Clinical trials in United States of America
50 indexed studies · 32 currently recruiting
Latest studies
- Not yet recruitingPhase III
A study of ramantamig plus daratumumab versus investigator’s choice in participants with newly diagnosed multiple myeloma
This study tests a new drug combination for adults recently diagnosed with multiple myeloma who cannot have a stem cell transplant. Researchers want to see if combining a new drug called ramantamig with daratumumab works better and is safer than standard NHS treatments.
Newly diagnosed multiple myelomaUnited States of America - RecruitingPhase II
Evaluation of novel thrombolytic TGD001 in patients with acute ischemic stroke
This clinical trial is testing an experimental clot-dissolving medicine called TGD001 for adults who have had an ischaemic stroke. Researchers want to see if the drug is safe, well-tolerated, and able to improve blood flow to the brain, alongside standard hospital stroke care over a 90-day monitoring period.
Acute ischemic strokeUnited States of America - RecruitingPhase I
Deferred registration - Klear Bio Code: KLR003-Clin-004
This is an early-stage Phase I clinical trial sponsored by Klear Bio for adults aged 18 to 65. The full study details and medical conditions are temporarily withheld under an official deferral approved by the UK Health Research Authority. Complete information will be published once the deferral period ends.
The Health Research Authority has approved a deferral. Full details will be added to the trial record on or before the deferral expiry dateUnited States of America - RecruitingPhase IV
A clinical trial to find out the best management of the bacteria called Staphylococcus aureus infection in the blood. A randomised clinical trial. Staphylococcus aureus Network Adaptive Platform trial (SNAP)
This hospital trial looks for the best ways to treat severe blood infections caused by Staphylococcus aureus bacteria. Researchers are testing standard, approved antibiotics, checking if patients can safely switch from a drip to tablets sooner, and seeing if body scans help doctors tailor treatment more effectively.
Staphylococcus aureus bacteraemiaUnited States of America - Not yet recruiting
Can readers understand findings from systematic reviews almost as well from artificial intelligence-assisted visual abstracts as from those published by The BMJ?
Medical research can be hard to read. Visual summaries use simple pictures and text to explain key findings quickly. This online study tests whether artificial intelligence (AI) can help create visual summaries that are just as clear and trustworthy as those made by experts at The British Medical Journal (The BMJ).
Health information communication and comprehension of findings from systematic reviews presented in visual abstracts.United States of America - RecruitingPhase III
A Phase III trial of inhaled mosliciguat in pulmonary hypertension associated with interstitial lung disease
This clinical trial is testing an inhaled medicine called mosliciguat for people with high blood pressure in the lungs caused by lung scarring. Researchers want to see if breathing in this drug helps people walk further over six minutes compared to a dummy inhaler with no active medicine.
Pulmonary hypertension associated with interstitial lung diseaseUnited States of America - CompletedNot Applicable
Finding out the genetic cause of Juvenile Myoclonic Epilepsy
This study aims to find the genetic causes of Juvenile Myoclonic Epilepsy (JME). Researchers are comparing DNA and brainwave tests (EEGs) from people with JME to people without epilepsy. The goal is to better understand JME, potentially helping scientists develop more targeted and personalised treatments in the future.
People with a diagnosis of Juvenile Myoclonic EpilepsyUnited States of America - CompletedPhase I
A study evaluating the interaction of the body with (pharmacokinetics), clinical activity, and safety of RO6870810 and atezolizumab (PD-L1 Antibody) in participants with advanced ovarian cancer or triple-negative breast cancer
This study looks at a new drug called RO6870810 given alongside an immunotherapy drug called atezolizumab. Researchers want to find the safest dose and see if this combination helps treat adults with advanced ovarian cancer or triple-negative breast cancer who have limited standard treatment options.
Advanced ovarian cancer, triple negative breast cancerUnited States of America - CompletedPhase I/II
Platform study Kaleidoscope: A Phase 1/2 Open-label Platform Study to Evaluate the Safety and Efficacy of Multiple Amivantamab-based Therapeutic Combinations in Participants with Advanced, Unresectable Lung Cancer (LC) ISA1 METalmark (now closed in UK): A phase I/II open-label platform study to evaluate the safety and efficacy of multiple amivantamab-based therapeutic combinations in participants with advanced, unresectable lung cancer ISA2 Polydamas: A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Cetrelimab Combination Therapy in Metastatic Non-small Cell Lung Cancer ISA3 SwalloWTail: A Phase 1/2 Study Evaluating the Safety and Efficacy of Amivantamab and Docetaxel Combination Therapy in Metastatic Non-small Cell Lung Cancer
This clinical trial tests new combination treatments for advanced non-small cell lung cancer that has spread. Researchers are checking whether combining a targeted drug called amivantamab with other cancer medicines is safe and helps slow cancer growth. Two study branches are currently open for adults at specialist UK cancer hospitals.
Unresectable metastatic non-small cell lung cancerUnited States of America - CompletedPhase III
A study comparing talquetamab in combination with daratumumab or in combination with daratumumab and pomalidomide versus daratumumab in combination with pomalidomide and dexamethasone in participants with multiple myeloma that returns after treatment or is resistant to treatment
This study tests whether a new medicine called talquetamab, given alongside other cancer drugs, helps people with multiple myeloma that has returned or stopped responding to past treatments. Researchers want to see if these new combinations keep the cancer under control for longer than the current standard treatment.
Relapsed or refractory multiple myelomaUnited States of America - RecruitingPhase II
A study to learn if ZED1227 can improve continued celiac disease symptoms despite a gluten-free diet
This study is testing a new capsule called ZED1227 for adults with coeliac disease. Researchers want to see if this medicine can protect the gut and ease lingering tummy symptoms caused by accidental gluten exposure, even in people who already follow a strict gluten-free diet.
Coeliac diseaseUnited States of America - Recruiting
Hypoglycemia in type 1 diabetes
This study looks at ways to help adults with type 1 diabetes who no longer feel warning signs when their blood sugar drops too low. Researchers are testing whether automated insulin devices, specialised education courses, or a combination of both can help people avoid dangerous low blood sugar episodes.
Type 1 diabetes with impaired awareness of hypoglycemiaUnited States of America - RecruitingPhase I
A study of JNJ-95804306 for relapsed or refractory hematological malignancies
This early-stage clinical trial is testing a new medicine called JNJ-95804306 for adults with blood cancers that have returned or stopped responding to standard treatments. Doctors want to find safe doses and check how well the body handles the drug when given alone or with other cancer therapies.
Hematologic neoplasms, blood cancerUnited States of America - CompletedPhase II
A Phase II study to understand the safety and effects of inhaled SNG001, the study medication, in patients who are mechanically ventilated due to a respiratory viral infection in the lungs
This study tests an inhaled medicine called SNG001 for people in intensive care with severe chest infections caused by viruses like flu or COVID-19. Researchers want to see if breathing in this natural virus-fighting protein helps patients recover faster and spend less time on a breathing machine.
Respiratory viral infectionsUnited States of America - Completed
Evaluating the efficacy of audio-based digital tools to improve sleep on the Unmind workplace wellbeing platform
Researchers at the University of Sussex are testing whether audio tracks on the Unmind app can help working adults sleep better. Participants will listen to relaxing sounds, bedtime stories, guided exercises, or daytime tracks for four weeks. Online surveys will measure how their sleep, mood, and daily wellbeing change.
Working adults experiencing poor sleepUnited States of America - RecruitingPhase III
Phase 3, randomised, double-blind, placebo- controlled, 3-arm study to investigate the safety and efficacy of efimosfermin alfa in participants with biopsy-confirmed F2- or F3-stage metabolic dysfunction-associated steatohepatitis (MASH) (ZENITH-1)
This clinical trial is testing a new injection called efimosfermin alfa for people with metabolic dysfunction-associated steatohepatitis (MASH), an inflamed fatty liver condition. Researchers want to see if monthly injections over four years can safely reduce liver fat, ease inflammation, and improve liver scarring compared to a dummy treatment.
Medical condition: Metabolic Dysfunction-Associated Steatohepatitis (MASH) Medical condition in lay language: Metabolic Fatty Liver Inflamation Therapeutic areas: Diseases [C] - Nutritional and Metabolic Diseases [C18]United States of America - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
Crohn’s diseaseUnited States of America - RecruitingPhase III
Efficacy and safety of DMX-200 in patients with focal segmental glomerulosclerosis
This clinical trial is testing a new medicine called DMX-200 for focal segmental glomerulosclerosis (FSGS), a rare kidney condition. Researchers want to see if adding DMX-200 to standard blood pressure medication helps protect kidney filters, reduces protein leaking into the urine, and slows down kidney damage better than a dummy pill.
Focal segmental glomerulosclerosisUnited States of America - RecruitingPhase I/II
RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Active Juvenile Idiopathic Inflammatory Myopathy
The RESET-Myositis trial tests an experimental cell therapy called CABA-201 for adults and children with severe inflammatory muscle disease. The treatment aims to reset the immune system by temporarily clearing faulty immune cells. It is designed for people whose muscle weakness has not improved with standard NHS treatments.
Active Idiopathic Inflammatory Myopathy including dermatomyositis, anti-synthetase syndrome, immune-mediated necrotizing myopathy, juvenile idiopathic inflammatory myopathy, juvenile dermatomyositis, juvenile polymyositis, juvenile myositisUnited States of America - Completed
The locally recurrent rectal cancer quality of life study
This study looks at how rectal cancer that has returned affects everyday life. By answering questions about your physical and emotional wellbeing, you can help doctors better understand the challenges patients face. The findings will help improve future care and support for people with this condition across the world.
Health-related quality of life and survivorship in locally recurrent rectal cancerUnited States of America - RecruitingPhase III
A clinical study to investigate the safety and tolerability of efimosfermin alfa injection in participants with known or suspected F2- or F3-stage metabolic dysfunction-associated steatohepatitis (BOS-580-302)
This clinical study tests a new monthly injection called efimosfermin alfa for adults with MASH, a condition where fat causes liver inflammation and scarring. Doctors want to see if the medicine is safe and well tolerated over 52 weeks compared to a dummy injection (placebo).
Metabolic dysfunction-associated steatohepatitis (MASH)United States of America - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active ulcerative colitis (DUET ENCORE-UC)
This clinical trial is testing a new combined injection called JNJ-78934804 for adults with moderate to severe ulcerative colitis. Researchers want to see if combining two different medicines into one injection works better and is safer at reducing gut inflammation than using a single medicine on its own.
Moderately to Severely Active Ulcerative ColitisUnited States of America - Completed
Randomised Evaluation of Surgery with Craniectomy for patients Undergoing Evacuation of Acute Subdural Haematoma (RESCUE-ASDH)
When someone suffers a severe head injury, blood can collect on the brain. Surgeons must remove it quickly. This UK study compares two standard operations: replacing the piece of skull right away, or leaving it off temporarily to allow for swelling. It looks at which approach helps recovery most.
Acute subdural haematomaUnited States of America - RecruitingPhase III
A Phase III placebo-controlled efficacy and safety study of mocravimod as an adjunctive and maintenance treatment in acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation
This study tests a new medicine called mocravimod for adults with acute myeloid leukaemia having a donor stem cell transplant. Researchers want to see if mocravimod can stop the cancer from returning and protect healthy organs from donor cell attacks, a common and serious complication called graft-versus-host disease.
Acute myeloid leukemiaUnited States of America - CompletedPhase II
A long-term extension study of JNJ-81201887 (AAVCAGsCD59) parent studies in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)
This study looks at the long-term safety of a new gene therapy, JNJ-81201887, for Geographic Atrophy (GA), a severe eye condition. It involves people who previously took part in earlier studies of this treatment, to see how they are doing over several years.
Geographic Atrophy, secondary to age-related macular degenerationUnited States of America - Not yet recruitingPhase II
A study testing two targeted medicines, bomedemstat, which helps normalise blood cell development, and momelotinib, which reduces symptoms and anaemia, to see whether the combination is safe and effective for people with myelofibrosis
This study looks at combining two medicines, bomedemstat and momelotinib, for people with myelofibrosis. It aims to see if this combination is safe and helps more than momelotinib alone, especially for those whose first treatment isn't working well.
MyelofibrosisUnited States of America - Recruiting
Multi-centre MRI study of the heart microstructure in healthy volunteers
This study uses special MRI scans to look at tiny details of the heart in healthy people. Researchers want to understand how these scans work best and improve them. This information could help spot heart problems earlier and develop new treatments in the future.
Evaluation of cardiac microstructure with cardiac DTIUnited States of America - RecruitingPhase III
A long-term extension (LTE) study of guselkumab in pediatric participants
This study looks at the long-term safety of a medicine called guselkumab for children and young people aged 2-17 with Crohn's disease, ulcerative colitis, or a type of arthritis called juvenile psoriatic arthritis. It's for those who have already benefited from guselkumab in a previous study.
Moderately to severely active ulcerative colitis (UC), moderately to severely active Crohn's disease (CD), Juvenile psoriatic arthritis (jPsA)United States of America - CompletedPhase II
A study of JNJ-95475939 in the treatment of participants with moderate to severe atopic dermatitis
This study is testing a new medicine, JNJ-95475939, for moderate to severe eczema (atopic dermatitis). Researchers want to see how well it works and if it's safe compared to a dummy treatment and an existing medicine. It involves adults aged 18 and over.
Atopic dermatitis (AD)United States of America - RecruitingPhase III
Astria STAR-0215-302 trial for Navenibart in Hereditary Angioedema
This study looks at a new medicine called navenibart for hereditary angioedema (HAE). It aims to see how safe it is and how well people tolerate it over a long time. Navenibart might help prevent HAE attacks, which can be severe and painful.
Hereditary angioedemaUnited States of America - RecruitingPhase I
Safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of ANB033 - Part 1c
This study is testing a new medicine called ANB033 for a condition called Eosinophilic Esophagitis (EoE). Researchers want to check if it's safe, how it works in the body, and if it could help stop the immune system from overreacting in people with EoE.
Eosinophilic Esophagitis (EoE)United States of America - Completed
Strength gel with Kaempferia Parviflora Extract for improving the appearance of cellulite.
This study is testing a new body gel designed to improve the look of cellulite. We want to see if the gel can really make cellulite less noticeable and if it's safe to use. Women aged 25-75 with cellulite can take part.
CelluliteUnited States of America - Recruiting
Security and effectiveness assessment of locking systems in ventriculostomy for traumatic brain injury
This study looks at new ways to treat serious head injuries by comparing two methods for draining fluid from the brain. It aims to make a procedure called ventriculostomy safer and more effective, especially for preventing complications like infections or the drain moving out of place.
Intracranial compartment syndrome in traumatic brain injury patientsUnited States of America - Completed
Evaluation of self-initiated humour protocol
This study explores a new digital humour program called SIHP to boost your emotional well-being. It involves daily exercises and weekly lessons over eight weeks, using a virtual coach to help you laugh more and feel better.
Emotional well-beingUnited States of America - Completed
A study of potential treatment-responsive biomarkers and clinical outcomes in Hunter syndrome
This study looked at how Hunter Syndrome affects people over time, including changes in behaviour, thinking abilities, and levels of certain signs in the body. It aimed to understand the condition better and find ways to measure if future treatments are working, without giving any new medicines.
Mucopolysaccharidosis IIUnited States of America - CompletedPhase I
A study of Pasritamig (JNJ-78278343) in combination with JNJ-86974680 for treatment of prostate cancer
This study is testing two new drugs, Pasritamig and JNJ-86974680, together for men with advanced prostate cancer. Researchers want to find the safest dose and see if it helps fight the cancer. It's a very early-stage trial.
Prostate cancerUnited States of America - Recruiting
The international ‘100 DU’ study
This study looks at how painful finger and toe sores (digital ulcers) of systemic sclerosis (a rare long-term condition) affect people's daily lives. Researchers want to create a new questionnaire to better understand how these sores make patients feel and function.
Systemic sclerosis (SSc) with active digital ulceration (DU)United States of America - Recruiting
Improving hormonal infertility treatment for men with hypogonadotropic hypogonadism
This study looks back at records of men with hypogonadotropic hypogonadism, a type of male infertility. Doctors want to find the best hormone treatment to help these men and their partners get pregnant. No new patients are needed for this study.
Infertility due to hypogonadismUnited States of America - Completed
Does removing both ovaries prior to menopause reduce breast cancer risk in BRCA1 and BRCA2 mutation carriers?
This study looks at existing health records to see if removing ovaries and fallopian tubes before menopause reduces breast cancer risk for women with BRCA1 or BRCA2 gene changes. It aims to understand if these operations help prevent cancer in these women.
Breast cancerUnited States of America - RecruitingPhase I
An early safety study testing a drug combination given before possible surgery for people with pancreatic cancer that can’t be easily removed yet or hasn’t spread far
This study looks at new drug combinations for pancreatic cancer that hasn't spread but is hard to remove. It combines standard chemotherapy with three new medicines to see if they can shrink the cancer before surgery and if they are safe.
Borderline resectable or locally advanced pancreatic ductal adenocarcinoma (PDAC)United States of America - RecruitingPhase III
A study of nipocalimab in adults with moderate to severe systemic lupus erythematosus
This study is testing a new drug called nipocalimab for adults with moderate to severe lupus (SLE). Researchers want to see if it works better than a dummy drug to reduce symptoms. It involves regular visits and monitoring over several years.
Systemic lupus erythematosusUnited States of America - Completed
Trial investigating the effects of a brief online uncertainty tolerance training for young people
This study looks at an online training for young people aged 18-24 to help them cope better with everyday uncertainties. It compares two online programs to see if one can reduce worry and improve how young adults handle unsure situations.
Reduction of intolerance of uncertainty and anxiety symptoms in an unselected population (i.e., with or without a psychiatric condition).United States of America - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaUnited States of America - RecruitingPhase I/II
Study of EN-374 gene therapy in participants with X-linked chronic granulomatous disease
This study is testing a new gene therapy called EN-374 for X-linked chronic granulomatous disease (X-CGD). It aims to see if EN-374 is safe and effective in adults first, and then in children. We hope to improve the health of people with this rare immune condition.
X-linked chronic granulomatous diseaseUnited States of America - CompletedPhase III
A study comparing JNJ-77242113 and ustekinumab in adult participants with moderate to severe plaque psoriasis
This study compares a new medicine, JNJ-77242113, with an existing one, Stelara, for adults with moderate to severe plaque psoriasis. It aims to see how well the new drug works to reduce red, scaly skin patches by targeting a protein involved in inflammation.
Plaque psoriasisUnited States of America - RecruitingPhase III
A study comparing JNJ-79635322 and an anti-B-cell maturation antigen (BCMA)xCD3 bispecific antibody in participants with relapsed or refractory multiple myeloma (Trilogy-4)
This study looks at a new injection called JNJ-79635322 for multiple myeloma that has come back or isn't responding to treatment. We're comparing it to another approved drug, teclistamab, to see if it helps patients aged 18 and over who have tried other therapies.
Relapsed or refractory multiple myelomaUnited States of America - RecruitingPhase III
JNJ-90301900 (NBTXR3) activated by radiotherapy with or without cetuximab in LA-HNSCC
This study looks at a new treatment called JNJ-90301900 with radiotherapy, sometimes with another drug called cetuximab. It's for older patients with a type of head and neck cancer who can't have standard chemotherapy.
Locally advanced head & neck squamous cell carcinomaUnited States of America - Recruiting
An international study of therapist-supported online cognitive behavioural therapy for the reduction of repetitive negative thought (overthinking, rumination, worry) in adults: the Calming Minds study
This study explores how online talking therapy (CBT) can help reduce overthinking, worry, and rumination in adults. It compares different versions of CBT to find the most effective parts, aiming to improve mental well-being for many people.
Repetitive negative thought (overthinking, rumination, worry)United States of America - Completed
Transatlantic registry of type A aortic dissection
This study looks at how people recover after surgery for a serious heart condition called Type A Aortic Dissection. Researchers are collecting information from patients across different hospitals to understand the best ways to treat it and improve outcomes.
Type A aortic dissectionUnited States of America - RecruitingPhase I
A study of JNJ-78278343 in combination with JNJ-95298177 for treatment of prostate cancer
This study is testing two new medicines, JNJ-78278343 and JNJ-95298177, together for advanced prostate cancer. Researchers want to find the safest and most effective dose in men whose cancer has spread and is no longer responding well to standard hormone treatments.
Prostate cancerUnited States of America