I'm all over the place
Posted , 13 users are following.
Hi, I'm a new person here. Just asking for some advice really.
I drink at least two bottles of strong wine every night, a lot of time it's more - I'm on my 3rd one now. I'm 54, I live on my own. For me, what else is there? Nothing really I suppose. Even so, I don't want this. I've tried quitting myself but I've never had any success. I've never had any kind of medical help. I'm just wondering if anyone thinks there's anything the NHS can really do for some like me. I think that only I can do anything - I can't of course. But what can doctors really do. What kind of practical help can they offer?
Is it really worth going to my doctor?
2 likes, 37 replies
sue08 taplow
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nicole36330 taplow
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I was referred by my gp to local alcohol services and all that that entails.Its not nice but I just metaphorically put my head down and faced into it.
I was prescribed Nalmefene which slowly stops you wanting to drink so much but it took a lot of effort on my part to get them to prescribe it to me.
emma84640 nicole36330
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Thanks loads x
nicole36330 emma84640
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Initially it was working but I think I'm over the honeymoon period and still drinking 1 to 1.5 bottles a day but it can take people a year to see results so I'm just plodding on.
I basically had to insist I be considered for this drug as it was my right to be assessed and luckily they agreed
emma84640 nicole36330
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For some reason I thought you was on naltrexone lol not nalmefene. Reading the posts too fast. This happened to me too on nalmefene, I didn't get same buzz but knew in my head more drink equals relaxed feeling etc. I also felt sick a lot of the time.
Would like to try naltrexone or campral but the alcohol outreach people said you must quit altogether and abstain before they will prescribe anything x
nicole36330 emma84640
Posted
Maybe Joanna or Paul could confirm this
Luckily I had no side effects on either
emma84640 nicole36330
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I think naltrexone is meant to have less side effects that is why I'd like to try it. How long were you on it for? Yes it is a worry if I only get honeymoon period on that drug too. Campral sounds good in reducing cravings but think you need to be abstinent.
X
nicole36330 emma84640
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ADEfree nicole36330
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Basically, they have different profiles when it comes to how they affect the opioid receptor subtypes. Both Nalmefene (Selincro) and Naltrexone antagonize (block) the Mu opioid receptor (MOR), but Selincro is a partial agonist (activates) the Kappa opioid receptor (KOR) and the Delta opioid receptor (DOR). Naltrexone blocks all three, but it's action on the DOR is weak. Have a look at the Wikipedia page for Nalmefene, down in the Pharmacology section it goes into a bit more detail. Nalmefene also has a longer half-life than Naltrexone.
nicole36330 ADEfree
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Would that mean that Nalmefene SHOULD be more effective?
Joanna-SMUKLtd nicole36330
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''The comparison of these two medications given the current state of knowledge and treatment evidence suggests that there are minimal if any differences in efficacy for reducing heavy drinking. In terms of adverse events, nalmefene may offer an advantage in no hepatotoxicity and the lack of need for liver function testing''.
It is important to find studies that use naltrexone in exactly the same way as nalmefene (ie as per The Sinclair Method). In a lot of studies, nalmefene looks to come out way more efficient than naltrexone BUT they were using nalmefene as it should be used, and naltrexone as an every day with abstinence medication so it was like comparing apples with oranges!
nicole36330 Joanna-SMUKLtd
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I think one of the main advantages as far as I'm concerned is that's it's not toxic to the liver which is reassuring when still drinking
angela26170 taplow
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ADEfree angela26170
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https://patient.info/health/sinclair-method-for-alcohol-use-disorder
It's what I used to cut back from 9 pints a day to 2 pints.
Robin2015 angela26170
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angela26170 Robin2015
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