Can I take Atorvastatin and Maitake together?

Speak to your doctor before taking atorvastatin and maitake together as combining them may increase the risk of muscle-related side effects or liver irritation.

If you decide to take both, monitor yourself closely for unusual muscle pain, tenderness, or weakness, as well as signs of low blood sugar (such as dizziness or shaking).

Why this happens

Maitake contains compounds that may interfere with the liver enzymes (CYP3A4) responsible for breaking down atorvastatin, potentially leading to higher levels of the medicine in your blood.

Additionally, both substances can lower blood sugar and cholesterol, which may lead to an additive effect.

What you should do

Important precautions

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Surgery

Stop taking maitake at least two weeks before any scheduled surgery because it can thin your blood and increase the risk of bleeding during or after the procedure.

Food and drink warnings

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

Blood sugar-lowering foods/drinks

Maitake mushrooms may lower blood sugar levels. If you are consuming other foods or supplements that lower blood sugar, monitor your glucose levels closely to avoid hypoglycaemia (low blood sugar).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.