sarcoglycan delta
Last updated 19 Nov 2025
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
The SGCD gene provides instructions for making the delta component (subunit) of a group of proteins called the sarcoglycan protein complex. The sarcoglycan protein complex is located in the membrane surrounding muscle cells. It helps maintain the structure of muscle tissue by attaching (binding) to and stabilizing the dystrophin complex, which is made up of proteins called dystrophins and dystroglycans. The large dystrophin complex strengthens muscle fibers and protects them from injury as muscles tense (contract) and relax. The dystrophin complex acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix).
Normal function
The SGCD gene provides instructions for making the delta component (subunit) of a group of proteins called the sarcoglycan protein complex. The sarcoglycan protein complex is located in the membrane surrounding muscle cells. It helps maintain the structure of muscle tissue by attaching (binding) to and stabilizing the dystrophin complex, which is made up of proteins called dystrophins and dystroglycans. The large dystrophin complex strengthens muscle fibers and protects them from injury as muscles tense (contract) and relax. The dystrophin complex acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix).
Conditions referring to this gene or chromosome
Other names
35 kDa dystrophin-associated glycoprotein
35DAG
35kD dystrophin-associated glycoprotein
CMD1L
DAGD
delta-sarcoglycan
delta-SG
LGMD2F
MGC22567
placental delta sarcoglycan
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SG-delta
SGCD_HUMAN
SGCDP
SGD
Related patient information and medicines
Patient information leaflet
SARS and MERS virus
Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) are viral infections. Both infections can cause very serious illnesses that particularly affect the lungs. The virus seems to cause an abnormal response in the body's defences (immune response) and this may be a reason for the infection ... The latest novel virus.
Patient information leaflet
Cannabis-based medicinal products
Since a change in the law in 2018, some cannabis-based medicines have been available on prescription in the UK. However, there is only evidence of benefit for treating a small number of conditions. Cannabis-based medicines (CBMs) are medic... CBMs contain cannabinoids derived from the cannabis plant, including delta-9-tetrahydrocannabinol (THC),.
Patient information leaflet
Thalassaemia
Thalassaemia is an inherited condition affecting the blood. There are different types, which vary from a mild condition to a serious or life-threatening condition. For the more severe forms of thalassaemia, modern treatment gives a good outlook, but lifelong monitoring and treatment are needed. Good treatment is important to prevent complications.
Patient information leaflet
COVID-19
COVID-19 is an infectious disease caused by a virus that was first identified in December 2019 in Wuhan, China. This leaflet deals with the symptoms, causes and treatment of COVID-19. What is COVID-19. COVID-19 is an infectious disease caused by a virus (SARS CoV-2). COVID-19 is short for "coronavirus disease 2019", because the disease was first.
Patient information leaflet
Schistosomiasis
Some stay in the body and are involved in the development of sympto... How common is schistosomiasis. The World Health Organization (WHO) reports that over 250 million people are infected with schistosomiasis worldwide, 137 million of which are school-aged children. How is schistosomiasis spread. Those who live in or travel to an area where.
Patient information leaflet
Restless legs syndrome
Restless legs syndrome causes uncomfortable feelings in your legs.
Further reading and references
- sarcoglycan delta; MedlinePlus, National Library of Medicine.
- Bauer R, Hudson J, Muller HD, Sommer C, Dekomien G, Bourke J, Routledge D, Bushby K, Klepper J, Straub V. Does delta-sarcoglycan-associated autosomal-dominant cardiomyopathy exist? Eur J Hum Genet. 2009 Sep;17(9):1148-53. doi: 10.1038/ejhg.2009.17. Epub 2009 Mar 4.
- Broglio L, Tentorio M, Cotelli MS, Mancuso M, Vielmi V, Gregorelli V, Padovani A, Filosto M. Limb-girdle muscular dystrophy-associated protein diseases. Neurologist. 2010 Nov;16(6):340-52. doi: 10.1097/NRL.0b013e3181d35b39.
- Guglieri M, Magri F, Comi GP. Molecular etiopathogenesis of limb girdle muscular and congenital muscular dystrophies: boundaries and contiguities. Clin Chim Acta. 2005 Nov;361(1-2):54-79. doi: 10.1016/j.cccn.2005.05.020.
- Guglieri M, Straub V, Bushby K, Lochmuller H. Limb-girdle muscular dystrophies. Curr Opin Neurol. 2008 Oct;21(5):576-84. doi: 10.1097/WCO.0b013e32830efdc2.
- Hack AA, Groh ME, McNally EM. Sarcoglycans in muscular dystrophy. Microsc Res Tech. 2000 Feb 1-15;48(3-4):167-80. doi: 10.1002/(SICI)1097-0029(20000201/15)48:3/43.0.CO;2-T.
- Meena AK, Sreenivas D, Sundaram C, Rajasekhar R, Sita JS, Borgohain R, Suvarna A, Kaul S. Sarcoglycanopathies: a clinico-pathological study. Neurol India. 2007 Apr-Jun;55(2):117-21. doi: 10.4103/0028-3886.32781.
- Ozawa E, Mizuno Y, Hagiwara Y, Sasaoka T, Yoshida M. Molecular and cell biology of the sarcoglycan complex. Muscle Nerve. 2005 Nov;32(5):563-76. doi: 10.1002/mus.20349.
- Sandona D, Betto R. Sarcoglycanopathies: molecular pathogenesis and therapeutic prospects. Expert Rev Mol Med. 2009 Sep 28;11:e28. doi: 10.1017/S1462399409001203.
- Straub V, Bushby K. The childhood limb-girdle muscular dystrophies. Semin Pediatr Neurol. 2006 Jun;13(2):104-14. doi: 10.1016/j.spen.2006.06.006.
- Trabelsi M, Kavian N, Daoud F, Commere V, Deburgrave N, Beugnet C, Llense S, Barbot JC, Vasson A, Kaplan JC, Leturcq F, Chelly J. Revised spectrum of mutations in sarcoglycanopathies. Eur J Hum Genet. 2008 Jul;16(7):793-803. doi: 10.1038/ejhg.2008.9. Epub 2008 Feb 20.
- Tsubata S, Bowles KR, Vatta M, Zintz C, Titus J, Muhonen L, Bowles NE, Towbin JA. Mutations in the human delta-sarcoglycan gene in familial and sporadic dilated cardiomyopathy. J Clin Invest. 2000 Sep;106(5):655-62. doi: 10.1172/JCI9224.
Join the conversation
Share your thoughts or experiences with others in our patient communities.
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.