Latest studies
- RecruitingPHASE3
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
This study is testing a new medicine, lunsekimig, for adults aged 40-80 with COPD that's not well-controlled. We want to see if it helps improve breathing, is safe, and has manageable side effects compared to a dummy medicine.
Chronic Obstructive Pulmonary DiseaseSaudi Arabia - Active not recruiting
Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System
This study looks at how safe and effective a new treatment called FARAPULSE is for atrial fibrillation. It collects real-world information about people treated with this system in hospitals to see how well it works and if it improves their quality of life.
Atrial FibrillationSaudi Arabia - Active not recruitingPHASE3
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
This study is testing a new medicine called Mim8 for people with haemophilia A, including those with inhibitors. Mim8 aims to prevent bleeding episodes by helping blood clot. It's for people already in other Mim8 studies.
Haemophilia AHaemophilia A With InhibitorsSaudi Arabia - RecruitingPHASE3
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
This study is looking into a new medication called Elecoglipron for weight management. It's for adults who are overweight or have obesity, with or without Type 2 diabetes, to see if it helps them lose weight safely when combined with diet and exercise.
Weight ManagementSaudi Arabia - RecruitingPHASE4
Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study
This study looks at how well a medicine called pegcetacoplan works and if it's safe for people in the UK with rare kidney diseases like C3G or IC-MPGN. It uses real-life information from patients to help doctors make better decisions about treatment.
C3 Glomerulopathy (C3G)Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)Saudi Arabia - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
Crohn's DiseaseSaudi Arabia - RecruitingPHASE3
Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
This study compares two types of lung surgery for osteosarcoma that has spread to the lungs. It aims to see if traditional open surgery is better than a keyhole approach for removing cancerous spots. This is a Phase 3 trial, meaning it's a key step in finding the best treatment.
Metastatic Malignant Neoplasm in the LungMetastatic OsteosarcomaOsteosarcomaSaudi Arabia - Not yet recruiting
Implementation of the International Classification of Functioning, Disability and Health Model in Paediatric Cochlear Implant Recipients
This study looks at how well children under 18 with hearing loss do after getting a cochlear implant. It uses a special checklist (ICF) to understand different aspects of their health and how they function in daily life after the implant.
Cochlear Impant ChildrenSaudi Arabia - RecruitingPHASE3
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
This study compares watchful waiting with radiation therapy for people who have had a common type of brain tumour called grade 2 meningioma completely removed. It aims to see if radiation after surgery helps prevent the tumour from returning.
Grade 2 MeningiomaIntracranial MeningiomaSaudi Arabia - Recruiting
Validity of ICU Clinician's Appraisal of Proportionality in CPR
This study looks at whether doctors and nurses in intensive care can predict how well patients who had a cardiac arrest outside hospital will recover. They do this by comparing the healthcare workers' early opinions with the patients' actual recovery and quality of life six months later.
Cardiac Arrest, Out-Of-HospitalSaudi Arabia - Recruiting
AutoInflammatory Disease Alliance Registry (AIDA)
This project is building a secure online registry to collect health information from people with rare inflammatory conditions. The goal is to better understand these diseases, how they affect people, and how different treatments work. Your information could help doctors improve care for others.
Hereditary Autoinflammatory DiseasesSchnitzler SyndromeBehcet SyndromePFAPA SyndromeSaudi Arabia - Active not recruitingPHASE3
A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow
This study looks at a new weekly medicine, somapacitan, for children who need help growing. It compares it to Norditropin®, a daily medicine already used. The study includes children born small, or with Turner, Noonan syndrome, or unexplained short stature, over up to 5.5 years.
SGA, Turner Syndrome, Noonan Syndrome, ISSSaudi Arabia - Recruiting
The K-Map Study, Global Prevalence of KC
The K-Map Study is looking for young people aged 6-23 to help understand how common a condition called keratoconus is. It uses a special camera to check eyes, even if they seem healthy, to see if more people have this eye problem than we currently think.
KeratoconusSaudi Arabia - Active not recruitingPHASE4
Effect of Celecoxib on Postoperative Analgesia and Disease Severity in AERD Patients with CRS
This study is looking at whether a medicine called celecoxib can help people with sinus problems and aspirin allergy feel better after surgery. We want to see if it reduces pain and swelling, making recovery easier without causing new issues.
Chronic Rhinosinusitis with Nasal PolypsAspirin-exacerbated Respiratory DiseaseSaudi Arabia - RecruitingPHASE2
A Study to Determine the Efficacy and Safety of Luspatercept in Adult Participants and to Evaluate the Safety and Pharmacokinetics in and Adolescent Participants With Alpha (α)-Thalassemia
This study looks at a new medicine called luspatercept for people with a type of anaemia called alpha-thalassaemia. It aims to see if the medicine is safe and helps reduce the need for blood transfusions.
AnemiaSaudi Arabia - RecruitingPHASE3
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
This study looks into a new treatment for adults with heart failure. It combines two medicines, vicadrostat and empagliflozin, to see if they can improve heart health in people with a specific type of heart failure. Participants take tablets daily and are closely monitored.
Heart FailureSaudi Arabia - Active not recruitingPHASE3
Study of Durvalumab With Tremelimumab Versus SoC as 1st Line Therapy in Metastatic Non Small-Cell Lung Cancer (NSCLC) (NEPTUNE)
This study is looking at two new drugs, durvalumab and tremelimumab, for advanced lung cancer. It compares them to standard chemotherapy. Researchers want to see if the new combination helps people live longer and is safe as a first treatment for this type of cancer.
Non Small Cell Lung Carcinoma NSCLCSaudi Arabia - Active not recruitingPHASE3
Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer
This study looks at a new drug, trastuzumab deruxtecan, for advanced breast cancer that is HER2-low and hormone receptor positive. We want to see if it works better and is safer than standard chemotherapy for people whose cancer has progressed after other treatments.
Advanced or Metastatic Breast CancerSaudi Arabia - RecruitingPHASE3
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
This study compares new ways to treat advanced lung cancer. It looks at two drug combinations, Nivolumab and Relatlimab plus chemotherapy, versus Pembrolizumab plus chemotherapy. The goal is to find the best treatment for a specific type of lung cancer.
Non-small Cell Lung CancerSaudi Arabia - RecruitingPHASE3
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
This study looks at a new drug, Dostarlimab, for adults with a certain type of head and neck cancer. It compares Dostarlimab to a dummy drug (placebo) after standard chemo and radiation, to see if it's safe and effective.
Neoplasms, Head and NeckSaudi Arabia - Active not recruitingPHASE3
Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL
This study looks at new drug combinations for people with newly diagnosed chronic lymphocytic leukemia (CLL). It compares these new treatments, acalabrutinib and venetoclax (with or without obinutuzumab), to standard chemotherapy to see which works best and is safest.
Chronic Lymphocytic LeukemiaSaudi Arabia - Active not recruitingPHASE3
Capivasertib+Paclitaxel as First Line Treatment for Patients With Locally Advanced or Metastatic TNBC
This study is looking into a new combination treatment for a type of breast cancer called triple-negative breast cancer (TNBC) that has spread or is advanced. It combines a new drug, Capivasertib, with a common chemotherapy, Paclitaxel, to see if it works better than just Paclitaxel alone.
Triple Negative Breast NeoplasmsSaudi Arabia - RecruitingPHASE2, PHASE3
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
This study is looking at a new medicine called vericiguat for children and young people aged 29 days to 17 years with heart failure. We want to see if it can improve their heart health compared to a dummy medicine.
Heart FailureLeft Ventricular Systolic DysfunctionSaudi Arabia - RecruitingPHASE3
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
This study investigates if a new drug, vicadrostat, combined with empagliflozin, can help adults with heart failure and a weakened heart pump. Participants will take study medications for up to 3.5 years, alongside their usual care.
Heart FailureSaudi Arabia - RecruitingPHASE3
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)
This study looks at a new medicine, BI 764198, for people aged 12 and over with a kidney condition called FSGS. It aims to see if this medicine helps improve kidney health. Participants will take a tablet daily and have their kidney function checked regularly.
Focal Segmental GlomerulosclerosisSaudi Arabia - RecruitingPHASE3
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
This study looks at new treatments for heart failure and kidney problems. Researchers are testing two different doses of a new drug combination against an existing medication to see if they can improve heart health and reduce hospital stays.
Heart Failure and Impaired Kidney FunctionSaudi Arabia - RecruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
Diabetes Mellitus, Type 2HypertensionCardiovascular DiseasesSaudi Arabia - Active not recruitingPHASE3
Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)
This study is testing a new medicine, povetacicept, for adults with a kidney condition called IgA Nephropathy. We want to see if it can help reduce protein in the urine and protect kidney function compared to a dummy medicine.
Immunoglobulin A NephropathySaudi Arabia - RecruitingPHASE3
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
This study looks at a long-term treatment called nerandomilast for people with pulmonary fibrosis. It's for those who've used it in a past study. We'll see how safe and effective it is over time, checking if it helps lung function and slows down the disease.
Idiopathic Pulmonary FibrosisProgressive Pulmonary FibrosisSaudi Arabia - Active not recruitingPHASE3
Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
This study looks at a new, higher dose of macitentan (75mg) for people with pulmonary arterial hypertension (PAH). Researchers want to see if this dose is better than the current 10mg dose at preventing serious health problems or death related to PAH.
Pulmonary Arterial HypertensionSaudi Arabia - Active not recruitingPHASE3
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
This study looks at a drug called abemaciclib, given with standard hormone therapy after surgery for a type of breast cancer. We want to see if it's safe and helps stop the cancer coming back in people with certain high-risk breast cancers.
Breast CancerSaudi Arabia - Active not recruiting
Study Evaluating LDL-C Change and Adherence to Inclisiran Lipid-lowering Therapy in ASCVD
This study looks at how well a medicine called inclisiran works for people with high cholesterol and helps prevent heart problems. We want to see if it lowers bad cholesterol and if people stick to taking it as part of their usual care.
Primary HypercholesterolemiaMixed DyslipidemiaSaudi Arabia - RecruitingPhase II
A phase 2b, open-label, two-cohort study of subcutaneous amivantamab in combination with lazertinib as first-line treatment, or subcutaneous amivantamab in combination with platinum-based chemotherapy as second-line treatment, for common EGFR-mutated locally advanced or metastatic non-small cell lung cancer
This study looks at new drug combinations for a common type of lung cancer called NSCLC, specifically when it has a certain gene change (EGFR mutation). It tests if these new treatments can help reduce or slow down the cancer.
Common EGFR-mutated locally advanced or metastatic non-small cell lung cancerSaudi Arabia - Active not recruitingPHASE3
Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)
This study looks at new treatments for HER2-positive breast cancer that has spread. It compares an experimental drug, trastuzumab deruxtecan (T-DXd), alone or with another drug, pertuzumab, to standard care, to see if they work better and are safe.
Breast Cancer; HER2-positive; MetastaticSaudi Arabia - Active not recruitingPHASE2, PHASE3
A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
This study investigates an injection called litifilimab for adults with active lupus that mainly affects the skin, known as cutaneous lupus erythematosus (CLE). Researchers want to see if it helps reduce skin symptoms and is safe, especially for those whose current treatments aren't working well.
Subacute Cutaneous Lupus ErythematosusChronic Cutaneous Lupus ErythematosusSaudi Arabia - Recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
This study looks at how well Medtronic heart devices, like pacemakers and defibrillators, perform over a long time. It helps ensure these devices are reliable and safe for people with heart conditions such as irregular heartbeats or heart failure.
ArrhythmiaBradycardiaHeart FailureSinus TachycardiaSaudi Arabia - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaSaudi Arabia - Recruiting
The Osteoporotic Fracture Classification-based Scoring System for Treatment Decision in Thoracolumbar Osteoporotic Fractures
This study looks at how a new scoring system helps doctors decide the best treatment for broken bones in the back caused by osteoporosis. It compares how well patients do when doctors follow the score's advice versus when they choose a different path.
Osteoporotic FracturesOsteoporosisSaudi Arabia - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Factor IX Gene Therapy With PF-06838435 in Adult Males With Moderately Severe to Severe Hemophilia B
This study looks at a new gene therapy, PF-06838435, for adult men with moderately severe to severe haemophilia B. It aims to see if the treatment can reduce bleeding better than usual care and if it's safe.
Hemophilia BSaudi Arabia - Active not recruitingPHASE3
A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors
This study compares a new medicine, crovalimab, to an existing one, eculizumab, for people with a rare blood condition called PNH. It's looking at how safe and effective crovalimab is in patients already receiving similar treatments.
Paroxysmal Nocturnal HemoglobinuriaSaudi Arabia - Active not recruitingPHASE3
A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients With Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis
This study is testing a new medicine called efgartigimod for people with a type of Myasthenia Gravis (MG). It checks how well it works and if it's safe compared to a dummy medicine. Some people will then get the new medicine openly.
Generalized Myasthenia GravisgMGMyasthenia Gravis, GeneralizedMyasthenia GravisSaudi Arabia - Enrolling by invitation
Registry of Patients With Hypophosphatasia
This study is gathering information over a long time about people in the UK and other countries who have a rare bone condition called Hypophosphatasia (HPP). It aims to understand how HPP affects people of all ages and how they respond to treatment.
Hypophosphatasia (HPP)Saudi Arabia - RecruitingPHASE2, PHASE3
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
This study is looking at a new medicine called osivelotor for people with sickle cell disease. It aims to see if it's safe, how well it works, and what dose is best. Both adults and teenagers can take part.
Sickle Cell DiseaseSaudi Arabia - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab on Background Topical Corticosteroids Therapy in Participants Aged 12 Years and Older With Moderate-to-severe AD Who Have Had an Inadequate Response to Prior Biologic Therapy or an Oral JAK Inhibitor
This study looks at a new medicine called amlitelimab for people aged 12 and over with moderate-to-severe eczema. These individuals haven't responded well to other common eczema treatments. Researchers want to see if amlitelimab is safe and helps improve their skin when used with their usual steroid creams.
Dermatitis AtopicSaudi Arabia - RecruitingPHASE3
A Study to Evaluate Atumelnant in Adults With Congenital Adrenal Hyperplasia
This study is testing a new medicine, atumelnant, for adults with a condition called congenital adrenal hyperplasia (CAH). It aims to see if the medicine is safe, works well, and how the body handles it.
Congenital Adrenal HyperplasiaClassic Congenital Adrenal HyperplasiaSaudi Arabia - RecruitingPHASE2
Safety and Tolerability of Difelikefalin in Adolescents on Haemodialysis With Moderate-to-Severe Pruritus
This study looks at a medicine called difelikefalin for teenagers (12-17) on dialysis who have very itchy skin from kidney disease. It checks if the medicine is safe and how much gets into their blood. We hope to find a new way to help young people with this problem.
PruritusChronic Kidney DiseasesSaudi Arabia - Active not recruitingPHASE2
A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)
This study is testing a new cell therapy called rapcabtagene autoleucel for severe lupus (SLE) or lupus affecting the kidneys (lupus nephritis). It aims to see how well it works and if it's safe for people whose current treatments aren't effective.
Lupus Erythematosus, SystemicLupus NephritisSaudi Arabia - Active not recruitingPHASE3
An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)
This study is looking into the long-term safety of a new medication, KVD900 (Sebetralstat), for teenagers and adults with Hereditary Angioedema (HAE). It is an extension of a previous study, continuing to monitor participants who have already been taking the drug.
Hereditary AngioedemaSaudi Arabia - Active not recruitingPHASE2
Phase 2 Study of Rapcabtagene Autoleucel in Myositis
This study is testing a new cell therapy called rapcabtagene autoleucel for severe inflammatory muscle diseases (myositis). It aims to see if it's safe and helps people whose current treatments aren't working well.
Idiopathic Inflammatory MyopathiesSaudi Arabia - Active not recruitingPHASE3
A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab
This study compares two approved medicines, risankizumab and vedolizumab, for adults with moderate to severe ulcerative colitis who haven't tried similar treatments before. It looks at how safe and effective they are. Around 530 people will take part worldwide.
Ulcerative ColitisSaudi Arabia