Can I take Atorvastatin and Omeprazole together?

It is generally considered safe to take atorvastatin and omeprazole together, but with caution, as omeprazole may increase blood levels of atorvastatin.

It is often helpful to take your atorvastatin at the same time each day to maintain steady levels in your body.

Why this happens

Omeprazole can affect the way the body breaks down atorvastatin by interfering with certain enzymes in the liver (CYP3A4) and transport proteins. It also changes the acidity of the stomach, which can slightly alter how much of the statin is absorbed into the bloodstream.

How to know if you're having a drug interaction

You may be experiencing an interaction between atorvastatin and omeprazole if:

• You develop new or worsening muscle pain, tenderness, or weakness.

• You feel unusually tired or weak without a clear reason.

• You notice dark-coloured pee (urine).

• You experience unexplained muscle cramps.

• Blood tests show raised muscle enzymes (CK levels) or changes in liver function.

• Symptoms start soon after starting or changing the dose of either medicine.

Serious interactions are uncommon, but always speak to a doctor or pharmacist if you notice new or worrying symptoms while taking both medicines.

What you should do

If you have any of the above symptoms, you should:

• Contact your GP or pharmacist for advice as soon as possible.

• Do not stop taking your medicines suddenly unless advised by a healthcare professional

• Seek urgent medical help if muscle pain is severe, widespread, or worsening

• Get medical advice immediately if you notice dark urine or severe weakness

• Tell your healthcare professional about all medicines and supplements you are taking

• Attend any blood tests arranged to check muscle or liver health

Important precautions

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can harm the developing baby. Use effective contraception while taking it.

Muscle pain or weakness - atorvastatin

Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. In rare cases, this can lead to serious kidney problems.

Severe or persistent diarrhoea

Contact your doctor if you develop severe or watery diarrhoea that does not stop, as omeprazole can increase the risk of a serious bowel infection called C. difficile.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the level of atorvastatin in your blood, which may increase the risk of side effects like muscle pain. Avoid drinking large amounts (more than 1.2 litres a day), though a small glass is usually fine.

Alcohol

Drinking large amounts of alcohol while taking atorvastatin can increase the risk of liver problems. It is best to keep your intake within the recommended limits.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.