PARKINSON DISEASE (Disorder) research hub
50 indexed studies · 41 currently recruiting
- recruitingNA
The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
This study looks at how gut health, especially methane gas levels, might be linked to Parkinson's disease and memory problems. It also tests if a probiotic can help reduce methane. We want to understand if gut issues affect how these conditions develop and progress.
United Kingdom - recruiting
Mobilise-D: Extension Study
This study looks at how Parkinson's disease affects movement and how our movement changes as we get older. Researchers will use a special device to track how people move, hoping to understand the condition better and improve ways to measure it in daily life.
United Kingdom - enrolling by invitation
An Observational Study of Patients With Moderate Parkinson's Disease
This study watches people with moderate Parkinson's disease to see how their symptoms change over time. Participants continue their usual medicine, but doctors might suggest adjustments. It helps us understand the condition better.
United States · Japan · Sweden - recruiting
Non-invasive Detection of Volatile Metabolites in Parkinson's Disease
This study is looking for a new, simple way to diagnose Parkinson's disease earlier. Researchers are checking if a breath test can spot early signs of the condition by looking at tiny molecules in your breath, combined with changes in gut bacteria.
United Kingdom - recruitingNA
Exercise to Improve Sleep in Parkinson's Disease
This study looks at how different types of exercise – cardio, strength, or a mix – can improve sleep for people with Parkinson's disease. Researchers want to see if better sleep also improves their quality of life.
Canada - enrolling by invitationNA
Brain-Machine Interface for Freezing of Gait
This study explores a new brain-machine interface to help people with Parkinson's disease who experience "freezing of gait." Researchers want to understand brain activity during freezing and test if gentle brain stimulation can stop it, hoping to develop better treatments.
Canada - recruiting
Prodromal Alpha-Synuclein Screening in Parkinson's Disease Study
This study is looking for people aged 50-99 to understand who might be at higher risk of developing Parkinson's disease in the future. Researchers will follow these individuals for five years to learn more about early signs and how the condition develops. There are no treatments involved, only observation and investigation.
Germany - recruitingNA
CANadian Adaptive DBS TriAl
This study looks at a new type of deep brain stimulation (DBS) called 'adaptive DBS' for Parkinson's disease. It aims to see if this smarter, adjustable DBS can better help with problems like walking difficulties and speech issues compared to standard DBS.
Canada - active not recruitingNA
Towards Noninvasive DBS of the Basal Ganglia in Parkinson's Disease Using TUS
This study is looking at a new, gentle way to stimulate the brain called Focused Ultrasound (TUS) for people with Parkinson’s disease or dystonia. It uses sound waves to deliver a treatment similar to deep brain stimulation (DBS) and aims to understand how it works.
Canada - recruiting
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
This study looks at how well Abbott's Deep Brain Stimulation (DBS) systems work and how safe they are over time for people with movement problems like Parkinson's or essential tremor. It helps doctors understand the long-term benefits.
United States · Australia · Finland - recruitingNA
Home-based Gait and Balance Training in Patients With Movement Disorders
This study looks at how a home-based exercise programme can help people with Ataxia or Parkinson's disease improve their walking and balance. It compares two training schedules to see which works best.
Germany - recruitingNA
Brain Training to Improve Balance in Parkinson's Disease
This study looks at new ways to help people with Parkinson's improve their balance and prevent falls. It tests a special 'brain training' exercise game to see if it can change brain activity and lead to better balance.
United Kingdom - recruitingNA
Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
This study looks at how increasing physical activity might help slow down memory and thinking problems in people with a condition called REM sleep behaviour disorder (iRBD). This condition can sometimes lead to Parkinson's disease. Participants will use a smartphone app to boost their activity levels.
Germany - recruiting
Serotonin Release in Premotor and Motor PD
This study aims to better understand Parkinson's disease by using special brain scans. Researchers hope to find a 'biomarker' – a sign of the disease – which could help develop new medicines to slow down Parkinson's symptoms.
United Kingdom - recruiting
Influence of Glucose on Metabolism and Clinical Symptoms of Patients With Parkinson's Disease
This study looks at how sugar affects people with Parkinson's and why some crave sweet foods. Researchers will see how blood sugar levels change after sweet drinks and measure how it affects their Parkinson's symptoms, both movement and non-movement related.
Germany - recruiting
Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases
This study looks at how swallowing and voice box problems affect people with conditions like Parkinson's and Motor Neuron Disease. Researchers will observe existing medical checks to understand more about these issues. This could help find better ways to diagnose and treat these conditions early.
Austria · Germany · Israel - active not recruitingNA
New Approaches in MRI at 3T Dedicated to Targeting Subthalamic Nucleus on Parkinsonian Patients
This study looks at new ways to use powerful MRI scans to better pinpoint specific brain areas in people with Parkinson's disease. This is important for improving a treatment called Deep Brain Stimulation (DBS), which can help reduce movement problems.
France - not yet recruiting
Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease.
This study is looking into a new medication called pimavanserin for people with Parkinson's disease who also experience impulse control disorders (ICDs). The aim is to see if this medicine can help manage these behaviours safely and effectively.
France - recruitingNA
Evaluation of the Safety of Electrical Spinal Cord Stimulation in Parkinson's Patients Presenting With Painful Camptocormia
This study looks at a treatment called electrical spinal cord stimulation for people with Parkinson's disease who have painful camptocormia (a bent-over posture). It wants to see if this treatment is safe and helps with pain and posture when other treatments haven't worked.
France - active not recruitingPHASE2
Safety and Pharmacodynamic Effects of BIIB122 in Participants With LRRK2-Associated Parkinson's Disease (LRRK2-PD)
This study is testing a new medicine called BIIB122 for people with a specific type of Parkinson's disease linked to a gene. We want to see if it's safe and how it affects the body.
United States · Germany · Israel - available
Compassionate Use for BIA 28-6156 in Patients With Parkinson's Disease (PD) Who Have a Pathogenic Variant in the GBA1 Gene (GBA-PD) and Completed the ACTIVATE Study
This programme offers continued access to an investigational drug, BIA 28-6156, for people with a specific type of Parkinson's disease (related to the GBA1 gene) who have already completed a previous study. It provides the medicine free of charge on compassionate grounds.
United States · Italy · Portugal - recruitingPHASE3
Ambroxol to Slow Progression in Parkinson Disease
This UK study is testing if a drug called ambroxol, already used for colds, can slow the progression of Parkinson's disease. Participants will take either ambroxol or a dummy pill, then all take ambroxol. We want to see if it's safe and effective.
United Kingdom - recruitingNA
Interdisciplinary + Intersectoral Telemedicine Evaluation, Coordination + Treatment in RhineMain+ Parkinson's Network
This study looks at new ways to support people with Parkinson's disease in the RhineMain+ area of Germany. It uses a special nurse and online tools to help manage care, aiming to improve health and treatment coordination.
Germany - not yet recruitingNA
Early Biomarkers of Neurodegeneration in Parkinsonian Syndromes
This study uses advanced MRI scans to find early signs of Parkinson's disease and a similar condition called PSP. The goal is to discover ways to diagnose these diseases earlier and help patients get better treatment.
France - recruitingNA
Exercise & Brain Energetics in PD
This study looks at how exercise might help the brain use energy better in people with Parkinson's disease. We're using special brain scans before and after an exercise programme to see if it makes a difference to brain energy.
Canada - active not recruitingNA
Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation
This study looks at how a new remote system for Deep Brain Stimulation (DBS) in Parkinson's disease might help patients get their treatment settings adjusted faster. It compares in-clinic visits with a mix of in-clinic and virtual visits.
United States · Germany · Spain - recruitingNA
Patient Engagement Investigation of NMS Assist
This study looks at a new digital helper called NMS Assist for people with Parkinson's. It aims to help manage common non-motor symptoms like pain and sleep problems, which can really affect daily life. We want to see if it helps people feel more confident and knowledgeable about their symptoms.
United Kingdom - recruitingNA
Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity
This study aims to find new, simple ways to spot early signs of Alzheimer's and Parkinson's diseases. Researchers will use special brain scans to look at how different parts of the brain connect, hoping to find unique patterns that point to these conditions sooner.
France - not yet recruitingNA
Minimal Electrophysiology and Imaging Enhanced Deep Brain Stimulation
This study looks at making Deep Brain Stimulation (DBS) surgery for Parkinson's disease simpler and safer. Researchers are testing a new method that uses less invasive techniques during surgery, hoping to improve results and make the process easier for patients.
Canada - active not recruitingNA
MST for Parkinson's Disease
This study is testing a new treatment called Magnetic Seizure Therapy (MST) for depression in people with Parkinson's disease. It wants to see if MST is a practical and safe option before it's compared to other treatments in the future. The trial is happening in Canada and involves 20 patients.
Canada - recruitingPHASE2
A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)
This study is testing a new gene therapy, AAV2-GDNF, for people with moderate Parkinson's disease. We want to see if it's safe and helps improve symptoms. It involves a single surgery and comparing the gene therapy to a control surgery.
United States · Germany · Poland - recruitingNA
Study in Parkinson Disease of Exercise
This study looks at how treadmill exercise affects people with early Parkinson's disease who haven't started medication. Participants will walk on a treadmill at different intensities four times a week for a year to see if it slows down their Parkinson's symptoms.
United States · Canada - recruiting
PD Frontline (Part of RAPSODI GD) Remote Assessment of People With Parkinson's
PD Frontline is an online study for people with Parkinson's. It helps researchers understand the disease better by looking at your genes. You'll give a saliva sample to check key genes linked to Parkinson's and get your results, letting you know about future research you might help with.
United Kingdom - not yet recruitingNA
Prevention of Medical, Social, and Psychosocial Risks Following a Parkinson's Disease Diagnosis: A Pilot Study
This study looks at a new way to support people newly diagnosed with Parkinson's disease and their families. It uses questionnaires and tools like booklets and a website to help manage the medical, social, and emotional challenges that can come with the diagnosis.
France - recruiting
Contribution of the Kinematic Theory in the Early Differential Diagnosis of the Parkinson's Disease
This study looks for early signs of Parkinson's disease by studying hand movements, speech, and eye movements. Researchers want to see if these measurements can help tell the difference between people with Parkinson's, similar conditions, and healthy older adults aged 50-75.
Canada - active not recruitingPHASE3
To Evaluate the Efficacy of CVN424 in Parkinson's Disease Participants With Motor Complications
This study is testing a new medicine, CVN424, for people with Parkinson's disease who experience 'OFF' times (when their medication isn't working as well). It aims to see if CVN424 can help reduce these 'OFF' periods. Participants will take the medicine or a dummy pill for 12 weeks.
United States · Australia · Czechia - recruitingNA
FMRI-neurofeedback in Parkinson's Disease
This study explores a new way to help people with Parkinson's by training their brains to improve movement. It uses a special scan (fMRI) to give real-time feedback, hoping to offer a non-drug, non-surgical option for managing symptoms.
Germany · Netherlands - recruiting
The GBA Multimodal Study in Parkinson's Disease
This study looks at how a specific gene change (GBA mutation) might be linked to Parkinson's disease. Researchers are using special brain scans and typing tests to understand changes in the brain and whether early signs of the disease can be found.
United States · Canada - recruitingPHASE2
Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease
This study looks at whether a special good-bacteria supplement (probiotic) can help improve feelings of sadness and depression in people with Parkinson's disease. Participants will take either the probiotic or a dummy pill for 12 weeks to see if it makes a difference.
Canada - enrolling by invitation
Continued Evaluation of Patients With Parkinson's Disease Who Previously Received BRT-DA01
This study is looking at people who previously received a special treatment called BRT-DA01 for Parkinson's disease. Researchers want to see how these people are doing after receiving the treatment in an earlier study. They will check on their health and how their Parkinson's symptoms are over five years.
United States · Canada - recruiting
Effect of a Vibrating Therapy Ball on Tremor and Daily Activities in Patients With Different Tremor Syndroms
This study looks into how a vibrating ball device might help people with shaky hands (tremor), such as those with Parkinson's disease. It aims to see if using this device can temporarily reduce tremors and make daily activities easier, compared to other treatments.
Germany - active not recruitingNA
Physiotherapy and Deep Brain Stimulation in Parkinson's Disease
This study looks at whether physiotherapy after deep brain stimulation (DBS) surgery helps people with Parkinson's disease move better and fall less. It compares those who get physiotherapy with those who don't, to see if combining these treatments improves daily movement.
Canada - not yet recruitingNA
Characterization of the Involvement of the Subthalamic Nucleus During Wakefulness and Sleep in Parkinson's Disease: Contribution of Deep Brain Stimulation
This study looks at how deep brain stimulation in a specific part of the brain called the subthalamic nucleus might help with sleep problems in people with Parkinson's disease. Researchers hope to understand how this brain area affects sleep and how to make the treatment better.
France - recruitingNA
Study of Sleep Disorders in Prodromal and Definite Parkinsons Disease
This study looks into sleep problems in people with Parkinson's and those at risk. Researchers use a sleep test called polysomnography to understand these issues better. The goal is to find out more about how sleep is affected in these conditions.
France - recruiting
Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR
This study looks into how inflammation might play a role in Parkinson's disease. Researchers will use special scans and tests to understand why inflammation happens and how it affects the disease, hoping to find new ways to help patients in the future.
United Kingdom - recruitingNA
Frontosubthalamic Networks in Parkinson's Disease.
This study looks at how deep brain stimulation (DBS) for Parkinson's disease affects brain networks, especially concerning changes in impulsive behaviour. We want to see if different DBS settings can help reduce impulsivity.
United Kingdom - recruiting
Digital App for Speech & Health Monitoring
This study is using a smartphone app to record and analyse speech from people with conditions like dementia, MND, MS, and Parkinson's. The goal is to see if speech changes can help diagnose and monitor these conditions, comparing them to healthy individuals, using simple digital technology.
United Kingdom - active not recruitingPHASE1
A Trial to Determine the Safety and Tolerability of Transplanted Stem Cell Derived Dopamine Neurons to the Brains of Individuals With Parkinson's Disease
This study is testing a new stem cell treatment for Parkinson's disease. Surgeons will place special cells into the brain to see if they are safe and can help replace damaged cells. It's hoped this could improve movement for people with Parkinson's.
Sweden · United Kingdom - enrolling by invitationNA
TUS to Disrupt Pathological Oscillations
This study explores a new, gentle sound wave method to correct faulty brain signals in Parkinson's. We're testing if this non-invasive technique can improve symptoms, offering a safer alternative to current brain surgery. It could also help treat other brain conditions in the future.
United Kingdom - recruiting
Observational Case Series of Patients With Parkinson's Disease (PD) Attending a Complementary Medicine Neuro-degenerative Disease (NDD) Clinic.
This study looks at how people with Parkinson's disease experience complementary therapies like homeopathy and herbalism in a London clinic. Researchers want to understand if these treatments help and how they are used alongside regular medical care.
United Kingdom