Can I take Amlodipine and Rybelsus together?

Why this happens

Amlodipine works by relaxing blood vessels to lower blood pressure. Rybelsus (a GLP-1 receptor agonist) can have mild effects on the cardiovascular system, including lowering blood pressure and increasing heart rate. Together, these effects can be additive, meaning they might lower your blood pressure more than either drug would on its own.

What you should do

You can take these medicines together, but you should monitor your blood pressure regularly at home. If you feel dizzy, lightheaded, or faint, sit or lie down until the feeling passes. Mention these symptoms to your doctor, as they may wish to adjust your amlodipine dose. Always stay well-hydrated, as Rybelsus can sometimes cause nausea or vomiting which can lead to dehydration and further lower your blood pressure.

Important precautions

Pancreatitis

Stop taking Rybelsus and seek immediate medical help if you experience severe, persistent stomach pain which may reach through to your back, as this can be a sign of acute pancreatitis.

Diabetic Retinopathy

If you have diabetic eye disease, you must have regular eye check-ups while taking Rybelsus, as rapid improvements in blood sugar can temporarily worsen your vision.

Severe Liver Disease

You must inform your doctor if you have liver problems, as amlodipine is broken down very slowly by the liver and may require a much lower dose to avoid dangerous accumulation in the body.

Food and drink warnings

Grapefruit and grapefruit juice

Grapefruit can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swollen ankles. It is best to avoid large amounts of grapefruit juice while taking this medicine.

Food and drink (general)

Rybelsus must be taken on an empty stomach with a small sip of plain water (no more than 120ml). You must wait at least 30 minutes before eating, drinking anything else, or taking other oral medicines. If you eat or drink too soon, the medicine will not be absorbed properly and will not work.

Alcohol

While there is no direct interaction, both amlodipine and alcohol can lower your blood pressure. Drinking alcohol while taking amlodipine may make you feel dizzy, lightheaded, or sleepy. It is best to keep your alcohol intake within recommended limits.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.