Latest studies
- Active not recruitingPHASE2, PHASE3
A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy.
This study looks at a new drug, efgartigimod PH20 SC, for adults with active idiopathic inflammatory myopathy (IIM), a condition causing muscle weakness and inflammation. It compares the drug to a dummy treatment to see if it helps improve muscle strength and overall well-being.
Active Idiopathic Inflammatory MyopathyMyositisDermatomyositisPolymyositisIreland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A phase II, randomized, open-label study to assess the efficacy, safety, and pharmacokinetics (PK) of maintenance cabozantinib (XL184) plus best supportive care (BSC) versus BSC in children, adolescents and young adults (AYA) with unresectable residual osteosarcoma either at diagnosis or at first relapse after standard treatment.
This study looks at a new medicine called cabozantinib for young people with a type of bone cancer called osteosarcoma. It compares cabozantinib plus supportive care with supportive care alone to see if it helps stop the cancer from growing.
Osteosarcoma in Children, Osteosarcoma in Adolescents and Young Adults, OsteosarcomaIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A 52-week, randomised, double-blind, double-dummy, parallel group, multi-centre, non-inferiority study assessing exacerbation rate, additional measures of asthma control and safety in adult and adolescent severe asthmatic participants with an eosinophilic phenotype treated with GSK3511294 (depemokimab) compared with mepolizumab or benralizumab
This study looks at a new medicine called depemokimab for severe asthma with high eosinophils. It compares it to existing treatments like mepolizumab and benralizumab over a year to see if it's just as good at preventing asthma attacks and improving control.
Severe asthma with an eosinophilic phenotypeIreland - Recruiting
How effective are walk-in mental health centers for young people with psychological distress in Europe and Australia?
This study looks at how well 'walk-in' mental health centres, called YEAHs, help young people aged 12-25 with mental health challenges. It checks if they improve mental well-being, are easy to use, and offer good value, comparing them to usual care.
Prevention and early intervention of mental disorders in youth with psychological distressIreland - RecruitingPHASE3
A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD)
This study looks at a new medicine called Vonicog Alfa for children with severe Von Willebrand Disease (VWD). It checks if this medicine can help prevent bleeding events in children who have previously used other VWD treatments.
Von Willebrand Disease (VWD)Ireland - Recruiting
Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body
This study looks at how well a drug called VITRAKVI works and how safe it is for people with TRK fusion cancer. This type of cancer happens when certain genes fuse together. Doctors want to see how VITRAKVI helps patients in real-world use.
Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene FusionIreland - Active not recruitingNA
Effectiveness of the SpaceOAR Vue System in Subjects With Prostate Cancer
This study looks at how well a product called SpaceOAR Vue helps men with prostate cancer. It aims to reduce gut problems when they have a type of radiation treatment called SBRT, by putting a special gel between the prostate and bowel.
Prostate CancerIreland - RecruitingPHASE1, PHASE2
HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
This study is for children and young adults aged 1-21 with specific types of aggressive blood cancers that have come back or not responded to treatment. It tests new drug combinations to see if they're safe and work well for those with certain genetic changes in their cancer.
Acute Lymphoblastic LeukemiaLymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) RecurrentLymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) RecurrentLymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) RefractoryIreland - RecruitingPHASE3
An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma
This study looks at a daily tablet called ivosidenib for adults with bile duct cancer that has come back or spread, and has been treated before. It aims to confirm if the treatment is safe and works well, and how it affects quality of life.
CholangiocarcinomaIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, phase 3 trial with anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) versus placebo for patients with early stage NSCLC after resection and completion of standard adjuvant therapy (PEARLS) KEYNOTE-091
This study looks at a drug called Keytruda after surgery for a type of lung cancer. It aims to see if Keytruda can stop the cancer from coming back for longer than a dummy treatment in patients with non-small cell lung cancer, especially those with certain cancer markers.
Stage IB (T ≥ 4 cm), II and IIIA NSCLCIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of AMX0035 Versus Placebo for 48-week Treatment of Adult Patients with Amyotrophic Lateral Sclerosis (ALS)
This study is testing a new medicine, AMX0035, for people with Motor Neurone Disease (ALS). It aims to see if the medicine can slow down the disease's progression over 48 weeks, compared to a dummy medicine.
Amyotrophic Lateral Sclerosis (ALS)Ireland - Active not recruitingPHASE3
Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate
This study looks at a new drug called darolutamide, along with standard treatments like radiotherapy and hormone therapy, for men with prostate cancer that's at a very high risk of coming back. The aim is to see if this combination can better stop the cancer from spreading and improve their long-term health.
Prostate CancerIreland - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaIreland - Active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)
This study looks at a new combination of drugs, pembrolizumab and enzalutamide, for men with advanced prostate cancer that has spread and no longer responds to hormone therapy. It compares this combination to enzalutamide alone to see if it helps men live longer and stops the cancer from growing.
Prostatic NeoplasmsIreland - RecruitingPHASE3
Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy
This study looks at a new way to treat a specific type of leukaemia (AML) with a gene change called IDH1. It adds a drug called venetoclax to standard treatment (ivosidenib and azacitidine) to see if it works better. It's for patients who can't have strong chemotherapy.
Acute Myeloid LeukemiaIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Open-label, Randomized, Noninferiority Trial of the Subcutaneous Formulation of Nivolumab Versus Intravenous Nivolumab in Participants With Advanced or Metastatic Clear Cell Renal Cell Carcinoma Who Had Received Prior Systemic Therapy
This study compares two ways of giving a medicine called Nivolumab for advanced kidney cancer. One way is an injection under the skin, and the other is a drip into a vein. Doctors want to see if the injection works just as well and is safe for patients.
Metastatic Clear Cell Renal Cell CarcinomaIreland - Active not recruitingNA
Evaluation of Safety and Performance of the Omega™ LAA (Left Atrial Appendage) Occluder and Omega™ Delivery System in Patients With Non-Valvular Atrial Fibrillation and High Bleeding Risk
This study looks at a new device, the Omega LAA Occluder, designed to prevent strokes in people with a type of irregular heartbeat called non-valvular atrial fibrillation, especially if they have a high risk of bleeding. It checks how safe and effective the device is.
Non-Valvular Atrial FibrillationIreland - Completed
An international cohort study of wound closure and surgical site infection prevention strategies in abdominal surgery
This study looks at how different ways of closing wounds and preventing infections after tummy surgery affect how well people recover. It aims to improve future surgical care worldwide by gathering information from adults undergoing these operations.
Adult patients (age 18 years and above) undergoing general or colorectal surgical procedures using any type of abdominal incision measuring at least 5 cm (including extraction sites)Ireland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Open-Label, Parallel Group, Multicenter, Extension Study Evaluating the Long-Term Treatment of Bimekizumab in Study Participants With Moderate to Severe Hidradenitis Suppurativa
This study is looking at the long-term safety and effectiveness of a new medicine called bimekizumab for adults with moderate to severe hidradenitis suppurativa (HS). It's an extension of an earlier study, helping us understand how well the treatment works and if it causes any side effects over a longer time.
Hidradenitis SuppurativaIreland - Ongoing, recruitingTherapeutic use (Phase IV)
Daily versus alternate day oral iron supplementation for the treatment of iron deficiency anaemia in pregnancy (IronMother)
This study is looking at the best way to give iron supplements to pregnant women who have too little iron (iron deficiency anaemia). We want to find out if taking iron every day or every other day works better to improve their iron levels and how they feel, while keeping side effects low.
Iron deficiency anaemia in pregnancyIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
ATLAS-OLE: An Open-label, Long-term Safety and Efficacy Study of Fitusiran in Patients with Hemophilia A or B, with or without Inhibitory Antibodies to Factor VIII or IX
This study is testing a new medicine, fitusiran, for people with haemophilia A or B. It wants to see how safe and effective it is over a long time, especially in stopping bleeding. Doctors are looking at side effects and how it improves daily life.
Hemophilia A or Hemophilia BIreland - RecruitingNA
Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy
This study looks at breast cancer patients whose lymph nodes cleared after chemotherapy. We want to see if skipping further surgery or radiation to their armpit causes fewer side effects like swelling, without making their cancer return more often compared to standard treatment.
Breast CancerSentinel Lymph NodeNeoplasm, BreastIreland - Active not recruitingPHASE3
A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery
This study looks at new drug combinations (fianlimab with cemiplimab) versus a standard drug (pembrolizumab) to see if they can stop melanoma from coming back after surgery. It's for people at high risk of their melanoma returning.
MelanomaIreland - RecruitingPHASE3
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
This study looks at the long-term safety and effectiveness of a cancer drug called pembrolizumab (and related treatments) for people with advanced cancers. It's for patients who are already receiving these treatments in other studies and want to continue.
Solid TumorsHematologic MalignanciesIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Prospective Phase III Multi-center, 2-Year Placebo Controlled, Double Blind Study to Evaluate the Efficacy and Safety of “Kamada-AAT for Inhalation” 80 mg per Day in Adult Patients with Congenital Alpha-1 Antitrypsin Deficiency with Moderate and Severe Airflow Limitation (40% ≤ FEV1 ≤ 80% of predicted; FEV1/SVC ≤ 70%), Followed by a 2-Year Open- Label Extension
This study looks at a new inhaled medicine, Kamada-AAT, for adults with a genetic lung condition called Alpha-1 antitrypsin deficiency. Researchers want to see if it improves breathing and overall lung health over two years compared to a dummy treatment, followed by two years where everyone gets the medicine.
Adult Patients with Congenital Alpha-1 Antitrypsin Deficiency with Moderate and Severe Airflow Limitation (40% ≤ FEV1 ≤ 80% of predictedFEV1/SVC ≤ 70%), and with no history of two or moremoderate or one or more severe exacerbations of COPD during the past year.Ireland - Active not recruitingPHASE2, PHASE3
An International, Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled, Phase 2/3 Study With Open-Label Extension Evaluating the Efficacy and Safety of Diacerein 1% Ointment for the Treatment of Generalized Epidermolysis Bullosa Simplex (EBS)
This study tests a special cream (AC-203) for a skin condition called Epidermolysis Bullosa Simplex (EBS). It looks at how well the cream works to reduce blistering and how safe it is for people with widespread EBS, including children.
Generalized Epidermolysis Bullosa SimplexIreland - Ongoing, recruitingTherapeutic exploratory (Phase II)
ApproaCH: A Phase 2b, Multicenter, Double-Blind, Randomized, Placebo-controlled Trial evaluating Efficacy and Safety of Subcutaneous Doses of TransCon CNP Administered Once Weekly for 52 Weeks in Children with Achondroplasia followed by an Open Label Extension period
This study, called ApproaCH, is testing a new medicine called TransCon CNP for children and teenagers with achondroplasia. It wants to see if the medicine helps them grow taller over a year, compared to a dummy medicine. After this, all children will get the new medicine.
Achondroplasia in Children and AdolescentsIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Two-Part Randomized, Phase 3 Study of Combinations of Cemiplimab (Anti- PD-1 Antibody) and Platinum-based Doublet Chemotherapy in First-line Treatment of Patients with Advanced or Metastatic Non-Small Cell Lung Cancer
This study is testing new combinations of anti-cancer medicines for people with advanced non-small cell lung cancer. It aims to see if these new approaches can help people live longer and improve their quality of life, compared to standard treatments.
Non-small Cell Lung CancerIreland - RecruitingPHASE1
A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis
This study is testing a new oral medication, SYX-5219, for moderate to severe eczema (atopic dermatitis). It aims to check the drug's safety, how well it's tolerated, and how it moves through the body in both healthy people and those with eczema.
Moderate to Severe Atopic DermatitisIreland - Active not recruitingPHASE2
A Phase 2 Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)
This study is testing a new medicine, ENV-101, for people with lung scarring conditions like Idiopathic Pulmonary Fibrosis (IPF). It aims to see if it improves breathing and is safe to use. Patients might continue their usual treatments.
Idiopathic Pulmonary FibrosisProgressive Fibrosing Interstitial Lung DiseaseIreland - Active not recruitingPHASE3
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
This study looks at a new drug, isatuximab, combined with standard treatments (lenalidomide and dexamethasone) for people with high-risk smoldering multiple myeloma. It aims to see if this combination can prevent the disease from getting worse compared to the standard treatments alone.
Plasma Cell MyelomaIreland - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Open-label, Multicenter Study of Mitapivat in Subjects With Sickle Cell Disease and Nephropathy
This study is testing a new medicine called Mitapivat for people with Sickle Cell Disease and kidney problems. Researchers want to see if it can help reduce kidney damage and improve health, checking for how safe and effective it is over six months.
Sickle Cell Disease (SCD) and NephropathyIreland - Enrolling by invitation
Zoledronate In the Prevention of Paget's Disease: Long Term Extension
This study looks at people with a higher risk of Paget's disease due to genetics. It's an extension of a previous study and aims to see if an early treatment helps prevent symptoms or slow down the disease over five years.
Paget DiseaseIreland - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, Multicenter, Open-label, Dose-escalation, and Dose-expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamic, and Antitumor Activity of CR-001 in Adult Participants with Locally Advanced or Metastatic Solid Tumors.
This study is testing a new medicine, CR-001, for adults with certain advanced or spreading cancers. It aims to find a safe and effective dose, understand how the body uses the medicine, and see if it can shrink tumors or slow their growth.
Locally Advanced or Metastatic Solid TumorsIreland - Active not recruitingPHASE3
An Investigational Immuno-therapy Study of Nivolumab, Compared to Placebo, in Patients With Bladder or Upper Urinary Tract Cancer, Following Surgery to Remove the Cancer
This study looks at a new immune-boosting medicine called Nivolumab for people who have had surgery for bladder or kidney drainage system cancer. It compares Nivolumab to a dummy drug to see if it's safe and helps stop the cancer from coming back.
Various Advanced CancerIreland - Active not recruitingPHASE2
(Summit) A Study to Evaluate the Efficacy and Safety of CGT9486 Versus Placebo in Patients With Indolent or Smoldering Systemic Mastocytosis
This study is testing a new medicine, bezuclastinib, for people with certain types of mastocytosis (a rare blood disorder). It compares bezuclastinib with a dummy pill (placebo) to see if it safely helps reduce symptoms that aren't well controlled by current treatments.
SSMMastocytosis, IndolentMastocytosis, SystemicMastocytosisIreland - RecruitingPHASE2, PHASE3
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
This study looks at a new drug called adagrasib, on its own and with another drug, pembrolizumab, for people with advanced lung cancer. It's for those with a specific gene change (KRAS G12C) who haven't had treatment yet.
Advanced Non-Small Cell Lung CancerMetastatic Non-Small Cell Lung CancerIreland - RecruitingPHASE3
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
This study looks at a long-term treatment called nerandomilast for people with pulmonary fibrosis. It's for those who've used it in a past study. We'll see how safe and effective it is over time, checking if it helps lung function and slows down the disease.
Idiopathic Pulmonary FibrosisProgressive Pulmonary FibrosisIreland - RecruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
Diabetes Mellitus, Type 2HypertensionCardiovascular DiseasesIreland - RecruitingPHASE2, PHASE3
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
This study looks at a new drug, ficerafusp alfa, combined with pembrolizumab (Keytruda®) for people with advanced head and neck cancer. It compares this combination against pembrolizumab alone to see if it works better and is safe.
Metastatic Head and Neck Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell CarcinomaIreland - RecruitingPHASE3
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
This study is looking into a new medicine, BI 1291583, for people with bronchiectasis. It aims to see if this medicine can help reduce flare-ups, which are common with the condition. Participants will take a tablet daily and be monitored for up to 1 year and 8 months.
BronchiectasisIreland - Recruiting
Abbott Structural Heart Device Registry
This study looks at how well Abbott heart devices work in day-to-day hospital care. It helps make sure these devices are safe and effective for people with different heart conditions, like holes in the heart or valve problems, as they are used in real life.
Heart DiseasesASD - Atrial Septal DefectVSD - Muscular Ventricular Septal DefectPFO - Patent Foramen OvaleIreland - Recruiting
Registry for Patients With X-Linked Hypophosphatemia
This study is gathering information on people with X-Linked Hypophosphatemia (XLH) to understand how it progresses and how different treatments work over a long time. It's for all ages and genders, whether they are on treatment or not.
X-Linked HypophosphatemiaIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
RANDOMISED DOUBLE-BLIND PLACEBO-CONTROLLED PHASE 3 TRIAL OF TRIUMEQ IN AMYOTROPHIC LATERAL SCLEROSIS - LIGHTHOUSE II
This study is looking at a medicine called Triumeq for people with Amyotrophic Lateral Sclerosis (ALS), also known as Motor Neuron Disease. Researchers want to see if Triumeq can help people live longer and improve their daily lives. We are comparing it to a dummy pill to see how well it works.
AMYOTROPHIC LATERAL SCLEROSISIreland - Recruiting
Friedreich Ataxia Global Clinical Consortium UNIFIED Natural History Study
Researchers are studying Friedreich ataxia to better understand how the condition progresses and to help develop new treatments. This study will follow people with Friedreich ataxia for many years, gathering information about their health and how the condition affects them.
Friedreich AtaxiaIreland - Active not recruitingPHASE3
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors
This study compares a new medicine, crovalimab, to an existing one, eculizumab, for people with a rare blood condition called PNH. It's looking at how safe and effective crovalimab is in patients already receiving similar treatments.
Paroxysmal Nocturnal HemoglobinuriaIreland - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Alnuctamab Compared to Standard of Care Regimens in Participants with Relapsed or Refractory Multiple Myeloma (RRMM) - ALUMMINATE RRMM
This study is testing a new medicine, Alnuctamab, for people in the UK with multiple myeloma whose cancer has come back or isn't responding to other treatments. Researchers want to see if Alnuctamab works better and is safer than current treatments, aiming to stop the cancer from growing for longer.
Relapsed and/orRefractory Multiple MyelomaIreland - RecruitingNot Applicable
Using light-based imaging to make heart stent treatment safer and more effective
This study looks at making heart attack treatment safer. It compares a new, clearer imaging method called OCT with standard X-rays to guide stent placement. We want to see if OCT helps doctors treat patients better and leads to improved recovery.
Optimizing percutaneous coronary intervention (PCI) for patients with ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI)Ireland - Active not recruiting
Male Breast Cancer: Understanding the Biology for Improved Patient Care
This study looks at breast cancer in men. Researchers are gathering information and samples from men with breast cancer to better understand the disease and improve how it's treated. It's a large international effort to learn more about this rare condition.
Breast CancerIreland - AuthorisedTherapeutic exploratory (Phase II)
Selective decontamination of the digestive tract in preventing surgical site infections in elective colorectal surgery: a randomised controlled trial (SELDDEC Trial)
This study looks at a special treatment for people having bowel surgery. It aims to see if giving certain antibiotics beforehand can help stop infections where the cut was made. We want to find better ways to keep patients healthy after their operation.
Surgical site infectionIreland