- recruitingTherapeutic exploratory (Phase II)
HERES trial: Trastuzumab and standard treatment with chemo- and immunotherapy as first line treatment for HER2 positive esophageal squamous cell carcinoma patients
This study looks at a new drug mix for food pipe cancer. Researchers are testing whether adding a targeted medicine called trastuzumab to standard chemotherapy and immunotherapy can shrink tumours more effectively in people whose cancer cells carry a specific protein known as HER2.
Denmark - recruitingHuman Pharmacology (Phase I)- Other
ADP-A2M4CD8 in advanced cancers
This early-stage clinical trial tests an experimental cell therapy called ADP-A2M4CD8 for adults with advanced solid cancers, including lung, bladder, and ovarian cancer. Researchers want to find out the safest dose, understand any side effects, and see if this new treatment can help shrink tumours.
Spain - recruitingHuman Pharmacology (Phase I)- First administration to humans
Optical PD-L1 imaging using Quantitative Fluorescence Endoscopy in locally advanced esophageal cancer using durvalumab-680LT: a phase I multicenter feasibility and safety study
This study looks at a new way to see if a particular treatment might work for advanced oesophageal cancer. It uses a special camera and a small amount of a drug to get a clearer picture inside the body, helping doctors understand the cancer better.
Netherlands - recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study of PF-08046031 in Adults With Advanced Melanoma and Other Solid Tumors
This study is testing a new medicine, PF-08046031, for adults with advanced melanoma (a type of skin cancer) and other solid cancers like lung, head and neck, and oesophageal cancer. This is an early-stage study to see if the medicine is safe and how it works in the body.
Germany · Sweden · France - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - recruitingPHASE3
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
This study is testing new combinations of medicines (sonesitatug vedotin, rilvegostomig, and capecitabine) for advanced stomach, gastroesophageal junction, or oesophageal cancers. It aims to see how well they work and if they are safe for people whose cancer has a specific marker called Claudin18.2.
United States · Australia · Austria - recruitingPHASE1, PHASE2
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
This study is looking at a new drug called MCLA-158 for advanced cancers like bowel and head and neck cancer. It aims to find the safest dose and see how well it works alone or with other treatments. It's for patients whose cancer has spread or come back.
United States · Belgium · France - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - recruitingPHASE3
The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III
This study looks at new ways to help people having surgery for lung, stomach, or food pipe cancer. It aims to reduce problems after surgery, improve quality of life, and explore how natural health approaches might help alongside standard care.
Canada - recruiting
Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS)
This study is looking at a new way to give radiotherapy using a special machine called ETHOS. It aims to make radiotherapy more accurate by adjusting treatment daily for cancers like prostate or head and neck, potentially improving how well it works and reducing side effects.
Germany - recruitingPHASE1, PHASE2
Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
This study looks at new drug combinations with a medicine called pembrolizumab and chemotherapy for advanced stomach or oesophageal cancer that can't be removed by surgery. It's in early stages (Phase 1/2) and aims to find safe doses and see how well the treatments work.
United States · Brazil · Chile - recruitingPHASE1, PHASE2
Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)
This study looks at new treatments for advanced stomach or gullet cancer that has already been treated once. It compares different drug combinations to see how safe and effective they are for patients whose cancer has come back or spread.
United States · Brazil · Chile - not yet recruitingPHASE2
Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
This study looks at using heat treatment (hyperthermia) with repeat radiation therapy for certain cancers that have come back after earlier radiation. It checks if this combined approach works as well as the first treatment for preventing the cancer from returning locally.
Germany - not yet recruitingPHASE3
Surveillance After Resection of Oesophageal aNd Gastric Cancer (SARONG-II) Trial
This study looks at how best to check for cancer returning after surgery for oesophageal or stomach cancer. Some patients will have regular scans, while others will have standard check-ups. We want to see if more scans help people live longer and have a better quality of life.
Germany · Ireland · Italy - recruitingNA
A Study Involving Neoadjuvant Chemoradiotherapy with Hypofractionated Radiotherapy in Patients with Esophageal and Gastroesophageal Junction Adenocarcinoma
This study is looking at a new, shorter way to give radiotherapy with chemotherapy before surgery for esophageal cancer. It aims to see if this quicker treatment is as good as the standard, longer treatment, possibly making it easier for patients.
Canada - recruitingPHASE3
PROton Versus Photon Therapy for Esophageal Cancer - a Trimodality Strategy
This study compares standard radiotherapy (photon therapy) with a newer type (proton therapy) for oesophageal cancer. It aims to see if proton therapy reduces side effects, especially lung problems, while still treating the cancer effectively.
Belgium · Denmark · France - active not recruitingPHASE1
MAGE-A4ᶜ¹º³²T for Multi-Tumor
This study is testing a new cell therapy for certain cancers that have a specific protein. It aims to see if it's safe and how well people tolerate it. The therapy uses your own modified cells to fight the cancer. Some participants will also receive a small amount of radiation.
United States · Canada - recruiting
Clinical Benefit and Biomarker Analysis of Combination of PD-1/PD-L1 Immune Checkpoint Inhibitors and Radiotherapy
This study looks at combining special cancer drugs (PD-1/PD-L1 inhibitors) with radiation. It aims to see how well this works for various cancers and if we can find new ways to predict who will benefit most from this treatment.
Germany - not yet recruitingNA
Radiation-induced Toxicity of the Heart
This study looks at how radiotherapy for certain cancers in the chest can affect the heart later on. Researchers are looking for warning signs, like from scans or blood tests, to help predict and prevent heart problems in patients.
Germany - recruiting
Oesophagectomy and Chest Wall and Respiratory Function
This study looks at how removing a part of the food pipe (oesophagectomy) for cancer affects breathing and chest movement. It aims to find better ways to measure chest movement and breathing capacity using new technologies, which could lead to improved physiotherapy after surgery.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
Optimizing Lymph Node Staging in Esophageal Cancer with USPIO-enhanced MRI
This study is comparing a new MRI scan using a special tracer called USPIO to standard PET-CT scans for finding cancer in the lymph nodes of people with oesophageal cancer. We want to see which one works better and is easier for patients.
Netherlands - recruitingPHASE1
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
This study is looking at a new medicine called PF-08046876 for people with advanced cancers like bladder, lung, head & neck, oesophageal, or pancreatic cancer. It checks how safe the medicine is and how well it works. The medicine is given through a drip.
United States · Canada · China - recruitingNA
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.
Belgium · France · Germany - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium