Latest studies
- RecruitingPhase III
A study of guselkumab versus risankizumab in participants with moderately to severely active Crohn's Disease
This study compares two approved medicines, guselkumab and risankizumab (Skyrizi), for adults with moderate to severe Crohn's Disease. Researchers want to see which one works better to reduce inflammation and symptoms, especially for those who haven't responded to other treatments.
Moderately to severely active Crohn's DiseaseCzech Republic - Completed
Transatlantic registry of type A aortic dissection
This study looks at how people recover after surgery for a serious heart condition called Type A Aortic Dissection. Researchers are collecting information from patients across different hospitals to understand the best ways to treat it and improve outcomes.
Type A aortic dissectionCzech Republic - Recruiting
Capillary markers to predict type 1 diabetes
This study is looking for easier, less painful ways to test children for early signs of type 1 diabetes, like using finger-prick tests instead of needles. The goal is to make these important tests possible at home, removing the need for hospital visits.
Type 1 diabetesCzech Republic - RecruitingPhase III
A study of nipocalimab in adults with moderate to severe systemic lupus erythematosus
This study is testing a new drug called nipocalimab for adults with moderate to severe lupus (SLE). Researchers want to see if it works better than a dummy drug to reduce symptoms. It involves regular visits and monitoring over several years.
Systemic lupus erythematosusCzech Republic - RecruitingPhase III
JNJ-90301900 (NBTXR3) activated by radiotherapy with or without cetuximab in LA-HNSCC
This study looks at a new treatment called JNJ-90301900 with radiotherapy, sometimes with another drug called cetuximab. It's for older patients with a type of head and neck cancer who can't have standard chemotherapy.
Locally advanced head & neck squamous cell carcinomaCzech Republic - CompletedPhase II
A long-term extension study of JNJ-81201887 (AAVCAGsCD59) parent studies in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)
This study looks at the long-term safety of a new gene therapy, JNJ-81201887, for Geographic Atrophy (GA), a severe eye condition. It involves people who previously took part in earlier studies of this treatment, to see how they are doing over several years.
Geographic Atrophy, secondary to age-related macular degenerationCzech Republic - RecruitingPhase I/II
A study to learn how the study medicine called PF-07868489 is tolerated and acts in people with pulmonary arterial hypertension
This study is looking into a new medicine, PF-07868489, for pulmonary arterial hypertension (PAH). Researchers want to see if it's safe and how it works in people with this lung condition. It's an early-stage study to understand the medicine better.
Pulmonary arterial hypertensionCzech Republic - Completed
Three gold-standard evaluations in Portugal, Czechia and the UK of an augmented social play intervention (Lina) to test its effects on belonging and costs for schools
This study looks at a new school activity called 'Lina' for 12-13 year olds in the UK, Portugal, and Czechia. It wants to see if Lina helps students feel more like they belong and improves their mental health, while also checking its cost for schools.
Sense of belonging and mental health and wellbeingCzech Republic - Completed
Does removing both ovaries prior to menopause reduce breast cancer risk in BRCA1 and BRCA2 mutation carriers?
This study looks at existing health records to see if removing ovaries and fallopian tubes before menopause reduces breast cancer risk for women with BRCA1 or BRCA2 gene changes. It aims to understand if these operations help prevent cancer in these women.
Breast cancerCzech Republic - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaCzech Republic - RecruitingPhase III
Astria STAR-0215-302 trial for Navenibart in Hereditary Angioedema
This study looks at a new medicine called navenibart for hereditary angioedema (HAE). It aims to see how safe it is and how well people tolerate it over a long time. Navenibart might help prevent HAE attacks, which can be severe and painful.
Hereditary angioedemaCzech Republic - Recruiting
In-Touch: person-centered palliative care to improve comfort and connection in advanced dementia
This study aims to make life better for people with advanced dementia in nursing homes. It tests new ways to keep residents comfortable and connected, and helps their families plan future care. It also supports staff caring for them.
DementiaCzech Republic