Can I take Amlodipine and Naproxen together?

Why this happens

Amlodipine works by relaxing blood vessels to lower blood pressure. Naproxen belongs to a group of medicines called NSAIDs, which can cause the body to hold onto salt and water. Naproxen also blocks certain natural chemicals (prostaglandins) that help keep blood vessels open and kidneys functioning well. This directly opposes the blood-pressure-lowering effect of amlodipine.

What you should do

If you need to take naproxen for a short time (a few days), monitor your blood pressure more frequently. If you need long-term pain relief, speak to your doctor or pharmacist about safer alternatives, such as paracetamol. Seek medical advice if you notice swelling in your ankles, decreased urination, or a significant rise in your blood pressure readings.

Important precautions

Asthma

Do not take naproxen if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a life-threatening asthma attack.

Stomach ulcers or bleeding

Naproxen significantly increases the risk of serious stomach bleeding and ulcers. You must not take it if you have a history of these conditions.

Severe liver disease

Amlodipine is processed slowly by the liver; if you have severe liver problems, the medicine can build up to dangerous levels in your body.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood. While the effect is usually small, it can lead to a greater drop in blood pressure or an increase in side effects like headaches or swollen ankles. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.

Alcohol

Drinking alcohol while taking naproxen can increase the risk of irritation to your stomach lining. This may lead to stomach ulcers or bleeding. It is advisable to limit alcohol intake while taking this medication.

Food (General)Naproxen should ideally be taken with or just after a meal or a snack. This helps to protect your stomach lining and reduces the risk of indigestion or stomach pain.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.