Latest studies
- Completed
A study to evaluate diagnostic tests used at the point of care for improving antibiotic prescribing for patients with respiratory tract infections in primary care in Europe
Antibiotics treat bacterial infections, but taking them when not needed makes them less effective over time. This European study checks whether rapid clinic tests can help GPs decide if patients with coughs or sore throats truly need antibiotics, safely cutting down unnecessary prescriptions without harming patient recovery.
Community-acquired acute respiratory tract infectionGreece - CompletedPhase III
A study comparing talquetamab in combination with daratumumab or in combination with daratumumab and pomalidomide versus daratumumab in combination with pomalidomide and dexamethasone in participants with multiple myeloma that returns after treatment or is resistant to treatment
This study tests whether a new medicine called talquetamab, given alongside other cancer drugs, helps people with multiple myeloma that has returned or stopped responding to past treatments. Researchers want to see if these new combinations keep the cancer under control for longer than the current standard treatment.
Relapsed or refractory multiple myelomaGreece - RecruitingPHASE3
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
This study looks at new ways to treat type 2 diabetes by testing two medicines, Elecoglipron and Dapagliflozin, both on their own and together. Researchers want to see how well they work and if they are safe for adults with type 2 diabetes.
Type 2 Diabetes MellitusGreece - RecruitingPHASE3
A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)
This study, called DLLEVATE, is looking at a new treatment, ZL-1310, for people with small cell lung cancer that has come back. It compares ZL-1310 to other standard treatments to see if it's safe and works well. You might be eligible if you're over 18 and have had previous treatments.
Small-cell Lung CancerGreece - RecruitingPHASE3
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
This study looks at a new drug, elritercept, for people with myelofibrosis and anaemia who are already taking ruxolitinib. It compares elritercept to a dummy drug (placebo) to see if it improves anaemia and other symptoms, and how safe it is.
MyelofibrosisAnemiaGreece - RecruitingPHASE3
An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.
This study looks at a new treatment called AAA617 for men with early-stage prostate cancer that has spread a little (oligometastatic). It compares AAA617 to careful watching, to see if it can stop the cancer from growing and help men live better for longer.
Oligometastatic Prostate Cancer (OMPC)Greece - RecruitingPhase III
Phase 3, randomised, double-blind, placebo- controlled, 3-arm study to investigate the safety and efficacy of efimosfermin alfa in participants with biopsy-confirmed F2- or F3-stage metabolic dysfunction-associated steatohepatitis (MASH) (ZENITH-1)
This clinical trial is testing a new injection called efimosfermin alfa for people with metabolic dysfunction-associated steatohepatitis (MASH), an inflamed fatty liver condition. Researchers want to see if monthly injections over four years can safely reduce liver fat, ease inflammation, and improve liver scarring compared to a dummy treatment.
Medical condition: Metabolic Dysfunction-Associated Steatohepatitis (MASH) Medical condition in lay language: Metabolic Fatty Liver Inflamation Therapeutic areas: Diseases [C] - Nutritional and Metabolic Diseases [C18]Greece - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
Crohn’s diseaseGreece - Not yet recruiting
Phase 3a and 3b update of the gastric cancer module, EORTC QLQ-STO22
Researchers are updating a widely used questionnaire that measures how stomach cancer and modern treatments affect daily life and well-being. If you have stomach cancer, you can help by completing the draft survey and sharing your feedback during a single, one-off chat lasting up to an hour.
Gastric adenocarcinomaGreece - Recruiting
New measurements of human sperm motility as a prediction of fertility
This study looks at whether smart computer software can track how sperm swim to predict fertility success. Researchers in Birmingham will analyse routine laboratory videos of sperm during normal fertility treatments. Taking part does not change your care or add appointments, but it could improve future fertility treatments for others.
Fertility; infertility; semen analysis; sperm testingGreece - RecruitingTherapeutic confirmatory (Phase III)
KontRASt-02: A randomized, controlled, open label, phase III study evaluating the efficacy and safety of JDQ443 versus docetaxel in previously treated subjects with locally advanced or metastatic KRAS G12C mutant non-small cell lung cancer.
This clinical trial compares a new targeted drug called JDQ443 with standard chemotherapy (docetaxel). It is for adults with advanced non-small cell lung cancer that carries a specific genetic change called KRAS G12C. Researchers want to find out which treatment keeps cancer from growing for longer.
Advanced non-small cell lung cancer harboring the KRAS G12C mutationGreece - CompletedPhase III
Prevention of complications to Improve outcome in elderly patients with acute stroke - A randomised clinical trial
This clinical trial looks at whether giving common medicines right after a stroke can prevent complications like fever, sickness, and chest infections before they start. Researchers want to see if treating older adults early with paracetamol, antibiotics, or anti-sickness medicine helps them recover better and stay independent.
Acute ischaemic stroke or intracerebral haemorrhageGreece - Completed
The SENSE-Cog Randomised Controlled Trial (RCT): Comparing individualised sensory intervention to standard care to improve quality of life in people with dementia and their companions
This trial looks at whether personalised support for hearing and sight loss improves daily life for people with dementia and their carers. Half of participants receive free hearing aids or glasses with home visits from a therapist, while the other half receive standard care and advice.
DementiaGreece - AuthorisedTherapeutic confirmatory (Phase III)
A Long-term Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder for Treatment of Pulmonary Hypertension Associated with Interstitial Lung Disease
This study tests an inhaled dry powder medicine called treprostinil palmitil for adults with high blood pressure in the lungs linked to lung scarring. The trial lasts up to two years to see if the medicine is safe and helps improve breathing, walking ability, and overall quality of life.
Pulmonary Hypertension Associated with Interstitial Lung DiseaseGreece - AuthorisedTherapeutic confirmatory (Phase III)
AugmENtation witH cAnnabidiol iN first episode psyChosis: a doublE blind randomised controlled trial (STEP-ENHANCE Trial)
This clinical trial looks at whether cannabidiol (CBD) can help people experiencing psychosis for the first time. Participants take either CBD liquid or a harmless dummy medicine alongside their standard care for six weeks. Researchers want to see if adding CBD helps reduce symptoms and improves overall recovery.
First Episode Psychosis (FEP)Greece - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2, open-label, randomized, dose optimization study evaluating the efficacy and safety of belantamab mafodotin administered in combination with cyclophosphamide, bortezomib, and dexamethasone in adult participants with newly diagnosed amyloid light chain amyloidosis (ALANIS)
This study is testing a new drug combination for people newly diagnosed with AL amyloidosis. Researchers want to see if adding a targeted medicine called belantamab mafodotin to standard treatments helps clear abnormal proteins from the blood, improves organ health, and works safely at the right dose.
newly diagnosed amyloid light chain amyloidosisGreece - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rozanolixizumab in adult participants with ocular myasthenia gravis
This clinical trial is testing a medicine called rozanolixizumab (Rystiggo) for adults with ocular myasthenia gravis. This condition causes eye muscle weakness, leading to droopy eyelids and double vision. Researchers want to see if this injection reduces eye symptoms and improves daily life compared to a dummy treatment (placebo).
Ocular Myasthenia GravisGreece - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Open-Label Study of Linvoseltamab Versus Daratumumab in Participants with Smoldering Multiple Myeloma at High Risk of Developing Multiple Myeloma
This study looks at adults with high-risk smoldering multiple myeloma, an early form of blood cancer. Researchers are comparing a newer medicine called linvoseltamab against an established treatment called daratumumab. The goal is to see which medicine is better at delaying or stopping the condition from turning into active cancer.
High Risk Smoldering Multiple Myeloma (HR-SMM)Greece - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study Evaluating the Efficacy, Pharmacokinetics, and Safety of Mitapivat in Pediatric Subjects With α- or β-Transfusion-Dependent Thalassemia (ENERGIZEKids-T)
This clinical study tests whether a medicine called mitapivat helps children and teenagers with thalassaemia need fewer blood transfusions. Researchers want to find out if taking this daily tablet safely cuts the amount of transfused blood they need by half or more, reducing hospital visits and iron build-up.
Transfusion-Dependent Alpha- or Beta-ThalassemiaGreece - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, open-label extension study to evaluate the long-term safety and efficacy of rozanolixizumab in adult participants with ocular myasthenia gravis
This clinical trial tests a medicine called rozanolixizumab (Rystiggo) for adults with ocular myasthenia gravis. This condition causes eye muscle weakness, leading to drooping eyelids and double vision. Researchers want to find out how safe and effective this medicine is when used over a longer period.
Ocular Myasthenia GravisGreece - AuthorisedTherapeutic confirmatory (Phase III)
A phase III, randomised, double-blind, placebo-controlled, multicentre trial comparing efficacy and safety of trilaciclib versus placebo in participants with limited-stage small cell lung cancer
This study is testing a drug called trilaciclib for adults with limited-stage small cell lung cancer. Chemotherapy can damage bone marrow and lower white blood cells, raising infection risks. Researchers want to see if trilaciclib protects healthy blood cells and reduces side effects during standard cancer treatment.
Limited-stage small cell lung cancer (LS-SCLC)Greece - AuthorisedTherapeutic confirmatory (Phase III)
A randomized, open-label, multicenter, Phase 3 study to investigate mocertatug rezetecan compared with chemotherapy in participants with endometrial cancer after platinum-based chemotherapy and immunotherapy
This Phase 3 clinical trial tests a new drug called mocertatug rezetecan for womb (endometrial) cancer. Researchers want to see if it works better and is safer than standard chemotherapy for people whose cancer has returned or worsened after earlier treatments like platinum chemotherapy and immunotherapy.
Neoplasms, EndometrialGreece - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, DoubleBlind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder in Participants with Pulmonary Arterial Hypertension (PALM-PAH)
This study is testing a new once-daily dry powder inhaler called treprostinil palmitil for pulmonary arterial hypertension (high blood pressure in the lungs). Doctors want to see if inhaling this medicine once a day helps people walk further and improves their daily symptoms compared with a dummy medicine (placebo).
Pulmonary Arterial HypertensionGreece - AuthorisedTherapeutic use (Phase IV)
A Single-Blind, Randomized, Placebo-Controlled Trial Evaluating the Impact of Clesrovimab on Nasopharyngeal Shedding of RSV and Other Viral and Bacterial Respiratory Pathogens in Infants: The RSV-SHIELD Trial
This study looks at a medicine called clesrovimab (Enflonsia) in babies. Researchers want to see how well it protects infants from respiratory syncytial virus (RSV). They also want to find out if it reduces how long the virus stays in the nose and if it affects other common germs.
Respiratory Syncytial Virus (RSV) prophylaxis (vaccination)Greece - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, 52-Week, Multicenter, Randomized, Placebo-controlled, Double-blind Study to Assess the Efficacy, Safety, and Tolerability of Rocatinlimab in Adult Subjects With Prurigo Nodularis Who are Inadequately Controlled on Topical Therapies or Not Eligible for Topical Therapies
This study tests whether a new medicine called rocatinlimab helps adults with prurigo nodularis. This skin condition causes intensely itchy, firm lumps to form on the skin. The trial checks if the treatment can reduce severe itching and heal skin bumps when prescription creams have not provided enough relief.
Prurigo NodularisGreece - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial: Multiple Independent Sub-studies of Setmelanotide in Patients with POMC/PCSK1, LEPR, NCOA1 (SRC1), or SH2B1 Gene Variants in the Melanocortin-4 Receptor Pathway
This study looks at a medicine called setmelanotide for people who struggle with severe weight issues and extreme hunger caused by rare genetic changes. Researchers want to find out if daily injections under the skin can help adults safely reduce hunger and manage their weight over one year.
Improper function of certain messenger materials in the body that control body weight and hunger inpeopleGreece - RecruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Dose Finding and Comparison Study of the Safety and Efficacy of High Doses of Eteplirsen, Preceded by an Open-Label Dose Escalation, in Patients with Duchenne Muscular Dystrophy With Deletion Mutations Amenable to Exon 51 Skipping
This clinical trial is testing whether higher doses of a medicine called eteplirsen are safe and helpful for boys with Duchenne muscular dystrophy. It is for males with a specific genetic change that can be treated by skipping exon 51, aiming to protect muscle strength over nearly three years.
Duchenne Muscular DystrophyGreece - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3 Global, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)
This study is testing a new injection called ION-682884 for adults with a serious heart condition called ATTR-CM. Researchers want to find out if this medicine can protect the heart, lower the need for hospital care, and help people live longer compared to a dummy treatment (placebo).
Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)Greece - RecruitingTherapeutic confirmatory (Phase III)
ATHENA (A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy)
This study looks at two medicines, rucaparib and nivolumab, for women with advanced ovarian, fallopian tube, or primary peritoneal cancer. It aims to see if using these drugs after standard chemotherapy helps keep the cancer away for longer compared to dummy treatments, known as placebos.
Ovarian epithelialcancer, Malignant peritonealneoplasm, advanced (FIGO stage III-IV), high-grade epithelial ovarian, fallopiantube, or primary peritoneal cancer (who responded to front-lineGreece - RecruitingPhase II and Phase III (Integrated)
A Phase 2/3, Randomized, Double-Blinded, Placebo-Controlled, Parallel-Group, 2-Arm, Multicenter, Operationally Seamless Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacodynamics, Pharmacokinetics, and Immunogenicity of Efgartigimod PH20 SC in Participants Aged 18 Years and Older With Active Idiopathic Inflammatory Myopathy
This clinical trial is testing a new injection called efgartigimod for adults with inflammatory muscle disease (myositis). Researchers want to see if the medicine can safely reduce muscle inflammation, improve strength, and help people lower their daily steroid dose compared to a dummy treatment over 52 weeks.
Active Idiopathic Inflammatory Myopathy (IIM)Greece - RecruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) 1.0 mg/1.0 mg s.c. once weekly versus tirzepatide 5 mg s.c. once weekly in participants with type 2 diabetes inadequately controlled on metformin, SGLT2 inhibitor or both
This study compares two weekly injectable medicines for type 2 diabetes: a new combined treatment called CagriSema and an existing medicine called Mounjaro (tirzepatide). Researchers want to see which treatment is better at lowering average blood sugar levels and helping people manage their body weight over 60 weeks.
Type 2 DiabetesGreece - RecruitingTherapeutic confirmatory (Phase III)
A 96-Week, Prospective, Multicenter, Randomised, Double-Blind, Placebo-Controlled, Phase 3 Study to Compare Efficacy and Safety of Masitinib Dose Titration to 4.5 mg/kg/day versus Placebo in the Treatment of Patients with Primary Progressive or Secondary Progressive Multiple Sclerosis Without Relapse
This study tests whether a medicine called masitinib can help slow down disability in people living with progressive forms of multiple sclerosis (MS). Researchers will compare masitinib to a dummy pill (placebo) over 96 weeks to see if it safely keeps physical and memory symptoms from getting worse.
Multiple SclerosisGreece - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3 Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial with Open-Label Extension to Evaluate the Efficacy, Safety, and Tolerability of Efgartigimod PH20 Subcutaneous Administered by Prefilled Syringe in Adult Patients with Primary Sjögren’s Disease
This study tests whether a medicine called efgartigimod can help adults with primary Sjögren’s disease. Researchers want to see if regular injections under the skin can ease symptoms like joint pain, dry eyes, and dry mouth, and lower overall body inflammation compared with a dummy treatment (placebo).
Primary Sjögren’s DiseaseGreece - RecruitingHuman Pharmacology (Phase I)- Other
C5001001 - A Phase 1/2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Escalating Doses of PF-07868489 in Healthy Adult Participants And, Additionally, Clinical Activity of Repeat Doses in Participants With Pulmonary Arterial Hypertension
This study tests a new medicine called PF-07868489 for pulmonary arterial hypertension (high blood pressure in the lungs). Researchers are checking its safety in healthy volunteers, and finding out if repeated doses help improve blood flow and walking ability in adults living with the condition.
Pulmonary Arterial HypertensionGreece - RecruitingTherapeutic use (Phase IV)
Early oral step-down antibiotic therapy versus continuing intravenous therapy for uncomplicated Gram-negative bacteraemia (the INVEST trial)
This study looks at the best way to treat bacterial blood infections. Researchers want to find out whether switching patients to antibiotic tablets early works just as well as keeping them on antibiotic drips in hospital, helping people recover safely with fewer complications from intravenous lines.
Gram-negative bacteraemiaGreece - Active not recruitingPHASE3
Study to Assess the Safety and Efficacy of Viltolarsen in Ambulant Boys With DMD (RACER53-X)
This study is testing a medicine called viltolarsen for boys with Duchenne muscular dystrophy who can still walk. It is an extension study for children who already completed an earlier trial. Every participant receives the medicine through a weekly drip for nearly two years to check its safety and long-term effects.
Duchenne Muscular DystrophyGreece - RecruitingTherapeutic confirmatory (Phase III)
A Greek multicenter, single-arm, low-intervention clinical trial to evaluate the efficacy and safety of irbesartan/amlodipine fixed combination in newly diagnosed patients or patients with uncontrolled arterial hypertension.
This clinical trial looks at a combined tablet containing two blood pressure medicines (irbesartan and amlodipine). Researchers want to see how safely and effectively this single daily pill lowers blood pressure over 16 weeks in adults who are newly diagnosed or whose current treatment is not working well enough.
Arterial HypertensionGreece - RecruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Atezolizumab with or without Tiragolumab (Anti-Tigit Antibody) in Patients with Unresectable Esophageal Squamous Cell Carcinoma whose Cancers have not Progressed following Definitive Concurrent Chemoradiotherapy
This study looks at new treatments for cancer of the gullet (oesophagus) that cannot be removed by surgery. Researchers want to see if using immunotherapy drugs, called atezolizumab and tiragolumab, after standard chemotherapy and radiotherapy can help stop the cancer from returning and help people live longer.
Unresectable Esophageal Squamous Cell CarcinomaGreece - RecruitingTherapeutic confirmatory (Phase III)
An Open-Label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH (MK-7962-004)
This study looks at a medicine called sotatercept for adults with pulmonary arterial hypertension (PAH). Researchers want to see how safe it is over a longer period when taken alongside usual treatments. It also checks whether the medicine helps improve walking ability, heart health, and everyday energy levels.
Pulmonary Arterial Hypertension (PAH)Greece - RecruitingPhase I and Phase II (Integrated)- Other
A randomised, double-blind, placebo-controlled, two-part study to evaluate the pharmacokinetics, safety and tolerability, and preliminary efficacy of two dose levels of golexanolone in subjects with primary biliary cholangitis, fatigue, and cognitive dysfunction.
This study tests a new medicine called golexanolone for adults with primary biliary cholangitis (PBC). Researchers want to see if the treatment is safe and whether it can help relieve severe tiredness and 'brain fog', which are common, distressing symptoms that currently have few good treatments.
Primary biliary cholangitis (PBC)Greece - RecruitingTherapeutic exploratory (Phase II)
EMAPALUMAB TREATMENT FOR ANTICIPATED CLINICAL BENEFIT IN SEPSIS DRIVEN BY THE INTERFERON-GAMMA ENDOTYPE (THE EMBRACE TRIAL)
This clinical trial is testing a medicine called emapalumab for people with severe sepsis. Sepsis happens when the body overreacts to an infection. Researchers want to see if this medicine helps vital organs recover better and faster compared to standard care with a simple salt-water drip.
SEPSISGreece - RecruitingTherapeutic confirmatory (Phase III)
A Double-Blind, Randomized, Active-Controlled, Parallel-Group, Phase 3 Study to Compare Efficacy and Safety of CT-P51 and Keytruda in Combination with Platinum-Pemetrexed Chemotherapy in Patients with Previously Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer
This study tests a new medicine called CT-P51 compared to an established treatment, Keytruda, for advanced non-small cell lung cancer. Both medicines are given with standard chemotherapy. The aim is to see if CT-P51 works just as well and is just as safe as Keytruda for newly diagnosed patients.
Previously Untreated Metastatic Non-Squamous Non-Small Cell Lung CancerGreece - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind, placebo-controlled, parallel-group study to investigate the efficacy and safety of dupilumab for the treatment of pruritus of Lichen Simplex Chronicus (LSC) in adults
This study tests whether a medicine called dupilumab can help adults with lichen simplex chronicus, also known as neurodermatitis. Researchers want to see if the treatment relieves severe itching, improves sleep, and clears thickened patches of skin compared to a dummy injection (placebo) over 24 weeks.
NeurodermatitisGreece - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind, placebo-controlled, parallel-group study to investigate the efficacy and safety of dupilumab for the treatment of pruritus of Lichen Simplex Chronicus (LSC) in adults
This clinical trial is testing a medicine called dupilumab for adults with lichen simplex chronicus, also known as neurodermatitis. This condition causes thick, intensely itchy patches of skin. Researchers want to see if regular dupilumab injections can safely reduce itching, improve sleep, and help clear the skin compared to a dummy drug.
NeurodermatitisGreece - RecruitingTherapeutic exploratory (Phase II)
KontRASt-06: An open-label phase II trial evaluating the activity and safety of JDQ443 single-agent as first-line treatment for patients with locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer with a PD-L1 expression < 1% or a PD-L1 expression ≥ 1% and an STK11 co-mutation.
This phase 2 clinical trial looks at a new targeted medicine called JDQ443. It is for adults with advanced non-small cell lung cancer that has specific gene changes, including KRAS G12C. The study tests how well this medicine shrinks tumours when used as a first treatment.
Locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer with a PD-L1 expression < 1% or a PD-L1 expression ≥ 1% and an STK11 co-mutation.Greece - RecruitingTherapeutic exploratory (Phase II)
A Phase 2b Open-label Study of Selinexor (KPT-330) in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
This clinical trial is testing a medicine called selinexor for adults with diffuse large B-cell lymphoma (DLBCL). It is designed for people whose cancer has returned or stopped responding to prior treatments. Doctors want to see how well selinexor shrinks tumours and controls the disease safely.
Relapsed/Refractory DLBCL, Relapsed/Refractory DLBCL, Relapsed/Refractory DLBCLGreece - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open-Label, Long-Term Trial to Evaluate the Safety and Efficacy of Efgartigimod (ARGX-113) PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia
This study looks at a medicine called efgartigimod for adults with primary immune thrombocytopenia (ITP). ITP causes low blood platelets, leading to easy bruising and bleeding. Researchers want to see if an injection under the skin is safe and helps keep platelet counts at a healthy level over time.
Primary Immune ThrombocytopeniaGreece - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
A follow-up extension study of patients who completed the U-LaserPrint-1 clinical trial to evaluate the long-term safety and efficacy of treatment with InvivoLPrint-U.
This study is checking the long-term safety of a newly made replacement bladder in adults treated for bladder cancer. Researchers want to see how well the new bladder works over time, check for any long-lasting side effects, and find out if it improves everyday quality of life.
Muscle-invasive bladder cancer (MIBC) patients, eligible for neobladder reconstruction following radical cystectomy.Greece - RecruitingTherapeutic confirmatory (Phase III)
A Randomized, Open-Label, Multicenter Phase 3 Trial of Domvanalimab, Zimberelimab, and Chemotherapy Versus Nivolumab and Chemotherapy in Participants with Previously Untreated Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma
This phase 3 clinical trial is looking at a new combination of immunotherapy drugs given alongside chemotherapy. It aims to find out if this new combination helps people with untreated, advanced cancer of the stomach or food pipe live longer compared to the current standard immunotherapy and chemotherapy treatment.
Metastatic Esophageal or Gastric Cancer, Esophageal or Gastric CancerGreece - RecruitingTherapeutic confirmatory (Phase III)
A Long-term Extension (LTE) Study to Characterize the Safety and Efficacy of Danicopan as an Add-on Therapy to a Complement Component 5 Inhibitor (C5i) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Previously Treated with Danicopan in an Alexion-sponsored Clinical Study.
This study looks at a medicine called danicopan for adults with paroxysmal nocturnal hemoglobinuria (PNH). It is an extension study for people who already took danicopan in an earlier trial. Researchers want to see if continuing this add-on treatment alongside standard care remains safe and helpful over a longer period.
Patients with Paroxysmal Nocturnal HemoglobinuriaGreece