- recruitingPHASE2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.
United States · Australia · Canada - recruitingPHASE3
Neoadjuvant Chemotherapy for Obstructive Colon cancER First Treated by cOlostomy
This study looks at giving chemotherapy to people with a type of colon cancer that's causing a blockage, before they have surgery. It aims to see if this helps them get the best possible treatment and recovery, by potentially shrinking the tumour and dealing with tiny cancer cells.
France - not yet recruitingPHASE2
Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer
This study is testing two medicines, Pembrolizumab and Porustobart, for a common type of colon cancer before surgery. The aim is to see if these medicines help the immune system fight the cancer and how safe they are. It’s for adults whose cancer can be removed by surgery and hasn’t spread.
United States · Belgium · Italy - active not recruitingPHASE1, PHASE2
Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS
This study is testing a new injection, IP-001, after a heat treatment called thermal ablation for certain advanced cancers (bowel, lung, soft tissue sarcoma) that haven't responded to previous treatments. It aims to see if it's safe and effective, potentially offering a new treatment option.
United States · France · Germany - authorisedTherapeutic exploratory (Phase II)
LEAn Body Mass Normalization of OXaliplatin Based Chemotherapy
This study is looking into a new way to give chemotherapy for colon cancer. It's called LEAn Body Mass Normalization of OXaliplatin Based Chemotherapy. The study aims to see if adjusting how much medicine is given based on a person's lean body mass (muscle and bones, not fat) can improve treatment.
France - authorisedTherapeutic exploratory (Phase II)
Effect of perioperative intravenous infusion of lidocaine on the postoperative course and the immune response in patients undergoing surgery for colon cancer - the PILDI study
This study is looking at whether giving a common pain medication called lidocaine through a drip during colon cancer surgery can help reduce strong painkiller use afterwards. Researchers want to see if lidocaine can help patients recover better and need less opioid medication.
Slovenia - recruitingNA
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.
Belgium · France · Germany - active not recruitingPHASE1, PHASE2
A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)
This study looks at a new drug, selpercatinib, for advanced cancers, including certain lung, thyroid, and other solid tumours that have a specific genetic change called a RET alteration. Researchers want to check its safety, how it works in the body, and if it helps shrink tumours.
United States · Australia · Canada - recruiting
Advanced Pelvic Surgical Oncology Database - Prospective Observational Study
This study looks at people in Glasgow having complex surgery for cancers in the tummy and pelvis, like bowel or gynaecological cancers. We're observing their recovery and health over time to understand common problems and improve future care.
United Kingdom - recruitingNA
A Clinico-biological Database in Cachexia in Patients With Colon Cancer
This study is gathering information and samples from patients with colon cancer to better understand severe weight loss (cachexia). The goal is to improve how we care for patients with colon cancer and this weight loss, leading to better treatments in the future.
France - active not recruitingPHASE3
EPA for Metastasis Trial 2
This study looks at whether a fish oil supplement (EPA) can help prevent bowel cancer spread returning in the liver after surgery. Patients get either the supplement or a dummy pill to see if it helps them stay cancer-free for longer.
United Kingdom - recruitingNA
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
This study looks at a new digital tool called GA-Mainstream. It helps people with certain cancers like breast, ovarian, and colon cancer understand genetic testing better. The goal is to make sure patients feel informed and supported while getting tested for genes that can affect their cancer treatment.
Canada - recruiting
Response Prediction of Hyperthermic Intraperitoneal Chemotherapy in Gastro- Intestinal Cancer
This study looks at stomach or bowel cancer that has spread to the tummy lining. Doctors take a small piece of your tumour during surgery. They grow it in the lab to test which treatments, like chemotherapy, might work best for you. This helps personalise future care.
Germany - recruiting
Cancer Loyalty Card Study 2 (CLOCS-2)
This study looks at shopping habits using loyalty card data from Tesco or Boots to see if certain purchases might hint at cancer earlier. It aims to help doctors diagnose pancreatic, bowel, oesophageal, stomach, liver, bladder, womb, vulval, and ovarian cancers sooner.
United Kingdom