Latest studies
- RecruitingPHASE3
ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)
This study looks at a new drug, darolutamide, along with standard hormone therapy for men with prostate cancer that has spread. It's for those who might not be able to have other treatments because of their general health.
Prostate Cancer MetastaticSwitzerland - Active not recruitingPHASE2
A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
This study looks at new drug combinations to treat advanced lung cancer. It compares two different drug mixes, each including chemotherapy, to see which works best and is safest for people with Stage IV or recurrent non-small cell lung cancer.
Non-small Cell Lung CancerRecurrent Non-small Cell Lung CancerMetastatic Non-small Cell Lung CancerSwitzerland - Recruiting
The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)
This study compares two ways to treat serious brain tumours (high-grade gliomas) in older patients or those who are not very active: having surgery to remove the tumour (resection) or taking a small tissue sample (biopsy). It looks at survival, quality of life, and if patients can then have other treatments.
GlioblastomaGlioblastoma, IDH-wildtypeGlioblastoma MultiformeGlioblastoma Multiforme, AdultSwitzerland - Active not recruitingNA
ALT-FLOW II Trial of the Edwards APTURE Transcatheter Shunt System
This study looks at a new device for people with heart failure. It wants to see if the Edwards APTURE shunt system can help improve symptoms for those whose hearts pump well but still feel unwell, even with their usual medicines.
Heart FailureSwitzerland - RecruitingPHASE4
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
This study looks at whether blood-thinning medicines (anticoagulants) can prevent strokes and other heart-related problems in people who have had temporary episodes of an irregular heartbeat called atrial fibrillation (AF) during stressful times like surgery or serious illness.
StrokeAtrial FibrillationSwitzerland - Active not recruitingPHASE3
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
This study compares a new medicine, luspatercept, with a standard one, epoetin alfa, for people with a type of blood disorder called myelodysplastic syndromes (MDS). It aims to see if luspatercept can reduce the need for blood transfusions.
Myelodysplastic SyndromesSwitzerland - RecruitingPHASE2, PHASE3
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
This study looks at a new drug, ficerafusp alfa, combined with pembrolizumab (Keytruda®) for people with advanced head and neck cancer. It compares this combination against pembrolizumab alone to see if it works better and is safe.
Metastatic Head and Neck Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell CarcinomaSwitzerland - RecruitingPHASE2
A Study to Learn More About the Study Medicine Called Inotuzumab Ozogamicin (InO) in Children (1 to <18 Years) With First Relapse ALL
This study looks at a new medicine, Inotuzumab Ozogamicin (InO), for children aged 1 to 17 with a type of blood cancer called Acute Lymphoblastic Leukaemia (ALL) that has come back. It compares InO to a standard treatment to see which works better and is safer.
ACUTE LYMPHOBLASTIC LEUKEMIASwitzerland - Active not recruitingNA
ASCEND CSP IDE Study
This study is testing a new type of heart device lead for people with heart failure. It looks at how safe and effective the "CSP ICD Lead" is when used with special heart devices to help control irregular heartbeats and improve heart function.
Heart FailureVentricular ArrythmiaSwitzerland - RecruitingNA
Closed-loop in Adults With Type 2 Diabetes
This study looks at a new 'artificial pancreas' system, CamAPS HX, for adults with type 2 diabetes who use insulin. It aims to see if this automated system can better control blood sugar at home compared to standard care, checking its safety and how easy it is to use.
Type 2 Diabetes Treated With InsulinSwitzerland - RecruitingPHASE2, PHASE3
An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma
This study aims to improve treatment and understanding of childhood ependymoma. It involves different treatment approaches, including chemotherapy and radiotherapy, for children and young adults up to 22 years old. The goal is to find better ways to help these patients.
Childhood EpendymomaSwitzerland - Active not recruitingNA
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer
This study aims to understand if temporarily stopping hormone therapy for early breast cancer to allow for pregnancy is safe. It will also look at fertility and emotional well-being for young women.
Early Breast CancerSwitzerland - RecruitingPHASE3
A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
This study is testing a new drug, Ersodetug, for adults with a rare condition called Tumour Hyperinsulinism (Tumour HI). It aims to see if the drug can help control very low blood sugar levels caused by certain tumours, when current treatments aren't enough.
Tumor Hyperinsulinism (Tumor HI)Switzerland - Active not recruitingPHASE1, PHASE2
A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100)
This study is testing a new medicine called sotorasib for people with specific advanced cancers carrying a KRAS p.G12C gene change. Researchers want to see if it's safe, how much to give, and if it helps shrink tumours. It's an early-stage trial looking for better cancer treatments.
KRAS p.G12C Mutant Advanced Solid TumorsSwitzerland - Active not recruitingPHASE2
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
This study is testing a new medicine, volixibat, for people with Primary Sclerosing Cholangitis (PSC) who experience bothersome itching. It aims to see if the medicine can reduce itching and affect how PSC progresses.
Primary Sclerosing CholangitisSwitzerland - Active not recruitingPHASE2
Study of Atezolizumab + FLOT vs. FLOT Alone in Patients With GC/GEJ and High Immune Responsiveness
This study compares a new drug, atezolizumab, plus standard chemotherapy (FLOT) against FLOT alone for stomach or food pipe cancer. It focuses on patients whose cancer shows certain immune markers, aiming to see if the new combination is safer and more effective before and after surgery.
Gastric CancerGastroesophageal Junction AdenocarcinomaSwitzerland - RecruitingPHASE2
Surgery for Recurrent Glioblastoma
This study looks at whether a second surgery for recurrent glioblastoma brain cancer, followed by treatment, is better than just having treatment alone. It aims to see if surgery helps people live longer, feel better, and have a good quality of life.
GlioblastomaSwitzerland - RecruitingPHASE2, PHASE3
A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions
This study is testing a new medicine, TAK-861, for people with narcolepsy type 1. It checks how safe the medicine is and if it helps reduce sleepiness and sudden muscle weakness. Participants have already taken TAK-861 in previous studies.
Narcolepsy Type 1Switzerland - Active not recruitingPHASE3
Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy
This study looks at new drug combinations for advanced liver cancer that hasn't been treated before. It compares cabozantinib with atezolizumab against a standard treatment, sorafenib, to see which works better and is safer.
Hepatocellular CarcinomaSwitzerland - RecruitingPHASE1, PHASE2
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
This study, FaR-RMS, is for children and adults with a type of cancer called rhabdomyosarcoma. It's looking for better ways to treat both newly diagnosed and returning cancer, using different combinations of medicines and radiotherapy.
RhabdomyosarcomaSwitzerland - Active not recruitingPHASE1, PHASE2
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
This study is looking at a new medicine called VX-264 for people with Type 1 Diabetes. We want to see if it's safe, how well people tolerate it, and if it helps manage the condition. It's for adults aged 18-65.
Type 1 DiabetesSwitzerland - RecruitingPHASE4
Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism
This study looks at the best way to treat small blood clots in the lungs (isolated subsegmental pulmonary embolism) in people at low risk. It compares watching carefully without treatment to giving blood-thinning medicine to reduce bleeding risks.
Pulmonary EmbolismEmbolismEmbolism and ThrombosisLung DiseasesSwitzerland - Active not recruitingPHASE2
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis
This study is testing a new medicine, Volixibat, for people with Primary Biliary Cholangitis (PBC) who experience bothersome itching. We want to see if Volixibat can reduce itching and if it affects how PBC develops. It's a Phase 2 study, meaning we're still learning about its effects.
Primary Biliary CholangitisPBCSwitzerland - RecruitingPHASE3
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
This study looks at a new drug, zilovertamab vedotin, combined with standard treatment for a type of blood cancer called diffuse large B-cell lymphoma (DLBCL). Researchers want to see if this new combination helps people live longer without their cancer growing or spreading, compared to standard treatment alone.
Diffuse Large B-Cell LymphomaSwitzerland - Active not recruitingPHASE3
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
This study is testing a new medicine called Mim8 for people with haemophilia A, including those with inhibitors. Mim8 aims to prevent bleeding episodes by helping blood clot. It's for people already in other Mim8 studies.
Haemophilia AHaemophilia A With InhibitorsSwitzerland - RecruitingPHASE3
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
This study is for people who have already taken part in other studies for a medicine called sotatercept, used to treat Pulmonary Arterial Hypertension (PAH). It aims to check the long-term safety and how well people tolerate sotatercept when taken with their usual PAH treatments.
Pulmonary Arterial HypertensionSwitzerland - RecruitingPHASE3
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
This study is testing new treatments for a type of lung cancer called non-small cell lung cancer. Researchers want to see if a combination of two medicines, calderasib and pembrolizumab, works better than pembrolizumab with chemotherapy to slow down cancer growth.
Non-small Cell Lung CancerSwitzerland - RecruitingNA
Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation Therapy
This study looks at whether a procedure to close off a part of the heart called the left atrial appendage (LAA) in addition to blood thinners can better prevent strokes in people with atrial fibrillation who have already had a stroke despite being on blood thinners.
Ischemic StrokeAtrial FibrillationSwitzerland - RecruitingPHASE4
Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study
This study looks at how well a medicine called pegcetacoplan works and if it's safe for people in the UK with rare kidney diseases like C3G or IC-MPGN. It uses real-life information from patients to help doctors make better decisions about treatment.
C3 Glomerulopathy (C3G)Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)Switzerland - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
Crohn's DiseaseSwitzerland - RecruitingPHASE3
Vorasidenib Maintenance for IDH Mutant Astrocytoma
This study is testing a new drug, vorasidenib, for people with a specific type of brain tumour called IDH-mutant astrocytoma. It aims to see if vorasidenib can help stop the tumour from growing back after initial treatment.
IDH-mutant Grade 2 or 3 AstrocytomaSwitzerland - Enrolling by invitationNA
Optical Coherence Tomography in Acute Vessel Evaluation
This study compares two ways to help people having a heart attack: one uses standard X-rays, the other uses a special camera called OCT. We want to see if the OCT camera leads to better results for patients.
Ischemic Heart DiseaseIschemic Coronary Artery DiseaseACS (Acute Coronary Syndrome)Switzerland - RecruitingPHASE3
A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant
This study is testing a new drug, linvoseltamab, for people with a type of blood cancer called multiple myeloma. It compares this new drug to standard treatments to see how safe and effective it is, for patients who cannot have a stem cell transplant.
Multiple MyelomaSwitzerland - Enrolling by invitation
Multicentre Prospective Observational Cohort Study Aiming to Collect Medical Data, Create a Database to Facilitate Clinical and Fundamental Research Into Urinary Tract Infections With the Ultimate Goal of Improving Their Treatment.
This study aims to understand urinary tract infections (UTIs) better. By collecting information from people with UTIs, researchers hope to improve treatments, patient care, and help fight antibiotic resistance over the next 2 to 5 years.
Urinary Tract Infection(UTI)Urinary Tract Infection, RecurrentUTI - Urinary Tract InfectionSwitzerland - Active not recruiting
A Registry on the FARAVIEW Technology of the OPAL HDx Mapping System When Used With the FARAWAVE NAV Ablation Catheter in the Treatment of Atrial Fibrillation
This study looks at how safe and effective a new treatment called FARAPULSE is for a heart condition called atrial fibrillation. It collects information for one year after the treatment. Doctors use the FARAPULSE system with special tools during the procedure.
Atrial FibrillationPulsed Field AblationFARAPULSESwitzerland - Recruiting
Online Adaptive Stereotactic Body Radiotherapy for Localized Prostate Cancer (X-SMILE)
This study looks at a new way to deliver radiation therapy (SBRT) for prostate cancer, specifically for men who also have urinary issues or an enlarged prostate. It aims to see if this new approach, using weekly treatments guided by scans, is safe and effective.
Localized Prostate CarcinomaProstate Cancer (Adenocarcinoma)Prostate HyperplasiaLower Urinary Track SymptomsSwitzerland - Recruiting
Prospective Assessment Project of AirwaY Management-related Incidents in Adult Anaesthesia Care PAPAYA III
This study looks at how anaesthesia teams manage breathing tubes and devices during operations in adults. It aims to find out how often minor or major problems with breathing support happen, what causes them, and how they are dealt with, to make anaesthesia safer in the future.
Airway Complication of AnesthesiaAdverse EventsSwitzerland - Active not recruitingPHASE4
A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy
This study looks at how a new medicine, mavacamten, affects the heart's structure in adults with a specific heart condition called hypertrophic cardiomyopathy. We'll use special MRI scans to see these changes, aiming to better understand the treatment's impact.
Cardiomyopathy, HypertrophicSwitzerland - Active not recruiting
WiCS-LV Post Market Surveillance Registry
This study looks at a new heart pacing system (WiCS-LV) for heart failure patients. It checks how well the system works in real life and collects information over five years. It helps doctors understand if this wire-free treatment is a good option for people who haven't responded to other treatments.
Cardiac Resynchronization TherapySwitzerland - Active not recruitingNA
Zimmer Trabecular Metal Total Ankle PMCF
This study looks at how well a new type of ankle replacement, called the Zimmer Trabecular Metal Total Ankle, works in people with different kinds of arthritis. It checks how long the ankle replacement lasts, how much pain people have, and how well they can move after the surgery.
Degenerative ArthritisRheumatoid ArthritisPost Traumatic ArthritisSwitzerland - Active not recruitingPHASE1
Cusatuzumab in Combination With Background Therapy for the Treatment of Participants With Acute Myeloid Leukemia
This study looks at a new drug called cusatuzumab, given with standard treatments, for people newly diagnosed with a type of blood cancer called Acute Myeloid Leukaemia (AML). It aims to find out how safe these treatments are together and if people can tolerate them well.
Leukemia, Myeloid, AcuteSwitzerland - RecruitingNA
Treatment of Complex Post-traumatic Stress Disorder Among Displaced People in Switzerland and Germany
This study looks at new ways to help refugees and asylum seekers in Switzerland and Germany with a condition called Complex Post-Traumatic Stress Disorder (CPTSD). It tests different approaches to therapy, which have been adjusted for their unique backgrounds, to see which works best.
Complex Post-Traumatic Stress DisorderSwitzerland - Recruiting
Validity of ICU Clinician's Appraisal of Proportionality in CPR
This study looks at whether doctors and nurses in intensive care can predict how well patients who had a cardiac arrest outside hospital will recover. They do this by comparing the healthcare workers' early opinions with the patients' actual recovery and quality of life six months later.
Cardiac Arrest, Out-Of-HospitalSwitzerland - Recruiting
Development of the PTSD-iMPACT to Measure PTSD-Related Functional Impairment in Children and Adolescents - A Validation Study in Switzerland and Germany
This study is developing a new tool, the PTSD-iMPACT, to better understand how PTSD affects daily life for children and teenagers. It aims to improve support for young people struggling with trauma by accurately measuring their difficulties with things like school, friends, and family.
PTSD - Post Traumatic Stress DisorderPTSD-Related Functional Impairment in Children and AdolescentsSwitzerland - Recruiting
Perform Humeral System Study
This study looks at how well a shoulder replacement called the PERFORM™ Humeral System works over time. It collects information on safety and how much it helps people with shoulder problems like arthritis or tendon tears. It tracks patients for up to 10 years after their surgery.
Osteoarthritis ShoulderAvascular NecrosisPost-traumatic Arthrosis of Other Joints, Shoulder RegionRotator Cuff Tear ArthropathySwitzerland - RecruitingPHASE3
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
This study looks at how safe a new medicine called finerenone is for children and young people (aged 1-18) with long-term kidney disease, when taken with other common kidney medicines. It also checks if it helps reduce protein in their urine.
Chronic Kidney DiseaseProteinuriaChildrenSwitzerland - Active not recruitingPHASE3
Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.
This study looks at a new medicine called remibrutinib for chronic spontaneous urticaria (CSU), comparing it to a dummy treatment (placebo) and another existing medicine, omalizumab. It aims to see if remibrutinib is safe and helps reduce hives and itching in adults whose CSU isn't well controlled by usual allergy medicines.
Chronic Spontaneous UrticariaSwitzerland - Recruiting
Study of the Use of Venetoclax in Participants With Chronic Lymphocytic Leukemia (CLL) Under Real-Life Setting
This study looks at how a medicine called venetoclax works for people with a type of blood cancer called Chronic Lymphocytic Leukemia (CLL) in everyday medical care. Researchers will check its effects, costs, and how patients feel while taking it, either alone or with other common treatments.
Chronic Lymphocytic Leukemia (CLL)Switzerland - Recruiting
Study to Collect Real-world Performance and Safety Data on Penumbra System® in Population With Acute Ischemic Stroke (AIS).
This study looks at how well a medical device, the Penumbra System, works and how safe it is for people who have had a type of stroke called an acute ischemic stroke. We want to understand its real-world benefits for patients.
Acute Ischemic Stroke (AIS)Switzerland - Active not recruitingPHASE1, PHASE2
First-in-Human Study of the GDF-15 Neutralizing Antibody Visugromab (CTL-002) in Patients With Advanced Cancer (GDFATHER)
This study is looking at a new drug called visugromab (CTL-002) for people with advanced cancer. It aims to see how safe the drug is, what doses work best, and if it can help fight different types of solid tumours, sometimes used with another cancer medicine.
Solid Tumor, AdultSwitzerland