Latest studies
- Completed
Smoking cessation support for people with severe mental illness in South Asia
This study looks at the best ways to help people living with severe mental illness in India and Pakistan quit smoking. Researchers are testing a programme combining personal counselling sessions with stop-smoking medicines, comparing it to brief advice, to see how well it works and how easy it is to deliver.
Smoking cessation in persons with severe mental illnessPakistan - Completed
Shifting the practice and attitude of private doctors with respect to unethical benefits from pharmaceutical companies for prescribing medicines
This study looks at ways to help private family doctors prescribe antibiotics more safely. Researchers want to see if special training about medical ethics and conflicts of interest can stop doctors from accepting rewards from drug companies, helping protect patients from unnecessary medicines and slowing down antibiotic resistance.
The practice and attitudes of private doctors with respect to unethical benefits from pharmaceutical companies for prescribing medicines (focusing on antibiotics)Pakistan - Recruiting
Pompe Disease Registry Protocol
This registry tracks people with Pompe disease globally. It helps us understand the condition better, how it changes over time, and the effects of treatments. The goal is to improve care for everyone with Pompe disease.
Glycogen Storage Disease Type IIPompe DiseasePakistan - Recruiting
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
This study tracks the health of people with Gaucher disease over time, whether or not they are receiving treatment. There's also a sub-study for pregnant women with Gaucher disease to see how their pregnancies and babies' health progress. It helps doctors learn more about the condition.
Gaucher DiseaseCerebroside Lipidosis SyndromeGlucocerebrosidase Deficiency DiseaseGlucosylceramide Beta-Glucosidase Deficiency DiseasePakistan - Recruiting
BPH Global Registry
This study is gathering information on men who are treated for an enlarged prostate (BPH) and related bladder symptoms. We want to understand what treatments are being used globally and how successful they are, to help improve care in the future.
Benign Prostatic HyperplasiaLower Urinary Tract SymptomsPakistan - Completed
The locally recurrent rectal cancer quality of life study
This study looks at how rectal cancer that has returned affects everyday life. By answering questions about your physical and emotional wellbeing, you can help doctors better understand the challenges patients face. The findings will help improve future care and support for people with this condition across the world.
Health-related quality of life and survivorship in locally recurrent rectal cancerPakistan - Completed
Randomised Evaluation of Surgery with Craniectomy for patients Undergoing Evacuation of Acute Subdural Haematoma (RESCUE-ASDH)
When someone suffers a severe head injury, blood can collect on the brain. Surgeons must remove it quickly. This UK study compares two standard operations: replacing the piece of skull right away, or leaving it off temporarily to allow for swelling. It looks at which approach helps recovery most.
Acute subdural haematomaPakistan - Completed
Evaluation of self-initiated humour protocol
This study explores a new digital humour program called SIHP to boost your emotional well-being. It involves daily exercises and weekly lessons over eight weeks, using a virtual coach to help you laugh more and feel better.
Emotional well-beingPakistan - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaPakistan - Recruiting
Prospective Study on Antimicrobial RESIstance in Chronic Pulmonary DiseasE
This study looks at antibiotic resistance in people with long-term lung conditions across the world. We want to understand how common it is, where it's happening most, and why some people are more likely to get it. This helps doctors treat lung infections better.
Chronic Lung DiseasesPakistan - RecruitingNA
HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial
This study looks at treating hip fractures quickly in older patients who also have heart problems. It compares fast surgery to usual care to see if it reduces deaths within 90 days, and also checks other important health outcomes.
Hip FracturesMyocardial InjuryPakistan - RecruitingPHASE3
C-Forward: Efficacy and Safety of BEM/RZR vs SOF/VEL in Subjects With Chronic HCV
This study compares two treatments, BEM/RZR and SOF/VEL, for chronic hepatitis C in adults. It's looking to see how well they work and if they are safe. It’s for people who haven't had these types of treatments before and usually have mild or no liver damage.
HEPATITIS C VIRUS CHRONIC INFECTIONHepatitis C, ChronicHepatitis C Virus InfectionHepatitis CPakistan - Not yet recruiting
An International Multicenter Study on Transcatheter Device Closure of Perimembranous Ventricular Septal Defects
This study looks at how well a procedure works to close a hole in the heart called a PmVSD. It gathers information from many hospitals to see how different devices perform in children and adults, focusing on safety and how patients recover.
Perimembranous Ventricular Septal DefectPakistan - Active not recruitingPHASE2
A Study to Evaluate Tobevibart+Elebsiran Versus Bulevirtide in Chronic HDV Infection
This study is testing new medicines, Tobevibart and Elebsiran, against an existing treatment, Bulevirtide. It's for people in the UK who have long-lasting hepatitis delta virus (HDV) infection to see which treatment works best to control the virus and improve liver health.
Viral HepatitisPakistan - Active not recruitingPHASE3
A Study to Evaluate Tobevibart + Elebsiran in Chronic HDV Infection
This study is testing new medicines, tobevibart and elebsiran, for people with chronic hepatitis D. It's a large study looking at how well they work and if they are safe, compared to starting treatment later.
Viral HepatitisPakistan - Not yet recruitingPHASE2
A Study to Assess the Safety, Pharmacokinetics, and Efficacy of ABI-6250 in Participants With Chronic Hepatitis D Virus Infection
This study is looking at a new medicine called ABI-6250 for people with chronic hepatitis D (HDV) infection. Researchers want to see if it's safe, how it works in the body, and if it helps treat the infection. It's a Phase 2 trial, meaning it's still in the earlier stages of testing.
Chronic Hepatitis D InfectionPakistan - Recruiting
Clinical and Molecular Studies in Families With Inherited Eye Disease
This study aims to find the genetic causes of inherited eye diseases in families. By looking at DNA and conducting eye exams, researchers hope to better understand why these conditions happen and find new ways to help people with them.
Inherited Eye DiseasePakistan - RecruitingNA
EUthyroid2: the Next Step Towards the Elimination of Iodine Deficiency and Preventable Iodine-related Disorders in Europe
This study, called EUthyroid2, is looking at ways to teach young women (18-24) about iodine deficiency in the UK and other countries. The aim is to help prevent health problems caused by not getting enough iodine, especially for future pregnancies.
Iodine DeficiencyPakistan - Active not recruitingPHASE2, PHASE3
A Trial Evaluating BJT-778 vs Delayed Treatment for the Treatment of Chronic Hepatitis Delta Infection
This study is looking at a new medicine called Brelovitug (BJT-778) for chronic Hepatitis Delta. It compares different doses of the medicine and also looks at starting treatment now versus starting it later to see how well it works and if it's safe.
Chronic Hepatitis D InfectionPakistan - RecruitingPHASE4
Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress
This study looks at whether blood-thinning medicines (anticoagulants) can prevent strokes and other heart-related problems in people who have had temporary episodes of an irregular heartbeat called atrial fibrillation (AF) during stressful times like surgery or serious illness.
StrokeAtrial FibrillationPakistan - Recruiting
Post Marketing Clinical Follow Up Study to Evaluate Efficacy and Safety of the Occlutech PDA Occluder in Patients With Patent Ductus Arteriosus Defects
This study looks at how well and how safely a special device, called the Occlutech® PDA Occluder, works to close a heart condition called Patent Ductus Arteriosus (PDA) in patients. It follows people over a few years after the device is put in.
Patent Ductus ArteriosusPakistan - RecruitingPHASE3
A Trial Evaluating Brelovitug (BJT-778) vs Bulevirtide for the Treatment of Chronic Hepatitis Delta Infection (AZURE-2)
This study compares two new treatments, brelovitug and bulevirtide, for chronic Hepatitis Delta. It aims to see which is more effective for people with this liver condition, helping us find better long-term solutions.
Chronic Hepatitis D InfectionPakistan - Not yet recruitingNA
Prescribing the Right Agent for Depression in Adults
This study aims to help doctors and patients choose the best antidepressant by using a new online tool. It combines personal health details, preferences, and genetic information to find the most suitable treatment for depression, hoping to improve how well people respond.
Major Depressive Disorder (MDD)Pakistan - Active not recruiting
A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice
This study looks at how a cancer drug called atezolizumab works in real patients. Researchers want to see its effects and safety under normal hospital care, for different types of cancer it's approved for.
Urothelial CarcinomaNon-Small Cell Lung CancerSmall Cell Lung CancerHepatocellular CarcinomaPakistan - RecruitingPHASE3
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
This study, called REMAP-CAP, looks at different treatments for serious lung infections like pneumonia, flu, and COVID-19 in adults needing intensive care. It aims to find out which treatments work best to help patients recover.
Community-acquired Pneumonia, Influenza, COVID-19Pakistan - RecruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease (NPC)
This study looks at a new drug, Nizubaglustat, for Niemann-Pick Type C (NPC) disease in children and young people. It aims to see if the drug can help with movement problems and if it's safe, compared to a dummy pill.
Niemann-Pick Type C DiseasePakistan - Active not recruiting
The OPBC-07/microNAC Study
This study looks at whether it's safe to skip a full lymph node removal surgery in breast cancer patients who have only tiny traces of cancer left in their armpit lymph nodes after chemotherapy. It checks how these patients have fared over time.
Breast CancerPakistan - RecruitingNA
The Next Step Towards the Elimination of Iodine Deficiency and Preventable Iodine-related Disorders in Europe
This study aims to teach young people in the UK and other countries about iodine deficiency and its health risks. It's an educational project in schools to help prevent problems caused by not getting enough iodine.
Iodine DeficiencyPakistan - RecruitingPHASE3
Low INR to Minimize Bleeding With Mechanical Valves Trial
This study is looking at whether taking a lower dose of a blood thinner called warfarin is safer for people with a mechanical heart valve in their main artery. We want to see if this lower dose can prevent serious bleeding without increasing the risk of blood clots or stroke.
Bleeding Post-mechanical Valve ReplacementThromboembolism Post-mechanical Valve ReplacementPakistan - RecruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis
This study is looking at a new medicine called AZ-3102 for children and young people with rare conditions like Niemann-Pick Type C, GM1 Gangliosidosis, or GM2 Gangliosidosis. It aims to see if the medicine is safe and if it helps improve their health over 18 months.
Niemann-Pick Type C DiseaseGM1 GangliosidosisGM2 GangliosidosisPakistan