Advanced/Metastatic Solid Tumors research hub
48 indexed studies · 31 currently recruiting
- recruitingPHASE1
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
This study is looking at a new medicine called PF-08046876 for people with advanced cancers like bladder, lung, head & neck, oesophageal, or pancreatic cancer. It checks how safe the medicine is and how well it works. The medicine is given through a drip.
United States · Canada · Puerto Rico - active not recruitingPHASE2
Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)
This study looks at a new drug, evorpacept, combined with pembrolizumab and chemotherapy for advanced head and neck cancer. It aims to see if this new combination is effective for patients who haven't had treatment for their advanced disease.
United States · Australia · Belgium - active not recruitingPHASE2
A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma
This study is looking at a new treatment called tislelizumab, sometimes combined with other medicines, for head and neck cancer that has come back or spread. The aim is to see if it can shrink tumours and if it's safe for patients.
United States · Australia · Canada - active not recruitingPHASE2
Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
This study looks at a new drug, evorpacept, combined with an existing one, pembrolizumab, for advanced head and neck cancer. It aims to see if this combination works better than pembrolizumab alone for patients who haven't had treatment for advanced stages of their cancer. It's a Phase 2 trial, meaning it's still in earlier stages of testing.
United States · Australia · Belgium - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - recruiting
To Assess the Correlation of High-resolution Specimen PET-CT Imaging, Using the XEOS AURA 10 PET-CT, With the Histopathology Results and Long-term Outcome of Patients Undergoing Resective Cancer Surgery.
This study looks at how well a special scan, called PET-CT, works on removed cancer tissue. It compares these scans with lab results and patient health over time to see if this technology can improve cancer care and treatment decisions.
Belgium · Germany · Netherlands - recruiting
Pilot Study to Evaluate Photoacoustic Imaging in Head and Neck Cancer
This study uses a special imaging technique called photoacoustic imaging to look at changes in lymph nodes in people with head and neck cancer. The goal is to see if these changes during treatment can help predict how well the treatment is working.
Canada - recruiting
Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS)
This study is looking at a new way to give radiotherapy using a special machine called ETHOS. It aims to make radiotherapy more accurate by adjusting treatment daily for cancers like prostate or head and neck, potentially improving how well it works and reducing side effects.
Germany - recruitingPHASE1
A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies
This study is testing a new cell therapy called ZI-MA4-1 for certain advanced cancers like ovarian, lung, and head and neck cancer. It's the first time this treatment designed to fight cancer will be given to people, aiming to see if it's safe and how well it works.
United Kingdom - recruitingNA
Prospective Validation of Adaptive Radiotherapy (ART) in Patients With Head and Neck Tumors
This study is looking at a new way to give radiation therapy for head and neck cancers, called Adaptive Radiotherapy (ART). It aims to see if ART can better protect healthy body parts while still treating the cancer effectively, by adjusting the treatment as your body changes.
Germany - recruitingNA
Evaluation of the Benefit of a New Surgical Procedure According to IDEAL Recommendations for ORL Cancer Patients: the External Pudendal Flap Used as a New Free Flap for Oral Cavity/Oropharyngeal Reconstruction to Limit Donor Site Sequelae
This study looks at a new way to rebuild parts of the mouth or throat after cancer surgery, using skin and tissue from a different part of the body. Its main goal is to see if this new method is safe and works well, helping patients recover with fewer problems.
France - recruitingPHASE2
Study Evaluating Near-infrared Imaging Coupled With Indocyanine Green for Intraoperative Control of Resection Margins in ENT Surgery
This study looks at a special dye and camera system, called indocyanine green and near-infrared imaging, during surgery for head and neck cancers. The aim is to see if it can help surgeons find and remove any tiny cancer cells left behind that they might not usually see.
Belgium · France - recruitingPHASE1, PHASE2
Ixovex-1 Single Agent and Combination Therapy
This study is testing a new virus treatment, Ixovex-1, for advanced solid tumours and head and neck cancer. It aims to find a safe dose, alone and with Pembrolizumab, for patients who have limited other treatment options.
United Kingdom - recruiting
The Head and Neck Registry of the European Reference Network on Rare Adult Solid Cancers
This project is building a secure online registry for rare head and neck cancers. It aims to collect information from across Europe to better understand these conditions, how they are treated, and what affects treatment success, helping improve care for patients.
Czechia · Germany · Italy - active not recruitingPHASE4
Impact of the Oral Microbiota on Relapse in HNSCC Patients
This study looks at how tiny living things (germs) in your mouth might affect how well head and neck cancer treatment works. Researchers want to understand if these germs, called the 'oral microbiota,' play a role in whether the cancer comes back after radiotherapy.
France - recruitingNA
Modulation of Anti-tumor T Cell Responses in Cancer Patients Treated by Concomitant Radiochemotherapy
This study looks at how combined radiation and chemotherapy for lung or head and neck cancers affects the body's natural cancer-fighting cells. Researchers hope to understand these immune responses better to improve future treatments.
France - recruitingPHASE2
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
This study looks at a medicine called atezolizumab for different cancers. We want to see if a special test of your cancer cells can predict if the medicine will work well for you. This helps us learn more about tailoring treatments.
Canada - active not recruitingPHASE1
MAGE-A4ᶜ¹º³²T for Multi-Tumor
This study is testing a new cell therapy for certain cancers that have a specific protein. It aims to see if it's safe and how well people tolerate it. The therapy uses your own modified cells to fight the cancer. Some participants will also receive a small amount of radiation.
United States · Canada - recruitingNA
Survivorship After HNC: A Randomized Controlled Trial Evaluating Patient Care and Adherence to Follow-up
This study looks at how best to support people after head and neck cancer treatment. It tests if a personalised plan and a chat with a nurse can improve care and quality of life compared to standard follow-up.
Canada - not yet recruitingNA
SPECT-CT Guided ELEctive Contralateral Neck Treatment in Lateralized Oropharyngeal Cancer
This study looks at a new way to treat throat cancer (oropharyngeal cancer). It aims to see if using a special scan (SPECT-CT) can help doctors decide if radiotherapy is needed on one or both sides of the neck, reducing side effects while remaining effective.
France - active not recruitingPHASE3
RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer
This study looks at whether adding a drug called cetuximab to standard radiation therapy helps patients with head and neck cancer after surgery. We want to see if this combination improves treatment success and helps people live longer with fewer side effects.
United States · Canada · China - recruiting
Exploratory Study of Clonal Evolution in Cancer for Patients Undergoing Transoral Robotic Surgery for Radiation Exposed Residual/reCurrent Tumours of the Upper Aerodigestive Tract
This study looks at how head and neck cancers change after radiotherapy. We want to understand why some cancers come back or new ones appear, which could help doctors choose better treatments for patients.
United Kingdom - recruitingNA
Improving Dental Care for Patients With Head and Neck Tumors
This study looks at how we can improve dental care for people with head and neck cancer. We're asking patients and dentists about their experiences and giving them information to see if it helps them understand things better.
Germany - recruiting
Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)
The SHERLOCK study aims to find tiny bits of cancer DNA in your blood after treatment. This helps doctors spot if cancer might return early, hoping to improve long-term health. We're looking for new ways to track different types of cancer.
Canada - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - not yet recruitingNA
Assessing Spinal Accessory Nerve Recovery After Post-operative Electrical Stimulation
This study looks at whether a gentle electrical treatment during neck cancer surgery can help nerves in the shoulder heal better. It aims to reduce shoulder pain and weakness, helping people get back to daily life faster after their operation.
Canada - not yet recruiting
Cisplatin-induced Cochlear and Vestibular Damage in Head and Neck Cancer
This study looks at how a cancer drug called cisplatin can affect hearing and balance in people with head and neck cancer. We aim to find better ways to check for these side effects and understand why they happen, especially by comparing patients receiving cisplatin with those who don't.
Germany - recruiting
Immune Biomarker Study for Head and Neck Cancer
This study looks at how your body's defence system (immune system) reacts to head and neck cancer. Researchers want to find early warning signs in your blood and tumour to help predict how the cancer might behave and improve future treatments.
Germany - recruiting
Radiotherapy of Head and Neck Cancer With SIB
This study looks at how new radiotherapy (SIB) helps people with head and neck cancer. It checks if the treatment works well, reduces side effects, and improves quality of life. It helps doctors understand the best ways to use this treatment in real life.
Germany - active not recruiting
Real-time Detection of ctDNA and/or HPV DNA in High-risk Locally-advanced Head and Neck Squamous Cell Carcinoma
This study looks at new ways to detect head and neck cancer coming back after treatment. We're testing a special blood test that can find tiny bits of cancer DNA in patients with advanced head and neck cancer, to see if it can help us understand and treat the disease better.
Canada - recruiting
Exploratory Study of Early Biomarkers Allowing Dynamic Assessment of Response to Treatment in Cancers of the Head and Neck
This study looks at head and neck cancer that can't be cured with surgery or radiotherapy. Researchers want to find early signs in blood and saliva that show if treatments, especially immunotherapy, are working. This could help doctors understand which treatments are best for each person.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Phase II Randomized Controlled Study Aiming to Evaluate the Interest of Qutenza in Patients With ORL Cancer in Remission and With Sequellae Neuropathic Pain.
This study looks into whether a skin patch called Qutenza can help people who have had head and neck cancer and are left with nerve pain. It compares Qutenza with another medicine, Laroxyl, to see if either can reduce pain by a significant amount over nine months.
France - enrolling by invitation
DENTOFACIAL-PBT Stage 2 - Feasibility Study
This study looks at how proton beam therapy for childhood head and neck cancer might affect teeth and jaws. Researchers want to understand these side effects better to improve future care for young patients in the UK.
United Kingdom - active not recruitingPHASE1
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
This study is testing two anti-cancer drugs, cabozantinib and atezolizumab, alone and together, for various advanced cancers. It aims to find a safe combination dose and see how well it works and any side effects.
United States · Australia · Belgium - active not recruitingPHASE1, PHASE2
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
This study is testing a new drug, BT5528, for advanced cancers like ovarian, lung, and breast cancer. We want to find a safe dose, understand side effects, and see how well it works, sometimes given with another drug called nivolumab.
United States · Belgium · South Korea - recruiting
The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck
The RESCUE study looks at how well people do after surgery for head and neck cancer that has come back or stayed. It also checks if past treatments or a person's genes can affect this.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
MOIO_Randomized phase III trial of standard immunotherapy (IO) by checkpoint inhibitors, versus reduced dose intensity of IO in patients with locally advanced or metastatic cancer in response after 6 months of standard IO
This study compares standard immunotherapy with a reduced dose for people whose cancer responded well after 6 months. It looks at how long they stay well and their quality of life. The aim is to see if a lower dose can be just as effective.
France - authorisedTherapeutic exploratory (Phase II)
Phase 2, open-label, multicentre, single-arm study to evaluate the activity of the combination of EGFR inhibitors and c-MET inhibitors in patients with platinum-resistant head and neck squamous cell carcinoma after relapse to immunotherapy.
This study is for people in the UK with head and neck cancer that has come back after other treatments. It's testing a new combination of two drugs, cetuximab and tepotinib, to see if they can shrink the cancer. It's called a 'Phase 2' study, meaning it's an early look at how well the treatment works.
Italy - active not recruitingPHASE2
A Clinical Study to Investigate the Efficacy of Tigilanol Tiglate Directly in Head and Neck Cancer
This study is testing a new medicine, Tigilanol Tiglate, for head and neck cancer. Doctors will inject the medicine directly into tumours to see how well it works at shrinking them and if it's safe. It's for patients who have recurring cancer or whose previous treatments haven't worked.
Australia · United Kingdom - active not recruitingPHASE1, PHASE2
Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors
This study is testing different combinations of new drugs, including EOS-448, with or without standard treatments for advanced cancers like lung and head & neck cancer, and melanoma. Researchers want to see if these combinations are safe and effective.
United States · Belgium · France - authorisedTherapeutic exploratory (Phase II)
PANACEA : Effect of PrehAbilitation by NutritionAl supplementation with Cannabidiol on skeletal muscle mass and mitochondrial function in hEad and neck cAncer : a proof of concept controlled randomized trial
This study looks into how nutritional support, including a cannabis-derived product (CBD), might help people with head and neck cancer. Researchers want to see if it improves muscle health and energy production in cells. It's a small, early-stage study to see if the idea has promise.
France - authorisedTherapeutic use (Phase IV)
Comparing intraoperative indocyanine green fluorescence imaging with standard clinical assessment for flap perfusion in head and neck reconstruction: A randomised controlled Trial (VISION Trial)
This study looks at a new way to check blood flow during surgery for head and neck cancer. It compares a special dye injection with the usual methods to see if it helps reduce problems with tissue flaps used for reconstruction.
Sweden - recruiting
Head and Neck Early Relapse Detection Study (HERD)
This study aims to find better ways to detect head and neck cancer coming back early after treatment. We're looking at different body tests to create a warning system so doctors can act quickly and improve chances of successful treatment.
United Kingdom - recruitingPHASE2
Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized Trial
This study compares different ways of giving radiotherapy after surgery for a type of mouth cancer. We want to see which method best protects swallowing and improves quality of life for patients with certain lymph node clear areas.
United States · Canada · Ireland - recruiting
Ex VIvo DEtermiNed Cancer Therapy
This study, called EVIDENT, wants to see if we can test a tiny piece of your tumour in the lab to predict how well cancer treatments will work for you. It's for people with various solid cancers, like bladder or kidney cancer, who are having surgery or a biopsy.
United Kingdom - recruitingNA
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.
Belgium · France · Germany - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - recruiting
Peer support – head and neck cancer
This study aims to improve support for people with head and neck cancer. It looks at creating a peer support service, where people with similar experiences help each other. Researchers will talk to patients, families, and healthcare staff to design the best service.
United Kingdom · England