Latest studies
- RecruitingPhase II
A study to learn if ZED1227 can improve continued celiac disease symptoms despite a gluten-free diet
This study is testing a new capsule called ZED1227 for adults with coeliac disease. Researchers want to see if this medicine can protect the gut and ease lingering tummy symptoms caused by accidental gluten exposure, even in people who already follow a strict gluten-free diet.
Coeliac diseaseCroatia - RecruitingPHASE3
Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis
This study is testing a new medicine, plozasiran, for people with very high triglycerides who have had pancreatitis. It will check if the medicine is safe and helps reduce the risk of future pancreatitis attacks. Participants will get either the study medicine or a dummy medicine.
Severe HypertriglyceridemiaCroatia - Completed
Multi-centre European study of major infectious disease syndromes (MERMAIDS) – Acute respiratory infections
This study looks at acute chest and throat infections to understand why some people get much sicker than others. Researchers from the University of Oxford are collecting blood and swab samples from adults treated at GP surgeries or hospitals to help develop better, more personalised treatments for future infections.
Acute respiratory infectionsCroatia - Completed
Evaluation of a dermocosmetic regimen for acne-prone skin in volunteers with mild, moderate or severe skin conditions
Acne is a common skin condition that affects confidence and well-being. This study tests whether a daily skincare routine using Eucerin products helps clear mild to severe spots. Researchers want to see how well these creams work over a year in people aged 12 to 50 across the UK and worldwide.
Subjects with acne-prone skin aged 12-50 years with Investigator's Global Assessment (IGA) grades 2-4, evaluating treatment of mild to severe acne vulgaris.Croatia - Not yet recruiting
Phase 3a and 3b update of the gastric cancer module, EORTC QLQ-STO22
Researchers are updating a widely used questionnaire that measures how stomach cancer and modern treatments affect daily life and well-being. If you have stomach cancer, you can help by completing the draft survey and sharing your feedback during a single, one-off chat lasting up to an hour.
Gastric adenocarcinomaCroatia - Completed
Implementing the concepts of mindfulness and community engagement to self-manage chronic diseases in four European cities
This study looks at a new community programme called SEFAC. It aims to help adults with long-term health issues, such as type 2 diabetes or heart disease. By combining mindfulness workshops, local community support, and a mobile app, it helps people build confidence and manage their health better day to day.
Citizens at risk of or has coronary heart disease and/or type 2 diabetes mellitusCroatia - AuthorisedTherapeutic exploratory (Phase II)
HOVON 168: Epcoritamab in Addition to R-Mini-CHOP Compared to R-Mini-CHOP in Elderly, Frail or Unfit Patients with Diffuse Large B-cell Lymphoma
This study looks at a new drug combination for older or frail adults with diffuse large B-cell lymphoma, a type of blood cancer. Researchers want to see if adding an antibody drug called epcoritamab to standard, gentler chemotherapy helps clear the cancer better and keeps people well for longer.
Diffuse large B-cell lymphoma (DLBCL)Croatia - RecruitingTherapeutic exploratory (Phase II)
A Phase 2, multinational, multicenter, randomized, double blind, placebo controlled, dose-ranging study to evaluate the efficacy and safety of SAR441566 in adults with moderate to severe Crohn’s disease.
This clinical study tests a new medicine called balinatunfib (SAR441566) for adults with moderate to severe Crohn's disease. Researchers want to see if different doses help heal the bowel lining and reduce symptoms compared to a dummy treatment (placebo), while checking for any unwanted side effects.
Crohn's diseaseCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Randomized, Multicenter, Double-blind, Parallel-group, Active-control Study of the Efficacy and Safety of Sparsentan for the Treatment of Immunoglobulin A Nephropathy (PROTECT)
This phase 3 clinical study tests a new medicine called sparsentan for adults with IgA nephropathy, a serious kidney condition. Researchers want to see if sparsentan is better at reducing protein leaks in urine and protecting kidney function over time compared to a standard medicine called irbesartan.
Immunoglobulin A Nephropathy (IgAN)Croatia - RecruitingTherapeutic confirmatory (Phase III)
Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults with Severe Hypertriglyceridemia (SHASTA-3 Study)
This study tests a new injection called plozasiran for adults with very high blood fat levels, known as severe hypertriglyceridemia. Researchers want to see if the medicine can safely lower blood fats over one year compared to a dummy jab, reducing the risk of serious problems like pancreas inflammation.
Severe hypertriglyceridemia (SHTG)Croatia - RecruitingTherapeutic confirmatory (Phase III)
An Open-Label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH (MK-7962-004)
This study looks at a medicine called sotatercept for adults with pulmonary arterial hypertension (PAH). Researchers want to see how safe it is over a longer period when taken alongside usual treatments. It also checks whether the medicine helps improve walking ability, heart health, and everyday energy levels.
Pulmonary Arterial Hypertension (PAH)Croatia - RecruitingTherapeutic confirmatory (Phase III)
A Double-Blind, Randomized, Active-Controlled, Parallel-Group, Phase 3 Study to Compare Efficacy and Safety of CT-P51 and Keytruda in Combination with Platinum-Pemetrexed Chemotherapy in Patients with Previously Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer
This study tests a new medicine called CT-P51 compared to an established treatment, Keytruda, for advanced non-small cell lung cancer. Both medicines are given with standard chemotherapy. The aim is to see if CT-P51 works just as well and is just as safe as Keytruda for newly diagnosed patients.
Previously Untreated Metastatic Non-Squamous Non-Small Cell Lung CancerCroatia - AuthorisedPhase III and phase IV (Integrated)
A Phase 3b/4, Multicenter, Parallel-Group, Double-Blind, Placebo-Controlled, Two-Arm, Long-Term Study to Evaluate the Safety and Efficacy of Saroglitazar Magnesium on Clinical Outcomes in Participants with Primary Biliary Cholangitis (PBC)
This study is looking at a medicine called saroglitazar magnesium for people living with primary biliary cholangitis (PBC). Researchers want to see if this daily tablet can protect the liver from long-term damage, reduce extreme tiredness, and lower the risk of serious complications or needing a liver transplant.
Primary Biliary Cholangitis (PBC)Croatia - RecruitingTherapeutic exploratory (Phase II)
A Phase 2, multinational, multicenter, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the efficacy and safety of SAR441566 in adults with moderate-to-severe ulcerative colitis
This study tests an experimental medicine called SAR441566 for adults with moderate-to-severe ulcerative colitis. Researchers want to see if different doses of this treatment can safely reduce bowel inflammation, relieve painful symptoms, and help bring the condition into remission compared to an inactive dummy treatment (a placebo).
Colitis UlcerativeCroatia - RecruitingTherapeutic confirmatory (Phase III)
ZEUS - Effects of ziltivekimab versus placebo on cardiovascular outcomes in participants with established atherosclerotic cardiovascular disease, chronic kidney disease and systemic inflammation
The ZEUS study is looking at whether a new medicine called ziltivekimab can protect people with heart and kidney problems. Researchers want to see if lowering body swelling and inflammation can reduce the chances of serious health events like heart attacks, strokes, or worsening kidney disease.
Atherosclerotic cardiovascular disease, chronic kidney disease and systemic inflammationCroatia - AuthorisedTherapeutic confirmatory (Phase III)
A Multicenter, Randomized, Double-Blind, Double-Dummy, Phase III Study to Evaluate the Efficacy and Safety of Letrozole SIE Compared to Femara® (both in Combination with the CDK4/6 Inhibitor Ribociclib) in Postmenopausal Women with HR-Positive, HER2-Negative, Inoperable Locally Advanced or Metastatic Breast Cancer (SIE-3)
This clinical trial looks at a new injection form of letrozole, a common hormone therapy for advanced breast cancer. Researchers want to see if this long-acting injection works just as well as daily tablets at slowing cancer growth, while also comparing side effects like joint and muscle aches.
HR-positive, HER2-negative, inoperable locally advanced or metastatic breast cancerCroatia - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blinded Study to Evaluate the Safety and Efficacy of Salanersen (BIIB115) After Onasemnogene Abeparvovec Treatment in Infants with Genetically Diagnosed Spinal Muscular Atrophy
This study tests a medicine called salanersen for babies with spinal muscular atrophy (SMA) who have already received gene therapy. Doctors want to see if salanersen is safe and whether it can give extra support to help infants build muscle strength, sit, crawl, and walk.
Spinal Muscular AtrophyCroatia - Recruiting
Severe Complications During Ventricular Tachycardia or Premature Ventricular Complex Ablation
This study looks back at information from hospitals to understand serious problems that can happen during or soon after a heart procedure called ablation for fast or extra heartbeats (VT/PVC). Researchers want to find out why these problems occur and how they were managed.
Ventricular Tachycardia (VT)Premature Ventricular ComplexesCroatia - RecruitingHuman Pharmacology (Phase I)- Other
An Open-Label Trial to Assess the Comparative Bioavailability of TV-44749 to Oral Olanzapine in Participants with Schizophrenia
This study is looking at a new way to give a medicine called olanzapine, which is used for schizophrenia, to see if it works as well as the usual pills. It's a very early-stage study to check how the body uses the new medicine compared to the old one.
SchizophreniaCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Phase IIIB, Multinational, Multicenter, Randomized, Open-Label Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Trastuzumab for Subcutaneous Administrationin Participants with Early or Locally Advanced/ Inflammatory HER2-Positive Breast Cancer
This study looks at treating HER2-positive breast cancer. It compares giving a special medicine called Phesgo at home versus in the hospital to see which patients prefer. Researchers also check how well the treatment works and any side effects.
Early or Locally Advanced/ Inflammatory HER2-Positive Breast CancerCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3 Clinical Trial to Compare Efficacy, Safety, Tolerability and Immunogenicity of RBS-001 to Eylea® in Subjects with Neovascular Age-Related Macular Degeneration
This study is looking into a new treatment, RBS-001, for a specific eye condition called wet age-related macular degeneration (wet AMD). It compares RBS-001 with an existing treatment, Eylea, to see if it works as well or better, and if it's safe for patients.
Neovascular age-related macular degeneration (nAMD)Croatia - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicenter, Open-Label Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease
This study is looking at a medicine called ozanimod for people with Crohn's disease that is moderate to severe. It wants to see how well the medicine helps reduce their symptoms and improve their gut health over a long period. Researchers will also check how it affects COVID-19 antibody levels.
Moderately to Severely Active Crohn's DiseaseCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Randomized, Double-Blind, Phase 3 Study to Evaluate the Efficacy and Safety of Vedolizumab Intravenous as Maintenance Therapy in Pediatric Subjects with Moderately to Severely Active Ulcerative Colitis Who Achieved Clinical Response Following Open-Label Vedolizumab Intravenous Therapy
This study looks at a medicine called Entyvio for children and teenagers with moderate to severe ulcerative colitis. It aims to see if Entyvio helps them stay in remission (when symptoms improve or disappear) and if it's safe to use over time.
Moderately to severely active Ulcerative Colitis (UC)Croatia - RecruitingPhase III and phase IV (Integrated)
Lowering of LDL-C with rosuvastatin or single-pill combination rosuvastatin/ezetimibe in high/very high-risk patients with hyperlipidaemia – LEASH
This study looks at how well different medications (Sorvasta and Sorvitimb) lower 'bad' cholesterol (LDL-C) in people who have high cholesterol and are at high risk of heart problems. It checks if patients reach their target cholesterol levels after 12 weeks.
HyperlipidaemiaCroatia - RecruitingTherapeutic confirmatory (Phase III)
An open label, single arm, extension trial to examine long-term safety of Iclepertin once daily in patients with schizophrenia who have completed previous Iclepertin Phase III trials.(CONNEX-X)
This study is looking at the long-term safety of a new medicine called Iclepertin for people with schizophrenia. It's for those who have already taken part in earlier studies of this medicine. We want to see how safe it is over a longer period.
SchizophreniaCroatia - RecruitingTherapeutic exploratory (Phase II)
A Phase 2, Double-Blind, Randomized, Parallel Group Study Evaluating the Efficacy, Safety, and Tolerability of Obeticholic Acid Administered in Combination with Bezafibrate in Subjects with Primary Biliary Cholangitis Who Had an Inadequate Response or Who Were Unable to Tolerate Ursodeoxycholic Acid
This study is testing new combinations of medicines for a liver condition called Primary Biliary Cholangitis (PBC). We want to see if these combinations are safe and work better than current treatments, especially for people who haven't responded well to their usual medication.
Primary Biliary Cholangitis (PBC)Croatia - RecruitingTherapeutic exploratory (Phase II)
A multi-center single arm Phase II study to evaluate the safety and efficacy of genetically engineered autologous cells expressing anti-CD20 and anti-CD19 specific chimeric antigen receptor in subjects with relapsed and/or refractory diffuse large B cell lymphoma
This study looks at a new type of cell therapy, called MB-CART2019.1, for people with a specific type of lymphoma that has come back or hasn't responded to other treatments. It checks how safe and effective it is.
Relapsed/refractory diffuse large B cell lymphoma (R-R DLBCL)Croatia - RecruitingTherapeutic exploratory (Phase II)
A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study to Assess Efficacy and Safety of Atuliflapon Given Orally Once Daily for Twelve Weeks in Adults with Moderate to Severe Uncontrolled Asthma
This study is testing a new medicine, Atuliflapon, for adults whose moderate-to-severe asthma isn't well controlled by their usual treatments. We want to see if it reduces asthma flare-ups and improves breathing, compared to a dummy pill, over 12 weeks.
Moderate-to-Severe Uncontrolled AsthmaCroatia - RecruitingHuman Pharmacology (Phase I)- Other
A Study to Investigate the Safety, Tolerability, Immunogenicity, Pharmacokinetics, and Pharmacodynamics of Ascending Intravenous Doses of Glofitamab, Administered after Ocrelizumab Pretreatment, in Patients with Multiple Sclerosis
This study is looking at a new treatment called glofitamab for multiple sclerosis (MS). Researchers want to see if it's safe, how well the body handles it, and how it works after patients have taken another medicine called ocrelizumab.
Multiple Sclerosis (MS)Croatia - RecruitingTherapeutic exploratory (Phase II)
Safety and efficacy of once-weekly subcutaneous and once-daily oral NNC0487-0111 in participants with type 2 diabetes – a dose finding study
This study is testing a new medicine, NNC0487-0111, for people with type 2 diabetes. It's looking at different ways to take the medicine (once a week shot or once a day pill) to see how safe and effective it is at controlling blood sugar.
Type 2 DiabetesCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with primary progressive multiple sclerosis (PERSEUS)
This study is testing a new medicine, SAR442168, for people with Primary Progressive Multiple Sclerosis (PPMS). It's comparing the new medicine to a dummy pill to see if it can slow down the disease's progress and if it's safe to use.
Primary Progressive Multiple SclerosisCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Multicenter, Double-blind, Randomized Withdrawal extension study of subcutaneous secukinumab to demonstrate long-term efficacy, safety and tolerability in subjects with moderate to severe hidradenitis suppurativa
This study is looking at a medicine called secukinumab for people with moderate to severe hidradenitis suppurativa (HS). It aims to see how well the medicine works long-term and if it is safe, especially after people have already seen some improvement.
Hidradenitis suppurativaCroatia - RecruitingPhase II and Phase III (Integrated)
C5041006 (APD334 202 or APD334-202EU): A Multicenter, Randomized, Double Blind, Parallel Group Study to Assess the Efficacy and Safety of Oral Etrasimod as Induction and Maintenance Therapy for Moderately to Severely Active Crohn’s Disease
This study is testing a new medicine called etrasimod for people with moderate to severe Crohn's disease. Researchers want to see if it helps improve symptoms and gut health, and if it is safe to use.
Crohn's DiseaseCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicentre, Double-masked, Randomised Study to Evaluate the Efficacy and Safety of Intravitreal OPT-302 in Combination with Aflibercept, Compared with Aflibercept Alone, in Participants with Neovascular Age-related Macular Degeneration (nAMD)
This study is testing a new treatment called OPT-302, given alongside an existing treatment (Eylea), for a serious eye condition called 'wet' Age-related Macular Degeneration (AMD). Doctors want to see if combining these treatments helps people see better than Eylea alone.
Neovascular Age-related Macular Degeneration (wet AMD)Croatia - RecruitingTherapeutic confirmatory (Phase III)
A 52-week, randomized, double-blind, double-dummy, placebo- and active- controlled (Roflumilast, Daliresp® 500μg), parallel group, study to evaluate the efficacy and safety of two doses of CHF6001 DPI add-on to maintenance triple therapy in subjects with Chronic Obstructive Pulmonary Disease (COPD) and chronic bronchitis
This study looks at new inhaled medications for people with a type of lung disease called COPD. It aims to see if these new medicines can help reduce flare-ups, improve breathing, and make everyday life better.
Chronic Obstructive Pulmonary Disease (COPD)Croatia - RecruitingTherapeutic confirmatory (Phase III)
Study of four-factor prothrombin complex concentrate, OCTAPLEX, in patients with acute major bleeding on direct oral anticoagulant (DOAC) therapy with factor Xa inhibitor.
This study looks at a medicine called Octaplex for people taking blood thinners (DOACs) who have serious bleeding. It checks if Octaplex helps stop the bleeding and if it's safe. Octaplex is a powder mixed into a liquid for a drip.
Acute major bleeding in patients receiving DOAC therapy with factor Xa inhibitorCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Parallel-Group Treatment, Double-Blind, 2-Arm Study to Investigate the Comparative Efficacy, Safety, and Immunogenicity Between Intravenous AVT16 and Entyvio® in Male and Female Subjects Aged 18 to 80 Years Inclusive with Moderate to Severe Active Ulcerative Colitis
This study is comparing two medicines, AVT16 and Entyvio, for people aged 18-80 with moderate to severe ulcerative colitis. It will check how well they work, how safe they are, and how the body reacts to them over 52 weeks. The main goal is to see if symptoms improve after 6 weeks.
Moderate to Severe Active Ulcerative ColitisCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multi-Center, Randomized, Single-Blind Study to Assess the Efficacy and Safety of Cefepime/Nacubactam and Aztreonam/Nacubactam Versus Best Available Therapy in Adults With Complicated Urinary Tract Infection, Acute Uncomplicated Pyelonephritis, Hospital-Acquired Bacterial Pneumonia, Ventilator-Associated Bacterial Pneumonia, and Complicated Intra-Abdominal Infection due to Carbapenem Resistant Enterobacterales (OP0595-6)
This study looks at new medicines for serious bacterial infections like complicated urine infections, pneumonia, and tummy infections. Researchers want to see if these new treatments work better and are safer than current standard care, especially for infections resistant to common antibiotics.
Croatia - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy in Newly Diagnosed Intermediate- and High-risk PAH Patients
This study is looking at a new medicine, sotatercept, for people recently diagnosed with a serious lung condition called Pulmonary Arterial Hypertension (PAH). It compares sotatercept to a dummy medicine to see if it improves well-being and reduces serious health events when added to standard treatments.
Therapeutic confirmatory (phase III)Croatia - RecruitingTherapeutic confirmatory (Phase III)
A Randomized, Multicenter, Double-blind, Parallel, Active-control Study of the Effects of Sparsentan, a Dual Endothelin Receptor and Angiotensin Receptor Blocker, on Renal Outcomes in Patients with Primary Focal Segmental Glomerulosclerosis (FSGS)
This study is testing a new medication called Sparsentan for people with a kidney condition called FSGS. It compares Sparsentan to an existing treatment (Irbesartan) to see how well it protects the kidneys and if it's safe over about two years.
Focal segmental glomerulosclerosis (FSGS)Croatia - RecruitingTherapeutic confirmatory (Phase III)
A double blind, randomized, placebo-controlled trial evaluating the efficacy and safety of BI 1015550 over at least 52 weeks in patients with Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)
This study is testing a new medicine, BI 1015550, for people with progressive fibrosing interstitial lung diseases (PF-ILDs). Researchers want to see if it helps improve lung function and is safe to use over about a year.
Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)Croatia - RecruitingTherapeutic confirmatory (Phase III)
AN OPEN-LABEL EXTENSION (OLE) PHASE 3 TRIAL TO ASSESS THE SAFETY OF INTRAVITREAL ADMINISTRATION OF AVACINCAPTAD PEGOL (COMPLEMENT C5 INHIBITOR) IN PATIENTS WITH GEOGRAPHIC ATROPHY WHO PREVIOUSLY COMPLETED PHASE 3 STUDY ISEE2008 (GATHER2)
This study is looking at the long-term safety of a medicine called Avacincaptad pegol for people with a serious eye condition called geographic atrophy. It's for those who have already been in a previous study using this medicine.
geographic atrophyCroatia - RecruitingPhase II and Phase III (Integrated)
A Phase 2/3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of BHV-7000 as Adjunctive Therapy in Subjects with Idiopathic Generalized Epilepsy with Generalized Tonic-clonic Seizures, with Open-label Extension
This study is testing a new medicine, BHV-7000, for people aged 18 and over who have a type of epilepsy called idiopathic generalised epilepsy with tonic-clonic seizures. Doctors want to see if the medicine can reduce these seizures and if it's safe to use.
Idiopathic Generalized Epilepsy with Generalized Tonic-clonic SeizuresCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3 Study to Evaluate the Efficacy and Safety of ARO-APOC3 in Adults with Familial Chylomicronemia Syndrome
This study is looking into a new medication called ARO-APOC3 for adults with a rare genetic condition called Familial Chylomicronemia Syndrome (FCS). Researchers want to see if this new medicine can help lower high levels of fats in the blood and if it's safe to use.
Familial Chylomicronemia Syndrome (FCS)Croatia - RecruitingTherapeutic confirmatory (Phase III)
An Open-label Extension Study of ARGX-113-2009 to Evaluate the Long-term Safety, Tolerability, and Efficacy of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid
This study looks at a new medicine called efgartigimod for adults with Bullous Pemphigoid. It's an ongoing study to see how safe and effective the medicine is long-term, and how well it helps manage symptoms and improve quality of life.
Bullous PemphigoidCroatia - RecruitingTherapeutic confirmatory (Phase III)
A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of Lumateperone in the Acute Treatment of Patients with Manic Episodes or Manic Episodes with Mixed Features Associated with Bipolar I Disorder (Bipolar Mania)
This study is testing a new medicine, lumateperone, for adults experiencing manic episodes as part of bipolar I disorder. Researchers want to see if it helps reduce symptoms and if it's safe compared to a dummy pill.
Bipolar I Disorder (Bipolar Mania)Croatia - RecruitingTherapeutic confirmatory (Phase III)
A Phase 3, Open-Label, Long-Term Safety Extension Study Evaluating the Safety and Tolerability of the Fixed-Dose Combination of Obeticholic Acid and Bezafibrate in Subjects with Primary Biliary Cholangitis
This study looks at a new drug combination for Primary Biliary Cholangitis (PBC). It checks if mixing two existing medicines, Obeticholic Acid and Bezafibrate, helps liver health over a long time. Researchers want to see how safe and effective this combination is for patients.
Primary Biliary Cholangitis (PBC)Croatia - RecruitingTherapeutic confirmatory (Phase III)
TACTI-004, a double-blinded, randomized phase 3 trial in patients with advanced/metastatic non-small cell lung cancer (NSCLC) receiving eftilagimod alfa (MHC class II agonist) in combination with pembrolizumab (PD-1 antagonist) and chemotherapy.
This study is testing a new combination of treatments for advanced lung cancer. It combines a new drug, eftilagimod alfa, with existing treatments like pembrolizumab and chemotherapy, to see if it can help people live longer and improve their quality of life. Participants will be randomly assigned to different treatment groups.
Advanced/metastatic non-small cell lung cancer (NSCLC)Croatia - RecruitingPHASE3
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
This study looks at a new medicine for agitation in people with Alzheimer's. It aims to see if an experimental drug, given as capsules, is safe and works well over a long time for those who've been in similar studies before.
Alzheimer DiseaseAgitationCroatia - Active not recruitingPHASE2
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease
This study is looking at a new combination treatment, JNJ-78934804, for people aged 18-65 with Crohn's disease that is moderate to severe. It compares this new treatment to existing medicines, guselkumab and golimumab, to see how well it works over 48 weeks.
Crohn's DiseaseCroatia