Can I take Sertraline and Vitamin d3 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known interaction between sertraline and vitamin D3. It is generally considered safe to take these two together.
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Why this happens
Sertraline (an antidepressant) and vitamin D3 (a supplement) are processed by different pathways in the body and do not interfere with how the other works.
What you should do
You can continue taking both as prescribed or recommended. As with any supplement, it is a good idea to let your doctor or pharmacist know you are taking it alongside your regular medication.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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