Can I take Amlodipine and Apixaban together?

Why this happens

Both drugs are processed by the same enzyme in the liver (CYP3A4) and a transport protein (P-gp). Amlodipine can slightly slow down how quickly the body clears apixaban, leading to a minor increase in the amount of apixaban in your system.

What you should do

You can usually take these medicines together, but you should be aware of the signs of bleeding. Contact your doctor if you notice unusual bruising, nosebleeds, bleeding gums, or blood in your urine or stools. Do not stop taking either medication without consulting your healthcare provider.

Important precautions

Bleeding risk and surgery

You must tell your doctor or dentist you are taking apixaban before any procedure or surgery, as it increases your risk of serious bleeding. Do not stop taking it without medical advice, as this increases your risk of a blood stroke.

Liver problems

If you have liver disease, amlodipine must be used with extreme caution as it is broken down slowly by the liver, which can lead to a dangerous build-up of the medicine in your body.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood, which may lower your blood pressure too much and increase the risk of side effects like headaches or swollen ankles. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.

Alcohol

While there is no direct interaction, drinking alcohol can lower your blood pressure (adding to the effect of amlodipine) and increase the risk of stomach bleeding (when combined with apixaban). It is best to keep your alcohol intake within the recommended

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.