Can I take Lion's mane and Shiitake together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known harmful interactions between Lion's Mane (Hericium erinaceus) and Shiitake (Lentinula edodes) mushrooms. Both are commonly consumed together as food or supplements.
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Why this happens
Both mushrooms contain bioactive compounds like beta-glucans that support the immune system. They do not interfere with each other's absorption or breakdown in the body. Instead, they may have a complementary effect on general health.
What you should do
Back to contentsIt is generally safe to take these together. However, if you are taking blood-thinning medication (like warfarin) or diabetes medication, speak to your doctor first, as both mushrooms may have mild effects on blood clotting and blood sugar levels.
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Important precautions
Back to contentsBleeding disorders or surgery
Both lion's mane and shiitake may slow blood clotting. This can increase the risk of bruising and bleeding, and may cause excessive bleeding during or after surgical procedures. Stop use at least 2 weeks before scheduled surgery.
Auto-immune diseases (e.g., MS, Lupus, Rheumatoid Arthritis)
Shiitake can make the immune system more active, which may worsen the symptoms of auto-immune diseases.
Food and drink warnings
Back to contentsAlcohol
It is best to avoid or strictly limit alcohol when taking these supplements. Alcohol can irritate the digestive system and may increase the risk of stomach upset or interact with the metabolic processes of these fungi.
Raw or undercooked Shiitake mushrooms
Eating raw or undercooked shiitake mushrooms can cause 'Shiitake Dermatitis', a rare skin reaction that looks like whip marks. Ensure mushrooms are thoroughly cooked to neutralise the compound (lentinan) responsible for this reaction.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking atorvastatin and clopidogrel together may slightly reduce the effectiveness of clopidogrel in preventing blood clots. However, for most people, the benefits of taking both medicines to prevent heart attacks or strokes far outweigh this small risk.
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Can I take Lion's mane and Reishi together?
Taking Lion's Mane and Reishi together is generally considered safe for most people. However, both mushrooms have mild blood-thinning properties and can lower blood sugar levels. When taken together, these effects might be slightly stronger, though they are unlikely to cause problems for healthy individuals.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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