Can I take Amitriptyline and Atorvastatin together?

Why this happens

Amitriptyline is an antidepressant that affects brain chemicals, while atorvastatin is a statin that lowers cholesterol in the liver. They are processed by different pathways in the body and do not interfere with each other's effectiveness or safety.

What you should do

You can continue taking both medicines as prescribed by your doctor. As with any medication, if you notice any unusual side effects like unexplained muscle pain (from the statin) or extreme drowsiness (from the antidepressant), you should mention them to your GP at your next appointment.

Important precautions

Suicidal thoughts and mood changes

Amitriptyline can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment or changing doses. Seek immediate medical help if your mood changes or you feel depressed.

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking it.

Muscle pain or weakness - atorvastatin

Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. In rare cases, this can lead to serious kidney problems.

Food and drink warnings

Alcohol

Drinking alcohol while taking amitriptyline can make you feel very sleepy and unsteady on your feet. It is best to avoid or strictly limit alcohol, especially when you first start the medicine or if your dose is increased.

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This can increase your risk of side effects, such as muscle pain. Avoid drinking large amounts (more than 1.2 litres daily), though a small glass occasionally is usually safe.

Caffeine

Amitriptyline can sometimes make you feel sleepy, while caffeine (found in coffee, tea, and energy drinks) is a stimulant. Large amounts of caffeine may interfere with the sedative effects of the medicine or increase feelings of restlessness.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.