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Can I take Pregabalin and Prozac together?

Drug interaction guide

Taking pregabalin and Prozac (fluoxetine) together can increase the risk of side effects that affect your brain and nervous system. You may feel more drowsy, dizzy, or confused. It can also make it harder to concentrate or perform tasks that require alertness. In some cases, especially in older adults, it may lead to impaired thinking or coordination.

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Why this happens

Both medications have 'depressant' effects on the central nervous system. When taken together, these effects are additive, meaning they stack on top of each other to produce a stronger sedative effect than either drug would alone.

What you should do

You should use caution when combining these medications. Avoid driving or operating heavy machinery until you know how the combination affects you. Limit or avoid alcohol, as it will make these side effects much worse. If you feel excessively sleepy or confused, contact your doctor to discuss your dosages.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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