FRAS1 related extracellular matrix 1
Last updated 11 Apr 2023
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
The FREM1 gene provides instructions for making a protein that is involved in the formation and organisation of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues.
Normal function
The FREM1 gene provides instructions for making a protein that is involved in the formation and organisation of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues.
The FREM1 protein is one of a group of proteins, including proteins called FRAS1 and FREM2, that interact during embryonic development as components of basement membranes. Basement membranes help anchor layers of cells lining the surfaces and cavities of the body (epithelial cells) to other embryonic tissues, including those that give rise to connective tissues (such as skin and cartilage) and the kidneys.
Conditions referring to this gene or chromosome
Other names
BNAR
C9orf143
C9orf145
C9orf154
extracellular matrix protein QBRICK
FLJ25461
FRAS1-related extracellular matrix protein 1
FREM1_HUMAN
TILRR
Related patient information and medicines
Patient information leaflet
Alpha-1 antitrypsin deficiency
A genetic condition is one that can be passed on from parents through genes. In alpha-1 antitrypsin deficiency the result of a genetic abnormality leads to lung and, in some people, liver damage. Alpha-1 antitrypsin (A1AT) is a protein made by cells in the liver. It passes from the liver into the bloodstream and can travel to the lungs. Its main.
Patient information leaflet
Ovarian cyst
Ovarian cysts are fluid-filled pockets that grow on the ovaries. Almost all ovarian cysts are non-cancerous (benign), but some are cancerous (malignant), or may become cancerous over time. Many people with ovarian cysts don't have any symptoms or require any treatment, as many go away on their own. However, some ovarian cysts may need removal with.
Patient information leaflet
Chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a condition where you have many abnormal B lymphocyte white blood cells. What is chronic lymphocytic leukaemia. Chronic lymphocytic leukaemia (CLL) is a condition where you have many abnormal B lymphocyte white blood cells. The lymphocytes look normal under a microscope but are abnormal as they do not.
Patient information leaflet
Can I take Oestrogel pump-pack and Vitamin C together?
This can lead to higher levels of the medicine in your bloodstream, p... Using other medicines Taking multiple medicines. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do.
Patient information leaflet
Gilbert's syndrome
Gilbert's syndrome is due to an inherited defect in processing bilirubin in the liver. Bilirubin is produced from the breakdown of red blood cells. When it cannot be cleared properly in the liver, its levels build up in the blood. This can cause mild jaundice from time to time and can also be seen as slightly raised bilirubin levels on a blood.
Patient information leaflet
Polymyalgia rheumatica
Polymyalgia rheumatica causes pain, stiffness and tenderness in large muscles, typically around the shoulders, upper arms and hips. The cause is not known. You need to take a low dose of steroid each day to keep symptoms away. Some people with polymyalgia rheumatica develop a related condition called giant cell arteritis which can be more serious..
Further reading and references
- FRAS1 related extracellular matrix 1; MedlinePlus, National Library of Medicine.
- Alazami AM, Shaheen R, Alzahrani F, Snape K, Saggar A, Brinkmann B, Bavi P, Al-Gazali LI, Alkuraya FS. FREM1 mutations cause bifid nose, renal agenesis, and anorectal malformations syndrome. Am J Hum Genet. 2009 Sep;85(3):414-8. doi: 10.1016/j.ajhg.2009.08.010.
- Pavlakis E, Chiotaki R, Chalepakis G. The role of Fras1/Frem proteins in the structure and function of basement membrane. Int J Biochem Cell Biol. 2011 Apr;43(4):487-95. doi: 10.1016/j.biocel.2010.12.016. Epub 2010 Dec 21.
- Slavotinek AM, Baranzini SE, Schanze D, Labelle-Dumais C, Short KM, Chao R, Yahyavi M, Bijlsma EK, Chu C, Musone S, Wheatley A, Kwok PY, Marles S, Fryns JP, Maga AM, Hassan MG, Gould DB, Madireddy L, Li C, Cox TC, Smyth I, Chudley AE, Zenker M. Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1. J Med Genet. 2011 Jun;48(6):375-82. doi: 10.1136/jmg.2011.089631. Epub 2011 Apr 20.
Join the conversation
Share your thoughts or experiences with others in our patient communities.
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.