Latest studies
- Active not recruitingPHASE3
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
This study is looking at a new medicine called Olezarsen for people with very high triglyceride levels. It's an ongoing study for those who have already started the treatment in previous trials, checking its long-term safety and how well it's tolerated.
Severe HypertriglyceridemiaGreece - RecruitingPHASE3
A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
This study is looking at a new treatment (BNT323) for women with advanced womb cancer that has come back. It compares BNT323 to standard chemotherapy to see if it works better at shrinking tumours and keeping the cancer from growing.
Endometrial CancerGreece - RecruitingPHASE2, PHASE3
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
This study is testing a new medicine, zilovertamab vedotin (ZV), combined with standard treatments for a type of lymphoma called diffuse large B-cell lymphoma (DLBCL). It's for people whose lymphoma has come back or hasn't responded to previous treatments.
DLBCLDiffuse Large B-Cell LymphomaGreece - Active not recruitingPHASE3
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
This study compares a new medicine, luspatercept, with a standard one, epoetin alfa, for people with a type of blood disorder called myelodysplastic syndromes (MDS). It aims to see if luspatercept can reduce the need for blood transfusions.
Myelodysplastic SyndromesGreece - RecruitingPHASE2, PHASE3
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
This study looks at a new drug, ficerafusp alfa, combined with pembrolizumab (Keytruda®) for people with advanced head and neck cancer. It compares this combination against pembrolizumab alone to see if it works better and is safe.
Metastatic Head and Neck Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell CarcinomaGreece - Active not recruiting
Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System
This study looks at how safe and effective a new treatment called FARAPULSE is for atrial fibrillation. It collects real-world information about people treated with this system in hospitals to see how well it works and if it improves their quality of life.
Atrial FibrillationGreece - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
This study is looking at a new medicine called KarXT + KarX-EC to see if it can help improve memory and thinking skills in people with Alzheimer's disease. It also checks if the medicine is safe to use. Some people will get the active medicine, others a dummy pill.
Alzheimer's DiseaseGreece - Active not recruitingNA
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer
This study aims to understand if temporarily stopping hormone therapy for early breast cancer to allow for pregnancy is safe. It will also look at fertility and emotional well-being for young women.
Early Breast CancerGreece - Active not recruitingPHASE1, PHASE2
A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100)
This study is testing a new medicine called sotorasib for people with specific advanced cancers carrying a KRAS p.G12C gene change. Researchers want to see if it's safe, how much to give, and if it helps shrink tumours. It's an early-stage trial looking for better cancer treatments.
KRAS p.G12C Mutant Advanced Solid TumorsGreece - Active not recruitingPHASE1
Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
This study, called MTAPESTRY 104, is testing a new drug called Anvumetostat, alone or with other treatments, for advanced lung cancers that have a specific genetic change (MTAP-deletion). It aims to find the safest and most effective dose.
Thoracic TumorsNon-small Cell Lung CancerGreece - Active not recruitingPHASE1, PHASE2
Sub-study of Belantamab Mafodotin (GSK2857916) in Combination With Nirogacestat in Participants With RRMM
This study is looking at a new combination of two drugs, Belantamab Mafodotin and Nirogacestat, for people with multiple myeloma that has come back or not responded to previous treatments. The main goal is to find a safe dose and see how well it works.
Multiple MyelomaGreece - RecruitingPHASE2
Surgery for Recurrent Glioblastoma
This study looks at whether a second surgery for recurrent glioblastoma brain cancer, followed by treatment, is better than just having treatment alone. It aims to see if surgery helps people live longer, feel better, and have a good quality of life.
GlioblastomaGreece - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Open-label, Multiple Ascending-Dose Study to Evaluate the Safety, Tolerability and Efficacy of ARCT-032 in People with Cystic Fibrosis
This study is testing a new medicine, ARCT-032, for people with cystic fibrosis. Researchers want to see if it's safe, how well people tolerate it, and if it helps improve their health, especially their breathing, by giving different doses.
Cystic FibrosisGreece - Active not recruitingPHASE2
Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy.
This study is for women with advanced womb cancer that has returned or worsened after chemotherapy. It tests a new drug called retifanlimab, sometimes alone and sometimes with other medicines, to see how safe and effective they are.
Endometrial CancerGreece - Active not recruitingPHASE3
ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions
This study looks at a new medicine called Luspatercept for adults with a certain type of blood disorder (MDS) who have anaemia but don't yet need blood transfusions. It compares Luspatercept to another common medicine, Epoetin Alfa, to see which is better and safer.
Myelodysplastic SyndromesGreece - Active not recruitingPHASE3
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both
This study looks at a new medicine called CagriSema to see how well it lowers blood sugar and helps with weight loss in people with type 2 diabetes. It's compared to another medicine called tirzepatide. Participants will get one of the medicines by chance.
Diabetes Mellitus, Type 2Greece - RecruitingPHASE1, PHASE2
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
This study, FaR-RMS, is for children and adults with a type of cancer called rhabdomyosarcoma. It's looking for better ways to treat both newly diagnosed and returning cancer, using different combinations of medicines and radiotherapy.
RhabdomyosarcomaGreece - Not yet recruitingPHASE2
A Study to Evaluate the Efficacy of VVD-133214 in Combination With Pembrolizumab Compared With Pembrolizumab Alone in Participants With Advanced Cancer of the Colon or Rectum
This study looks at a new combination treatment for advanced bowel cancer that has spread. It combines a new drug, VVD-133214, with an existing immunotherapy, pembrolizumab. The aim is to see if this combination works better than pembrolizumab alone for certain types of bowel cancer.
Colorectal AdenocarcinomaGreece - Recruiting
CRS Questionnaire Validation Project
This study helps check if two new questionnaires accurately measure how severe and controlled chronic sinus problems (with or without nasal polyps) are, from a patient's viewpoint. Doctors across many countries are working together to validate them with 1000 patients.
Chronic Rhinosinusitis (CRS) With and Without Nasal PolypsGreece - RecruitingPHASE3
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
This study looks at a new drug, zilovertamab vedotin, combined with standard treatment for a type of blood cancer called diffuse large B-cell lymphoma (DLBCL). Researchers want to see if this new combination helps people live longer without their cancer growing or spreading, compared to standard treatment alone.
Diffuse Large B-Cell LymphomaGreece - Enrolling by invitationNA
Alleviant ALLAY-HFrEF Study
This study is investigating a new treatment for heart failure called the Alleviant ALV1 System. It aims to see if creating a small opening between the heart's upper chambers can help people whose hearts aren't pumping blood effectively.
Heart FailureGreece - RecruitingPHASE2
A Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary Disease
This study is testing a new medicine, AZD6793, for people with moderate to very severe COPD. It will compare different doses of the medicine against a dummy pill to see if it helps and is safe.
Chronic Obstructive Pulmonary Disease (COPD)Greece - RecruitingPHASE3
A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
This study is testing a new drug, Telisotuzumab Vedotin, against a standard treatment, Docetaxel, for advanced non-small cell lung cancer. It aims to see if the new drug works better and is safe for adults who have already had treatment.
Non Small Cell Lung CancerGreece - RecruitingPHASE3
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
This study is for people who have already taken part in other studies for a medicine called sotatercept, used to treat Pulmonary Arterial Hypertension (PAH). It aims to check the long-term safety and how well people tolerate sotatercept when taken with their usual PAH treatments.
Pulmonary Arterial HypertensionGreece - RecruitingPHASE3
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
This study is looking at a new medicine called Elecoglipron for people with certain types of heart failure. It compares Elecoglipron to a dummy medicine (placebo) to see if it helps improve heart health outcomes for adults already taking other heart failure medications, including dapagliflozin.
Heart Failure With Preserved Ejection Fraction (HFpEF)Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)Greece - RecruitingPHASE2
A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
This study is testing a new medicine called MK-8690 for people with moderate to severe ulcerative colitis. Researchers want to see if it's better than a dummy medicine (placebo) at helping people feel better and achieve remission.
Colitis UlcerativeUlcerative ColitisGreece - RecruitingPHASE3
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
This study is testing new treatments for a type of lung cancer called non-small cell lung cancer. Researchers want to see if a combination of two medicines, calderasib and pembrolizumab, works better than pembrolizumab with chemotherapy to slow down cancer growth.
Non-small Cell Lung CancerGreece - RecruitingPHASE1, PHASE2
Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer
This study looks at new drug combinations (Elacestrant and Abemaciclib) for people with breast cancer that has spread to the brain. It aims to find the right dose and see how well the new combination works for ER-positive, HER-2 negative breast cancer.
Breast NeoplasmsBrain NeoplasmsNeoplasms by SiteNeoplasmsGreece - RecruitingPHASE3
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
This study compares two treatments for multiple myeloma that has come back or not responded to previous treatments. It looks at a new drug, mezigdomide, combined with standard medicines (bortezomib and dexamethasone), against another combination (pomalidomide, bortezomib, and dexamethasone). The aim is to see which combination is more effective and safe.
Relapsed or Refractory Multiple MyelomaGreece - Active not recruitingPHASE3
ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack
This study, called ARTEMIS, is testing a new medicine called ziltivekimab for people who have had a heart attack. It aims to see if ziltivekimab can prevent future heart problems compared to a dummy medicine.
Cardiovascular RiskAcute Myocardial Infarction (AMI)Greece - RecruitingPHASE3
A Study of Gammagard Liquid (Immune Globulin Infusion, 10%) to Prevent Infections in Adults With Multiple Myeloma
This study looks at a medicine called IGI to see if it can help prevent infections in adults with a type of blood cancer called multiple myeloma. Participants will either get IGI for a year or only if they develop a serious infection.
Multiple MyelomaSecondary ImmunodeficiencyGreece - RecruitingPHASE3
A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.
This study looks at a new medicine called elecoglipron for people with long-term kidney disease. We want to see if it helps improve health compared to a dummy pill (placebo). Participants will also be taking existing kidney disease treatments like dapagliflozin. It's a large study, involving many people to get clear results.
Chronic Kidney DiseaseGreece - Active not recruitingPHASE3
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
This study investigates how a medicine called semaglutide affects eye problems in people with type 2 diabetes over five years. Participants will get either semaglutide or a dummy medicine, injected once a week, along with their usual diabetes treatments.
Diabetes Mellitus, Type 2Greece - RecruitingPHASE3
A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia
This study looks at how safe and effective a medicine called mezagitamab is for adults with a bleeding condition called ITP. If you’ve been in a previous mezagitamab study, you might be invited to join this longer follow-up.
Immune Thrombocytopenic Purpura (ITP)Greece - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
Crohn's DiseaseGreece - Active not recruitingPHASE3
A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer
This study looks at treating a specific type of advanced lung cancer. It compares two treatments, atezolizumab alone or combined with lurbinectedin, after initial chemotherapy. The aim is to see which approach works best to keep the cancer stable.
Small-Cell Lung CancerGreece - RecruitingPHASE3
A Study to Investigate the Long-term Safety and Efficacy of Belimumab in Adults With Interstitial Lung Disease (ILD) Associated With Systemic Sclerosis (SSc) and Other Connective Tissue Diseases (CTD) (BLISSconneCTD-OLE)
This study looks at the long-term safety and how well a medicine called belimumab works for people with lung problems linked to certain conditions like lupus. It's for people who've already been in a previous study.
Connective Tissue DiseasesGreece - RecruitingPHASE2
A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis
This study is looking into a new medicine called Ianalumab for people in the UK with a specific type of scleroderma called diffuse cutaneous systemic sclerosis. It aims to see if the drug is safe and helps with symptoms, compared to a dummy treatment.
Diffuse Cutaneous Systemic SclerosisGreece - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (TITANIA)
This study is testing a new medicine, Tozorakimab, for people with severe COPD who often have flare-ups. We want to see if it reduces these flare-ups and is safe to use. Some people will get the new medicine, others a dummy medicine (placebo).
Chronic Obstructive Pulmonary Disease (COPD)Greece - RecruitingPHASE3
A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant
This study is testing a new drug, linvoseltamab, for people with a type of blood cancer called multiple myeloma. It compares this new drug to standard treatments to see how safe and effective it is, for patients who cannot have a stem cell transplant.
Multiple MyelomaGreece - Active not recruiting
A Registry on the FARAVIEW Technology of the OPAL HDx Mapping System When Used With the FARAWAVE NAV Ablation Catheter in the Treatment of Atrial Fibrillation
This study looks at how safe and effective a new treatment called FARAPULSE is for a heart condition called atrial fibrillation. It collects information for one year after the treatment. Doctors use the FARAPULSE system with special tools during the procedure.
Atrial FibrillationPulsed Field AblationFARAPULSEGreece - Active not recruitingNA
Carotid Artery Implant for Preventing Stroke in Atrial Fibrillation Patients Taking Oral Anticoagulants
This study is looking at a new device called the Vine™ Embolic Protection System. It's like a tiny filter placed in the neck arteries to help prevent strokes in people with atrial fibrillation who are already taking blood thinners but are still at high risk.
Atrial FibrillationStrokeGreece - Active not recruitingPHASE3
A Safety and Efficacy Study of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-Severe Symptom State
This study is looking at a new medicine called Dazodalibep for people with Sjögren's Syndrome. It aims to see how well it helps with symptoms and whether it's safe to use, especially for those with moderate to severe symptoms.
Sjögren's Syndrome (SS)Greece - Active not recruitingPHASE3
Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Patients With Hormone Receptor-positive/Human Epidermal Growth Factor Receptor 2 Negative (HR+/HER2-) Metastatic Breast Cancer Who Have Received Endocrine Therapy
This study looks at a new drug, Sacituzumab Govitecan, for advanced breast cancer. It compares it to standard treatments to see if it can slow cancer growth or spread, helping people live longer and healthier lives.
Locally Advanced or Unresectable Metastatic Breast CancerStage IV Breast CancerGreece - Active not recruitingPHASE3
A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis Including Those Who Have a History of Inadequate Response or Intolerance to Biologic Therapy(Ies)
This study is testing a new medicine, risankizumab, for adults with active psoriatic arthritis, especially those who haven't responded well to other treatments. It aims to see how safe and effective it is in reducing symptoms.
Psoriatic Arthritis (PsA)Greece - Recruiting
AutoInflammatory Disease Alliance Registry (AIDA)
This project is building a secure online registry to collect health information from people with rare inflammatory conditions. The goal is to better understand these diseases, how they affect people, and how different treatments work. Your information could help doctors improve care for others.
Hereditary Autoinflammatory DiseasesSchnitzler SyndromeBehcet SyndromePFAPA SyndromeGreece - Active not recruitingPHASE2
A Study to Evaluate the Long-Term Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Advance)
This study looks at a new oral medicine called paltusotine for people with acromegaly. It checks how safe and effective it is over a long time for those who have already tried it in previous studies. The aim is to see if it continues to help manage the condition.
AcromegalyGreece - Active not recruitingPHASE3
A Study to Investigate the Clinical Benefit of Isatuximab in Combination With Bortezomib, Lenalidomide and Dexamethasone in Adults With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
This study is looking at a new treatment called isatuximab, combined with other treatments, for adults newly diagnosed with a type of blood cancer called multiple myeloma. It's for those who aren't able to have a stem cell transplant and aims to see if the new combination can help people live longer without their cancer getting worse.
Plasma Cell MyelomaGreece - Active not recruitingPHASE4
CINC424A2X01B Rollover Protocol
This study is for patients already taking ruxolitinib, or ruxolitinib with panobinostat, in a previous trial, and who are still benefiting. It lets them continue their treatment and helps researchers learn more about the long-term safety of these medications.
Primary MyelofibrosisPolycythemia VeraGraft Versus Host DiseaseAcute Myeloid LeukemiaGreece - Active not recruitingPHASE3
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
This study allows some cancer patients who are already benefiting from certain treatments in another study to continue receiving that treatment. It’s for those who wouldn't be able to get the treatment otherwise, helping them keep accessing therapies that are working for them.
CancerGreece