Can I take Omeprazole and Paracetamol together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
There is no known harmful interaction between omeprazole and paracetamol. It is generally safe to take these two medicines together.
In this article:
Continue reading below
Why this happens
Omeprazole works by reducing stomach acid, while paracetamol is a painkiller processed mainly by the liver. They do not interfere with how each other is absorbed, broken down, or removed from the body.
What you should do
Back to contentsYou can take these medicines at the same time. Always follow the dosage instructions on the packet or as advised by your doctor or pharmacist.
Continue reading below
Important precautions
Back to contentsLiver disease or heavy alcohol consumption
You are at a significantly higher risk of fatal liver damage if you exceed the maximum dose or take multiple products containing paracetamol (such as cold and flu remedies).
Vitamin B12 deficiency or long-term use
Long-term use can mask the symptoms of stomach cancer and may lead to low magnesium levels or increased risk of bone fractures. Seek urgent medical advice if you experience unexplained weight loss or persistent vomiting.
Food and drink warnings
Back to contentsAlcohol
While alcohol does not directly interact with omeprazole, it can increase stomach acid production and irritate the stomach lining, which may worsen the symptoms you are taking omeprazole to treat.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Losartan and Metformin together?
Taking losartan and metformin together is generally safe, but it may slightly increase the risk of your blood sugar levels dropping too low (hypoglycaemia). Additionally, both drugs can affect your kidney function, especially if you become dehydrated.
Treatment and medication
Can I take Lisinopril and Potassium together?
Taking lisinopril and potassium supplements together can cause the levels of potassium in your blood to become dangerously high (a condition called hyperkalaemia). While your body needs potassium for your heart and muscles to work, too much of it can lead to serious heart rhythm problems or even cause the heart to stop. Symptoms of high potassium can include muscle weakness, tingling sensations, or palpitations, but often there are no symptoms until the level is very high.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.