Latest studies
- RecruitingPHASE3
ADT +/- Darolutamide in de Novo Metastatic Prostate Cancer Patients With Vulnerable Functional Ability (PEACE6-Vulnerable)
This study looks at a new drug, darolutamide, along with standard hormone therapy for men with prostate cancer that has spread. It's for those who might not be able to have other treatments because of their general health.
Prostate Cancer MetastaticIreland - RecruitingPHASE1, PHASE2
A Study to Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)
This study is testing a new medicine, BEAM-302, for adults with Alpha-1 Antitrypsin Deficiency (AATD). It will check if the medicine is safe, how well it works, and find the best dose to help people with lung or liver problems caused by AATD.
Alpha 1-Antitrypsin DeficiencyIreland - Active not recruitingPHASE2
A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
This study looks at new drug combinations to treat advanced lung cancer. It compares two different drug mixes, each including chemotherapy, to see which works best and is safest for people with Stage IV or recurrent non-small cell lung cancer.
Non-small Cell Lung CancerRecurrent Non-small Cell Lung CancerMetastatic Non-small Cell Lung CancerIreland - RecruitingNA
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention
This study looks at a new way to lower ovarian cancer risk in women with certain gene changes. Instead of removing both ovaries and fallopian tubes at once, it explores removing only the fallopian tubes first, and the ovaries later, to delay menopause and its effects. We want to see if this new approach is safe and effective.
BRCA1 Gene MutationBRCA2 Gene MutationRAD51C Gene MutationRAD51D Gene MutationIreland - RecruitingNA
Comprehensive LEFt Atrial Appendage Occlusion With Rhythm Restoration
This study looks at combining two heart procedures: one to control an irregular heartbeat (AF) and another to reduce stroke risk. It's for people with AF who need both treatments and aims to see if doing them together is safe and works well.
Atrial Fibrillation (AF)Paroxysmal AFPersistent Atrial FibrillationIreland - RecruitingPHASE3
A Study of Sepiapterin in Participants With Phenylketonuria (PKU)
This study is looking at a new medicine called sepiapterin for children with Phenylketonuria (PKU). It aims to see if starting this medicine early can help protect their brain development over a long time.
PhenylketonuriaIreland - RecruitingPHASE2, PHASE3
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
This study looks at a new drug, ficerafusp alfa, combined with pembrolizumab (Keytruda®) for people with advanced head and neck cancer. It compares this combination against pembrolizumab alone to see if it works better and is safe.
Metastatic Head and Neck Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell CarcinomaIreland - Active not recruiting
Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System
This study looks at how safe and effective a new treatment called FARAPULSE is for atrial fibrillation. It collects real-world information about people treated with this system in hospitals to see how well it works and if it improves their quality of life.
Atrial FibrillationIreland - RecruitingPHASE2, PHASE3
An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma
This study aims to improve treatment and understanding of childhood ependymoma. It involves different treatment approaches, including chemotherapy and radiotherapy, for children and young adults up to 22 years old. The goal is to find better ways to help these patients.
Childhood EpendymomaIreland - Active not recruitingNA
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer
This study aims to understand if temporarily stopping hormone therapy for early breast cancer to allow for pregnancy is safe. It will also look at fertility and emotional well-being for young women.
Early Breast CancerIreland - Enrolling by invitationPHASE2, PHASE3
HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP
This study looks at a new medicine called DISC-1459 (Bitopertin) for people with Erythropoietic Protoporphyria (EPP). It's an ongoing study to see if the medicine is safe, well-tolerated, and effective over a long time for those who have already tried it in earlier studies.
Erythropoietic ProtoporphyriaIreland - Active not recruitingPHASE3
Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy
This study looks at new drug combinations for advanced liver cancer that hasn't been treated before. It compares cabozantinib with atezolizumab against a standard treatment, sorafenib, to see which works better and is safer.
Hepatocellular CarcinomaIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF ORAL OZANIMOD AS MAINTENANCE THERAPY FOR MODERATELY TO SEVERELY ACTIVE CROHN’S DISEASE
This study is looking into a new medication called Ozanimod for people with moderately to severely active Crohn's disease. Researchers want to see if it can help keep symptoms under control and reduce inflammation in the gut over time.
Moderately to Severely Active Crohn's DiseaseIreland - RecruitingPHASE1, PHASE2
FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma
This study, FaR-RMS, is for children and adults with a type of cancer called rhabdomyosarcoma. It's looking for better ways to treat both newly diagnosed and returning cancer, using different combinations of medicines and radiotherapy.
RhabdomyosarcomaIreland - Active not recruitingPHASE3
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
This study is testing a new medicine called Mim8 for people with haemophilia A, including those with inhibitors. Mim8 aims to prevent bleeding episodes by helping blood clot. It's for people already in other Mim8 studies.
Haemophilia AHaemophilia A With InhibitorsIreland - RecruitingPHASE3
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
This study is looking at new treatments for triple-negative breast cancer that remains after surgery. It compares a new drug combination (sacituzumab govitecan-hziy and pembrolizumab) with standard treatments to see if it's more effective and safe for patients.
Triple Negative Breast CancerIreland - RecruitingPHASE3
A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD)
This study looks at a new medicine called Vonicog Alfa for children with severe Von Willebrand Disease (VWD). It checks if this medicine can help prevent bleeding events in children who have previously used other VWD treatments.
Von Willebrand Disease (VWD)Ireland - RecruitingPHASE1
A Phase 1/1b Study of IAM1363 in HER2 Cancers
This study is testing a new medicine called IAM1363 for advanced cancers with a specific change called HER2. It aims to find a safe and effective dose, including for breast, lung, and stomach cancers that have spread to the brain.
HER2 Mutation-Related TumorsHER2HER2-positive Breast CancerHER2 + Breast CancerIreland - Active not recruitingPHASE4
Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF (RECOVER)
This study, called RECOVER, looks at how well the medicine Kaftrio works for people with cystic fibrosis (CF) in real life. It checks many things like breathing, tummy problems, and how people feel overall, for two years, starting with those aged 12 and over.
Cystic FibrosisCystic Fibrosis Liver DiseaseCystic Fibrosis in ChildrenAdherence, MedicationIreland - RecruitingPHASE3
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
This study compares two treatments for multiple myeloma that has come back or not responded to previous treatments. It looks at a new drug, mezigdomide, combined with standard medicines (bortezomib and dexamethasone), against another combination (pomalidomide, bortezomib, and dexamethasone). The aim is to see which combination is more effective and safe.
Relapsed or Refractory Multiple MyelomaIreland - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
Crohn's DiseaseIreland - RecruitingPHASE3
A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients With Multiple Myeloma Who Are Not Eligible for Transplant
This study is testing a new drug, linvoseltamab, for people with a type of blood cancer called multiple myeloma. It compares this new drug to standard treatments to see how safe and effective it is, for patients who cannot have a stem cell transplant.
Multiple MyelomaIreland - RecruitingNA
A Pivotal Study Evaluating Safety and Effectiveness of Adaptative Tip Catheter in Patients With Acute Ischemic Stroke
This study is testing a new device called an 'Adaptive Tip Catheter' for people who have had a stroke caused by a blood clot. It aims to see if this device is safe and effective in removing the clot and helping patients recover.
Ischemic StrokeIreland - Active not recruiting
A Registry on the FARAVIEW Technology of the OPAL HDx Mapping System When Used With the FARAWAVE NAV Ablation Catheter in the Treatment of Atrial Fibrillation
This study looks at how safe and effective a new treatment called FARAPULSE is for a heart condition called atrial fibrillation. It collects information for one year after the treatment. Doctors use the FARAPULSE system with special tools during the procedure.
Atrial FibrillationPulsed Field AblationFARAPULSEIreland - Active not recruitingNA
The OCTOBER Trial - European Trial on Optical Coherence Tomography Optimized Bifurcation Event Reduction (OCTOBER)
This study compares two ways to unblock heart arteries using stents for complex cases. It looks at whether using a special scanning tool, called OCT, during the procedure leads to better results over two years than standard methods.
Ischaemic Heart DiseaseIschemic Heart DiseaseIreland - Not yet recruitingPHASE2
A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
This study is for people with advanced solid tumours that have a specific genetic change called an MTAP deletion. It's testing a new medicine, BMS-986504, alone and with other cancer treatments, to see how safe and effective they are.
Solid TumorsIreland - Active not recruitingPHASE3
An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma
This study looks at a daily tablet called ivosidenib for adults with bile duct cancer that has come back or spread, and has been treated before. It aims to confirm if the treatment is safe and works well, and how it affects quality of life.
CholangiocarcinomaIreland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Double-blind, Randomized, Active-control, Parallel Group Study to Assess the Pharmacokinetics, Pharmacodynamics, Immunogenicity, and safety of SAR447537 (INBRX-101) Compared to Plasma Derived Apha1-Proteinase Inhibitor (A1PI) Augmentation Therapy in Adults with Alpha-1 Antitrypsin Deficiency (AATD) Emphysema
This study compares a new medicine, INBRX-101, with standard treatment for Alpha-1 Antitrypsin Deficiency (AATD) emphysema. It looks at how the medicines work in the body, their effects, and if they are safe, to help people with this lung condition.
Alpha-1 Antitrypsin Deficiency (AATD) EmphysemaIreland - RecruitingPHASE3
A Long-term Extension Study of PCI-32765 (Ibrutinib)
This study offers ongoing access to a drug called ibrutinib for people already using it for certain blood cancers and conditions, who are still benefiting. It also helps gather more long-term information on how safe and effective ibrutinib is.
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaMantle Cell LymphomaFollicular LymphomaIreland - Active not recruitingPHASE3
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
This study is testing new combinations of medicines for advanced kidney cancer (renal cell carcinoma). Its aim is to see if these new combinations work better and are safe compared to a standard treatment, for people who haven't had treatment for their advanced cancer before.
Carcinoma, Renal CellIreland - Active not recruitingPHASE3
A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow
This study looks at a new weekly medicine, somapacitan, for children who need help growing. It compares it to Norditropin®, a daily medicine already used. The study includes children born small, or with Turner, Noonan syndrome, or unexplained short stature, over up to 5.5 years.
SGA, Turner Syndrome, Noonan Syndrome, ISSIreland - Active not recruitingPHASE3
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma
This study looks at a medicine called selinexor for people with advanced or recurring womb cancer (endometrial carcinoma). It's for patients whose cancer responded well to previous platinum-based treatment, to see if selinexor can help keep the cancer from coming back.
Endometrial CancerIreland - Not yet recruitingNA
A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer
This study looks at new ways to predict cancer recurrence in people with Barrett's Oesophagus. It also checks how knowing your risk affects your quality of life. We'll collect samples and ask you to fill out questionnaires to help improve care.
Barrett EsophagusBarrett Esophagus AdenocarcinomaAdenocarcinoma - GEJGastroenterologyIreland - Active not recruiting
Long-Term Observational Study on Effectiveness and Safety of Lecigon in Patients With Advanced Parkinson's Disease
This study looks at how a medicine called Lecigon® works and its safety for people with advanced Parkinson's disease in their everyday lives. It gathers information from around 300 patients who are already using Lecigon® to help manage their symptoms that aren't well controlled by other treatments.
Advanced Parkinson DiseaseIreland - Not yet recruitingPHASE2
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
This study looks at a new drug, imlunestrant, for premenopausal women with a common type of early breast cancer. Researchers want to see how it affects cancer cells and the ovaries, comparing it to an existing treatment called tamoxifen. It’s for women whose breast cancer is sensitive to hormones.
Breast NeoplasmsIreland - Recruiting
A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems
This study aims to understand how liver problems develop in adults with Alpha-1 Antitrypsin Deficiency (AATD) when left untreated. Researchers will follow participants for five years to learn about the condition's progression, diagnosis, and how it affects lung health.
Alpha1-Antitrypsin DeficiencyIreland - Recruiting
Trial-Ready Cohort-Down Syndrome (TRC-DS)
This study looks at adults with Down syndrome to understand how Alzheimer's disease develops. It aims to find better ways to measure changes in the brain for future drug trials, helping to speed up the search for effective treatments.
Down SyndromeAlzheimer DiseaseDementiaIreland - RecruitingPHASE3
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
This study is for women with cervical cancer that has spread. It's testing new combinations of medicines (sac-TMT, pembrolizumab, and possibly bevacizumab) to see if they are safe and can help people live longer or stop their cancer from getting worse.
Cervical CancerIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Niraparib Maintenance Treatment in Patients with Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy
This study looks at a new drug called niraparib to see if it can help women with advanced ovarian cancer stay well longer after their first round of chemotherapy. It compares niraparib to a dummy pill to find out how effective and safe it is.
Homologous recombination deficiency advanced ovarian cancerIreland - RecruitingPHASE2
A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis
This study is looking into new medicines, Eltrekibart and Mirikizumab, for adults with moderate to severe ulcerative colitis. Researchers want to see if these medicines are safe and if they can help people feel better.
Ulcerative ColitisUlcerative Colitis ChronicIreland - Recruiting
AI-driven Narrow-band Imaging Score for Disease Assessment and Outcome Prediction in Ulcerative Colitis
This study aims to create a new, simple way to check how active Ulcerative Colitis is using special camera tests (colonoscopies). It will also explore using artificial intelligence to make these checks more accurate and help predict how the disease might progress over time.
Ulcerative Colitis (UC)Ireland - RecruitingPHASE3
A Trial of 5 Fraction Prostate SBRT Versus 5 Fraction Prostate and Pelvic Nodal SBRT
This study compares two ways of giving radiotherapy in 5 sessions for prostate cancer. Half of men receive radiotherapy to the prostate, while the other half get it for both the prostate and surrounding lymph nodes, to see which is safer and more effective.
Prostate CancerIreland - Active not recruitingPHASE3
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension
This study is testing if a medicine called selexipag can help children aged 2-17 with a serious lung condition called pulmonary hypertension. It aims to see if adding selexipag to their usual treatment can slow down the disease compared to a dummy medicine.
Hypertension, PulmonaryIreland - Active not recruitingPHASE3
Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE
This study is looking at a new tablet, deucrictibant, to see if it can help prevent swelling attacks in people with Hereditary Angioedema (HAE). It includes adults and children aged 12 and over, comparing the new drug to a dummy pill (placebo).
Hereditary Angioedema (HAE)Ireland - RecruitingPHASE3
Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)
This study is testing a new medicine, Trimodulin, for severe lung infection (pneumonia) in hospital. It will compare Trimodulin to a dummy medicine to see if it makes people better and is safe when used with usual treatments.
Community-acquired PneumoniaIreland - RecruitingNA
iCorMicA - Stratified Medicine in Angina
This study looks at how best to treat chest pain (angina) when blockages aren't found in the main heart arteries. It tests if personalised treatment, guided by special heart tests, improves symptoms and health for people with this condition.
Microvascular AnginaAngina, StableIschemia With No Obstructive Coronary Arteries (INOCA)Coronary Microvascular Dysfunction (CMD)Ireland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Double-blind Trial Comparing Trastuzumab Plus Chemotherapy and Pembrolizumab With Trastuzumab Plus Chemotherapy and Placebo as First-line Treatment in Participants With HER2 Positive Advanced Gastric or Gastroesophageal Junction Adenocarcinoma (KEYNOTE 811)
This study looks at a new combination of medicines for a type of stomach or food pipe cancer that has spread. It compares adding the drug pembrolizumab to standard treatment to see if it helps patients live longer without their cancer growing.
Gastric or gastroesophageal junction (GEJ) adenocarcinomaIreland - Active not recruitingPHASE3
A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy
This study is looking at a new combination medicine, VX-121/TEZ/D-IVA, for people with cystic fibrosis. We want to understand how safe and effective it is over a longer period, especially for those who have been in previous studies with this medication.
Cystic FibrosisIreland - Not yet recruitingPHASE3
Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis
This study looks at a medicine called Admilparant for people with pulmonary fibrosis. It's for those who have already been in similar studies and helps us understand its long-term safety and how well people tolerate it over time.
Pulmonary FibrosisIreland - Active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
This study compares a new drug, Giredestrant, with standard hormone therapy for early breast cancer. It's for people with a specific type of breast cancer (ER-positive, HER2-negative) who have already had surgery.
Early Breast CancerIreland