Can I take Maitake and Shiitake together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking maitake and shiitake mushrooms together may increase the risk of bruising or bleeding. Both mushrooms contain natural compounds that can thin the blood and slow down the clotting process. While they are commonly eaten together in food, taking them in concentrated supplement form increases this effect.
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Why this happens
Both maitake and shiitake mushrooms have 'antiplatelet' properties. This means they make the tiny cells in your blood (platelets) less 'sticky', which makes it harder for your blood to form clots. When used together, this effect is additive.
What you should do
For most healthy people eating these mushrooms in normal food amounts, there is no cause for concern. However, if you are taking concentrated supplements, you should be cautious. Stop taking these supplements at least two weeks before any scheduled surgery. If you are already taking blood-thinning medications (like warfarin or aspirin), speak to your doctor before combining these supplements.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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