Venous Thromboembolism research hub
18 indexed studies · 17 currently recruiting
- authorisedTherapeutic exploratory (Phase II)
Randomized, Double blind, Phase II Trial of Vortosiran to Evaluate Safety, Tolerability, and Pharmacodynamic Efficacy in Participants with Prior Venous Thromboembolism After Completion of Initial Anticoagulant Therapy (Cohort A) and in Cancer Patients at High Risk of Venous Thromboembolism (Cohort B)
This study tests a new injection called vortosiran to see if it can safely prevent blood clots. It is for adults who have had a blood clot in the past, or people with cancer who have a high risk of getting one. Researchers want to see how it affects clotting proteins.
Poland · Romania · France - recruitingTherapeutic exploratory (Phase II)
A Master Protocol for a Phase 2 Randomized, Double-blind, Placebo-controlled Study of REGN9933 and REGN7508, Monoclonal Antibodies against Factor XI for Prevention of Venous Thromboembolism in Patients with a Peripherally Inserted Central Catheter (ROXI-CATH).
This study is testing new medicines to help prevent blood clots in people who have a long-term drip called a PICC line. We want to see if these medicines are safe and if they can stop clots from forming. It's a key step in finding better ways to protect patients.
Spain · Romania · Bulgaria - recruiting
A randomised controlled trial investigating the effects of compression stockings in patients who require blood thinning medication post discharge from elective surgery
This study looks at whether wearing compression stockings after planned surgery provides extra protection against blood clots when you already take blood-thinning medicine. Researchers want to find out if the stockings are truly helpful, or if blood thinners on their own provide all the protection you need.
United Kingdom · England - recruitingTherapeutic use (Phase IV)
Cluster randomised trial of low molecular weight heparins - Directly through Epic
This study is looking at two common blood-thinning medicines, Tinzaparin and Dalteparin, given to patients in hospitals. Researchers want to see if one is safer regarding serious bleeding or death within 30 days.
Denmark - recruiting
PRospective Evaluation of Peripartum Anticoagulation ManaGement for ThrOmboembolism
This study looks at how blood thinners are used for pregnant people at risk of blood clots. It aims to understand the best ways to manage these medications during and after childbirth to keep mothers safe and healthy.
United States · Canada · Denmark - recruitingNA
Shared Decision-making Process for Unprovoked vEnous THromboEmbolism Management. (ETHER )
This study looks at how decisions about blood clot treatment are made. It explores working with patients to decide the best length of time to take blood thinners for unprovoked blood clots, hoping to reduce risks like new clots or bleeding.
France - recruitingPHASE3
RIVAroxaban Versus Low-molecular Weight Heparin in Patients With Lower Limb Trauma Requiring Brace or CASTing
This study compares two medicines, rivaroxaban and LMWH, for preventing blood clots in people with leg injuries needing a cast or brace. It aims to see if rivaroxaban is as good as, and easier to use than, LMWH for those at higher risk of clots.
France - recruitingNA
DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis
This study compares two ways to treat deep vein thrombosis (DVT) in the leg: a special device called ClotTriever, or standard blood-thinning medicines. The aim is to see which method works best to clear blood clots and prevent future problems.
United States · Austria · Finland - recruiting
CoMbination of Data From European Cohorts as Part of the European MORPHEUS Project [HORIZON-HLTH-2022-11-01] - "MC-MORPHEUS".
This study combines health information from many European patients to better understand Venous Thromboembolism (VTE). Researchers hope to find new ways to predict who might be at risk of VTE problems and how to give them the best long-term treatment. It's about improving care for VTE patients.
France - recruitingNA
GEKO Venous Thromboembolism Prevention Study
This study compares two ways to prevent blood clots (VTE) in stroke patients who can't move much. It looks at the standard treatment (IPC) versus a new device called geko™ to see which works better over three months.
United Kingdom - not yet recruitingNA
Intermediate Versus Standard Dose Enoxaparin to Prevent Venous Thromboembolism in Severe Trauma Patients: a Multicenter Double Blind Randomised Controlled Trial
This study compares two doses of a blood-thinning medicine (Enoxaparin) to prevent dangerous blood clots in seriously injured patients. We want to see if a slightly higher dose works better than the usual dose in trauma patients admitted to intensive care.
France - recruitingPHASE3
Statins for Venous Event Reduction in Patients With Venous Thromboembolism
This study looks at whether adding a common cholesterol-lowering drug called a statin (rosuvastatin) to standard blood thinner treatment can prevent new blood clots and reduce vein damage after a deep vein thrombosis or pulmonary embolism. Some people will get the statin, while others get a dummy pill.
Canada · France · Ireland - recruitingPHASE4
THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE)
This study looks at whether blood-thinning medicines can help prevent blood clots after common varicose vein operations. It aims to see if giving these medicines after keyhole procedures for varicose veins is a good idea to keep you safe.
United Kingdom - recruitingPHASE4
Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism
This study looks at the best way to treat small blood clots in the lungs (isolated subsegmental pulmonary embolism) in people at low risk. It compares watching carefully without treatment to giving blood-thinning medicine to reduce bleeding risks.
Belgium · Canada · France - recruitingPHASE3
Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism
This study is looking at whether a medicine called omeprazole can help prevent stomach bleeding in older people who are taking blood thinners for blood clots. It's a small first step to see if a bigger study is possible.
Canada - recruiting
Post-Market Celect Platinum Vena Cava Filter and Gunther Tulip Retrieval Set Study
This study looks at how well a device called a Celect Platinum Vena Cava Filter works over time. This filter helps stop blood clots from reaching your lungs. Researchers want to make sure it's safe and effective for patients with blood clot issues.
United States · Spain · United Kingdom - recruitingNA
GRACE: Evaluating Compression Stockings in Patients That Require Extended Duration Pharmacological Thromboprophylaxis
This study looks at whether wearing special stockings helps prevent blood clots after major surgery, even when patients are already taking blood-thinning medicine. It aims to see if the stockings add extra benefit or if they can be safely avoided, considering their costs and potential downsides.
United Kingdom - recruiting
Computerized Registry of Patients With Venous Thromboembolism (RIETE)
The RIETE study is building a large database of information from patients with blood clots (venous thromboembolism). It helps doctors better understand and treat patients, especially those with other health problems, to improve care and understand what medicine works best for different groups.
United States · Argentina · Austria