Peripheral arterial disease research hub
22 indexed studies · 17 currently recruiting
- recruiting
Home-based blood flow restriction exercise in people with peripheral arterial disease
Peripheral arterial disease (PAD) causes painful leg cramps during walking due to narrowed blood vessels. This UK study tests whether a gentle home exercise programme, using special cuffs that briefly restrict blood flow, can safely improve walking ability, relieve pain, and help people exercise without travelling to hospital.
United Kingdom · England - recruitingTherapeutic exploratory (Phase II)
A Phase IIa Open Label, Dose-Finding, Clinical Trial to Evaluate Safety, Tolerability and Preliminary Efficacy of Etrinabdione in Patients with Peripheral Arterial Disease (PAD). CLAUDIA Trial
This study, called CLAUDIA, is testing a new medicine called Etrinabdione for peripheral arterial disease (PAD). It's looking at how safe the medicine is and if it helps improve blood flow and symptoms like leg pain while walking. It's an early-stage study.
Spain - recruitingTherapeutic confirmatory (Phase III)
VIRTUOSE: Efficiency of sildenafil on the absolute claudication distance of peripheral arterial disease patients with intermittent claudication. A phase III, National, Multicenter, Prospective, Randomized, Double-blind, Placebo-Controlled trial.
This study is testing a medicine called sildenafil to see how much it helps people with leg pain from poor circulation walk longer. It's a major study comparing the medicine to a dummy pill to find out if it's an effective treatment.
France - recruitingTherapeutic use (Phase IV)
Genotype-guided strategy for antithrombotic treatment versus conventional clopidogrel therapy in peripheral arterial disease (GENPAD)
This study looks at how well different blood-thinning medicines work for people with narrowed leg arteries (PAD). It compares standard care with a new approach using genetic tests to help choose the best medicine to prevent serious problems like heart attacks, strokes, or limb issues.
Netherlands - active not recruiting
Safety and Effectiveness Evaluation of iCover Covered Stent for the Treatment of the Aorto-iliac Occlusive Disease
This study looks at a new type of covered stent called iCover for people with narrowed leg arteries due to a condition called Peripheral Arterial Disease. It aims to see how safe and effective this stent is over two years, helping improve blood flow and reduce symptoms.
Belgium · France · Germany - recruiting
VITUS Post-Market Registry
This study looks at how a special coated balloon works for people with blocked leg arteries. It checks the long-term safety and performance of the VITUS catheter a device that helps open up arteries and improve blood flow.
Belgium · Germany · Singapore - active not recruitingNA
Clinical Trial Investigating the BeGraft Peripheral Plus Stent Graft System for Iliac Lesion Treatment
This study looks at how well a device called BeGraft Peripheral Plus works for people with blocked or narrowed leg arteries caused by Peripheral Arterial Disease. It aims to see if this stent helps blood flow and if it's safe over several years.
Belgium · France - recruiting
Developing Trustworthy Artificial Intelligence (AI)-Driven Tools to Predict Vascular Disease Risk and Progression
This study uses AI to predict heart and blood vessel problems like aneurysms and blockages. Researchers are looking at existing patient information to develop computer programs that can spot who might be at higher risk or whose condition might worsen.
Finland · Germany · Netherlands - active not recruiting
SIGNATURE Study : DCB (Legflow) vs POBA in Fempop Arteries
This study compares two treatments for blocked leg arteries: a special coated balloon (Legflow DCB) versus a standard balloon (POBA). It aims to find out if the coated balloon is safer and works better for people with poor blood flow in their legs.
Brazil · Germany · Switzerland - active not recruitingNA
BEST SFA Pilot Study - Best Endovascular STrategy for Complex Lesions of the Superficial Femoral Artery
This study compares two ways to treat blocked leg arteries caused by Peripheral Arterial Disease (PAD). It looks at using medicine-coated balloons versus stents to see which works best for complex blockages and is safest for patients.
Germany - recruitingNA
Early Percutaneous Transluminal Angioplasty in Diabetic Foot Syndrome (PTA-DFS)
This study looks at treating diabetic foot ulcers with a procedure called angioplasty. Researchers want to know if having this treatment quickly makes a bigger difference to healing than having it later. It's about finding the best timing for care.
Germany - active not recruitingNA
SELUTION4SFA Trial
This study looks at a new treatment called SELUTION SLR™ 018 DEB for poor circulation in the legs, a condition known as Peripheral Arterial Disease (PAD). It compares this new treatment to a standard balloon treatment to see if it's safer and works better for blocked leg arteries.
United States · Austria · Germany - recruiting
Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel Imaging
This study uses special scans to look at how narrowed leg arteries (PAD) cause problems, not just in the legs, but elsewhere too. Researchers want to understand the connections between inflammation, tiny calcium deposits, and blood clots in artery blockages.
United Kingdom - recruitingPHASE3
Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease
This study is testing a new medicine, Orforglipron, for people with a common blood vessel problem called Peripheral Arterial Disease (PAD) that causes leg pain when walking. It aims to see if the medicine is safe and helps improve symptoms.
United States · Argentina · Australia - recruiting
Impact of Stress on Cardiovascular Events in Patients with Peripheral Arterial Disease
This study looks at how stress affects people with Peripheral Arterial Disease (PAD). Researchers want to find better ways to measure stress and see if it leads to heart problems or issues with legs and feet in these patients.
Germany - recruiting
European All-comers' Multicentric Prospective REGISTRY on LUMINOR© Drug Eluting Balloon in the Superficial Femoral Artery and Popliteal Artery With 5 Years Follow-up.
This study looks at a special balloon (LUMINOR©) used to open blocked leg arteries. It checks how safe and effective it is over 5 years for people with poor circulation in their legs.
France - recruitingNA
The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients With Complex Iliac Occlusive Disease
This study compares two ways to open narrowed leg arteries using stents. It looks at a newer stent called VBX versus standard bare metal stents for people with blockages in their iliac arteries, aiming to see if the VBX works better to keep the arteries open.
United States · Australia · Germany - recruiting
Leg Ischaemia Management Collaboration
This study looks at how many people with severe leg circulation problems need an amputation within a year. It compares care before and after a new special clinic was set up to help save limbs.
United Kingdom - recruitingPHASE3
Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk
This study, called LEADER-PAD, is looking into whether a low dose of colchicine, a common anti-inflammatory medicine, can help people with a condition called Peripheral Artery Disease (PAD) reduce their risk of serious heart and circulation problems.
United States · Australia · Belgium - not yet recruitingNA
Mechanistic Study of Anti-Platelet Therapy in Atherosclerosis
This study looks at how common heart medications, aspirin and clopidogrel, affect small blood cell clumps in people with hardening of the arteries. It aims to see if these medicines can reduce these clumps, which are linked to heart problems, especially in those showing no symptoms.
United Kingdom - not yet recruitingNA
Heat Therapy and Peripheral Artery Disease
This study looks at whether regular warm water soaks can help people with a condition called Peripheral Artery Disease (PAD) who experience leg pain when walking. Researchers compare this 'heat therapy' to usual care to see if it improves walking ability and overall health.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom