Latest studies
- Recruiting
EPIDURAL- Evaluation of Preexisting Information Regarding Neuroaxial Procedures for Labour Analgesia
This study asks pregnant women about their understanding of pain relief options like epidurals before they talk to a doctor. It looks at where they get their information to help doctors know how to best explain these procedures.
Neuroaxial Analgesia ProceduresGermany - RecruitingPHASE2
Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in Curative mIDH1 Cholangiocarcinoma
This study is looking at a drug called ivosidenib for people with a type of bile duct cancer (cholangiocarcinoma) that has a specific gene change (IDH1 mutation). It aims to see if taking ivosidenib after standard chemotherapy and surgery can stop the cancer from coming back.
CholangiocarcinomaIDH MutationGermany - Recruiting
Evaluation of the Epilepsy-related Quality of Life, Seizure-related Accidents and Validation of the Mjn-SERAS Solution in the Normalised Patient Environment with Real-World Data
This study is testing a medical device called mjn-SERAS, designed to detect epileptic seizures early and give a warning. It's for people aged 12-65 in the UK, Spain, and Germany who have epilepsy that hasn't responded well to medication. The aim is to see if using the device improves their daily life.
Quality of LifeEpilepsy (treatment Refractory)Germany - Active not recruiting
International Post Market Surveillance Study of Intracranial Aneurysms Treated With an Endovascular Approach
This study looks at how well a special device, called a flow-diverting stent, works for treating brain aneurysms. It tracks how safe and effective these devices are in real-world use after they've been approved.
Intracranial AneurysmGermany - Active not recruitingPHASE3
A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD
This study looks at the long-term safety of a new medicine, itepekimab, for people with severe lung disease (COPD). It will also check if the medicine continues to help over time. Participants will have already been part of a previous study on this medicine.
Chronic Obstructive Pulmonary DiseaseGermany - Recruiting
CRICKET: Critical Events in Anaesthetised Kids Undergoing Tracheal Intubation
This study looks at issues during intubation (when a breathing tube is put in) for children aged 0-16 under anaesthesia. It aims to understand common problems and find ways to make the procedure safer for young patients in hospitals worldwide.
Intubation ComplicationAdverse EventsGermany - RecruitingPHASE1, PHASE2
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements
This study is looking at a new drug called repotrectinib for advanced cancers that have specific gene changes (ALK, ROS1, or NTRK). It aims to find the best dose and see how well it works in shrinking tumours and how safe it is.
Locally Advanced Solid TumorsMetastatic Solid TumorsGermany - Recruiting
Clinical Course Of Disease In Participants With FA-CM
This study looks at how a heart condition linked to Friedreich Ataxia (FA-CM) changes over time. It aims to understand how the heart gets worse and could lead to new gene therapy treatments in the future for people with FA-CM.
Friedreich AtaxiaCardiomyopathyGermany - Active not recruitingPHASE3
A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer
This study looks at a medicine called abemaciclib for people in the UK with a certain type of advanced lung cancer (non-small cell lung cancer) that has a specific gene change (KRAS mutation) and has come back after other treatments. It aims to see how safe and effective abemaciclib is.
Non Small Cell Lung CancerGermany - Active not recruitingPHASE2
Study of Olaparib (MK-7339) in Combination With Pembrolizumab (MK-3475) in the Treatment of Homologous Recombination Repair Mutation (HRRm) and/or Homologous Recombination Deficiency (HRD)-Positive Advanced Cancer (MK-7339-007/KEYLYNK-007)
This study is looking at a new combination treatment, olaparib and pembrolizumab, for adults with advanced cancers. It focuses on specific types of solid tumours that have certain genetic changes or deficiencies in how their cells repair themselves.
Solid TumorsGermany - RecruitingPHASE3
A Study of JNT-517 in Participants With Phenylketonuria (PKU)
This study is looking into a new tablet called JNT-517 for adults with Phenylketonuria (PKU). We want to see if it's safe, how well it works, and how the body handles it. You might take JNT-517 or a dummy pill called a placebo.
PhenylketonuriaGermany - Active not recruitingPHASE3
A Study of Guselkumab in Participants With Active Psoriatic Arthritis
This study is looking at a new medicine called guselkumab for people with psoriatic arthritis. It aims to see how well it reduces pain, swelling, and other symptoms compared to a dummy treatment, and if it helps improve their condition.
Arthritis, PsoriaticGermany - RecruitingPHASE2
Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA)
This study looks at combining a treatment called faecal microbiota transplant (FMT) with standard immunotherapy (Atezolizumab/Bevacizumab) for advanced liver cancer. We want to see if FMT can help the immunotherapy work better and if it's safe.
ImmunotherapyHCC - Hepatocellular CarcinomaGermany - Not yet recruitingNA
Efficacy and Safety of Synchronized Cardiac Support in Cardiogenic Shock Patients
This study looks at a special heart support system called Synchronized Cardiac Support (SCS) for people with severe heart failure (cardiogenic shock). It aims to see if SCS, used with a machine called VA ECMO, is safe and helps improve heart function by reducing a chemical called lactate in the blood.
Cardiogenic ShockExtracorporeal Membrane OxygenationECLSVA ECMOGermany - Recruiting
Clinical Study for the Investigation and Validation of a Therapy Procedure for the Adjustment of Risk Factors in Patients With Coronary Heart Disease by Means of Digital Therapy Control
This study is testing a new digital health app called iATROS. It aims to help people with heart disease manage their health better by tracking risk factors on their smartphone. We want to see if it works as well as, or better than, standard care.
Coronary Artery DiseaseCardiovascular DiseasesCoronary Heart DiseaseIschemic Heart DiseaseGermany - RecruitingPHASE4
A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE)
This study looks at a medicine called Belimumab for people with Systemic Lupus Erythematosus (SLE), also known as lupus. It aims to see how well and how safely it works over three years in people who have had lupus for a short time and whose current treatment isn't fully controlling their symptoms.
Systemic Lupus ErythematosusGermany - Available
Expanded Access Program (EAP) for Ciltacabtagene Autoleucel (Cilta-Cel) Out-of-Specification (OOS) in Participants With Multiple Myeloma
This program offers a special cell therapy called cilta-cel to people with a type of blood cancer called multiple myeloma. It's for patients who can't get this treatment elsewhere and for whom regular cilta-cel or other treatments aren't suitable.
Multiple MyelomaGermany - Not yet recruitingNA
Expectation Effects on Emotional Processing
This study looks at how your expectations and past experiences affect how you process emotions. Researchers are using a nasal spray and brain scans to understand why positive expectations might improve mood and how your brain reacts to happy faces.
Expectation Effects on Emotional ProcessingGermany - RecruitingNA
Early Versus Late Initiation of ECMO (Extracorporal Membrane Oxygenation) Trial (ELIEO-Trial)
This study looks at treating severe lung failure (ARDS) with a special life support machine called ECMO. Doctors want to see if starting ECMO early works better than trying other treatments first.
Acute Respiratory Distress SyndromeGermany - Active not recruiting
Data-driven Development of a Core Dataset for Difficult Airway Alerts
This study is developing a better way to record important information about patients' airways during anaesthesia. It aims to create a clear, easy-to-use digital system to help doctors plan future procedures, making them safer, especially for people who have had airway problems before.
Airway ManagementIntubation; Difficult or FailedAirway Complication of AnesthesiaGermany - Active not recruitingPHASE2
A Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Itacitinib
This study is for people already taking the drug itacitinib in other Incyte studies. It allows them to continue getting the treatment if it's helping and they are tolerating it well. It's for conditions like myelofibrosis, lung transplant problems, and chronic graft-versus-host disease.
MyelofibrosisPostlung Transplant (Bronchiolitis Obliterans)Chronic Graft Versus Host DiseaseGermany - Not yet recruitingNA
Catheter Ablation for AF in Patients With Severe Mitral Regurgitation After Successful Transcatheter Mitral-Valve Repair
This study looks at whether a heart procedure called catheter ablation helps patients who have irregular heartbeats (AF) and have recently had a repair for a leaky heart valve. It compares ablation to usual care to see which is better at preventing serious heart problems.
Atrial Fibrillation (AF)Mitral Valve (MV) RegurgitationGermany - Active not recruitingPHASE1
A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3
This study is for adults with a brain tumour called glioma, where previous treatments haven't worked. It's looking to find the safest highest dose of a new drug, BI 764532, which helps your immune system fight the cancer.
GliomaGermany - Recruiting
Post-market Surveillance Study to Evaluate the Quality of Life and the Safety and Effectiveness of the TIGR® Matrix After Reconstructive Breast Surgery
This study looks at the quality of life, safety, and effectiveness of a special mesh (TIGR® Matrix) used in breast reconstruction surgery after mastectomy. It aims to see how patients feel and if the mesh works well and is safe.
Implant Based Breast ReconstructionGermany - Recruiting
A Study on the Tolerability, Safety and Effectiveness of Asciminib in Patients With Philadelphia Chromosome-positive Chronic Myeloid Leukemia in the Chronic Phase in Germany
This study in Germany looks at how well a medicine called asciminib works for people with a type of blood cancer called chronic myeloid leukemia (CML), specifically if they have a special 'Philadelphia chromosome' gene. It compares it to other treatments for newly diagnosed or previously treated patients.
Leukemia, Chronic MyeloidGermany - RecruitingNA
Auricular Acupuncture in Patients With Advanced Cancer: a Randomized Clinical Trial.
This study is looking at how a type of ear acupuncture, called ear acupressure, might help people with advanced cancer. It aims to see if it can improve how they feel overall, and if it helps with common problems like tiredness, pain, feeling down, and sleep issues.
FatiguePainDepressionAdvanced Tumour DiseasesGermany - RecruitingPHASE1
Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes
This study looks at a new medicine, NNC0487-0111, for adults with Type 2 diabetes. It aims to understand how this medicine affects how your body uses insulin and how well your pancreas works to control blood sugar.
Diabetes MellitusGermany - Recruiting
METABolic Deterioration in HTX Determines Outcomes
This study looks at how your body's metabolism changes after a heart transplant. Researchers want to understand if these changes affect your new heart and your long-term health, hoping to find better ways to care for transplant patients.
Heart TransplantationGermany - RecruitingNA
MacuTherm Performance Study in Patients With iAMD
This study looks at a new light treatment called photothermal therapy for people with intermediate Age-related Macular Degeneration (iAMD). We want to see if this treatment can help protect vision cells and slow down the worsening of iAMD.
Intermediate AMDGermany - RecruitingNA
Using Neurofeedback to Understand the Relationship Between Stress and Alcohol Consumption
This study looks at how stress affects alcohol cravings and drinking. We're using brain scans to understand how different brain parts are involved. If you drink problematically and want to understand how stress impacts your habits, this study might be for you.
Alcohol AbuseCravingPsychosocial StressorNeural Stress ResponseGermany - RecruitingPHASE2
Discontinuation of CDK4/6 Inhibitors in Patients With Metastatic HR Positive, HER2 Negative Breast Cancer
This study looks at whether some women with advanced breast cancer, already doing well on certain treatments, can safely stop one of their medicines (CDK4/6 inhibitors) and continue with other hormone therapy. The aim is to see if they can maintain control over their cancer without it.
Breast CancerGermany - Recruiting
Post-Market Registry for the Evaluation of RefluxStop in GERD Treatment
This study looks at how well a device called RefluxStop works for heartburn and acid reflux, compared to standard surgery. It checks its safety and how well it helps people with long-term acid reflux.
Gastroesophageal Reflux Disease (GERD)Germany - Recruiting
Mitochondrial Substrate Utilization in the Diabetic Human Heart
This study looks at how diabetes affects the heart's energy use, especially in people with heart failure. Researchers want to understand why diabetes leads to heart problems, hoping to find better ways to diagnose and treat them early.
Heart FailureType2diabetesInsulin ResistanceMitochondrial DiseasesGermany - RecruitingPHASE4
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
This study looks at whether a special dye called gadolinium, used in MRI scans, affects how people move or think when they have it many times over five years. It compares people who get the dye with those who don't.
Motor FunctionCognitive FunctionContrast MediaGermany - Enrolling by invitationNA
Decrease Caregiving Fatigue in Group Leaders of a Support Group for Women After Cancer
This study looks at a special online course for leaders of cancer support groups. It aims to see if self-compassion training can help them feel less tired and stressed, and learn to be kinder to themselves while supporting others.
Caregiver BurdenGermany - Enrolling by invitation
Accuracy of Prediction Equations to Calculate Maximum Strength
This study is looking for better ways to measure how strong someone is, especially in older adults. It's trying to find an easier and safer method than the usual "one-rep max" test, which can be tough. The goal is to make resistance exercise safer and more effective for everyone.
Healthy AgingGermany - Active not recruitingPHASE3
Durvalumab With or Without Olaparib as Maintenance Therapy After First-Line Treatment of Advanced and Recurrent Endometrial Cancer
This study is looking into new ways to treat advanced or recurrent womb cancer. We're testing a combination of medicines called durvalumab and olaparib, given after initial chemotherapy, to see if they can help patients live longer and better.
Endometrial NeoplasmsGermany - Active not recruitingPHASE2
Efficiency of Vaccination with Lysate-loaded Dendritic Cells in Patients with Newly Diagnosed Glioblastoma
This study looks at a new vaccine to treat a serious type of brain tumour called glioblastoma. It combines a special vaccine made from your own tumour cells with standard treatments to see if it helps people live longer.
GlioblastomaGermany - Recruiting
Giessen Pulmonary Hypertension in Lung Cancer Registry
This study looks at how often high blood pressure in the lung arteries (pulmonary hypertension) affects people with lung cancer. Doctors will use information from patients already being treated at Giessen University Hospital to understand this better.
Pulmonary Hypertension Due to Lung Diseases and HypoxiaGermany - RecruitingPHASE2
A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM)
This study looks at a new way to give belantamab mafodotin, along with other common medicines, for multiple myeloma that has come back or isn't responding well. We want to see if giving it less often can still work well and cause fewer eye side effects.
Multiple MyelomaGermany - Recruiting
Biological Determinants and Neural Compensation of Dysphagia in Parkinson's Disease
This study looks into why people with Parkinson's disease have trouble swallowing. Researchers want to understand the brain and body changes that cause this, hoping to find better ways to help patients and improve their quality of life.
Parkinsons Disease (PD)Oropharyngeal DysphagiaGermany - RecruitingPHASE2
T-cell Therapy in Patients With PML
This study is testing a new cell therapy for PML, a serious brain infection. It aims to see if this treatment, involving special immune T-cells, is safe and can improve patients' health and quality of life. There's currently no standard cure for PML.
Progressive Multifocal Leucoencephalopathy (PML)Germany - RecruitingPHASE1, PHASE2
Intracochlear Application of VSF1.01 for the Reduction of Cochlear Implant Surgery Related Trauma
This study looks at a new treatment called VSF1.01 for people getting a cochlear implant. It aims to see if VSF1.01 can make the surgery safer and help protect the inner ear. We also want to know if it improves hearing.
Hearing LossGermany - Recruiting
Endovascular Recanalization for Symptomatic Chronic Intradural Occlusions
This study looks at a procedure called endovascular recanalisation to open up blocked arteries in the brain. It's for people who have had a stroke or are at risk because of narrowed brain arteries. The study wants to see how safe and effective this treatment is.
Intracranial StenosisIntracranial Atherosclerotic DiseaseGermany - Active not recruiting
Retrospective Data Analysis PelviGYNious/EndoGYNious
This study looks back at patient records to check how safe and effective two medical devices, PelviGYNious and EndoGYNious, have been. These devices are used to treat pelvic organ prolapse, a condition where pelvic organs can drop or bulge.
ProlapseSacrocolpopexyPelvic Organ Prolapse (POP)Germany - Recruiting
Intelligent Lung Support in the Intensive Care Unit
This study looks at a new AI-powered computer program called IntelliLung. It helps doctors set up breathing machines for very ill patients in intensive care. Researchers want to see how closely doctors' choices match the program's suggestions to help patients breathe better.
Mechanical VentilationIntensive Care MedicineGermany - Recruiting
Analysis of TPE Treatments With multiFiltratePRO
This study looks at how well a special filtering machine, called multiFiltratePRO, works for people with autoimmune diseases. It checks how effectively the machine removes harmful substances from the blood, aiming to improve treatments like therapeutic plasma exchange (TPE).
Autoimmune DiseasesGermany - Active not recruiting
Rate of Progression in EYS Related Retinal Degeneration
This study aims to understand how an eye condition called EYS-related retinitis pigmentosa progresses over time. Researchers want to learn more about how it affects vision to help develop treatments in the future. It involves monitoring people with EYS gene mutations for four years.
Retinitis PigmentosaEye DiseasesGermany - Active not recruiting
Post Market Clinical Follow Up of LEGION™ Primary TKS With VERILAST™
This study is looking at how well a new type of knee replacement, called LEGION™ Primary TKS with VERILAST™, works for people with joint problems. It compares its results to older knee replacements to see if it's safe and effective in the long run.
Degenerative Joint DiseaseGermany - Recruiting
Master Framework For Relapse or Refractory Acute Myeloid Leukemia
This study looks at how people with acute myeloid leukaemia (AML) respond to treatment when their cancer comes back or doesn't respond well to initial therapy. It collects important real-world information to help improve care for patients across Europe.
Acute Myeloid Leukemia, in RelapseAcute Myeloid Leukemia RefractoryGermany