Latest studies
- Enrolling by invitationNA
Decrease Caregiving Fatigue in Group Leaders of a Support Group for Women After Cancer
This study looks at a special online course for leaders of cancer support groups. It aims to see if self-compassion training can help them feel less tired and stressed, and learn to be kinder to themselves while supporting others.
Caregiver BurdenGermany - Enrolling by invitation
Accuracy of Prediction Equations to Calculate Maximum Strength
This study is looking for better ways to measure how strong someone is, especially in older adults. It's trying to find an easier and safer method than the usual "one-rep max" test, which can be tough. The goal is to make resistance exercise safer and more effective for everyone.
Healthy AgingGermany - Active not recruitingPHASE3
Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
This study is looking into new ways to treat advanced or recurrent womb cancer. We're testing a combination of medicines called durvalumab and olaparib, given after initial chemotherapy, to see if they can help patients live longer and better.
Endometrial NeoplasmsGermany - Active not recruitingPHASE2
Efficiency of Vaccination with Lysate-loaded Dendritic Cells in Patients with Newly Diagnosed Glioblastoma
This study looks at a new vaccine to treat a serious type of brain tumour called glioblastoma. It combines a special vaccine made from your own tumour cells with standard treatments to see if it helps people live longer.
GlioblastomaGermany - Recruiting
Giessen Pulmonary Hypertension in Lung Cancer Registry
This study looks at how often high blood pressure in the lung arteries (pulmonary hypertension) affects people with lung cancer. Doctors will use information from patients already being treated at Giessen University Hospital to understand this better.
Pulmonary Hypertension Due to Lung Diseases and HypoxiaGermany - RecruitingPHASE2
A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM)
This study looks at a new way to give belantamab mafodotin, along with other common medicines, for multiple myeloma that has come back or isn't responding well. We want to see if giving it less often can still work well and cause fewer eye side effects.
Multiple MyelomaGermany - Recruiting
Biological Determinants and Neural Compensation of Dysphagia in Parkinson's Disease
This study looks into why people with Parkinson's disease have trouble swallowing. Researchers want to understand the brain and body changes that cause this, hoping to find better ways to help patients and improve their quality of life.
Parkinsons Disease (PD)Oropharyngeal DysphagiaGermany - RecruitingPHASE2
T-cell Therapy in Patients With PML
This study is testing a new cell therapy for PML, a serious brain infection. It aims to see if this treatment, involving special immune T-cells, is safe and can improve patients' health and quality of life. There's currently no standard cure for PML.
Progressive Multifocal Leucoencephalopathy (PML)Germany - RecruitingPHASE1, PHASE2
Intracochlear Application of VSF1.01 for the Reduction of Cochlear Implant Surgery Related Trauma
This study looks at a new treatment called VSF1.01 for people getting a cochlear implant. It aims to see if VSF1.01 can make the surgery safer and help protect the inner ear. We also want to know if it improves hearing.
Hearing LossGermany - Recruiting
Endovascular Recanalization for Symptomatic Chronic Intradural Occlusions
This study looks at a procedure called endovascular recanalisation to open up blocked arteries in the brain. It's for people who have had a stroke or are at risk because of narrowed brain arteries. The study wants to see how safe and effective this treatment is.
Intracranial StenosisIntracranial Atherosclerotic DiseaseGermany - Active not recruiting
Retrospective Data Analysis PelviGYNious/EndoGYNious
This study looks back at patient records to check how safe and effective two medical devices, PelviGYNious and EndoGYNious, have been. These devices are used to treat pelvic organ prolapse, a condition where pelvic organs can drop or bulge.
ProlapseSacrocolpopexyPelvic Organ Prolapse (POP)Germany - Recruiting
Intelligent Lung Support in the Intensive Care Unit
This study looks at a new AI-powered computer program called IntelliLung. It helps doctors set up breathing machines for very ill patients in intensive care. Researchers want to see how closely doctors' choices match the program's suggestions to help patients breathe better.
Mechanical VentilationIntensive Care MedicineGermany - Recruiting
Analysis of TPE Treatments With multiFiltratePRO
This study looks at how well a special filtering machine, called multiFiltratePRO, works for people with autoimmune diseases. It checks how effectively the machine removes harmful substances from the blood, aiming to improve treatments like therapeutic plasma exchange (TPE).
Autoimmune DiseasesGermany - Active not recruiting
Rate of Progression in EYS Related Retinal Degeneration
This study aims to understand how an eye condition called EYS-related retinitis pigmentosa progresses over time. Researchers want to learn more about how it affects vision to help develop treatments in the future. It involves monitoring people with EYS gene mutations for four years.
Retinitis PigmentosaEye DiseasesGermany - Active not recruiting
Post Market Clinical Follow Up of LEGION™ Primary TKS With VERILAST™
This study is looking at how well a new type of knee replacement, called LEGION™ Primary TKS with VERILAST™, works for people with joint problems. It compares its results to older knee replacements to see if it's safe and effective in the long run.
Degenerative Joint DiseaseGermany - Recruiting
Master Framework For Relapse or Refractory Acute Myeloid Leukemia
This study looks at how people with acute myeloid leukaemia (AML) respond to treatment when their cancer comes back or doesn't respond well to initial therapy. It collects important real-world information to help improve care for patients across Europe.
Acute Myeloid Leukemia, in RelapseAcute Myeloid Leukemia RefractoryGermany - Active not recruiting
The European Robotic Spinal Instrumentation (EUROSPIN) Study
This study looks at different ways to place screws in your spine for conditions like back pain, slipped discs, or infections. It compares traditional surgery to methods using computer navigation or robotic assistance to see which works best and is safest.
Degenerative Disc DiseaseSpondylolisthesisSpinal StenosisRecurrent Disc HerniationGermany - Recruiting
Microvascular Cardiac Allograft Vasculopathy Trial
This study aims to understand why some people who have had a heart transplant develop problems with the tiny blood vessels in their new heart. We're looking at genes, how the heart looks and works, and other factors to find out more.
Cardiac Allograft VasculopathyGermany - Not yet recruitingNA
Effect of Gum Acacia and Electrolytes on Hydration After an Exercise-indued Dehydration
This study looks at how new drinks help men rehydrate after exercise. It compares special drinks with gum acacia, with or without 'sea electrolytes', to plain water to see which is best at getting your body fluids back to normal.
Healthy Adult MaleGermany - Recruiting
Ropeginterferon Alfa-2b in Patients With Polycythemia Vera (PV) Without Symptomatic Splenomegaly
This study looks at how a medicine called ropeginterferon alfa-2b works for adults with Polycythemia Vera (PV), a blood condition, who don't have a swollen spleen causing symptoms. It checks how people feel, if the treatment helps, and if it's safe in real-world use.
Polycythemia VeraGermany - Active not recruitingPHASE1
A Study to Test KISIMA-02 Vaccine-based Immunotherapy and Ezabenlimab in People With Pancreatic Cancer
This study for advanced pancreatic cancer tests a new treatment. It combines an immunotherapy (a protein alongside a virus that may kill cancer cells) with ezabenlimab, a drug that may boost your immune system. The aim is to find safe doses and see if it helps people live longer.
Pancreatic Ductal AdenocarcinomaGermany - Recruiting
A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa
This study looks at the safety of a new medicine called efgartigimod for people with myasthenia gravis (gMG). Researchers are observing patients as they take the medicine in their everyday lives to understand its effects.
Myasthenia GravisGermany - Recruiting
Biomedical Signal Extraction From Symptom Descriptions: An Observational Registry Using the OpenGenome Platform
This study looks at how a computer program called OpenGenome understands what people type about their symptoms. It uses artificial intelligence to find links between symptoms and medical information from scientific papers. The goal is to see how well the computer works and what patterns emerge from many anonymous submissions.
Signs and SymptomsFeverMyalgiaSkin DiseasesGermany - Recruiting
AI-driven Narrow-band Imaging Score for Disease Assessment and Outcome Prediction in Ulcerative Colitis
This study aims to create a new, simple way to check how active Ulcerative Colitis is using special camera tests (colonoscopies). It will also explore using artificial intelligence to make these checks more accurate and help predict how the disease might progress over time.
Ulcerative Colitis (UC)Germany - Recruiting
An Observational Study to Assess the Effectiveness and Safety of a Cemiplimab in Adult Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) in Routine Clinical Practice Settings in Europe
This study looks at how a medicine called cemiplimab (Libtayo®) works for adults with advanced non-small cell lung cancer in everyday healthcare. Researchers want to understand its benefits and safety in real-world use.
Non-small Cell Lung CancerGermany - Active not recruitingPHASE3
A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension
This study is testing if a medicine called selexipag can help children aged 2-17 with a serious lung condition called pulmonary hypertension. It aims to see if adding selexipag to their usual treatment can slow down the disease compared to a dummy medicine.
Hypertension, PulmonaryGermany - RecruitingPHASE2
A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases
This study looks at new treatments (inebilizumab and blinatumomab) for people with Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). It mainly checks how safe these medicines are and if they help reduce symptoms of these conditions.
Systemic Lupus ErythematosusActive Refractory Rheumatoid ArthritisGermany - RecruitingPHASE3
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
This study looks at a new medicine for agitation in people with Alzheimer's. It aims to see if an experimental drug, given as capsules, is safe and works well over a long time for those who've been in similar studies before.
Alzheimer DiseaseAgitationGermany - Active not recruitingPHASE3
Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.
This study looks at a new medicine called remibrutinib for chronic spontaneous urticaria (CSU), comparing it to a dummy treatment (placebo) and another existing medicine, omalizumab. It aims to see if remibrutinib is safe and helps reduce hives and itching in adults whose CSU isn't well controlled by usual allergy medicines.
Chronic Spontaneous UrticariaGermany - Active not recruitingPHASE3
A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy
This study looks at a new medicine called empasiprubart compared to a standard treatment, IVIg, for adults with a rare muscle condition called Multifocal Motor Neuropathy (MMN). It aims to see if empasiprubart is safe and works well.
Multifocal Motor Neuropathy (MMN)MMNGermany - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Dose Finding Study Evaluating the Safety and Efficacy of Linaclotide in Pediatric Subjects 6 Months to Less Than 2 Years of Age with Functional Constipation (FC).
This study is looking at a medicine called Linaclotide for very young children (6 months to under 2 years old) who have ongoing tummy troubles and can't go to the toilet properly. We want to see if it's safe and helps them go more easily.
Functional Constipation (FC)Germany - Active not recruitingPHASE3
Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)
This study compares two medicines, Acalabrutinib and Ibrutinib, for people in the UK with a type of blood cancer called Chronic Lymphocytic Leukemia (CLL) that has been treated before. It wants to see which medicine works better at stopping the cancer from getting worse.
Chronic Lymphocytic LeukemiaGermany - Active not recruitingPHASE3
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial
This study is testing a new treatment for a type of stroke called 'intracerebral haemorrhage' (bleeding in the brain). Doctors want to see if giving a drug called rFVIIa soon after the stroke can reduce bleeding and improve recovery.
Intracerebral HemorrhageGermany - RecruitingPHASE2
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis
This study is testing a new medicine, AZD1163, for people with rheumatoid arthritis (RA) who haven't found enough relief from other treatments. It aims to see if the new medicine is safe and helps reduce RA symptoms.
Rheumatoid ArthritisGermany - RecruitingPHASE3
A Study of Daratumumab
This study offers ongoing access to specific treatments for people with multiple myeloma or smouldering multiple myeloma who have already benefited from them in previous studies. It helps ensure continued care and collects long-term safety information.
Multiple MyelomaGermany - Active not recruitingPHASE2
Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)
This study is testing new treatments for advanced bladder cancer. It compares a new drug, zelenectide pevedotin, alone and with pembrolizumab, against standard chemotherapy. We want to see how well these treatments work and if they are safe for people with bladder cancer that has spread.
Metastatic Urothelial CancerGermany - Recruiting
The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study
This study looks at how certain tiny markers in your blood might predict how well people recover after a spinal cord injury. Researchers will take blood samples over time and check how people's movement and daily function change.
Spinal Cord InjuryGermany - Active not recruiting
Registry for Patients Undergoing AUS Surgery for Female SUI Due to ISD
This study is looking at how well an operation for bladder leakage works in women. It's collecting information from different hospitals about women who have surgery for stress urinary incontinence caused by a weak bladder valve. They want to see how these women do over several years.
Urinary IncontinenceUrinary Incontinence, StressLower Urinary Tract SymptomsUrination DisordersGermany - Active not recruitingPHASE3
A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)
This study is looking at a new medicine called resmetirom for people with a type of liver scarring called NASH cirrhosis. It aims to see if the medicine can prevent serious liver problems or death over about three years, compared to a dummy pill.
NASHCirrhosis, LiverGermany - RecruitingPHASE2
A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
This study is looking at a new combination treatment for people with severe liver disease (cirrhosis) who have recently been in hospital. We want to see if combining two existing medicines, albumin and enoxaparin, is safe and helps improve outcomes after leaving the hospital.
Liver CirrhosisDecompensated Cirrhosis of LiverAcute on Chronic Liver Failure (ACLF)Germany - Enrolling by invitationNA
Alleviant ALLAY-HF Study
This study is for people with certain types of heart failure where their heart doesn't pump blood as well as it should. It's testing a new device, the Alleviant ALV1, which aims to improve how the heart works. Researchers want to see if it's safe and helps people feel better.
Heart FailureGermany - RecruitingPHASE2, PHASE3
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
This study is testing a new drug, iza-bren, for advanced triple-negative breast cancer or ER-low, HER2-negative breast cancer. It compares iza-bren with standard chemotherapy in patients who haven't had previous treatment for advanced disease and can't receive certain immunotherapy drugs.
Breast NeoplasmsGermany - RecruitingPHASE1
A Study of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis
This study looks at a new medicine called LY4256984 for people with ALS, also known as Motor Neurone Disease. We want to see if it's safe, what side effects it might cause, and how the body handles it. It's given as an injection into the spine.
ALS (Amyotrophic Lateral Sclerosis)Germany - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome
This study is testing a new medicine, Deucravacitinib, for adults with an active form of Sjögren's Syndrome. Researchers want to see if it's safe and effective compared to a dummy pill. It's a key step to finding better treatments for this autoimmune condition.
Sjögren's SyndromeGermany - Active not recruitingPHASE2
An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)
This study looks at the long-term safety of a medicine called zagociguat for people with MELAS syndrome. It's for patients who have already been part of a previous study. The medicine is taken daily, and we'll check how participants are doing over time.
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)Germany - Active not recruitingPHASE3
Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE
This study is looking at a new tablet, deucrictibant, to see if it can help prevent swelling attacks in people with Hereditary Angioedema (HAE). It includes adults and children aged 12 and over, comparing the new drug to a dummy pill (placebo).
Hereditary Angioedema (HAE)Germany - RecruitingNA
Apnoeic Oxygenation During Pediatric Tracheal Intubation
This study looks at whether giving extra oxygen through a thin tube during a child's anaesthetic helps keep their oxygen levels up. It aims to make anaesthesia safer for children aged up to 6 years old undergoing surgery, specifically reducing problems with low oxygen.
AnesthesiaAirway Complication of AnesthesiaAnesthesia; Adverse EffectGermany - Enrolling by invitation
Longitudinal Assessment of Pain-Related Patient-Reported Outcomes After Surgery
This study looks at how people feel in the first few weeks after surgery, especially regarding pain. It aims to understand pain, how it affects daily life, and if signs of nerve pain appear early on, to help improve care after patients go home.
Pain, PostoperativeAdultPain MeasurementFunctional StatusGermany - Active not recruiting
A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described
This study looks at how a medicine called darolutamide (Nubeqa) works in real life for men with prostate cancer that hasn't spread and has stopped responding to other treatments. Doctors have already decided these men will receive darolutamide.
Prostate CancerGermany - Recruiting
Efficacy, Safety & Utilisation of Nuwiq, Octanate and Wilate in Previously Untreated & Minimally Treated Haemophilia A Patients
This study looks at how well Octapharma's treatments (Nuwiq, Octanate, and Wilate) work in real life for children and young people with severe haemophilia A who haven't had much treatment before. It checks their safety and how they are used.
Haemophilia AGermany