Can I take Atorvastatin and Shiitake together?

Why this happens

Shiitake mushrooms naturally contain a substance called eritadenine, which helps lower cholesterol. They also contain small amounts of naturally occurring statin-like compounds (similar to lovastatin). When taken with atorvastatin, these effects can add together (an additive effect), potentially increasing the level of statin activity in your body beyond what was intended by your prescription.

What you should do

If you eat shiitake mushrooms occasionally as part of a normal diet, the risk is very low. However, you should avoid taking concentrated shiitake supplements or large medicinal amounts without speaking to your doctor first. If you experience any unexplained muscle pain, tenderness, or weakness while taking these together, contact your GP immediately.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.