Can I take Maitake and Turkey tail together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known harmful interactions between maitake and turkey tail mushrooms. Both are medicinal fungi that are often taken together to support the immune system. However, because both can stimulate the immune system, there is a theoretical possibility of an additive effect.
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Why this happens
Both maitake (Grifola frondosa) and turkey tail (Trametes versicolor) contain complex sugars called beta-glucans. These compounds work in a similar way by activating certain immune cells (like natural killer cells and macrophages). Taking them together may increase this immune-stimulating effect.
What you should do
It is generally considered safe to take these two supplements together. However, if you have an autoimmune condition (such as lupus or rheumatoid arthritis) or are taking immunosuppressant medication, you should consult your doctor before combining them, as they may interfere with your treatment. Always start with the recommended dose on the product packaging.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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