- recruiting
A population-based digital study offering people testing for cancer genes, to identify people at increased risk of cancer so they can take steps to prevent it or detect it early
This study offers a genetic test for cancer risk to people in the UK. It uses a saliva sample to check for genes linked to breast, ovarian, bowel, and womb cancers. The aim is to find people at higher risk so they can take steps to prevent cancer or detect it early.
United Kingdom · England · Northern Ireland - recruiting
Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy
This study aims to predict side effects from radiotherapy for cancer using computer models. It collects information from patients having image-guided radiotherapy to help develop better ways to understand and manage treatment risks, making radiotherapy safer and more effective for everyone.
United Kingdom - recruiting
A Platform Study for solId orgaN CancERs
This study aims to collect tiny samples of tissue and blood from cancer patients undergoing surgery or biopsy. These samples will help researchers understand solid organ cancers better and develop new ways to diagnose and treat them. It's designed to make it easier for researchers to get high-quality samples.
United Kingdom - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
Phase 1/2, Open-label, Dose Escalation and Dose Expansion Study of TransCon TLR7/8 Agonist Alone or in Combination with Pembrolizumab in Participants with Locally Advanced or Metastatic Solid Tumor Malignancies
This study is testing a new cancer medicine, TransCon TLR7/8 Agonist, sometimes given with another drug called Keytruda. It's for adults with advanced cancer. Researchers want to see if it's safe, what dose works best, and if it can shrink tumours.
Spain · Netherlands - active not recruitingPHASE1
Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors
This study is testing a new treatment called RP2, alone and with nivolumab, for adults with advanced cancers. It aims to find the safest dose and see how well it works. RP2 is a modified virus designed to fight cancer.
Spain · United Kingdom - active not recruiting
CCP Cancer UK Companion Study
This study looks at how COVID-19 affects people with cancer in the UK. We want to understand their symptoms, treatment, and recovery, comparing them to people without cancer. This helps us learn how to better care for cancer patients during outbreaks.
United Kingdom - recruiting
APACE - Feasibility of Using Accelerometers to Measure Physical Activity in Cancer Patients on Early Phase Clinical Trials
This study looks at how we can better measure physical activity and sleep in cancer patients using a wearable device. It helps us understand if these devices are useful for people with advanced cancer participating in early clinical trials, potentially improving care and support.
Italy · Spain · United Kingdom - recruitingNA
RESCUE: A Workplace Dietary Intervention for UK Firefighters
This study looks at how diet affects firefighters' health, especially their cancer risk. Firefighters often have unhealthy eating habits due to their demanding jobs. Researchers are testing a new education programme called RESCUE to help them eat better and improve their long-term health.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A PHASE 1 STUDY TO ASSESS THE MASS BALANCE, PHARMACOKINETICS, AND METABOLISM OF ORAL [14C]-ZIPALERTINIB IN HEALTHY ADULT MALE SUBJECTS
This early-stage study in healthy adult men looks at how a new cancer drug called zipalertinib is handled by the body. We want to understand how it's absorbed, changed, and leaves the body, and check for any side effects.
Netherlands - recruitingPHASE4
The STOP-MED CTRCD Trial
This study looks at whether it's safe for cancer survivors to stop heart failure medicines if their heart has recovered well. It's for people whose hearts were affected by cancer treatment but are now working normally again.
United States · Australia · Canada - active not recruitingPHASE3
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
This study is for men with cancer who are already taking darolutamide in another Bayer study and are doing well. It lets them keep taking the same medicine at the same dose, continuing their treatment journey under medical supervision.
United States · Argentina · Australia - recruiting
Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion
This study looks at a new way to understand bowel cancer spread. We're taking blood samples from patients having surgery for bowel cancer to see if blood changes can tell us more about how the cancer might spread through blood vessels. This could help improve how we treat bowel cancer in the future.
United Kingdom - active not recruitingNA
Does Screening With the Galleri Test in the NHS Reduce the Likelihood of a Late-stage Cancer Diagnosis in an Asymptomatic Population? A Randomised Clinical Trial
This study is looking at a new blood test called the Galleri test. It aims to see if using this test with usual NHS care can help find many types of cancer earlier in people aged 50-77 who don't have symptoms. Finding cancer early often makes it easier to treat.
United Kingdom - recruitingNA
Introduction of Y90-PET-CT Post Radioembolisation Therapy Scans
This study looks at a new type of scan for liver cancer patients having a treatment called Y-90 radioembolisation. We want to see if this new scan, Y90-PET-CT, gives clearer pictures than the usual scan, to better understand how the treatment works.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Open-label, Phase 2 study of tusamitamab ravtansine (SAR408701) combined with pembrolizumab and tusamitamab ravtansine (SAR408701) combined with pembrolizumab and platinum-based chemotherapy with or without pemetrexed in patients with CEACAM5-positive expression advanced/metastatic nonsquamous non-small-cell lung cancer (NSQ NSCLC)
This study is testing new combinations of medicines for a type of advanced lung cancer. It combines an experimental drug (tusamitamab ravtansine) with existing treatments like pembrolizumab (Keytruda) and chemotherapy to see how safe and effective they are. It's for adults whose cancer has a specific marker called CEACAM5.
France - recruitingNA
Glasgow Low-dose CT and AI-based Diagnostics to Case Find Lung Cancer and Other Cardio-respiratory Long-term Conditions - Feasibility Study
This study offers a Lung Health Check for those at higher lung cancer risk. It includes a low-dose CT scan, plus heart and breathing tests, aiming to find lung cancer early and check for other conditions like heart disease and emphysema, all in one visit.
United Kingdom - enrolling by invitation
Investigating the Role of Genetics in Disease Predisposition
This study looks at how tiny changes in the sperm and eggs we inherit can affect our health, especially the risk of certain cancers and rare diseases in our children. Researchers want to understand where these changes come from and how they pass them on.
United Kingdom - recruitingPHASE3
A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
This study offers continued treatment to cancer patients already in certain Genentech/Roche studies. It's for those still benefiting from their current treatment and who can't get it elsewhere. The aim is to bridge care for these patients.
Belgium · Canada · China - recruiting
Public Survey on Breath Testing for Health and Disease
This survey asks what people think about using an easy breath test to check their health and find illnesses like cancer. Your answers will help researchers understand how to make health checks better and guide future studies.
United Kingdom - not yet recruiting
Chemotherapy-Induced Hearing Loss and Health Inequality
This study looks at how chemotherapy for cancer can cause hearing loss, especially in people from poorer backgrounds. It also checks if hearing loss affects memory and thinking, to help improve care for cancer patients in the North West of England.
United Kingdom - active not recruiting
Digital Monitoring in Cancer Survivors
This study looks at how digital tools, like smartwatches and questionnaires on phones, can help monitor cancer survivors' well-being after treatment. It aims to see if these tools are easy to use and helpful for keeping track of symptoms and quality of life.
United Kingdom - recruitingNA
Effects of a Second-generation Mindfulness-based Intervention on Quality of Life, Pain Management, and Psycho-spiritual Wellbeing in Cancer Patients: A Randomised Controlled Trial
This study explores if Meditation Awareness Training (MAT) can improve well-being, pain management, and quality of life for cancer patients. It combines traditional spiritual ideas with mindfulness to offer deeper support beyond standard approaches.
United Kingdom - recruiting
Breaking Barriers to Research Access
This study aims to understand why some cancer patients, especially those from certain backgrounds, find it hard to join research studies. By finding out what these barriers are, we hope to make sure more people can take part in research, leading to fairer and better cancer care for everyone in Cheshire and Merseyside.
United Kingdom - recruiting
Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
This study looks at how cancer, specifically weight loss due to cancer, affects the brain and body signals. Researchers want to understand changes in appetite, motivation, and brain activity to help develop new treatments for cancer-related weight loss.
United Kingdom - ongoing, recruitingPhase I and Phase II (Integrated)- Other
An open-label, multicenter Phase 1/2 dose escalation and expansion study of THOR-707 as a single agent and as a combination therapy in adult subjects with advanced or metastatic solid tumors
This study is testing a new medicine, THOR-707, for people with advanced cancer. It aims to find the safest and most effective dose, and see how well it works alone or with other treatments to shrink tumours and improve health.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1, open-label, multiple-ascending dose study to investigate the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of KD033 (SAR445710) in subjects with metastatic or locally advanced solid tumors
This study is testing a new medicine, KD033, for people with advanced cancer. It's a very early-stage trial focusing on how safe the medicine is, how it moves through the body, and if it shows any signs of working.
France · Spain - active not recruitingPHASE3
A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
This study is for people with cancer who are already receiving specific cancer treatments in another study. It allows them to continue their treatment if their original study ends and they can't get the medicine elsewhere. It's about safely extending access to these important cancer drugs.
United States · Argentina · Australia - active not recruiting
LEVANTIS-0093A: GAGomes for Multi-Cancer Early Detection in High-Risk Adults (LEV93A)
This study looks for early signs of many cancers in people aged 55-80 who have a history of smoking. It uses blood samples from existing screening programmes in Yorkshire to find new ways to detect cancer sooner.
United Kingdom - ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase 1/2 trial evaluating isatuximab in combination with pegenzileukin in relapsed or refractory multiple myeloma (RRMM) previously exposed to anti-CD38 and anti-BCMA
This study is looking at a new combination of treatments for multiple myeloma that has come back or isn't responding to current treatments. It aims to find the safest dose of these new drugs and see how well they work together to shrink the cancer or stop it from growing.
Greece · Germany · Italy - recruiting
Testing a digital, comprehensive, standardised assessment approach to improve the management of people with cancer
This study is testing a new digital tool called MyPath to help people with cancer. It lets patients record their symptoms on a phone or tablet, so doctors can better understand how they are feeling and give more personalised care. The aim is to make cancer treatment better for everyone.
United Kingdom · England · Scotland - recruiting
Palliative Care and Oncology Survey on Terminology
This study asks people with cancer how they feel about words used to describe them, like 'cancer survivor'. We want to understand if these terms are helpful, especially for those receiving palliative care or active cancer treatment. Your views can help improve how care is given.
Ireland · United Kingdom - active not recruitingPHASE3
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)
This study is for cancer patients who are already taking osimertinib (Tagrisso) in another AstraZeneca study and are still benefiting from it. It allows them to keep taking the drug to see if it continues to help.
China · France · Malaysia - enrolling by invitationPHASE3
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Durvalumab
This study is for cancer patients who have already been in another durvalumab drug trial and are still benefiting from the treatment. It lets them continue receiving the drug to see if it keeps helping them.
United States · Argentina · Australia - active not recruiting
Epidemiology of Complications After Solid Organ Transplantation - EpCOT Study
This study looks at health problems, especially cancer, after organ transplants in the UK. Researchers are combining existing patient information to better understand why cancer happens and how it affects people after a transplant, to help improve care.
United Kingdom - recruiting
RDC Biomarker Study
This study aims to find new, simple tests, like breath, blood, or saliva tests, to help doctors quickly find cancer in patients at Rapid Diagnostic Centres. It also wants to identify people at higher risk of cancer to help them get screenings or monitoring.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingPHASE2
Pan Tumor Rollover Study
This study looks at the long-term safety of different cancer treatments, including nivolumab, alone or combined with other medicines. It's for people with various types of cancer who are already receiving treatment in a related study, aiming to see how these treatments work over time.
United States · Argentina · Australia - recruitingNA
IMPLEMENT - Model Project for Quality-assured Exercise Therapy for Cancer Patients
This project aims to make sure cancer patients in Germany can easily access high-quality exercise programmes. It will find out what helps and what makes it difficult for people to join these programmes, and then create better ways for everyone to get involved.
Germany - active not recruitingPHASE1, PHASE2
Investigation of a Therapeutic Vaccine (ACIT-1) in Cancer
This study is testing a new treatment called ACIT-1, which is a therapeutic vaccine for cancer. Researchers are looking at different doses to see if it's safe and helps the body's immune system fight cancer, including pancreatic cancer and other types.
United Kingdom - recruitingNA
Evidence Development in Cancer Treatment - Real World: PREDiCTrw
This study looks at how new cancer treatments affect patients' quality of life and survival in real-world settings. We want to understand how well these treatments work outside of strict trials to help doctors make better decisions.
Canada - recruitingPHASE2
Maitake for Integrative Cancer Care
This study looks at a mushroom extract, Maitake, to see if it helps the immune system of people with cancer who are also having regular cancer treatment. Researchers want to find out if it can work alongside standard therapies.
Canada - recruitingNA
Adapting The Fear Of Recurrence Therapy (FORT) for Parents and Establishing Acceptability and Feasibility
This study looks at a new type of therapy called Parent-FORT for parents of children who have had cancer. It aims to help parents deal with the fear that their child's cancer might come back, and to see if the therapy is easy to do and helpful.
Canada - recruitingNA
Cycling-Based Aerobic Exercise Intervention for Individuals With Chemotherapy-Induced Peripheral Neuropathy (CIPN)
This study looks into whether cycling exercises can help reduce tingling, numbness, and pain in hands and feet caused by chemotherapy. It's a small study to see if a bigger one should be done. It involves 12 weeks of supervised cycling twice a week.
Canada - not yet recruitingPHASE2, PHASE3
Partner4Exercise Randomized Controlled Trial
This study helps older adults with cancer exercise more and feel less alone. It checks if having peer support and exercise coaching, or just a peer, helps improve fitness and mental wellbeing over 10 weeks.
Canada - recruitingNA
STING MARK Universal Fiducial Marker System
This study is testing a new, small marking device called STING-MARK. It helps doctors accurately pinpoint the exact location of a tumour in organs for more effective treatments. We're checking how well it works and stays in place in organs that have been removed.
Canada - recruitingNA
MR Imaging Study Using the Northern Alberta Linac-MR (Northern LIGHTs - 1)
This study is testing a new type of MRI scanner that works with radiotherapy machines. It aims to take clearer pictures of cancer to help doctors give more accurate treatment. We want to make sure the scanner is safe and takes good quality images for future patients.
Canada - authorisedTherapeutic exploratory (Phase II)
FINACCESS - Finnish National Study for Early Access to Cancer Therapies
The FINACCESS study is looking at how well new cancer medicines work and if they cause side effects. It's for adult patients with different types of cancer. Doctors want to find out more about early access treatments.
Finland - recruitingNA
Flexi Band Resistance Training Versus EMS Exercise in Patients With the Diagnosis of Malignant Diseases
This study looks at how exercise, using either special resistance bands or a modern electrical muscle stimulation (EMS) method, can help cancer patients. We want to see if these exercises improve strength, body shape, fitness, and how patients feel overall during their treatment.
Germany - recruiting
Comparison of 30-day Morbidity and Mortality in Cancer Patients Based on Emergency Department Location
This study looks at how where you go for emergency care affects cancer patients. We want to see if visiting an emergency department (ED) that specialises in cancer care, or one connected to your cancer centre, leads to better outcomes compared to a general ED.
France - recruiting
Understanding and Anticipating Therapeutic and ADverse Responses in Anti-cancer Immune Checkpoint Inhibition Towards a Better Therapeutic Management of Patients
This study looks at blood tests from cancer patients getting immunotherapy. We want to find early signs of side effects, called irAEs, to help doctors give better care and predict who might respond well to treatment.
France