- recruitingNA
The PRIMROSE Trial
This study looks at how a special breathing device, used alongside standard pre-surgery exercises, can help people with lung cancer prepare for surgery. The aim is to make them fitter, reduce complications, and shorten their time in hospital.
United Kingdom - recruiting
ORganoid GeneratioN Study for Cancer
This study aims to grow cancer cells from patient samples in the lab, like 'mini-tumours.' This helps scientists understand why some cancers respond to treatments and others don't, hopefully leading to better treatments for cancer patients in the future.
United Kingdom - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations
This study is testing a cancer drug called capmatinib to see if it can help adults with different types of cancer that share a specific genetic change (MET mutation). It's already approved for some lung cancers, and now researchers want to know if it works for other cancers too.
United Kingdom - recruiting
Performance Indicators and Impact on the Care Pathway of Sequencing on the SeqOIA and AURAGEN (Seqogen) Platforms for Oncology Patients
This study looks at how advanced genetic tests (genomic sequencing) help doctors treat cancer in France. It checks if these tests improve patient care, how quickly results are ready, and how hospitals share information, helping to improve future healthcare for cancer patients.
France - recruitingPHASE1
A Single- and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY4066708 in Healthy Participants
This study looks at a new medicine called LY4066708 in healthy volunteers. We want to check it's safe, how well the body handles it, and how long it stays in the system. It's a first step to see if it could help with certain health conditions later on.
United Kingdom - recruiting
Prospective Observational Study of a Precision Medicine Approach in Patients With Advanced Cancer
Researchers are looking at a new way to treat advanced cancer using 'precision medicine'. This means checking a person's cancer cells closely to find the best treatment for them. This study will follow patients in Berlin to see how well this approach works and if it helps them.
Germany - not yet recruiting
Hair Isotope Analysis for Early Cancer Detection
This study looks at hair to find early signs of cancer. We think cancer changes how your body uses nutrients, and this might show up in your hair. By analysing hair from people with cancer, we hope to find new ways to detect the disease simply and without needles.
United Kingdom - recruitingPHASE1
Impact of PEG Bowel Preparation on Gut Microbiome Composition Recovery
This study looks at how a common bowel cleansing drink, PEGLyte, affects the helpful germs (microbiome) in your gut. It aims to understand these changes and how quickly your gut returns to normal after taking the drink.
Canada - recruitingNA
Impact of a Collaborative Program of Physical Activity of Newly-diagnosed Cancer Patients
This study looks at how a special exercise programme helps people newly diagnosed with cancer. We want to see if a personalised plan works better than standard advice for staying active, which could improve quality of life and treatment tolerance.
France - recruitingNA
Optimization of Radiation Protection Through Genomic Analyses
This study looks at how radiation affects our DNA by using new genetic tests. We want to find ways to measure radiation exposure, understand its effects, and predict how well someone might recover from it. This helps improve safety from radiation.
Germany - recruiting
E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe
The E²-RADIatE study is collecting information from cancer patients across Europe who are having radiotherapy. This helps researchers better understand how radiotherapy is used and how it works alongside other treatments to improve care for people with cancer.
Austria · Belgium · Czechia - recruitingNA
Impact of Virtual Reality on the Quality of Life of Oncology Patients
This study explores if virtual reality (VR) can help cancer patients, especially children, feel better during chemotherapy. VR aims to reduce anxiety, sickness, and pain, improving their overall comfort and quality of life while undergoing treatment. It also checks how happy patients and nurses are with the VR experience.
France - recruiting
Assessing Cancer Treatment Response to Therapy Using 18F-FSPG PET
This study investigates if a new scan, 18F-FSPG PET, can better show how well cancer treatments are working for lung and head & neck cancers. We're comparing it to standard scans to see if it predicts treatment success earlier.
United Kingdom - active not recruiting
Management of Bone Metastases
This study looks at how we treat bone issues in people with cancer, especially how often important bone-strengthening medicines are used. We want to understand what makes these treatments work best and help more patients.
France - recruiting
Population-based Cancer Observatory
This study, called a Cancer Observatory, in France collects information on people with cancer. Researchers want to understand cancer trends, how well treatments and prevention plans work, and if where people live affects cancer risk. It's an observational study, meaning no medical treatments are given.
France - recruiting
LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study
This study looks at how new cancer treatments affect daily life for people with long-term cancer. It aims to understand how to best support them while they are on these treatments, often for many months or years.
Canada - recruitingPHASE3
Abatacept in Immune Checkpoint Inhibitor Myocarditis
This study is looking into whether a drug called abatacept can help people with heart inflammation (myocarditis) caused by cancer treatment. It compares abatacept to a dummy drug (placebo) to see if it reduces serious heart problems.
United States · Canada - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.
This study is testing a drug called entrectinib for different cancers in adults and children. It focuses on cancers with a specific change in their cells, called ROS1 gene fusion, to see if entrectinib can be a new treatment option.
United Kingdom - recruitingNA
Analysis of Circulating Tumor mArkers in Blood 4 - ALCINA 4
ALCINA 4 is a study looking at cancer markers in blood. We want to see if a simple blood test can help us understand cancer better, perhaps even replacing painful biopsies. It won't change your current cancer treatment.
France - active not recruiting
Definition for the Assessment of Time-to-event Endpoints in CANcer Trials (DATECAN-1)
This study helps cancer researchers agree on how to measure important treatment effects like how long people live or how long their cancer stays stable. It aims to make sure everyone uses the same rules, so we can better compare different cancer treatments and improve care.
France - not yet recruitingNA
Peri-procedural Management of Direct Oral Anticoagulants for Central VENOus Catheters in CAncer Patients With Venous Thromboembolism or Atrial Fibrillation Pilot Study
This study looks at how best to manage blood-thinning medicines (DOACs) for cancer patients needing a special tube (CVC) inserted. It compares stopping DOACs briefly versus continuing them to see what's safest and most effective.
Canada - recruiting
Immune Resistance Interrogation Study
This study looks at why some cancers stop responding to immunotherapy. We collect tumour samples, blood, and stool from patients who had immunotherapy to understand how their bodies react differently.
Canada - enrolling by invitation
Vaginal Ecosystem and Network in the United States Study
This study looks at the tiny living things inside the Vagina to understand how they affect common female health issues. By collecting a simple swab, researchers hope to improve how doctors diagnose and treat conditions like thrush and UTIs.
United States · Canada - recruiting
Cancer and Literacy in Health
This study is looking at how well people with cancer understand health information. It uses a questionnaire to check how clear health messages are for patients in France. This helps make sure health information is easy to understand for everyone dealing with cancer.
France - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 01: Alectinib in Adult, Paediatric and Teenage/Young Adult Patients With ALK Positive Cancers
This study is testing a drug called alectinib for different types of cancer that have a special gene change called ALK. It's already used for some lung cancers, and now doctors want to see if it can help other cancers with the same change.
United Kingdom - not yet recruiting
Validation of the European Oncology Quality of Life Toolkit
This study is testing a new set of online surveys called the EUonQoL-Kit. These surveys help understand the quality of life for people with cancer at different stages – during treatment, after treatment, and in palliative care. The goal is to make sure the surveys are accurate and helpful across Europe.
Albania · Austria · Belgium - not yet recruitingPHASE2
Time Restricted Eating in Haematological Malignancies
This study is looking into whether a special eating plan called Time-Restricted Eating (TRE) can help people with Chronic Lymphocytic Leukaemia (CLL). Participants will fast for 16 hours and eat for 8 hours each day to see if it affects their cancer and general health.
Canada - recruitingNA
Enhancing the Patient Journey to Clinical Trial Enrolment With Navigation to Optimize Accrual
This study looks at how a special support program, called a Clinical Trials Navigator (CTN), can help more people with cancer in Canada find and join suitable clinical trials. The program aims to make it easier for patients to access important new treatments.
Canada - recruiting
Childhood Cancer Survivor Study
This study looks at the long-term health of people who had cancer as children or young adults. Researchers want to understand how cancer treatments like chemotherapy, radiation, or surgery might affect their health many years later, comparing them to healthy siblings.
United States · Canada - active not recruitingNA
Incidental Genomics
This study looks at how people with cancer react to finding out extra health information from advanced genetic tests. We want to see if this extra information causes worry or helps people make healthier choices, and how useful and costly these tests are.
Canada - active not recruitingNA
PRecision Oncology Evidence Development in Cancer Treatment - Liquid
This study looks at new blood tests for cancer to see if they're as good as, or better than, standard tissue tests for finding important genetic changes. It compares different ways of using these tests to help doctors choose the best treatment for patients with advanced cancer in the UK.
Canada - active not recruitingPHASE3
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
This study looks at whether taking aspirin daily after cancer treatment can stop cancer coming back and help people live longer. It focuses on common cancers like breast, bowel, and prostate cancer.
Ireland · United Kingdom - recruiting
PACOME (PAtient Cancer Oral MEdication) Cohort of Patients Treated With Oral Anticancer Drugs Benefiting From Oncoral Multidisciplinary Monitoring in Real Life: Predictive Factors and Safety of Treatments
This study looks at how people with cancer taking oral medications at home are supported through a special programme called Oncoral. It aims to understand how well these treatments work in real life and how to make care better for patients outside of the hospital.
France - not yet recruitingPHASE2
Adaptive Radiotherapy for Safe Hypofractionation
This study compares a new, more flexible way of giving radiotherapy called 'adaptive radiotherapy' with the standard treatment for certain cancers. It aims to see if this new method, which uses fewer, stronger doses, is just as safe and effective.
Canada - active not recruitingNA
UW WELL-FIT Exercise Program for Cancer Patients
This study looks at how a special exercise programme, called UW WELL-FIT, can help people with cancer manage side effects from their treatment. It aims to improve their health through exercise and education, and learn more about successful exercise for cancer patients.
Canada - recruiting
Influence of Sarcopenia on the Course of the Diseases
This study looks at how muscle weakness, called sarcopenia, affects people with serious illnesses like cancer or liver problems. We're using simple ultrasound scans and blood tests to find better ways to spot sarcopenia early and understand its impact on a patient's health journey.
Germany - recruiting
Tumour Characterisation to Guide Experimental Targeted Therapy - National
This study, called TARGET National, helps doctors understand advanced cancers better. By looking closely at your tumour, we aim to find the best experimental immune, hormone or targeted treatments suited to you. It's for people with advanced solid cancers across the UK.
United Kingdom - active not recruitingPHASE3
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
This study allows some cancer patients who are already benefiting from certain treatments in another study to continue receiving that treatment. It’s for those who wouldn't be able to get the treatment otherwise, helping them keep accessing therapies that are working for them.
United States · Australia · Belgium - recruitingPHASE1, PHASE2
Phase 1/2 Study of IMC-R117C in Selected Advanced Cancers
This study is testing a new drug, IMC-R117C, for advanced cancers like bowel, stomach, or ovarian cancer. It's for people whose cancer has a specific marker (HLA-A*02:01) and an adult protein called PIWIL1. Researchers want to see if it's safe and effective, alone or with other treatments.
Australia · Belgium · Germany - available
(Bispecific) Antibodies in Cancer Patients
This study is for people with advanced cancer where standard treatments haven't worked. It uses special immune treatments called 'bispecific antibodies,' which are designed to help your body fight the cancer. The aim is to offer new hope when other options are limited.
Germany - recruiting
Small Bowel Capsule Endoscopy in Lynch Syndrome
This study looks back at records of people with Lynch syndrome who had a small bowel capsule endoscopy. It aims to understand how well this test finds early changes or cancers in the small bowel and how it helped with their care.
France - recruitingNA
Vulnerability and Risk of Neuropathic Pain in Cancer
This study looks at why some cancer patients get long-lasting nerve pain and how to predict who might be at risk. It aims to find better ways to understand and prevent this type of pain.
France - recruitingPHASE2
Exome Analysis (Complexe vs Simple) to Help the Therapeutic Decision for the Precision Medicine
This study looks at how detailed gene testing (exome analysis) for cancer can help doctors choose the best treatments. It compares a basic test with a more advanced one to see if the advanced test gives more useful information for patients starting their first cancer treatment.
France - active not recruiting
Real-time Detection of ctDNA and/or HPV DNA in High-risk Locally-advanced Head and Neck Squamous Cell Carcinoma
This study looks at new ways to detect head and neck cancer coming back after treatment. We're testing a special blood test that can find tiny bits of cancer DNA in patients with advanced head and neck cancer, to see if it can help us understand and treat the disease better.
Canada - active not recruitingNA
PATHFINDER 2: A Multi-Cancer Early Detection Study
The PATHFINDER 2 study is looking at a new blood test called the GRAIL multi-cancer early detection (MCED) test. This test aims to find many types of cancer early. It's for people aged 50 and over in North America who already get regular cancer screenings.
United States · Canada - recruitingNA
PRecision Oncology Evidence Development in Cancer Treatment - Clinical: PREDiCTc
This study looks at how well new cancer treatments work in real life for people with rare cancers or unusual cancer changes. We want to see how these treatments affect quality of life and how long people live, to help decide if these treatments should be more widely available.
Canada - recruitingNA
Development of a Clinical and Biological Database in Peritoneal Carcinosis (BCB CARCINOSE)
This study collects samples from people with a type of cancer called peritoneal carcinosis. Researchers hope to understand this cancer better by studying the samples. The goal is to discover new ways to treat it and improve care for patients in the future.
France - recruiting
Cisplatin Induced Kidney Toxicity
This study looks for ways to predict and detect kidney damage caused by a cancer drug called Cisplatin. We'll examine blood and urine samples from children and adults with cancer to find early warning signs, aiming to improve treatment and protect kidneys.
Canada - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
This study is testing a cancer drug called atezolizumab in people with certain cancers that have specific genetic changes. Atezolizumab is already used for some cancers, and this study wants to see if it can help other types of cancer that share these same genetic features.
United Kingdom - recruitingPHASE2
Pan Tumor Rollover Study
This study looks at the long-term safety of different cancer treatments, including nivolumab, alone or combined with other medicines. It's for people with various types of cancer who are already receiving treatment in a related study, aiming to see how these treatments work over time.
United States · Argentina · Australia