potassium inwardly rectifying channel subfamily J member 5
Last updated 12 Apr 2023
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The KCNJ5 gene provides instructions for making a protein that functions as a potassium channel, which means that it transports positively charged atoms (ions) of potassium (K+) into and out of cells. Potassium channels produced from the KCNJ5 gene are found in several tissues, including the adrenal glands, which are small hormone-producing glands located on top of each kidney. In these glands, the flow of ions creates an electrical charge across the cell membrane, which affects the triggering of certain biochemical processes that regulate aldosterone production. Aldosterone helps control blood pressure by maintaining proper salt and fluid levels in the body.
Normal function
The KCNJ5 gene provides instructions for making a protein that functions as a potassium channel, which means that it transports positively charged atoms (ions) of potassium (K+) into and out of cells. Potassium channels produced from the KCNJ5 gene are found in several tissues, including the adrenal glands, which are small hormone-producing glands located on top of each kidney. In these glands, the flow of ions creates an electrical charge across the cell membrane, which affects the triggering of certain biochemical processes that regulate aldosterone production. Aldosterone helps control blood pressure by maintaining proper salt and fluid levels in the body.
Conditions referring to this gene or chromosome
Other names
cardiac ATP-sensitive potassium channel
CIR
G protein-activated inward rectifier potassium channel 4
GIRK4
heart KATP channel
inward rectifier K+ channel KIR3.4
IRK-4
KATP1
KIR3.4
LQT13
potassium channel, inwardly rectifying subfamily J, member 5
potassium inwardly-rectifying channel, subfamily J, member 5
Related patient information and medicines
Patient information leaflet
Can I take Bisoprolol and Ramipril together?
This might make you feel dizzy, lightheaded, or faint. It can also occasionally lead to increased levels of potassium in your blood or affect how your kidneys work. Why this happens Both medicines work to lower blood pressure but in different ways. Bisoprolol is a beta-blocker that slows the heart rate, while ramipril is an ACE inhibitor that.
Patient information leaflet
Can I take Atenolol and Ramipril together?
Why this happens Both medicines work to lower blood pressure but in different ways: atenolol is a beta-blocker that slows the heart rate, while ramipril is an ACE inhibitor that relaxes blood vessels. Salt substitutes (Potassium-rich) Ramipril can increase the levels of potassium in your blood. Many salt substitutes (such as Lo-Salt) contain.
Patient information leaflet
Can I take Bisoprolol and Losartan together?
Taking bisoprolol and losartan together can cause your blood pressure to drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when standing up quickly. Why this happens Both medicines work to lower blood pressure but in different ways. Bisoprolol is a beta-blocker that slows the heart rate, while losartan is an.
Patient information leaflet
Can I take Co-amoxiclav and Ramipril together?
Taking co-amoxiclav and ramipril together can occasionally increase the risk of a rare but serious allergic reaction called angioedema (swelling under the skin). It may also increase the risk of high potassium levels in the blood or affect your kidney function, especially if you are already unwell with an infection. Salt substitutes.
Patient information leaflet
Refeeding syndrome
Refeeding syndrome was first described in Far East prisoners after the second world war when they developed heart failure after starting to eat again after a prolonged period of starvation. Refeeding syndrome is a dangerous and life threatening shift of fluids and body salts (electrolytes) that can occur when malnourished patients receive.
Patient information leaflet
Can I take Amlodipine and Losartan together?
Taking amlodipine and losartan together can cause your blood pressure to drop lower than if you took either medicine alone. While this is often the intended goal of your treatment, it can sometimes lead to side effects like dizziness, lightheadedness, or fainting, ... High potassium levels (hyperkalaemia) Losartan can increase potassium levels in.
Further reading and references
- potassium inwardly rectifying channel subfamily J member 5; MedlinePlus, National Library of Medicine.
- Choi M, Scholl UI, Yue P, Bjorklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, Akerstrom G, Wang W, Carling T, Lifton RP. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science. 2011 Feb 11;331(6018):768-72. doi: 10.1126/science.1198785.
- Funder JW. The genetic basis of primary aldosteronism. Curr Hypertens Rep. 2012 Apr;14(2):120-4. doi: 10.1007/s11906-012-0255-x.
- Lenzini L, Rossitto G, Maiolino G, Letizia C, Funder JW, Rossi GP. A Meta-Analysis of Somatic KCNJ5 K(+) Channel Mutations In 1636 Patients With an Aldosterone-Producing Adenoma. J Clin Endocrinol Metab. 2015 Aug;100(8):E1089-95. doi: 10.1210/jc.2015-2149. Epub 2015 Jun 11.
- Monticone S, Hattangady NG, Penton D, Isales CM, Edwards MA, Williams TA, Sterner C, Warth R, Mulatero P, Rainey WE. a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III. J Clin Endocrinol Metab. 2013 Nov;98(11):E1861-5. doi: 10.1210/jc.2013-2428. Epub 2013 Sep 13.
- Moraitis AG, Rainey WE, Auchus RJ. Gene mutations that promote adrenal aldosterone production, sodium retention, and hypertension. Appl Clin Genet. 2013 Dec 24;7:1-13. doi: 10.2147/TACG.S35571.
- Mulatero P, Monticone S, Rainey WE, Veglio F, Williams TA. Role of KCNJ5 in familial and sporadic primary aldosteronism. Nat Rev Endocrinol. 2013 Feb;9(2):104-12. doi: 10.1038/nrendo.2012.230. Epub 2012 Dec 11.
- Mulatero P, Tauber P, Zennaro MC, Monticone S, Lang K, Beuschlein F, Fischer E, Tizzani D, Pallauf A, Viola A, Amar L, Williams TA, Strom TM, Graf E, Bandulik S, Penton D, Plouin PF, Warth R, Allolio B, Jeunemaitre X, Veglio F, Reincke M. KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism. Hypertension. 2012 Feb;59(2):235-40. doi: 10.1161/HYPERTENSIONAHA.111.183996. Epub 2011 Dec 27.
- Scholl UI, Lifton RP. New insights into aldosterone-producing adenomas and hereditary aldosteronism: mutations in the K+ channel KCNJ5. Curr Opin Nephrol Hypertens. 2013 Mar;22(2):141-7. doi: 10.1097/MNH.0b013e32835cecf8.
- Scholl UI, Nelson-Williams C, Yue P, Grekin R, Wyatt RJ, Dillon MJ, Couch R, Hammer LK, Harley FL, Farhi A, Wang WH, Lifton RP. Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2533-8. doi: 10.1073/pnas.1121407109. Epub 2012 Jan 30.
- Stowasser M. Primary aldosteronism and potassium channel mutations. Curr Opin Endocrinol Diabetes Obes. 2013 Jun;20(3):170-9. doi: 10.1097/MED.0b013e32835ef2fd.
- Zennaro MC, Jeunemaitre X. Mutations in KCNJ5 gene cause hyperaldosteronism. Circ Res. 2011 Jun 10;108(12):1417-8. doi: 10.1161/RES.0b013e318224a359. No abstract available.
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