caseinolytic mitochondrial matrix peptidase proteolytic subunit
Last updated 18 Aug 2020
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
The CLPP gene provides instructions for making the ClpP subunit protein. Multiple copies of this protein interact with each other to form a barrel-shaped chamber known as the ClpP complex. This complex is one of two parts of the ClpXP protease, which breaks down abnormally folded proteins. The other part of the ClpXP protease, called the ClpX complex, unfolds the abnormal proteins and feeds them into the chamber formed by the ClpP complex, where they are broken down into small fragments.
Normal function
The CLPP gene provides instructions for making the ClpP subunit protein. Multiple copies of this protein interact with each other to form a barrel-shaped chamber known as the ClpP complex. This complex is one of two parts of the ClpXP protease, which breaks down abnormally folded proteins. The other part of the ClpXP protease, called the ClpX complex, unfolds the abnormal proteins and feeds them into the chamber formed by the ClpP complex, where they are broken down into small fragments.
The ClpP complex is found in structures in the cell called mitochondria, which are the energy-producing centers of cells.
Conditions referring to this gene or chromosome
Other names
ATP-dependent Clp protease proteolytic subunit, mitochondrial
ATP-dependent protease ClpAP, proteolytic subunit, human
ClpP caseinolytic peptidase ATP-dependent, proteolytic subunit
ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog
endopeptidase Clp
PRLTS3
putative ATP-dependent Clp protease proteolytic subunit, mitochondrial
Related patient information and medicines
Patient information leaflet
Type 2 diabetes treatment
You should avoid starting one of these diets while you are on an SGLT-2 inhibitor without discussing it with your doctor or nurse. DPP-4 (dipeptidyl peptidase-4) inhibitors - also known as incretin enhancers This group includes alogliptin , linagliptin , saxagliptin , sitagliptin and vildagliptin. Dipeptidyl peptidase 4 (DPP-4) is a chemical (an.
Patient information leaflet
Muscle weakness
Some rare muscular dystrophies : These can present in adulthood and inclu... Examples include: Glycogen storage diseases (in which glycogen, a carbohydrate, infiltrates muscles as well as other organs). Even rarer, mitochondrial diseases which occur when the energy systems inside muscle cells don't work properly. Myotonic dystrophy : This is a.
Patient information leaflet
Cyclical vomiting syndrome
Cyclical vomiting syndrome is a condition which occurs mainly in children but can also affect adults. It is more common in people who have migraines. Children have severe episodes of feeling sick (nausea) and being sick (vomiting), sometimes with other symptoms. In between these episodes the person is completely well. There are various treatments.
%20vaccination/og.png)
Patient information leaflet
Respiratory syncytial virus (RSV) vaccination
The RSV vaccine helps protect babies and older people from the common infectious disease of the airways and lungs. Here we have information about the respiratory syncytial virus (RSV) vaccine and who should get it. What is the RSV vaccine. RSV is a common virus which causes lung infections (respiratory tract disease). An RSV infection can happen.
Medicine leaflet
Sodium valproate for epilepsy
Read the information leaflet from inside your pack. Take sodium valproate regularly every day. Do not suddenly stop taking it as this can cause your symptoms to return. If you develop tummy (abdominal) pain, sickness, yellowing of your skin or of the whites of your eyes (jaundice) or any unexplained bruising or bleeding, tell your doctor.
Patient information leaflet
Nail psoriasis
Psoriasis is a persistent (chronic) skin condition which tends to flare up from time to time. About half of the people who have psoriasis also have changes affecting their nails. Psoriatic nail disease is very variable in appearance and severity. Psoriasis affecting the nails can be mild and not need any treatment. More severe nail psoriasis is.
Further reading and references
- caseinolytic mitochondrial matrix peptidase proteolytic subunit; MedlinePlus, National Library of Medicine.
- Baker TA, Sauer RT. ClpXP, an ATP-powered unfolding and protein-degradation machine. Biochim Biophys Acta. 2012 Jan;1823(1):15-28. doi: 10.1016/j.bbamcr.2011.06.007. Epub 2011 Jun 27.
- Jenkinson EM, Rehman AU, Walsh T, Clayton-Smith J, Lee K, Morell RJ, Drummond MC, Khan SN, Naeem MA, Rauf B, Billington N, Schultz JM, Urquhart JE, Lee MK, Berry A, Hanley NA, Mehta S, Cilliers D, Clayton PE, Kingston H, Smith MJ, Warner TT; University of Washington Center for Mendelian Genomics; Black GC, Trump D, Davis JR, Ahmad W, Leal SM, Riazuddin S, King MC, Friedman TB, Newman WG. Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease. Am J Hum Genet. 2013 Apr 4;92(4):605-13. doi: 10.1016/j.ajhg.2013.02.013. Epub 2013 Mar 28.
- Kang SG, Dimitrova MN, Ortega J, Ginsburg A, Maurizi MR. Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX. J Biol Chem. 2005 Oct 21;280(42):35424-32. doi: 10.1074/jbc.M507240200. Epub 2005 Aug 22.
- Yu AY, Houry WA. ClpP: a distinctive family of cylindrical energy-dependent serine proteases. FEBS Lett. 2007 Jul 31;581(19):3749-57. doi: 10.1016/j.febslet.2007.04.076. Epub 2007 May 8.
Join the conversation
Share your thoughts or experiences with others in our patient communities.
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.