Can I take Vitamin C and Vitamin D together?

Why this happens

These vitamins use different pathways for absorption and metabolism. Vitamin C is water-soluble and Vitamin D is fat-soluble, meaning they do not compete for the same transport systems in the body.

What you should do

It is safe to take these two vitamins together. For the best absorption of Vitamin D, it is recommended to take it with a meal that contains some fat (such as yoghurt, eggs, or avocado).

Important precautions

Kidney stones (renal calculi)

High doses of vitamin C can increase the amount of oxalate in your urine, which significantly raises the risk of developing kidney stones, especially if you have had them before.

Hypercalcaemia (high blood calcium)

You must not take Vitamin D if you have high levels of calcium in your blood or urine, as it can cause calcium to build up in your body and damage your kidneys or heart.

G6PD deficiency

Very high doses of vitamin C can cause oxidative stress and lead to the breakdown of red blood cells (haemolysis) in individuals with G6PD deficiency.

Food and drink warnings

High-fat meals

Vitamin D is fat-soluble. It is best absorbed when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy). Taking it on an empty stomach may reduce its effectiveness.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.