Can I take Amlodipine and Losartan together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking amlodipine and losartan together can cause your blood pressure to drop lower than if you took either medicine alone. While this is often the intended goal of your treatment, it can sometimes lead to side effects like dizziness, lightheadedness, or fainting, especially when you stand up quickly. There is also a small risk of affecting your kidney function or increasing potassium levels in your blood.
In this article:
Continue reading below
Why this happens
Both medicines work to lower blood pressure but in different ways: amlodipine relaxes the muscles in your blood vessel walls, while losartan blocks a hormone that causes blood vessels to tighten. Using them together has an 'additive' effect, meaning their combined power is stronger.
What you should do
This is a very common and effective combination prescribed by doctors. You should continue taking your medication as directed, but be mindful of feeling dizzy or faint. To prevent this, try to stand up slowly from a sitting or lying position. Your doctor may want to perform routine blood tests to check your kidney function and potassium levels. If you feel severely dizzy or have a fainting spell, contact your GP.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Atorvastatin and Levothyroxine together?
Taking these two medicines together is generally safe, but there is a minor interaction where atorvastatin might slightly increase the levels of levothyroxine in your blood. Conversely, your thyroid levels can affect how well atorvastatin works to lower your cholesterol.

Treatment and medication
Can I take Atorvastatin and Sertraline together?
Taking atorvastatin and sertraline together may slightly increase the levels of atorvastatin in your blood. This can increase the risk of side effects, particularly muscle pain or weakness.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.