Can I give my child antihistamines?
Drug interaction guide
Originally published 30 Apr 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Antihistamines can affect children differently than adults. While they usually cause sleepiness, they can sometimes cause 'paradoxical excitation,' making a child hyperactive, shaky, or unable to sleep. In very young children (under 6), some older antihistamines can cause serious breathing problems or severe drowsiness.
Why this happens
Children's brains and bodies are still developing. Their metabolism processes drugs at different speeds, and their central nervous system is more sensitive to the effects of these medicines, which can lead to unpredictable reactions.
What you should do
Always check the packaging or speak to a pharmacist to ensure the medicine is age-appropriate. For children under 6, do not give over-the-counter antihistamines for coughs and colds without a doctor's advice. Stick strictly to the recommended dose for the child's age and weight, and never use two different antihistamines at the same time (such as a hay fever syrup and an itch cream).
Important precautions
Children under 2 years old
Sedating antihistamines must not be given to children under 2 years old as they can cause life-threatening breathing difficulties (respiratory depression).
Drowsiness and hyperactivity
While these medicines usually cause drowsiness, they can sometimes cause 'paradoxical excitation' in children, making them unusually hyperactive, agitated, or unable to sleep.
Food and drink warnings
Fruit Juices (Grapefruit, Orange, Apple)
Do not drink grapefruit, orange, or apple juice while taking fexofenadine. These juices can significantly reduce the amount of medicine absorbed by your body, making it less effective at treating your symptoms. Wait at least 2 hours after taking the medicine before drinking these juices.
More about Fexofenadine (Allegra/Telfast)
High-fat meals
Taking fexofenadine with a meal that is very high in fat can reduce how much of the medicine your body absorbs. It is best to take this medicine on an empty stomach or with a light snack.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Patient picks for Drug interactions

Drug interactions checker
Can I take Ashwagandha and Vitamin B12 together?
There are no known clinical interactions between ashwagandha and vitamin B12. It is generally considered safe to take these two supplements together.

Drug interactions checker
Can I take Losartan and Vitamin D together?
There is no known direct interaction between losartan and vitamin D supplements. Taking these two together is generally considered safe.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
30 Apr 2026 | Originally published
Join the conversation
Share your thoughts or experiences with others in our patient communities.

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Alcohol and Atorvastatin together?
- Can I take Alogliptin and Bisoprolol together?
- Can I take Alogliptin and Fibre supplements together?
- Can I take Apixaban and Metformin together?
- Can I take Aspirin and Diclofenac together?
- Can I take Atenolol and Ramipril together?
- Can I take Atorvastatin and Cod liver oil together?
- Can I take Bisoprolol and Fibre supplements together?
- Can I take Candesartan and Nortriptyline together?
- Can I take Co-codamol and Omeprazole together?
- Can I take Doxycycline and Ibuprofen together?
- Can I take Ezetimibe and Magnesium together?
- Can I take Felodipine and Grapefruit together?
- Can I take Ginger and Turmeric with black pepper together?
- Can I take Magnesium and Oestrogel pump-pack together?
- Can I take Nustendi and Ramipril together?
- Can I take Paracetamol and Rosuvastatin together?
- Can I take Paracetamol and Simvastatin together?
- Can I take Royal sun and Turkey tail together?