- recruitingHuman Pharmacology (Phase I)- Other
ADP-A2M4CD8 in advanced cancers
This early-stage clinical trial tests an experimental cell therapy called ADP-A2M4CD8 for adults with advanced solid cancers, including lung, bladder, and ovarian cancer. Researchers want to find out the safest dose, understand any side effects, and see if this new treatment can help shrink tumours.
Spain - active not recruitingPHASE3
AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2
This study is testing a new drug, AZD0901, for advanced stomach cancer or where the food pipe meets the stomach. It's for people whose cancer has Claudin18.2 protein and has already been treated before. Researchers want to see if AZD0901 works better and is safer than other treatments.
United States · Brazil · Canada - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - recruitingPHASE2
Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
This study is testing new combinations of medicines for advanced stomach or food pipe cancer that has spread or can't be removed by surgery. It aims to see how well they work and if they are safe. Researchers want to find better ways to treat this type of cancer.
United States · China · Japan - recruitingPHASE2
AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
This study is looking at a new medicine called AZD0901 for people with certain advanced cancers like stomach or pancreatic cancer. We want to see how safe it is, if it works, and how the body handles it, sometimes on its own and sometimes with other cancer drugs.
United States · Australia · Canada - active not recruitingPHASE2
Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)
This study looks at new treatments for advanced stomach or oesophageal cancer with a specific protein called HER2. We're testing a new drug, trastuzumab deruxtecan, by itself or with other common cancer medicines to see if it's safe and effective.
United States · Brazil · Canada - recruitingPHASE3
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
This study is testing new combinations of medicines (sonesitatug vedotin, rilvegostomig, and capecitabine) for advanced stomach, gastroesophageal junction, or oesophageal cancers. It aims to see how well they work and if they are safe for people whose cancer has a specific marker called Claudin18.2.
United States · Australia · Austria - recruitingPHASE1, PHASE2
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
This study is looking at a new drug called MCLA-158 for advanced cancers like bowel and head and neck cancer. It aims to find the safest dose and see how well it works alone or with other treatments. It's for patients whose cancer has spread or come back.
United States · Belgium · France - recruitingPHASE1, PHASE2
Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors
This study is testing a new experimental medicine, AZD5863, for people with advanced stomach, oesophageal, or pancreatic cancer. It aims to see if the medicine is safe, what dose works best, and if it can help fight the cancer.
United States · China · France - recruitingPHASE3
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
This study looks at new drug combinations for stomach or food pipe cancer that has spread. It compares an experimental treatment with standard care, aiming to find better ways to treat patients whose cancer has specific features.
United States · Argentina · Australia - active not recruitingPHASE2, PHASE3
A Study of Evorpacept (ALX148) in Patients With Advanced HER2+ Gastric Cancer (ASPEN-06)
This study, called ASPEN-06, looked into an experimental drug called Evorpacept for people in the UK with advanced stomach cancer (gastric cancer) that has a specific genetic marker (HER2-positive). It aimed to see if adding Evorpacept to standard treatments improved outcomes. The study has now been stopped due to strategic reasons.
United States · Australia · Belgium - recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2 Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of BLU-222 as a Single Agent and in Combination Therapy for Patients with Advanced Solid Tumors
This study is testing a new drug, BLU-222, for people with certain advanced cancers, including breast, ovarian, and stomach cancers. It aims to see how safe the drug is, how it moves through the body, and if it helps shrink tumors, both on its own and with other treatments.
France · Italy · Belgium - recruitingPHASE1, PHASE2
Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors
This study is testing a new medicine, TH9619, for people with advanced cancers like bowel, head and neck, lung, and stomach cancer. It's the first time TH9619 is being given to people, and doctors want to find the safest and most effective dose.
France · Spain · United Kingdom - recruitingPHASE1
A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours
This study is testing a new medicine for people with advanced cancers that haven't responded to other treatments. It aims to see how safe the medicine is, how it moves through the body, and what dose works best.
United States · Canada - recruitingPHASE3
The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III
This study looks at new ways to help people having surgery for lung, stomach, or food pipe cancer. It aims to reduce problems after surgery, improve quality of life, and explore how natural health approaches might help alongside standard care.
Canada - recruiting
Helicobacter Pylori Local Prevalence and Antibiotic Resistance
This study looks at how common a tummy bug called H. pylori is in Germany and if medicines are still working against it. It aims to help doctors better treat infections and identify people at risk of stomach problems.
Germany - active not recruiting
A Study of Nivolumab Plus Chemotherapy in First Line Treatment of Adult Participants With Advanced or Metastatic Gastric Cancer
This study looks at a medicine called nivolumab, given with chemotherapy, for adults with advanced stomach cancer (and related cancers). It aims to see how well it works and if it's safe when used as the first treatment for this condition.
Germany - active not recruitingPHASE1, PHASE2
Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)
This study looks at a new treatment called M9140 for different advanced cancers like stomach, lung, and pancreatic cancer. It aims to see if it's safe and effective for patients whose cancers have a specific marker called CEACAM5.
United States · Australia · Austria - not yet recruitingNA
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients
This study looks at using a special type of electrical muscle stimulation (like gentle zaps) on the whole body, combined with healthy eating advice. It's for people with certain tummy and bowel cancers to see if it helps build muscle and improve energy better than exercise alone.
Germany - recruitingPHASE1
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
This study is testing a new drug, PF-08046054/SGN-PDL1V, alone and with an existing medicine called pembrolizumab, for various advanced cancers. Researchers want to see how safe it is and if it has any effect on the cancer. It's a very early stage study.
United States · Belgium · Canada - recruitingPHASE3
A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer
This study looks at a new medicine called HLX22, combined with standard treatments, for people newly diagnosed with a certain type of stomach and food pipe cancer. It aims to see how well it works and if it's safe compared to current treatments.
United States · Argentina · Australia - active not recruitingPHASE1, PHASE2
Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination
This study is looking into a new drug, MCLA-129, for some advanced cancers like lung or stomach cancer. It will see how safe and effective it is, both by itself and with other treatments. It's for people who haven't responded to previous treatments.
United States · Belgium · France - active not recruitingPHASE2
Clinical Trial Evaluating FOLFIRI + Durvalumab vs FOLFIRI + Durvalumab and Tremelimumab in Second-line Treatment of Patients With Advanced Gastric or Gastro-oesophageal Junction Adenocarcinoma
This study looks at new drug combinations (Durvalumab and Tremelimumab with FOLFIRI chemotherapy) for advanced stomach or food pipe cancer that has already been treated. It aims to see how well patients respond and if these combinations can help people live longer.
France - recruitingPHASE1
A Study of NX-1607 in Adults With Advanced Malignancies
This study is looking into a new treatment called NX-1607 for various advanced cancers, including ovarian, stomach, and lung cancer. It aims to see how safe the treatment is and if it can help fight the cancer, sometimes combined with another drug called Paclitaxel.
United States · United Kingdom - recruiting
Response Prediction of Hyperthermic Intraperitoneal Chemotherapy in Gastro- Intestinal Cancer
This study looks at stomach or bowel cancer that has spread to the tummy lining. Doctors take a small piece of your tumour during surgery. They grow it in the lab to test which treatments, like chemotherapy, might work best for you. This helps personalise future care.
Germany - recruitingPHASE2
Study Evaluating the Efficacy of the myDIET Software Tool in the Nutritional Management of Patients With Localized and Resectable Gastric or Esogastric Junction Cancer.
This study looks at how a new software tool called myDIET can help people with stomach or oesophagus cancer eat well. The goal is to see if better nutrition can help them recover faster and have fewer problems during their treatment, especially around surgery.
France - not yet recruitingPHASE3
Surveillance After Resection of Oesophageal aNd Gastric Cancer (SARONG-II) Trial
This study looks at how best to check for cancer returning after surgery for oesophageal or stomach cancer. Some patients will have regular scans, while others will have standard check-ups. We want to see if more scans help people live longer and have a better quality of life.
Germany · Ireland · Italy - recruitingPHASE2, PHASE3
DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations
This study is testing a cancer drug called capmatinib to see if it can help adults with different types of cancer that share a specific genetic change (MET mutation). It's already approved for some lung cancers, and now researchers want to know if it works for other cancers too.
United Kingdom - recruitingPHASE2
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This study is testing a new oral medicine, APL-101, for people with advanced cancers. It focuses on lung cancer and other solid tumours where specific genetic changes linked to a protein called MET are found. Researchers want to see how well it works and if it's safe.
United States · Australia · Canada - not yet recruiting
MRinRT: Swansea University and SWWCC Collaboration Study.
This study looks at using MRI scans to make radiotherapy for cancers like brain, stomach, and gullet cancer more accurate. It aims to see if MRI can help doctors better plan and adjust treatment, potentially reducing side effects.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
"Contribution of 68Ga-FAPI-46 PET-CT in the initial staging of gastric cancers eligible for curative treatment" "FAPGASTRO"
This study looks at a special type of scan called 68Ga-FAPI-46 PET-CT for people with stomach cancer. It wants to see if this scan helps doctors better understand the stage of the cancer before treatment, which could lead to better treatment plans.
France - active not recruitingPHASE2, PHASE3
Trial of Preoperative Therapy for Gastric and Esophagogastric Junction Adenocarcinoma
This study is looking at better ways to treat stomach cancer. It compares giving chemotherapy with or without radiotherapy before surgery to see which approach works best for patients whose cancer can be removed with an operation.
Australia · Belgium · Canada - active not recruitingPHASE1
MAGE-A4ᶜ¹º³²T for Multi-Tumor
This study is testing a new cell therapy for certain cancers that have a specific protein. It aims to see if it's safe and how well people tolerate it. The therapy uses your own modified cells to fight the cancer. Some participants will also receive a small amount of radiation.
United States · Canada - recruitingNA
Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)
This study looks for early signs of stomach and gullet cancer using a simple breath test. Researchers hope to make this test more accurate by giving people a special drink to help show up certain chemicals in their breath that are linked to cancer.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
Diagnostic Efficacy of 18F-FAPI-74 PET/CT in Patients with Gastric Cancer
This study is looking at a new type of scan called 18F-FAPI-74 PET/CT for people with stomach cancer. It aims to see how well this scan can find the main tumour, spread to lymph nodes, and other parts of the body, to help doctors understand the cancer better.
Finland - active not recruitingPHASE2
Study of Atezolizumab + FLOT vs. FLOT Alone in Patients With GC/GEJ and High Immune Responsiveness
This study compares a new drug, atezolizumab, plus standard chemotherapy (FLOT) against FLOT alone for stomach or food pipe cancer. It focuses on patients whose cancer shows certain immune markers, aiming to see if the new combination is safer and more effective before and after surgery.
Germany · Switzerland - not yet recruitingPHASE2
The Efficacy of PIPAC and Minimally Invasive Radical Resection in High-risk Gastric Cancer Patients.
This study looks at a new way to treat high-risk stomach cancer after surgery. It combines standard chemotherapy with a special treatment called PIPAC, where chemotherapy drugs are sprayed directly inside the tummy, to see if it can stop the cancer from coming back.
United States · Denmark · France - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - active not recruitingPHASE1
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
This study is testing two anti-cancer drugs, cabozantinib and atezolizumab, alone and together, for various advanced cancers. It aims to find a safe combination dose and see how well it works and any side effects.
United States · Australia · Belgium - active not recruitingPHASE1, PHASE2
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.
United States · Australia · Canada - active not recruitingPHASE1, PHASE2
Study for AZD4360 in Participants With Advanced Solid Tumours
This study is testing a new drug, AZD4360, for people with advanced stomach, bile duct, or pancreatic cancers that have a specific marker called CLDN18.2. It aims to see how safe it is and if it helps shrink tumors.
United States · China · Germany - active not recruitingPHASE1, PHASE2
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This study is testing a new drug, HMBD-001, for advanced cancers where a protein called HER3 is active. We want to find the best dose, understand side effects, and see if it helps stop cancer growth, sometimes with another drug called enzalutamide.
United Kingdom - recruitingPHASE2
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
This study looks at a new drug, Dato-DXd, by itself and with other treatments for different advanced cancers like those affecting the stomach, ovaries, and prostate. It checks if the treatment is safe and effective.
United States · Canada · China - not yet recruitingPHASE2
Neoadjuvant Systemic and Peritoneal Chemotherapy for Advanced Gastric Cancer
This study looks at a new way to treat advanced stomach cancer that has spread to the lining of the abdomen. It combines standard chemotherapy with a special treatment delivered directly into the abdomen, aiming to improve outcomes for a specific group of patients.
United Kingdom - recruitingNA
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.
Belgium · France · Germany - active not recruitingPHASE3
Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab for FGFR2b Overexpressed Untreated Advanced Gastric and Gastroesophageal Junction Cancer.
This study looks at a new drug, bemarituzumab, in combination with standard chemotherapy and nivolumab for advanced stomach or food pipe cancer. It aims to see if this new combination is safe and works better than current treatments, helping people with specific types of cancer live longer.
United States · Argentina · Australia - recruiting
REVOLUTION Surgery (REVOLUTION Surgery)
This study looks into why some cancer patients lose weight and muscle, a condition called cachexia. It aims to understand this problem better by gathering information from patients undergoing surgery for certain cancers and comparing it with people having surgery for non-cancer conditions.
United Kingdom