Latest studies
- RecruitingPHASE1, PHASE2
European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
This study is for children and young people with cancer that hasn't responded to usual treatments. It tests new medicines that target specific changes in cancer cells, aiming to find the right dose and see if they help. The goal is to find better ways to treat childhood cancer.
Pediatric CancerDenmark - RecruitingPHASE2
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This study is testing a new medicine, Imeroprubart, for adults with a nerve condition called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Researchers want to see if it's safe and helps improve symptoms compared to a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathyDenmark - RecruitingPHASE3
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
This study looks at a new medicine called zilebesiran for people with high blood pressure that isn't well controlled, especially if they also have heart problems or are at high risk of developing them. The aim is to see if zilebesiran can reduce serious heart-related events like heart attacks or strokes.
High Risk Cardiovascular DiseaseHypertensionHigh Cardiovascular RiskDenmark - RecruitingPHASE3
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
This study is for people with advanced HR+/HER2- breast cancer. It compares a new drug, sacituzumab tirumotecan (alone or with pembrolizumab), against standard chemotherapy, to see which treatment best controls the cancer's growth.
Breast NeoplasmsDenmark - Active not recruitingPHASE3
A Phase III Study to Evaluate the Efficacy and Safety of Benralizumab in Patients With Hypereosinophilic Syndrome (HES)
This study looks at a new drug called benralizumab for Hypereosinophilic Syndrome (HES) in people aged 12 and over. It compares benralizumab to a dummy drug to see if it's safe and helps reduce HES symptoms.
Hypereosinophilic SyndromeDenmark - RecruitingPHASE3
Efficacy, Safety, and Tolerability of Zeleciment Basivarsen (DYNE-101) in Participants With Myotonic Dystrophy Type 1
This study looks at a new medicine called zeleciment basivarsen (DYNE-101) for Myotonic Dystrophy Type 1. We want to see if it's safe, works well, and how people tolerate it. Participants will receive either the study medicine or a dummy medicine for nearly a year.
Myotonic Dystrophy Type 1 (DM1)DM1Myotonic DystrophySteinert DiseaseDenmark - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
This study looks at a new treatment called sacituzumab tirumotecan, sometimes with another medicine called bevacizumab. We want to see if it's safe and helps women with ovarian, fallopian tube, or primary peritoneal cancer live longer without their cancer getting worse, compared to standard care.
Ovarian CancerFallopian Tube CancerPrimary Peritoneal CancerDenmark - RecruitingPHASE3
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
This study compares a new medicine called nemtabrutinib with existing treatments (ibrutinib or acalabrutinib) for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who haven't had treatment before. The aim is to see if the new drug is as good or better.
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaDenmark - RecruitingPHASE1
A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )
This study is testing a new drug, LY4152199, for people with certain types of B-cell lymphoma that have returned or not responded to previous treatments. Researchers want to find the best dose and see how safe and effective it is.
Lymphoma, Non-HodgkinB-cell LymphomaLymphoma, Large B-Cell, DiffuseLymphoma, FollicularDenmark - RecruitingPHASE3
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Researchers are studying a new drug called Maridebart Cafraglutide to see if it can help people with heart disease and who are overweight or obese. The goal is to find out if this drug can lower the risk of heart attacks, strokes, and other serious heart problems.
Atherosclerotic Cardiovascular DiseaseOverweightObesityDenmark - Active not recruitingPHASE3
Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)
This study is for people who have had surgery for bile duct cancer. It's testing a new medicine called rilvegostomig with chemotherapy, to see if it stops the cancer from coming back. It compares the new medicine to a dummy pill.
Biliary Tract CancerDenmark - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus
This study is testing a new medication called dapirolizumab pegol (DZP) for people with moderate to severe lupus (SLE). It aims to see if DZP, when added to usual treatments, can safely improve their symptoms over a long time.
Systemic Lupus ErythematosusDenmark - RecruitingPHASE3
A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)
This study looks at new treatments, sacituzumab tirumotecan alone or with pembrolizumab, for triple-negative breast cancer. It compares their effectiveness with standard chemotherapy to see if they help people live longer or stop cancer growth.
Triple Negative Breast NeoplasmsDenmark - Active not recruitingPHASE3
Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis
This study is looking at a new combination treatment for myelofibrosis, a blood disorder. It combines a drug called Selinexor with Ruxolitinib to see if it's safe and helps people who haven't tried other similar treatments for myelofibrosis before.
MyelofibrosisDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open-Label 156-Week Extension Study To Evaluate The Long-Term Safety And Tolerability Of Oral Atogepant For The Prevention Of Migraine In Participants With Chronic Or Episodic Migraine
This study looks at the long-term safety of a new medicine called atogepant for preventing migraine headaches. It's for people who get migraines often, either regularly or sometimes, and they will take the medicine for up to three years to see how well they tolerate it.
Chronic or Episodic Migraine (Migraine without aura, migraine with aura, or chronic migraine)Denmark - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-Tumor Activity of Inavolisib in Combination with Paclitaxel in Patients with Locally Advanced or Metastatic Solid Tumors
This study is looking at a new medicine called Inavolisib, given with Paclitaxel, for people with advanced solid cancers. It aims to see if the treatment is safe, how the body handles it, and if it can help shrink tumours.
Locally Advanced or Metastatic Solid TumorsDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Randomized, Double-blind, Placebo-controlled, Multicenter Phase 3 Study to Assess the Efficacy, Safety And Immunogenicity of Vaccination With ExPEC9V in the Prevention of Invasive Extraintestinal Pathogenic Escherichia coli Disease in Adults Aged 60 Years And Older with a History of Urinary Tract Infection in the Past 2 Years
This study is testing a new vaccine to prevent serious infections caused by certain types of E. coli bacteria in adults aged 60 and over who have had urinary tract infections. It compares the vaccine to a dummy treatment.
Invasive Extraintestinal Pathogenic Escherichia coli DiseaseDenmark - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)
This study looks at a new drug, claseprubart, for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). It aims to see if the drug helps people with CIDP and if it's safe. Some participants will receive the drug, and others a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathyDenmark - Active not recruitingNA
SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial
This study compares two types of replacement heart valves (self-expanding vs. balloon-expandable) for people with a common heart condition called aortic stenosis. It focuses on patients with smaller heart valve openings to see which valve works best.
Symptomatic Aortic StenosisAortic Valve StenosisAortic Valve ReplacementDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
(20289) A Phase 2 Basket Study of the Oral TRK Inhibitor larotrectinib in Subjects with NTRK Fusion-Positive Tumors
This study is testing a new medicine, larotrectinib, for adult patients with certain types of cancer that have a specific genetic change called an 'NTRK fusion'. Doctors want to see how well the medicine shrinks these tumours and if it's safe.
Solid tumors harboring NTRK fusionDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Open-label Study Evaluating the Pharmacokinetics, Safety, and Tolerability of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects 12 to Less Than 24 Months of Age
This study is testing a new combination medicine for babies and toddlers aged 12 to 24 months with Cystic Fibrosis. Researchers want to ensure the medicine is safe and well-tolerated, and how it moves through the body.
Cystic FibrosisDenmark - Active not recruitingPHASE3
A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer
This study looks at a new drug, tucatinib, combined with T-DM1 to treat advanced HER2-positive breast cancer. It aims to see if this combination works better than T-DM1 alone for cancer that has spread or can't be removed by surgery.
HER2-positive Breast CancerDenmark - Active not recruitingPHASE3
A Study of Dato-DXd With or Without Durvalumab Versus Investigator's Choice of Therapy in Patients With Stage I-III Triple-negative Breast Cancer Without Pathological Complete Response Following Neoadjuvant Therapy (TROPION-Breast03)
This study looks at new drug combinations for stage I-III triple-negative breast cancer that hasn't fully responded to initial treatment. It compares Dato-DXd with or without Durvalumab against standard treatments to see if they're more effective and safe.
Breast CancerDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE)
This study is testing a new medicine called semaglutide for people with early Alzheimer's disease. Researchers want to see if it can help improve memory and thinking, and how safe it is to use.
Mild cognitive impairment (MCI) or mild dementia, both of the Alzheimer’s typeDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A parallel-group, prevention, Phase III, modified double-blind, 2-arm, study to investigate the immunogenicity and describe the safety of a quadrivalent meningococcal conjugate vaccine (MenACYW conjugate vaccine) compared with Nimenrix® when administered in a 1+1 schedule in healthy infants and toddlers at 6 and 12 months of age
This study is looking at a new vaccine to protect babies and young children from meningococcal disease. We are comparing how well this new vaccine works and its safety compared to a current vaccine, Nimenrix, in healthy infants and toddlers in the UK.
Healthy volunteers (Meningococcal infection)Denmark - Active not recruitingPHASE3
Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Follicular Lymphoma
This study looks at a new drug, epcoritamab, combined with standard medicines (R2) for adults with follicular lymphoma that has come back or not responded to previous treatments. It aims to see how safe and effective this new combination is.
Follicular Lymphoma (FL)Denmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-controlled Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacokinetics of Budigalimab and/or ABBV-382 in People Living with HIV on Stable Antiretroviral Therapy Undergoing Analytical Treatment Interruption.
This study looks at new medicines (Budigalimab and ABBV-382) for people with HIV. It tests if these medicines can help control HIV without daily treatment, by carefully pausing regular medication. The goal is to see if HIV stays low after stopping usual drugs.
HIV infectionDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Single-arm, Open-label Extension of the Vericiguat VALOR Study in Pediatric Participants with Heart Failure due to Systemic Left Ventricular Systolic Dysfunction (VALOR EXT)
This study looks at a medicine called Vericiguat for children with a type of heart failure. It checks how safe the medicine is and if it causes any unwanted effects. This is a follow-up study for those already taking part.
Heart Failure due to Systemic Left Ventricular Systolic DysfunctionDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized, Multicenter, Double Blind, Phase III Study of Adjuvant Nivolumab or Placebo in Subjects with Resected Esophageal, or Gastroesophageal Junction Cancer
This study looks at whether a drug called Nivolumab can help prevent cancer from coming back in people who have had surgery for oesophageal or stomach cancer. It compares Nivolumab to a dummy drug to see if it improves the time patients live without their cancer returning.
Subjects with resected adenocarcinoma or squamous cell carcinoma esophageal or gastroesophageal junction cancerDenmark - AuthorisedTherapeutic exploratory (Phase II)
Repurposing Everolimus to enhance musculoskeletal Vitality and Ageing in The Elderly (RENOVATE)
This study, called RENOVATE, is looking at whether a drug called Everolimus, usually used for other conditions, can improve bone and muscle health in healthy older adults. It involves comparing Everolimus with a dummy pill and another medicine called Tetracycline.
General healthy elderly with stable medical conditionsDenmark - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study Evaluating the Safety and Pharmacokinetics of Escalating Doses of Forimtamig in Participants With Relapsed or Refractory Multiple Myeloma
This study is testing a new medicine called Forimtamig for people in the UK with multiple myeloma that has come back or isn't responding to treatment. We want to see if different doses are safe and how the medicine works in the body.
Relapsed or Refractory Multiple MyelomaDenmark - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1/2a Randomized, Double-Blind Placebo-controlled Study of Intra-articular Allocetra in Knee Osteoarthritis
This study is looking at a new treatment called Allocetra for knee osteoarthritis. We want to see how safe it is and if it helps reduce knee pain and improve daily activities for people with this condition.
Knee osteoarthritisDenmark - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Study to evaluate the addition of an experimental drug, CC-90010, to the usual treatment of brain cancer after surgery
This study is testing a new experimental drug, CC-90010, alongside standard treatments for a type of brain cancer called glioblastoma. It's for adults whose brain tumour has been recently diagnosed and surgically removed, either fully or in part, to see if the new drug can help.
Subjects with newly diagnosed WHO Grade IV glioblastoma (ndGBM) who have undergone complete or partial tumor resectionDenmark - Active not recruitingPHASE3
Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer
This study is looking at how well two new drugs, enfortumab vedotin and pembrolizumab, work together to treat advanced bladder cancer that has spread. It compares them to standard chemotherapy treatments to see if they are a better option.
Urothelial CancerDenmark - RecruitingPHASE3
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)
This study offers ongoing treatment with pelacarsen for people who have finished a previous trial for heart disease. It aims to check the long-term safety of the medicine, which helps lower a type of cholesterol called Lp(a).
Cardiovascular Disease and Lipoprotein(a)Denmark - Ongoing, recruitingTherapeutic use (Phase IV)
Effect of ultrasound guided lateral infraclavicular brachial plexus block with Lidocaine or Ropivacaine for closed reduction of distal radius fractures - A randomized controlled non-inferiority trial
This study looks at two types of numbing medicine (Lidocaine or Ropivacaine) used for reducing broken wrists. Researchers want to see if one is as good as the other in quickly numbing the area using ultrasound guidance, to help set the bone without surgery.
Distal radius fractures with need of acute closed reductionDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
CA209-8HW A Phase 3 Randomized Clinical Trial of Nivolumab alone, Nivolumab in Combination with Ipilimumab, or Investigator’s Choice Chemotherapy in Participants with Microsatellite Instability High (MSI-H) or Mismatch Repair Deficient (dMMR) Metastatic Colorectal Cancer
This study looks at new drug combinations for advanced bowel cancer that has specific genetic changes (MSI-H or dMMR). It compares them to standard chemotherapy to see which is better at stopping the cancer from growing.
Microsatellite Instability High (MSI-H) or Mismatch Repair DeficientMetastatic Colorectal Cancer (dMMR)Denmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
This study looks at a new medicine called Evolocumab to see if it can lower the chance of serious heart problems like heart attacks or strokes in people at high risk who haven't had them before. It compares Evolocumab to a dummy medicine.
Adults at high risk of cardiovascular events without prior MI or stroke.Denmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind, placebo-controlled, parallel-group, 3-arm, multinational, multicenter study to evaluate the efficacy and safety of amlitelimab monotherapy by subcutaneous injection in participants aged 12 years and older with moderate-to-severe atopic dermatitis.
This study is testing a new medicine, amlitelimab, for moderate-to-severe eczema in people aged 12 and over. It compares amlitelimab to a dummy medicine (placebo) to see if it improves eczema symptoms like itching and skin clearing.
Dermatitis atopicDenmark - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase I/II, Multicenter, Non-randomized, Open Label, Adaptive Design, 5-year Follow-up, Single Dose-escalation Study of VTX-801 in Adult Patients with Wilson's Disease
This study is testing a new medicine, VTX-801, for adults with Wilson's disease. Researchers want to see if it's safe, how well people tolerate it, and if it helps by looking at things like copper levels and brain scans over five years. It's an early-stage study.
Wilson's DiseaseDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind clinical study of pembrolizumab (MK-3475) plus chemotherapy versus placebo plus chemotherapy as first-line treatment in participants with HER2 negative, previously untreated, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma (KEYNOTE-859)
This study is testing a new medicine, pembrolizumab (Keytruda), alongside standard chemotherapy for advanced stomach or food pipe cancer. It aims to see if this combination helps people live longer compared to chemotherapy alone, especially for cancers that don’t have too much of a protein called HER2.
Gastric and gastric esophageal junction (GEJ) adenocarcinomaDenmark - Active not recruitingPHASE3
Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)
This study is looking at the long-term safety of a treatment called secukinumab for people with Polymyalgia Rheumatica (PMR). It's for those who have already been in a previous study for secukinumab and had their PMR symptoms come back after stopping treatment.
Polymyalgia RheumaticaDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A randomized, two-arm, placebo-controlled, participant, investigator and sponsor-blinded, proof-of-concept study investigating the efficacy, safety and tolerability of QUC398 in patients with symptomatic knee osteoarthritis
This study is testing a new medicine, QUC398, for people with knee osteoarthritis. We want to see if it helps reduce pain and is safe to use. Patients will receive either QUC398 or a dummy treatment, along with standard pain relief.
Knee osteoarthritisDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multi-center, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Neurological Effects of EryDex on subjects with Ataxia-Telangiectasia.
This study is looking for children and adults with Ataxia-Telangiectasia (A-T) to see if a new treatment called EryDex can help with their symptoms. It compares EryDex to a dummy treatment (placebo) to find out if it's effective and safe.
Ataxia TelangiectasiaDenmark - Active not recruitingPHASE3
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
This study looks at a drug called abemaciclib, given with standard hormone therapy after surgery for a type of breast cancer. We want to see if it's safe and helps stop the cancer coming back in people with certain high-risk breast cancers.
Breast CancerDenmark - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Adenoassociated Virus Serotype 8-mediated Gene Transfer of Glucose-6-phosphatase in Patients With Glycogen Storage Disease Type Ia.
This study looks at a new gene therapy called Pariglasgene brecaparvovec for people with a rare liver condition called GSDIa. It aims to see if this new treatment can help reduce the amount of cornstarch they need to eat daily to keep their blood sugar stable.
Glycogen Storage Disease Type Ia (GSDIa)Denmark - Active not recruitingPHASE2, PHASE3
International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma
This study looks at new ways to treat medulloblastoma, a type of brain tumour, in children and young people. It aims to find the best treatments based on the tumour's specific characteristics, hoping to improve the chances of recovery with fewer side effects.
Brain TumorsDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to investigate the efficacy and safety of daxdilimab subcutaneous injection in reducing disease activity in adult participants with moderate-to-severe primary discoid lupus erythematosus.
This study is looking into a new medication called daxdilimab for adults with a type of lupus called discoid lupus erythematosus. Researchers want to see if this medicine can improve skin symptoms and if it's safe to use compared to a dummy treatment.
Primary Discoid Lupus ErythematosusDenmark - Recruiting
The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)
This registry tracks new adult cases of a rare cancer called Epithelioid Hemangioendothelioma (EHE). It aims to better understand the disease, its progression, and how different treatments work, by collecting information from patients across Europe and the UK.
Epithelioid HemangioendotheliomaSarcoma,Soft TissueDenmark - Ongoing, recruitingTherapeutic exploratory (Phase II)
Effects of NNC0194-0499 alone and in combination with semaglutide, of semaglutide alone, and of cagrilintide alone and in combination with semaglutide on liver damage and alcohol use in people with alcohol-related liver disease
This study is testing different new medicines, alone or in combination, to see if they can help improve liver damage and reduce alcohol use in people with liver problems caused by alcohol. One of the medicines is similar to a type already used for diabetes.
alcohol-related liver diseaseDenmark