- completed
Delivering inclusive, accessible support for psychological adjustment after stroke
Having a stroke can change your life, and adjusting can be difficult. The WAterS-2 study tests an online support group designed to help stroke survivors manage emotional challenges and feel better. Led by the University of Manchester, it aims to make mental health support easier to access across the UK.
United Kingdom · England - recruiting
A study to evaluate whether power assisted exercise can help people living with stroke to improve their mobility and fitness
This UK study tests whether special motorised exercise machines can help stroke survivors improve their fitness and movement. Participants attend two seated exercise sessions a week for eight weeks in Sheffield. The machines give gentle support to help make moving easier, safer, and more comfortable after a stroke.
United Kingdom - completedNot Applicable
Rehabilitation using virtual gaming for hospital and home-based arm and hand exercise post stroke
This UK study tests whether a video-gaming controller called the NeuroBall helps people regain arm and hand movement after a recent stroke. Researchers want to know if playing these rehabilitation games in hospital or at home is safe, enjoyable, and practical alongside standard NHS stroke therapy.
United Kingdom · England - recruiting
Coproduction and evaluation of a self-management intervention for post-stroke fatigue
Feeling exhausted after a stroke or mini-stroke is very common and distressing. This UK study tests an online programme called 'Rethink Fatigue'. It aims to help people manage extreme tiredness through six weeks of digital sessions and healthcare support, exploring whether this approach works well for stroke survivors.
United Kingdom · England - completed
Understanding cognitive decline after stroke and the impact of COVID-19
Stroke can often lead to memory and thinking difficulties. This UK study tracks people who have had a stroke or mini-stroke over two years. Researchers want to understand why these changes happen, how COVID-19 affects recovery, and how doctors can best protect brain health and prevent dementia in the future.
United Kingdom · England · Scotland - authorisedTherapeutic confirmatory (Phase III)
Effect of GABAergic treatments on cortical plasticity and motor learning capacity in the subacute phase after stroke: a single-case experimental study (GABAPLAST)
After a stroke, the brain must rewire itself to recover movement. Doctors often prescribe medicines to ease muscle tightness, pain, or anxiety. This study looks at how these common medications affect the brain's natural ability to learn and recover movement in the weeks and months following a stroke.
France - authorisedTherapeutic exploratory (Phase II)
Effects of a CB1 Antagonist/Reverse Agonist (Rimonabant) on Functional Recovery in Stroke Patients During Subacute Phase.
This study is looking at whether a medicine called rimonabant can help people recover after a stroke. Researchers want to see if the treatment helps patients walk better and manage daily tasks more easily, while carefully checking for any unwanted side effects or changes in mood.
Spain - authorisedTherapeutic exploratory (Phase II)
Effects of a CB1 Receptor Antagonist/Inverse Agonist (Rimonabant) on Walking Ability in Patients in the Chronic Phase of Stroke
This clinical trial is testing whether a medicine called rimonabant can help people walk better after having a stroke. Researchers want to see if a dissolving tablet improves walking speed and distance, while carefully monitoring participant safety, mood, and everyday comfort compared to a dummy tablet.
Spain - recruitingTherapeutic exploratory (Phase II)
Long-term iron chelation in the prevention of secondary remote degeneration after stroke
This study looks at whether a medicine called Ferriprox can help prevent further problems after a stroke. It checks if the medicine reduces iron levels in specific brain areas. Researchers want to see if this could protect against long-term brain damage.
France - recruitingHuman Pharmacology (Phase I)- Other
DMT in healthy subjects
This study is looking for healthy people over 18 to test a new medicine (DMT). It's an early-stage study to see how safe the medicine is and how it works in the body, not to treat a specific illness. It's an important first step towards understanding potential future treatments for conditions like stroke.
Netherlands - not yet recruitingNA
Telerehabilitation Decision Support System: Pilot Testing Protocol
This study tests a new online exercise system for people with conditions like stroke or long COVID. It uses special technology, including holograms, to help improve balance and movement from home. We want to see how well it works and if it's easy to use before a larger study.
Germany · Greece · Portugal - completedNot Applicable
A trial investigating the effectiveness of vagus nerve stimulation during rehabilitation therapy in patients with a weak arm following a stroke
This UK clinical trial is testing whether gentle electrical stimulation through an earpiece can help improve arm movement after a stroke. Participants follow a tailored 12-week home exercise programme while wearing the device. The goal is to see if nerve stimulation helps the brain rewire and improves everyday arm function.
United Kingdom · England · Wales - completed
European Carotid Surgery Trial 2
This study looks at whether people with narrowed neck arteries and a low-to-medium risk of stroke need an operation or stent, or if modern medications alone are just as safe. It compares optimal tablets and lifestyle advice against having a procedure alongside modern medical treatment.
United Kingdom · England · Scotland - recruiting
Mental practice for arm recovery early after stroke
Many people struggle to move their arm after a stroke. This UK study explores whether "mental practice"—imagining moving your arm—helps early recovery alongside standard NHS care. Patients will use a borrowed tablet computer for 20 minutes a day, five days a week, for six weeks.
United Kingdom · England - recruiting
Patient portal for stroke survivors
This study looks at how a special website can help stroke survivors see their own health information and manage their blood pressure. It aims to see if this online tool is easy to use and helpful for people who have had a stroke.
United Kingdom · England - recruitingTherapeutic exploratory (Phase II)
CONCISE COlchicine iN Circulating Inflammatory markers after StrokE
The CONCISE study is looking into whether a medicine called colchicine can help reduce swelling and inflammation in people after a stroke. Researchers want to see if it changes certain markers in the blood related to inflammation.
Ireland - recruiting
Studying how body chemistry affects stroke recovery: using blood, clots, and scans to predict treatment results
This study investigates how body chemistry, blood clots, and brain scans affect stroke recovery. Researchers use samples from stroke patients and healthy volunteers to understand stroke and improve future treatments. It aims to develop better ways to predict treatment success.
United Kingdom · England - recruiting
Spatial inattention grasping therapy for neglect post-stroke
This study looks at a new therapy, SIGHT, for people who've had a stroke and have spatial inattention. This condition makes it hard to notice things on one side. SIGHT uses special rods to help the brain relearn how to pay attention. We want to see if it helps and for whom.
United Kingdom · England - recruiting
Teaching carers to deliver therapy for the arm and hand post stroke
This study explores if family or friends can be taught to help stroke survivors with arm and hand recovery at home. It aims to improve ongoing daily therapy for people after a stroke.
United Kingdom · England - completed
Emotional and language recovery in aphasia (ELLA)
This study, ELLA, looks at a new therapy for people with language problems (aphasia) after a stroke. It aims to improve their speaking, understanding, confidence, and mood. We want to see if it works well in NHS clinics after good results in our university clinic.
United Kingdom · England - recruiting
Falls in stroke survivors
This study looks at a new programme, called SAF, to help stroke survivors avoid falls after leaving hospital. It compares SAF with usual care to see if it reduces falls over 12 months. SAF involves a checklist and action plan to manage fall risks.
United Kingdom · England · Wales - completed
Implementation of VR for upper limb rehabilitation after stroke (v1)
This study looks at a virtual reality (VR) system called NeuroVirt to help stroke survivors recover arm movement. It checks if it works well in the NHS, how much it costs, and if it encourages people to do their arm exercises to get better.
United Kingdom · England - recruiting
Feasibility study of the Clear Water Protocol in acute stroke
This study looks into a new way for stroke patients with swallowing problems to drink water safely. It aims to see if giving water between meals is possible and helpful, while making sure it's done safely.
United Kingdom · England - active not recruitingNA
Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion
This study compares a new device (Occlutech Flex II) for closing a small hole in the heart called a PFO, often linked to strokes, with existing standard devices. It checks if the new device is as safe and effective at closing the hole and preventing future strokes.
United States · Canada · Denmark - not yet recruitingNA
Virtual Reality in Occupational Therapy Upper Limb Stroke Rehabilitation
This study looks at using a virtual reality (VR) system called Resynk to help stroke survivors improve movement in their arm and hand. We want to see if it's practical and helpful for patients both in hospital and at home.
United Kingdom - recruitingNA
EMG-Directed Virtual-Reality Training for Motor Stroke Rehabilitation
This study explores if special virtual reality training, using your muscle signals, can help people with stroke or spinal cord injury move their arms and hands better. It looks at how this training affects recovery and body changes.
United Kingdom - recruitingPHASE2, PHASE3
Transcutaneous Spinal Cord Stimulation for Upper Extremity Function
This study explores a non-invasive treatment called transcutaneous spinal cord stimulation (tcSCS) for people with spinal cord injuries or stroke. It aims to improve arm and hand movement by gently stimulating the spinal cord through the skin. We want to understand the best ways to use this treatment and how it helps recovery.
Canada - recruitingNA
Virtual Reality and Field Training to Enhance Community Walking After Stroke
This study looks at whether using virtual reality and outdoor training can help stroke survivors walk better in their communities. It aims to improve walking skills and confidence using a four-week programme that combines special VR goggles and real-world practice.
Canada - recruitingNA
Biofeedback for Hemianopia Vision Rehabilitation
This study looks at a new training method called biofeedback for people who have lost half of their vision (hemianopia) due to brain injury like a stroke. It aims to see if this method helps improve eye movements and vision, and how best to use it.
Canada - recruiting
Changes in Sensitivity, Taste and Smell in Stroke Patients
This study looks at how stroke affects swallowing, taste, and smell. It gently checks swallowing with a small camera, measures sensitivity in the throat, and tests taste and smell. This helps us understand why some stroke patients have trouble eating and drinking.
Germany - not yet recruiting
High Risk of Death or Disability in Brain Hemorrhage: Role of Spot Sign and Secondary Markers
This study is looking at people who've had a brain bleed to see if certain signs on their brain scans can help predict their risk of death or long-term problems. It aims to improve how we identify patients who might need extra care.
France - recruitingNA
Evaluation of the Impact of the AVanCer Program Provided by the ARRPAC Day Center
This study looks at a new support program called AVanCer in Lyon, France, for adults who have had a stroke or brain injury. It aims to see how well the program helps people and their families, and if it could be used in other places.
France - recruitingNA
Assessment of an Intensive Motor Telerehabilitation Program for Stroke Patients
This study looks at a home-based exercise program using a special device for people recovering from a stroke. It aims to see if doing extra rehab at home can help improve movement and recovery, supervised remotely by a therapist.
France - active not recruiting
Anatomical and Functional Predictions of Blindsight Capabilities in Patients With Lateral Hemianopsia
This study looks at how your brain's structure and activity might explain why some people with vision loss after a stroke can still react to things they can't consciously see. It hopes to find better ways to understand and help manage this ‘blindsight’ phenomenon.
France - recruitingNA
Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys
This study looks at how a condition called Cerebral Small Vessel Disease (cSVD) affects thinking skills. We want to find new ways to spot these changes early using brainwave tests (EEG) and see if brain training or gentle electrical brain stimulation can help improve them.
France - not yet recruitingNA
Evaluation of the NEUROSWING Orthosis on Walking Speed in a Population With Dorsal and/or Plantar Flexor Deficits, With a View to a Reimbursement Application
This study looks at a new ankle support, the NEUROSWING orthosis, to see if it helps people with walking difficulties caused by conditions like stroke or MS. Researchers will compare it to a standard carbon ankle support to see if it improves walking speed.
France - active not recruitingNA
CHAMPION-AF Clinical Trial
This study compares a small heart device (WATCHMAN FLX) with standard blood-thinning medicines (such as DOACs) for people with an irregular heartbeat called atrial fibrillation. It aims to see if the device can prevent strokes just as well as the medicines.
United States · Australia · Belgium - recruiting
Evolution of Walking Abilities in Subacute Stroke Patients Hospitalized in Neurorehabilitation Center
This study looks at how walking improves in people recovering from a stroke. It follows stroke patients in rehabilitation centers for up to six months to see changes in their walking abilities. The aim is to better understand their recovery jouney.
France - recruitingNA
Neural Mechanisms of Music Intervention Chronic Arm Hemiparesis Following Stroke: A Single Case Series EEG Study
This study looks at how playing music might help people recover arm movement after a stroke. Researchers want to see if music therapy can reorganise the brain and improve arm function for stroke survivors. It involves home-based music sessions and brain wave measurements.
United Kingdom - active not recruiting
Systematic Assessment of Treatment Effectiveness for Long-Term Management of Stable Atrial Tachycardia in Inpatient and Outpatient Environments
This study looks at how well treatments work over a long time for people with a fast or irregular heartbeat called atrial tachycardia. Researchers want to see the long-term effects of these treatments on people's health, including their risk of stroke and even how long they live.
Germany - recruitingNA
Pilot Study: Home Use of Wearable Grasping Neuroprosthesis in Vascular Hemiparesis
This study looks at a special device called a Grasp Neuroprosthesis (GNP) that helps people who've had a stroke open and close their hand. It's already been tested in hospitals, and now researchers want to see how well it works when used at home for a whole year.
France - recruiting
The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
This study looks at how blood clots cause strokes. We're using a special scan to find these clots and see where they come from. The aim is to better understand different types of stroke, especially when the cause isn't clear, to improve future treatments.
United Kingdom - recruiting
Prediction of Post-stroke Motor Recovery
This study looks at how well we can predict arm recovery after a stroke. It uses information like a patient's age and initial arm movement to guess how much their arm will improve three months later. This helps doctors plan the best care.
France - recruitingNA
MUSic Therapy In Complex Specialist Neurorehabilitation
This study looks at whether adding music therapy to standard rehabilitation helps people recover better after serious brain or spinal cord injuries. It compares music therapy to usual care to see if it improves daily activities and well-being in patients aged 16-80.
United Kingdom - recruitingPHASE3
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
This study looks at how best to prevent blood clots and bleeding in people who develop an irregular heartbeat (atrial fibrillation) after bypass surgery. It compares different common blood-thinning treatments.
United States · Brazil · Canada - not yet recruitingNA
Potential for Recovery of Voluntary Finger Extension After Stroke
This study looks at how some stroke survivors might regain finger movement, even years after their stroke. It tests a home exercise program with electrical stimulation to see who benefits and why.
United Kingdom - not yet recruitingNA
Volunteer Facilitated Discharge Assistance and Supports at Home (DASH) for People With Stroke
This study looks at whether a volunteer visiting stroke survivors at home can help them cope better. Researchers want to see if this support, alongside usual care, improves recovery for people who have recently left the hospital after a stroke.
Canada - recruitingNA
Somatosensory Stimulation for Unilateral Neglect Post Stroke (SSUN)
This study looks at a hands-on therapy called Mobilisation and Tactile Stimulation (MTS) for people who have had a stroke. It aims to see if MTS can help with 'neglect,' where people aren't aware of one side of their body, after at least 20 weeks post-stroke.
United Kingdom - not yet recruitingNA
Telerehabilitation of Balance Clinical and Economic Decision Support System
This study looks at a new way to help people with balance problems caused by stroke, memory issues, inner ear problems, or Long Covid. It uses a virtual coach at home to guide exercises and improve balance and well-being.
Germany · Greece · Portugal - recruitingNA
B2AD-Risk AFDAS Evolution of Burden of AF
This study looks at people who have had a stroke and then found out they have an irregular heartbeat called atrial fibrillation (AF). We want to understand how this AF changes over time to help improve treatments and prevention for future strokes.
Canada