- recruiting
Ex VIvo DEtermiNed Cancer Therapy
This study, called EVIDENT, wants to see if we can test a tiny piece of your tumour in the lab to predict how well cancer treatments will work for you. It's for people with various solid cancers, like bladder or kidney cancer, who are having surgery or a biopsy.
United Kingdom - recruitingNA
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
This study looks at adding special radiation to standard care for rare cancers that have spread a little. It wants to see if this addition helps people live longer compared to standard care alone.
Belgium · France · Germany - authorisedPhase I and Phase II (Integrated)- Other
Phase 1b/2 Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Previously Treated Unresectable Advanced or Metastatic Sarcomas
This study is looking at a new drug, Risvutatug Rezetecan, for people with advanced sarcoma that can't be removed by surgery or has spread. It aims to see how well the drug works and if it's safe for patients who have already had other treatments.
France - recruitingNA
Salutare One Referral Software Impact on Multi-Disciplinary Team (MDT) Meetings Effectiveness and Safety
This study is testing new software called 'Salutare One Referral'. It helps hospital teams better plan care for cancer patients by making their meetings quicker and more effective. The aim is to improve how decisions are made and get patients better care, faster.
United Kingdom - not yet recruitingPHASE2
Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors
This study looks at using heat treatment (hyperthermia) with repeat radiation therapy for certain cancers that have come back after earlier radiation. It checks if this combined approach works as well as the first treatment for preventing the cancer from returning locally.
Germany - recruitingPHASE1, PHASE2
HTL0039732 in Participants With Advanced Solid Tumours
This study is testing a new drug, HTL0039732, alone and with another cancer medicine, atezolizumab. It's for people with advanced solid tumours, aiming to see if blocking certain signals can help the immune system fight cancer. The goal is to find the right dose and see how well it works.
United Kingdom - recruitingNA
This is a Randomized Study of Early Involvement of Palliative Care Along Side Standard Treatment Versus Standard Treatment Alone in Newly Diagnosed Patients With Advanced or Metastatic Soft Tissue Sarcoma (SARQUALITY)
This study looks at whether getting support from a palliative care team early on improves quality of life for people with advanced sarcoma. It compares this early support with standard care alone to see the difference.
Canada - recruiting
The Sarcoma Biology and Outcome Project
This project, called SarcBOP, is creating a detailed database and sample bank for sarcoma research. It aims to gather lots of information, from scans to patient experiences, to improve understanding and treatment of sarcoma, helping both doctors and patients in the future.
Germany - recruitingPHASE1
FIH, Bispecific CD276xCD3 Antibody CC-3 in Patients With Colorectal Cancer
This study is testing a new medicine called CC-3 for people with advanced bowel, breast, or other cancers that haven't responded to usual treatments. It aims to see if CC-3 is safe and effective in fighting cancer by helping the body's immune system target cancer cells.
Germany - recruitingPHASE2
Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an Alteration of the HER2 Gene.
This study is testing a new drug, zanidatamab, for different cancers like lung, sarcoma, head and neck, bowel, and womb cancer. It's for people whose cancer has a specific change in the HER2 gene and hasn't responded to previous treatments.
France - recruitingNA
Establishment of a Prospective Clinical-biological Database
This study is building a confidential database of samples and information from sarcoma patients in the UK. Researchers will use this to learn more about sarcoma and help develop new treatments to improve care for people with this type of cancer.
France - recruitingPHASE2
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
This study looks at a medicine called atezolizumab for different cancers. We want to see if a special test of your cancer cells can predict if the medicine will work well for you. This helps us learn more about tailoring treatments.
Canada - active not recruitingEARLY_PHASE1
CAR T Therapy With GCAR1 for Relapsed Alveolar Soft Part Sarcoma
This study is looking at a special cell therapy called GCAR1 for a rare type of cancer called alveolar soft part sarcoma (ASPS). It's for patients whose cancer has come back and isn't responding to other treatments. The aim is to see if GCAR1 is safe and helpful.
Canada - recruitingNA
Development of Clinical and Biological Database
This study creates a vital collection of patient information and tissue samples from people with certain cancers. It helps scientists understand cancer better, find new ways to prevent and treat it, and improve care by making this information available for important research.
France - recruitingNA
Evaluating the Use of Educational Videos in Newly Diagnosed Patients in a Medical Oncology Sarcoma Clinic
This study looks at whether short videos can help people newly diagnosed with sarcoma understand their condition and treatment better before their first hospital appointment. We want to see if these videos improve their knowledge and make them feel more prepared for their medical oncology visit.
Canada - recruiting
Quality of Life and Medical Care of Long-term Sarcoma Survivors in Germany (PROSa+)
This study looks at how people in Germany who have lived with sarcoma for five years or more are doing. It asks about their health, how they feel, their experiences with care, and their life situation to better understand long-term effects.
Germany - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - recruitingPHASE1
Multi-modular Chimeric Antigen Receptor T Cells tarGeting B7-H3 in Children, Teenage & Young Adult Sarcoma
This study looks at a new cell therapy called CAR T cells for children, teenagers, and young adults (ages 1-24) with specific types of sarcoma (a type of cancer) that have come back or not responded to previous treatments.
United Kingdom - recruiting
Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients
This study looks at how new ways to treat high-risk sarcoma, a type of cancer, can be made more personal. Researchers are collecting information and samples from patients to find the best treatments before surgery, aiming for better results.
United Kingdom - recruitingPHASE1
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
This study is testing a new drug, OKN4395, alone and with an existing cancer treatment, pembrolizumab, for various solid tumours. The main goals are to check its safety, how well it's tolerated, and if it helps fight cancer.
United States · Australia · United Kingdom - not yet recruitingPHASE2
Sarcoma Surgery Wound Complications Comparing Usual Versus Negative Pressure Dressing
This study compares two types of wound dressings after sarcoma surgery: standard ones and special 'negative pressure' dressings. We want to see if the special dressings reduce wound problems and how they affect recovery and NHS costs. It's for people aged 16+ having sarcoma surgery.
United Kingdom