Can I take Cordyceps and Lions mane together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known negative interactions between Cordyceps and Lion's Mane mushrooms. In fact, they are frequently taken together in 'mushroom blends' because they work in different ways.
Cordyceps is typically used for energy and physical stamina, while Lion's Mane is used for brain health and focus. Taking them together may provide a combined benefit for both physical and mental performance.
In this article:
It is safe to take cordyceps and Lions mane together. These two supplements do not compete for the same metabolic pathways in the liver, nor do they cancel each other out.
They have 'additive' effects, meaning they work alongside each other without interfering with how the body absorbs or uses them.
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What you should do
When taking cordyceps and Lions mane, you should:
Start with a low dose to see how your body reacts.
Speak to your doctor if you are taking blood-thinning medication or have an upcoming surgery as both mushrooms may have very mild blood-thinning properties.
Important precautions
Back to contentsAuto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)
Cordyceps may increase immune system activity, which can worsen the symptoms of auto-immune diseases.
Bleeding disorders or upcoming surgery
Cordyceps may slow blood clotting. Using it might increase the risk of bleeding or interfere with blood loss control during surgical procedures.
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Food and drink warnings
Back to contentsAlcohol
It is best to avoid or strictly limit alcohol when taking these supplements. Both Cordyceps and Lion's Mane may have mild sedative or blood-sugar-lowering effects; alcohol can unpredictably increase these effects, leading to increased drowsiness or dizziness.
Caffeine (Coffee, Tea, Energy Drinks)
Cordyceps may have mild stimulant properties. Consuming caffeine alongside this supplement may increase feelings of jitteriness, rapid heartbeat, or difficulty sleeping.
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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