Can I take Amlodipine and Apixaban together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking amlodipine and apixaban together may slightly increase the level of apixaban in your blood. This could potentially increase the risk of bleeding or bruising, although for most people, this effect is very small.
Why this happens
Both drugs are processed by the same enzyme in the liver (CYP3A4) and a transport protein (P-gp). Amlodipine can slightly slow down how quickly the body clears apixaban, leading to a minor increase in the amount of apixaban in your system.
What you should do
You can usually take these medicines together, but you should be aware of the signs of bleeding. Contact your doctor if you notice unusual bruising, nosebleeds, bleeding gums, or blood in your urine or stools. Do not stop taking either medication without consulting your healthcare provider.
Important precautions
Bleeding risk and surgery
You must tell your doctor or dentist you are taking apixaban before any procedure or surgery, as it increases your risk of serious bleeding. Do not stop taking it without medical advice, as this increases your risk of a blood stroke.
Liver problems
If you have liver disease, amlodipine must be used with extreme caution as it is broken down slowly by the liver, which can lead to a dangerous build-up of the medicine in your body.
Food and drink warnings
Grapefruit juice
Grapefruit juice can increase the amount of amlodipine in your blood, which may lower your blood pressure too much and increase the risk of side effects like headaches or swollen ankles. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.
Alcohol
While there is no direct interaction, drinking alcohol can lower your blood pressure (adding to the effect of amlodipine) and increase the risk of stomach bleeding (when combined with apixaban). It is best to keep your alcohol intake within the recommended
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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