of cancer.
United States · Australia · Brazil - active not recruiting
A Study of Tumor Imaging With Multispectral Optoacoustic Tomography
This study looks at a new imaging method, called Multispectral Optoacoustic Tomography (MSOT), for breast cancer and melanoma. We want to see how well MSOT images breasts right before a biopsy, to help doctors get a clearer picture of suspicious areas.
United States · Germany - active not recruitingPHASE3
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
This study looks at whether taking aspirin daily after cancer treatment can stop cancer coming back and help people live longer. It focuses on common cancers like breast, bowel, and prostate cancer.
Ireland · United Kingdom - recruitingPHASE2
Genomic and Transcriptomic Predictors of Sequential SG Sensitivity After T-DXd in ER+/HER2-Low Metastatic Breast Cancer
This study looks at how well a new treatment called sacituzumab govitecan (SG) works for advanced breast cancer after another treatment (T-DXd) has been used. We want to find clues in tumour samples to see who might benefit most from SG.
Canada - recruitingNA
Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery
This study compares two ways to treat lymph nodes in breast cancer: standard surgery or a newer surgery combined with radiotherapy. It aims to see which method leads to better arm comfort and fewer swelling problems two years later.
United States · Austria · Canada - active not recruitingNA
Single Pre-Operative Radiation Therapy - With Delayed Surgery for Low Risk Breast Cancer
This study is looking at a new way to treat early-stage breast cancer in women aged 65 and over. It's testing if a single dose of radiation therapy before surgery, given three months earlier, is safe and effective for certain low-risk breast tumours.
Canada - recruitingNA
Sodium-glucose Transporter Type 2 Inhibition in Anthracycline-related Cardiotoxicity
This study looks at whether a drug called dapagliflozin can protect the heart of breast cancer patients receiving certain chemotherapy. This chemotherapy can sometimes cause heart damage, and researchers want to see if this new drug can reduce that risk.
United Kingdom - active not recruitingPHASE1, PHASE2
TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B)
This study looks at a new medicine, vepdegestrant (also called ARV-471), with ribociclib for advanced breast cancer. It's for cancer that has spread, is hormone-sensitive, and isn't responding to past treatments. The goal is to see if it's safe and effective.
United States · Canada · Italy - not yet recruitingNA
BreastCancerPEP: A Six-Month Online Empowerment Program to Improve Mental and Physical Health in Women With Breast Cancer
This study is testing an online program for women with newly diagnosed breast cancer. It offers videos and support for exercise, stress relief, and healthy living, aiming to improve mental and physical well-being compared to standard care.
Canada - active not recruitingPHASE1
A Study of Abemaciclib (LY2835219) in Participants With Non-Small Cell Lung Cancer or Breast Cancer
This study looks at a new combination of medicines, abemaciclib and pembrolizumab, for people with advanced non-small cell lung cancer or a specific type of breast cancer. It aims to see how safe and effective these treatments are together.
United States · Belgium · France - recruiting
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
The SHERLOCK study aims to find tiny bits of cancer DNA in your blood after treatment. This helps doctors spot if cancer might return early, hoping to improve long-term health. We're looking for new ways to track different types of cancer.
Canada - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - active not recruitingPHASE3
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
This study looks at a drug called abemaciclib, given with standard hormone therapy after surgery for a type of breast cancer. We want to see if it's safe and helps stop the cancer coming back in people with certain high-risk breast cancers.
United States · Argentina · Australia - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium