LIM domain kinase 1
Last updated 12 Apr 2023
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The LIMK1 gene provides instructions for making a protein that is highly active in the brain, where it is thought to be involved in the growth and development of nerve cells. Studies suggest that this protein may play an important role in areas of the brain that are responsible for processing visual-spatial information (visuospatial constructive cognition). These parts of the brain are important for visualizing an object as a set of parts and performing tasks such as writing, drawing, constructing models, and assembling puzzles.
Normal function
The LIMK1 gene provides instructions for making a protein that is highly active in the brain, where it is thought to be involved in the growth and development of nerve cells. Studies suggest that this protein may play an important role in areas of the brain that are responsible for processing visual-spatial information (visuospatial constructive cognition). These parts of the brain are important for visualizing an object as a set of parts and performing tasks such as writing, drawing, constructing models, and assembling puzzles.
Within cells, the LIMK1 protein likely regulates aspects of the cytoskeleton, the structural framework that helps to determine cell shape, size, and movement. The LIMK1 protein helps control the organisation of actin filaments, which are long, thin fibers that are part of the cytoskeleton. Actin filaments are necessary for several normal cellular functions, such as cell division, cell movement (motility), maintenance of cell shape, transport of proteins and other molecules within cells, and chemical signaling between cells.
Conditions referring to this gene or chromosome
Other names
LIM kinase
LIM kinase 1
LIM motif-containing protein kinase
LIMK
LIMK-1
LIMK1_HUMAN
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Further reading and references
- LIM domain kinase 1; MedlinePlus, National Library of Medicine.
- Davila M, Frost AR, Grizzle WE, Chakrabarti R. LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer. J Biol Chem. 2003 Sep 19;278(38):36868-75. doi: 10.1074/jbc.M306196200. Epub 2003 Jun 23.
- Davila M, Jhala D, Ghosh D, Grizzle WE, Chakrabarti R. Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer. Mol Cancer. 2007 Jun 8;6:40. doi: 10.1186/1476-4598-6-40.
- Frangiskakis JM, Ewart AK, Morris CA, Mervis CB, Bertrand J, Robinson BF, Klein BP, Ensing GJ, Everett LA, Green ED, Proschel C, Gutowski NJ, Noble M, Atkinson DL, Odelberg SJ, Keating MT. LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition. Cell. 1996 Jul 12;86(1):59-69. doi: 10.1016/s0092-8674(00)80077-x.
- Gray V, Karmiloff-Smith A, Funnell E, Tassabehji M. In-depth analysis of spatial cognition in Williams syndrome: A critical assessment of the role of the LIMK1 gene. Neuropsychologia. 2006;44(5):679-85. doi: 10.1016/j.neuropsychologia.2005.08.007. Epub 2005 Oct 10.
- Gregory MD, Mervis CB, Elliott ML, Kippenhan JS, Nash T, B Czarapata J, Prabhakaran R, Roe K, Eisenberg DP, Kohn PD, Berman KF. Williams syndrome hemideletion and LIMK1 variation both affect dorsal stream functional connectivity. Brain. 2019 Dec 1;142(12):3963-3974. doi: 10.1093/brain/awz323.
- Hoogenraad CC, Akhmanova A, Galjart N, De Zeeuw CI. LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome. Bioessays. 2004 Feb;26(2):141-50. doi: 10.1002/bies.10402.
- Kozel BA, Barak B, Kim CA, Mervis CB, Osborne LR, Porter M, Pober BR. Williams syndrome. Nat Rev Dis Primers. 2021 Jun 17;7(1):42. doi: 10.1038/s41572-021-00276-z.
- Meyer-Lindenberg A, Mervis CB, Sarpal D, Koch P, Steele S, Kohn P, Marenco S, Morris CA, Das S, Kippenhan S, Mattay VS, Weinberger DR, Berman KF. Functional, structural, and metabolic abnormalities of the hippocampal formation in Williams syndrome. J Clin Invest. 2005 Jul;115(7):1888-95. doi: 10.1172/JCI24892. Epub 2005 Jun 9.
- Morris CA. Williams Syndrome. 1999 Apr 9 [updated 2023 Apr 13]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1249/
- Ravindran S, Nalavadi VC, Muddashetty RS. BDNF Induced Translation of Limk1 in Developing Neurons Regulates Dendrite Growth by Fine-Tuning Cofilin1 Activity. Front Mol Neurosci. 2019 Mar 20;12:64. doi: 10.3389/fnmol.2019.00064. eCollection 2019.
- Rosso S, Bollati F, Bisbal M, Peretti D, Sumi T, Nakamura T, Quiroga S, Ferreira A, Caceres A. LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons. Mol Biol Cell. 2004 Jul;15(7):3433-49. doi: 10.1091/mbc.e03-05-0328. Epub 2004 Apr 16.
- Scott RW, Olson MF. LIM kinases: function, regulation and association with human disease. J Mol Med (Berl). 2007 Jun;85(6):555-68. doi: 10.1007/s00109-007-0165-6. Epub 2007 Feb 10.
- Stanyon CA, Bernard O. LIM-kinase1. Int J Biochem Cell Biol. 1999 Mar-Apr;31(3-4):389-94. doi: 10.1016/s1357-2725(98)00116-2.
- Tassabehji M. Williams-Beuren syndrome: a challenge for genotype-phenotype correlations. Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R229-37. doi: 10.1093/hmg/ddg299. Epub 2003 Sep 2.
- Todorovski Z, Asrar S, Liu J, Saw NM, Joshi K, Cortez MA, Snead OC 3rd, Xie W, Jia Z. LIMK1 regulates long-term memory and synaptic plasticity via the transcriptional factor CREB. Mol Cell Biol. 2015 Apr;35(8):1316-28. doi: 10.1128/MCB.01263-14. Epub 2015 Feb 2.
- Yoshioka K, Foletta V, Bernard O, Itoh K. A role for LIM kinase in cancer invasion. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7247-52. doi: 10.1073/pnas.1232344100. Epub 2003 May 30.
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