- recruiting
Accelerated community multi cancer diagnostic evaluation platform
The ARMADILO study is testing new multi-cancer blood tests in NHS GP surgeries. It aims to see if a simple blood sample can help doctors spot different cancers early in people aged 50 and over who have common symptoms like tummy pain, bloating, feeling sick, or unexpected weight loss.
United Kingdom · England - completed
International Collaborative Ovarian Neoplasm studies (1): A trial of adjuvant chemotherapy for early-stage ovarian cancer
This study looks at whether women with early-stage ovarian cancer benefit from having chemotherapy straight after surgery, or whether it is better to wait and only give treatment if the cancer returns. It aims to help doctors find the safest, most effective treatment plan.
United Kingdom · England - completed
Add-Aspirin: the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours.
The Add-Aspirin study looks at whether taking everyday aspirin can stop cancer from coming back after standard treatment. Adults with early-stage breast cancer and other common tumours take either a low dose of aspirin, a higher dose, or a dummy tablet to see if it helps them live longer, healthier lives.
United Kingdom · England · India - recruitingPhase I and Phase II (Integrated)- Other
Phase 1/2 trial evaluating isatuximab in combination with pegenzileukin in relapsed or refractory multiple myeloma (RRMM) previously exposed to anti-CD38 and anti-BCMA
This study is looking at a new combination of treatments for multiple myeloma that has come back or isn't responding to current treatments. It aims to find the safest dose of these new drugs and see how well they work together to shrink the cancer or stop it from growing.
Greece · Germany · Italy - recruitingPhase I and Phase II (Integrated)- First administration to humans
Phase 1/2, Open-label, Dose Escalation and Dose Expansion Study of TransCon TLR7/8 Agonist Alone or in Combination with Pembrolizumab in Participants with Locally Advanced or Metastatic Solid Tumor Malignancies
This study is testing a new cancer medicine, TransCon TLR7/8 Agonist, sometimes given with another drug called Keytruda. It's for adults with advanced cancer. Researchers want to see if it's safe, what dose works best, and if it can shrink tumours.
Spain · Netherlands - recruitingTherapeutic exploratory (Phase II)
Open-label, Phase 2 study of tusamitamab ravtansine (SAR408701) combined with pembrolizumab and tusamitamab ravtansine (SAR408701) combined with pembrolizumab and platinum-based chemotherapy with or without pemetrexed in patients with CEACAM5-positive expression advanced/metastatic nonsquamous non-small-cell lung cancer (NSQ NSCLC)
This study is testing new combinations of medicines for a type of advanced lung cancer. It combines an experimental drug (tusamitamab ravtansine) with existing treatments like pembrolizumab (Keytruda) and chemotherapy to see how safe and effective they are. It's for adults whose cancer has a specific marker called CEACAM5.
France - recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1 /2 study for the safety, efficacy, pharmacokinetic and pharmacodynamics evaluation of amcenestrant (SAR439859 ), administered orally as monotherapy, then in combination with other anti-cancer therapies in postmenopausal women with estrogen receptor-positive advanced breast cancer
This study looks at a new drug, amcenestrant, for postmenopausal women with advanced breast cancer. It tests its safety and how well it works, both alone and with other common cancer medicines.
Belgium · Spain - recruitingPHASE2
Pan Tumor Rollover Study
This study looks at the long-term safety of different cancer treatments, including nivolumab, alone or combined with other medicines. It's for people with various types of cancer who are already receiving treatment in a related study, aiming to see how these treatments work over time.
United States · Argentina · Australia - enrolling by invitationPHASE3
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Durvalumab
This study is for cancer patients who have already been in another durvalumab drug trial and are still benefiting from the treatment. It lets them continue receiving the drug to see if it keeps helping them.
United States · Argentina · Australia - active not recruitingPHASE3
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)
This study is for cancer patients who are already taking osimertinib (Tagrisso) in another AstraZeneca study and are still benefiting from it. It allows them to keep taking the drug to see if it continues to help.
China · France · Japan - recruitingPHASE3
A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
This study offers continued treatment to cancer patients already in certain Genentech/Roche studies. It's for those still benefiting from their current treatment and who can't get it elsewhere. The aim is to bridge care for these patients.
Belgium · Canada · China - completed
CONTEST Study - Accuracy of contrast enhanced breast tomosynthesis: A comparison with digital mammography and breast MRI
The CONTEST study looks at a new type of breast X-ray called CE-DBT. It uses a special dye to help doctors see tumours more clearly, especially in dense breast tissue. Researchers want to find out if it works better than a standard mammogram and as well as an MRI scan.
United Kingdom · England · Scotland - completedNot Applicable
Electronic Risk Assessment for Cancer for Patients in General Practice
The ERICA trial tests whether a smart computer tool can help family doctors (GPs) spot cancer earlier. The software alerts doctors during everyday appointments if a patient's symptoms suggest cancer tests might be needed. The goal is to improve early cancer diagnosis across GP practices in England.
United Kingdom · England - recruiting
The Shared Safety Net Action Plan (SSNAP): Exploring the viability of a safety-netting tool in primary care that encourages partnership between patients and staff to support earlier diagnosis of cancer
This study looks at a new tool called SSNAP to help doctors and patients work together for an earlier cancer diagnosis. It helps patients understand symptoms to watch for and when to see the doctor again, especially for unclear symptoms like tiredness or weight loss.
United Kingdom · England - recruitingPhase I and Phase II (Integrated)- Other
An open-label, multicenter Phase 1/2 dose escalation and expansion study of THOR-707 as a single agent and as a combination therapy in adult subjects with advanced or metastatic solid tumors
This study is testing a new medicine, THOR-707, for people with advanced cancer. It aims to find the safest and most effective dose, and see how well it works alone or with other treatments to shrink tumours and improve health.
Spain - recruitingHuman Pharmacology (Phase I)- Other
A PHASE 1 STUDY TO ASSESS THE MASS BALANCE, PHARMACOKINETICS, AND METABOLISM OF ORAL [14C]-ZIPALERTINIB IN HEALTHY ADULT MALE SUBJECTS
This early-stage study in healthy adult men looks at how a new cancer drug called zipalertinib is handled by the body. We want to understand how it's absorbed, changed, and leaves the body, and check for any side effects.
Netherlands - recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1, open-label, multiple-ascending dose study to investigate the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of KD033 (SAR445710) in subjects with metastatic or locally advanced solid tumors
This study is testing a new medicine, KD033, for people with advanced cancer. It's a very early-stage trial focusing on how safe the medicine is, how it moves through the body, and if it shows any signs of working.
France · Spain - recruiting
Testing a digital, comprehensive, standardised assessment approach to improve the management of people with cancer
This study is testing a new digital tool called MyPath to help people with cancer. It lets patients record their symptoms on a phone or tablet, so doctors can better understand how they are feeling and give more personalised care. The aim is to make cancer treatment better for everyone.
United Kingdom · England · Scotland - recruiting
A population-based digital study offering people testing for cancer genes, to identify people at increased risk of cancer so they can take steps to prevent it or detect it early
This study offers a genetic test for cancer risk to people in the UK. It uses a saliva sample to check for genes linked to breast, ovarian, bowel, and womb cancers. The aim is to find people at higher risk so they can take steps to prevent cancer or detect it early.
United Kingdom · England · Northern Ireland - recruiting
To Assess the Correlation of High-resolution Specimen PET-CT Imaging, Using the XEOS AURA 10 PET-CT, With the Histopathology Results and Long-term Outcome of Patients Undergoing Resective Cancer Surgery.
This study looks at how well a special scan, called PET-CT, works on removed cancer tissue. It compares these scans with lab results and patient health over time to see if this technology can improve cancer care and treatment decisions.
Belgium · Germany · Netherlands - recruitingNA
IMPLEMENT - Model Project for Quality-assured Exercise Therapy for Cancer Patients
This project aims to make sure cancer patients in Germany can easily access high-quality exercise programmes. It will find out what helps and what makes it difficult for people to join these programmes, and then create better ways for everyone to get involved.
Germany - active not recruitingPHASE1, PHASE2
Investigation of a Therapeutic Vaccine (ACIT-1) in Cancer
This study is testing a new treatment called ACIT-1, which is a therapeutic vaccine for cancer. Researchers are looking at different doses to see if it's safe and helps the body's immune system fight cancer, including pancreatic cancer and other types.
United Kingdom - recruitingNA
Evidence Development in Cancer Treatment - Real World: PREDiCTrw
This study looks at how new cancer treatments affect patients' quality of life and survival in real-world settings. We want to understand how well these treatments work outside of strict trials to help doctors make better decisions.
Canada - recruitingPHASE2
Maitake for Integrative Cancer Care
This study looks at a mushroom extract, Maitake, to see if it helps the immune system of people with cancer who are also having regular cancer treatment. Researchers want to find out if it can work alongside standard therapies.
Canada - recruitingNA
STING MARK Universal Fiducial Marker System
This study is testing a new, small marking device called STING-MARK. It helps doctors accurately pinpoint the exact location of a tumour in organs for more effective treatments. We're checking how well it works and stays in place in organs that have been removed.
Canada - recruitingNA
Cycling-Based Aerobic Exercise Intervention for Individuals With Chemotherapy-Induced Peripheral Neuropathy (CIPN)
This study looks into whether cycling exercises can help reduce tingling, numbness, and pain in hands and feet caused by chemotherapy. It's a small study to see if a bigger one should be done. It involves 12 weeks of supervised cycling twice a week.
Canada - not yet recruitingPHASE2, PHASE3
Partner4Exercise Randomized Controlled Trial
This study helps older adults with cancer exercise more and feel less alone. It checks if having peer support and exercise coaching, or just a peer, helps improve fitness and mental wellbeing over 10 weeks.
Canada - recruitingNA
Adapting The Fear Of Recurrence Therapy (FORT) for Parents and Establishing Acceptability and Feasibility
This study looks at a new type of therapy called Parent-FORT for parents of children who have had cancer. It aims to help parents deal with the fear that their child's cancer might come back, and to see if the therapy is easy to do and helpful.
Canada - recruitingNA
MR Imaging Study Using the Northern Alberta Linac-MR (Northern LIGHTs - 1)
This study is testing a new type of MRI scanner that works with radiotherapy machines. It aims to take clearer pictures of cancer to help doctors give more accurate treatment. We want to make sure the scanner is safe and takes good quality images for future patients.
Canada - authorisedTherapeutic exploratory (Phase II)
FINACCESS - Finnish National Study for Early Access to Cancer Therapies
The FINACCESS study is looking at how well new cancer medicines work and if they cause side effects. It's for adult patients with different types of cancer. Doctors want to find out more about early access treatments.
Finland - recruitingPHASE4
The STOP-MED CTRCD Trial
This study looks at whether it's safe for cancer survivors to stop heart failure medicines if their heart has recovered well. It's for people whose hearts were affected by cancer treatment but are now working normally again.
United States · Australia · Canada - recruitingNA
Flexi Band Resistance Training Versus EMS Exercise in Patients With the Diagnosis of Malignant Diseases
This study looks at how exercise, using either special resistance bands or a modern electrical muscle stimulation (EMS) method, can help cancer patients. We want to see if these exercises improve strength, body shape, fitness, and how patients feel overall during their treatment.
Germany - recruiting
Understanding and Anticipating Therapeutic and ADverse Responses in Anti-cancer Immune Checkpoint Inhibition Towards a Better Therapeutic Management of Patients
This study looks at blood tests from cancer patients getting immunotherapy. We want to find early signs of side effects, called irAEs, to help doctors give better care and predict who might respond well to treatment.
France - not yet recruitingNA
Impact of Respiratory Rehabilitation on Quality of Life in Patients With Metastatic Non-small Cell Lung Cancer Treated With Immunotherapy and Chemotherapy in the Maintenance Phase
This study looks at how a breathing exercise programme (respiratory rehabilitation) affects the quality of life for people with advanced lung cancer who are having ongoing chemotherapy and immunotherapy. It aims to see if these exercises can make a positive difference.
France - recruiting
Comparison of 30-day Morbidity and Mortality in Cancer Patients Based on Emergency Department Location
This study looks at how where you go for emergency care affects cancer patients. We want to see if visiting an emergency department (ED) that specialises in cancer care, or one connected to your cancer centre, leads to better outcomes compared to a general ED.
France - recruiting
Evaluation of the Therapeutic Approach of Aromatherapy by Olfaction of Essential Oils in Association With Hypnosis in the Management of Patients Followed for Cancer
This study looks at whether a mix of aromatherapy (smelling essential oils) and hypnosis can help cancer patients feel more comfortable during routine medical procedures like blood tests or dressing changes. It aims to reduce anxiety and improve well-being.
France - recruiting
Effects of Oncological Treatment During Pregnancy on Mother and Child
This study looks at how cancer and its treatments during pregnancy affect mums and their babies. Researchers want to see if babies exposed to treatments like chemotherapy develop normally, and they'll also track the mothers' health.
United States · Argentina · Austria - recruitingNA
The Therapeutic Effect of Expressive Writing.
This study explores how writing about cancer, especially using a kind and understanding approach, affects well-being. It looks at how people with cancer feel about their bodies and their overall happiness by comparing two types of expressive writing.
United Kingdom - recruitingPHASE3
Randomized Controlled Trial of Remote Symptoms Monitoring With Resilience PRO Compared to Care As Usual Only
This study looks at whether a phone app, Resilience PRO, can help improve the quality of life for cancer patients undergoing treatment. It aims to see if regular symptom reporting through the app, which alerts care teams to important changes, makes a difference compared to standard care.
France · Germany - recruitingNA
Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing
This study looks at a new digital tool called GA-Mainstream. It helps people with certain cancers like breast, ovarian, and colon cancer understand genetic testing better. The goal is to make sure patients feel informed and supported while getting tested for genes that can affect their cancer treatment.
Canada - recruitingNA
Strategy for EArly Recognition of Cancer, COPD & Heart Failure in the Emergency Department
This study at Queen Elizabeth University Hospital checks if a computer program can help doctors find heart and lung problems like cancer earlier from chest X-rays. It aims to improve how quickly and accurately these conditions are diagnosed.
United Kingdom - active not recruitingPHASE3
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
This study is for men with cancer who are already taking darolutamide in another Bayer study and are doing well. It lets them keep taking the same medicine at the same dose, continuing their treatment journey under medical supervision.
United States · Argentina · Australia - recruiting
Met Non Small Cell Cancer Registry (MOMENT)
This study looks at how treatments for a specific type of lung cancer (NSCLC with METex14 changes) are working in real patients and how patients are doing over time. It's a way to learn more about this cancer and its treatments without testing new medicines.
United States · Austria · Belgium - active not recruitingPHASE3
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
This study is for people who have already been taking a medicine called venetoclax for their cancer in another trial. It allows them to keep taking venetoclax if it's helping them and they're not having bad side effects, so doctors can learn more about its long-term safety.
United States · Australia · Austria - not yet recruitingNA
Finding My Way-UK: Promoting Positive Psychological Outcomes in People Living With and Beyond Curatively Treated Cancer
This study looks at an online program, "Finding My Way-UK", for people who have finished cancer treatment. It checks if the program is easy to use and helpful for improving feelings like hope and resilience after cancer.
United Kingdom - recruitingNA
Bliss DTx Assessment During Course Care Including Port-A-Catheter Setting
This study looks at a new virtual reality (VR) tool called Bliss DTx for managing pain and stress when a Port-a-Cath is put in. It compares VR to standard pain relief methods to see if it works as well.
France - active not recruitingPHASE2
Acute Immunological Effects of Exercise in Cancer Patients
This study looks at how a single session of intense exercise affects the immune system in young people with cancer compared to healthy individuals. We want to understand if exercise can help the body fight illness during cancer treatment.
Germany - recruiting
Feasibility and Acceptability of Collecting Sociodemographic Data in CCTG Trials
This study asks people with cancer in clinical trials to share information about their lives, like their income, education, and housing. It helps researchers understand what makes it easier or harder for people to join research and get healthcare.
Canada - recruiting
Prospective Hyperthermia Database in Cancer Patients (HT Register)
This study is gathering information about cancer patients treated with hyperthermia at Charité hospital. It aims to understand how well hyperthermia works in real-world settings, identify any risks, and improve treatments. Patients are followed to see how their cancer responds and if they experience side effects.
Germany - active not recruitingPHASE1
IMA401 TCER® in Recurrent and/or Refractory Solid Tumors, Alone or in Combination With a Checkpoint Inhibitor
This study is testing a new medicine, IMA401, for people with advanced cancers that have come back or haven't responded to other treatments. We want to see if it's safe, how well people tolerate it, and if it can help shrink tumours, either alone or with another cancer drug called pembrolizumab.
Germany