Latest studies
- RecruitingHuman Pharmacology (Phase I)- Other
A study to test different doses of BI 765049 in people with advanced cancer of the colon, rectum, stomach, or pancreas
This early-stage clinical trial tests a new drug called BI 765049. It is for adults with advanced cancer of the bowel, stomach, or pancreas. Doctors want to find out what dose is safe, learn how the body handles the drug, and look for any early signs that it helps.
colorectal carcinoma (CRC)Germany - Completed
Magnet4Europe - Improving mental health and wellbeing in the health care workplace
Hospital staff often face heavy workloads and stress. Magnet4Europe is a study testing a new way of organising hospital work to improve doctors' and nurses' mental health and wellbeing. By taking short yearly surveys, staff help researchers see if redesigning workplace culture makes hospital care safer and workplaces happier.
The impact of organizational redesign of acute care hospitals according to the Magnet© principles of organizational redesign on mental health and wellbeing of health professionalsGermany - Completed
A study to evaluate diagnostic tests used at the point of care for improving antibiotic prescribing for patients with respiratory tract infections in primary care in Europe
Antibiotics treat bacterial infections, but taking them when not needed makes them less effective over time. This European study checks whether rapid clinic tests can help GPs decide if patients with coughs or sore throats truly need antibiotics, safely cutting down unnecessary prescriptions without harming patient recovery.
Community-acquired acute respiratory tract infectionGermany - CompletedPhase III
A study comparing talquetamab in combination with daratumumab or in combination with daratumumab and pomalidomide versus daratumumab in combination with pomalidomide and dexamethasone in participants with multiple myeloma that returns after treatment or is resistant to treatment
This study tests whether a new medicine called talquetamab, given alongside other cancer drugs, helps people with multiple myeloma that has returned or stopped responding to past treatments. Researchers want to see if these new combinations keep the cancer under control for longer than the current standard treatment.
Relapsed or refractory multiple myelomaGermany - RecruitingPhase II
A Phase Ib/II, open-label study of amivantamab monotherapy and amivantamab in addition to other therapeutic agents in participants with head and neck squamous cell carcinoma
This study tests a targeted drug called amivantamab for head and neck cancer. Doctors want to see if giving amivantamab on its own or alongside other cancer drugs works well to shrink tumours and is safe for patients whose cancer has spread, returned, or requires surgery.
Head and neck squamous cell carcinomaGermany - RecruitingPhase II
A study to learn if ZED1227 can improve continued celiac disease symptoms despite a gluten-free diet
This study is testing a new capsule called ZED1227 for adults with coeliac disease. Researchers want to see if this medicine can protect the gut and ease lingering tummy symptoms caused by accidental gluten exposure, even in people who already follow a strict gluten-free diet.
Coeliac diseaseGermany - RecruitingPhase I/II
A trial looking at different treatments for neuroblastoma which has come back after initial therapy
The BEACON2 trial is testing new combinations of cancer medicines for children and young people whose neuroblastoma has returned or worsened after initial treatment. The goal is to find out which drug combinations are safest and work best to control the disease and improve future care.
Relapsed NeuroblastomaGermany - CompletedPhase III
A randomized, open-label phase 3 study of amivantamab + FOLFIRI versus cetuximab/bevacizumab + FOLFIRI in participants with KRAS/NRAS and BRAF wildtype recurrent, unresectable or metastatic colorectal cancer who have received prior chemotherapy
This clinical trial is testing a new targeted drug, amivantamab, combined with chemotherapy for people with advanced bowel cancer. Researchers want to see if this combination works better at slowing cancer growth and helping people live longer than current standard targeted treatments after their first chemotherapy has stopped working.
Recurrent, unresectable or metastatic colorectal cancerGermany - CompletedPhase I
CAR T cells to fight acute myeloid leukaemia
This Phase I clinical trial tests a new cell therapy called BE-CAR33 for children and teenagers with acute myeloid leukaemia that has returned. Researchers use modified donor immune cells to clear out cancer cells before a planned stem cell transplant, aiming to keep the leukaemia from coming back.
Paediatric relapsed CAR33+ acute myeloid leukaemiaGermany - RecruitingPhase I
A study of JNJ-95804306 for relapsed or refractory hematological malignancies
This early-stage clinical trial is testing a new medicine called JNJ-95804306 for adults with blood cancers that have returned or stopped responding to standard treatments. Doctors want to find safe doses and check how well the body handles the drug when given alone or with other cancer therapies.
Hematologic neoplasms, blood cancerGermany - CompletedPhase II
Testing new medicine for adults with Cystic Fibrosis who do not have access to the currently available CFTR-modulating drugs due to genetic mutations
This clinical trial tests a new three-in-one medicine for adults with cystic fibrosis who have rare genetic mutations. These patients cannot access currently approved treatments. Researchers are checking whether this daily combination of capsules can safely improve lung health after promising results in laboratory tests using patient cell samples.
Treatment of Cystic Fibrosis (CF) in patients with CFTR mutations who are responders in the organoid assayGermany - RecruitingNot Applicable
Safety and performance of the Nurotron CS-30A cochlear implant system in adults with hearing loss
This study looks at how safe and effective the Nurotron CS-30A cochlear implant is for adults with severe hearing loss in both ears. It aims to see how well the device helps people hear and understand speech when ordinary hearing aids are no longer enough.
Post-lingual severe-to-profound bilateral sensorineural hearing loss in adultsGermany - RecruitingPHASE2, PHASE3
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
This study looks at a new medicine called ponsegromab for advanced pancreatic cancer that has spread, especially when patients have lost a lot of weight and feel very tired. It aims to see if adding ponsegromab to standard chemotherapy helps more than chemotherapy alone.
CachexiaMetastatic Pancreatic Ductal AdenocarcinomaGermany - RecruitingPHASE3
A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
This study looks at new ways to treat type 2 diabetes by testing two medicines, Elecoglipron and Dapagliflozin, both on their own and together. Researchers want to see how well they work and if they are safe for adults with type 2 diabetes.
Type 2 Diabetes MellitusGermany - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes
This study looks at a new medicine called enicepatide for people who are overweight or have obesity and also have type 2 diabetes. We want to see if it helps with weight loss and if it's safe to use.
Obesity or OverweightType 2 Diabetes MellitusGermany - RecruitingPHASE3
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
This study is testing a new medicine, Elecoglipron, for adults with type 2 diabetes and kidney problems. It compares Elecoglipron to a dummy pill (placebo) to see if it's safe and effective when taken with other usual diabetes medicines, including dapagliflozin.
Type 2 Diabetes MellitusType 2 Diabetes With Chronic Kidney DiseaseGermany - RecruitingPHASE3
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
This study compares a new medicine, Elecoglipron, to an existing one, Semaglutide, for adults with Type 2 Diabetes. It aims to see if the new drug is safe and effective for people whose diabetes isn't well-controlled and who have a higher risk of heart problems.
Type 2 Diabetes MellitusGermany - RecruitingPHASE3
A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)
This study, called DLLEVATE, is looking at a new treatment, ZL-1310, for people with small cell lung cancer that has come back. It compares ZL-1310 to other standard treatments to see if it's safe and works well. You might be eligible if you're over 18 and have had previous treatments.
Small-cell Lung CancerGermany - RecruitingPHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
This study is testing a new medicine, enicepatide, for people who are overweight or have obesity but do not have type 2 diabetes. It aims to see if the medicine helps with weight loss and if it's safe compared to a dummy medicine.
Obesity or OverweightGermany - RecruitingPHASE3
A Study to Compare Elritercept to Placebo in Adults With Myelofibrosis and Anemia Who Are Taking Ruxolitinib
This study looks at a new drug, elritercept, for people with myelofibrosis and anaemia who are already taking ruxolitinib. It compares elritercept to a dummy drug (placebo) to see if it improves anaemia and other symptoms, and how safe it is.
MyelofibrosisAnemiaGermany - Completed
Multi-centre European study of major infectious disease syndromes (MERMAIDS) – Acute respiratory infections
This study looks at acute chest and throat infections to understand why some people get much sicker than others. Researchers from the University of Oxford are collecting blood and swab samples from adults treated at GP surgeries or hospitals to help develop better, more personalised treatments for future infections.
Acute respiratory infectionsGermany - CompletedPhase II
A two-part study to assess the effectiveness, safety, and blood levels of repeat doses of inhaled ETD001 in people with cystic fibrosis
This study looks at a new inhaled medicine called ETD001 for adults with cystic fibrosis. The treatment aims to loosen sticky lung mucus to help make breathing easier. Researchers want to see if the medicine is safe, well tolerated, and improves lung function when taken alongside usual daily care.
Cystic fibrosisGermany - Recruiting
Development and Multi-Centre Validation of a Novel Non-Invasive Melanoma Molecular Diagnostic Test
Researchers are testing a gentle sticky-tape test to detect melanoma, a serious skin cancer. Currently, doctors must cut away suspicious moles to test them. This study investigates whether simple skin tape can accurately collect cells and spot cancer markers, potentially saving many patients from having unnecessary minor surgery in the future.
MelanomaGermany - RecruitingPHASE2, PHASE3
A Safety and Efficacy Study of hu14 in High-Risk Neuroblastoma Patients
This study is testing a new treatment called hu14.18K322A, given with chemotherapy, for children and young people with a type of cancer called high-risk neuroblastoma. It aims to see if this combination treatment is safe and effective in fighting the cancer.
High-Risk NeuroblastomaGermany - RecruitingPHASE3
An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.
This study looks at a new treatment called AAA617 for men with early-stage prostate cancer that has spread a little (oligometastatic). It compares AAA617 to careful watching, to see if it can stop the cancer from growing and help men live better for longer.
Oligometastatic Prostate Cancer (OMPC)Germany - RecruitingPHASE2
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
This study is testing a new medicine called belzutifan for certain types of advanced cancers, including rare adrenal gland, gut, and kidney cancers. We want to see how well it works and if it's safe for people aged 12 and over.
Pheochromocytoma/ParagangliomaPancreatic Neuroendocrine TumorVon Hippel-Lindau DiseaseAdvanced Gastrointestinal Stromal TumorGermany - Completed
To compare the Efficacy of additional Tumor DebulKing Surgery versus chemotherapy alone in recurrent Platinum-sensitive Ovarian cancer
This study looks at whether having a second surgery helps women whose ovarian cancer has returned. Half of the participants have an operation to remove tumours followed by chemotherapy, while the other half receive standard chemotherapy alone. The aim is to find out if extra surgery helps patients live longer.
Ovarian CancerGermany - RecruitingPhase III
Phase 3, randomised, double-blind, placebo- controlled, 3-arm study to investigate the safety and efficacy of efimosfermin alfa in participants with biopsy-confirmed F2- or F3-stage metabolic dysfunction-associated steatohepatitis (MASH) (ZENITH-1)
This clinical trial is testing a new injection called efimosfermin alfa for people with metabolic dysfunction-associated steatohepatitis (MASH), an inflamed fatty liver condition. Researchers want to see if monthly injections over four years can safely reduce liver fat, ease inflammation, and improve liver scarring compared to a dummy treatment.
Medical condition: Metabolic Dysfunction-Associated Steatohepatitis (MASH) Medical condition in lay language: Metabolic Fatty Liver Inflamation Therapeutic areas: Diseases [C] - Nutritional and Metabolic Diseases [C18]Germany - Completed
Evaluation of a dermocosmetic regimen for acne-prone skin in volunteers with mild, moderate or severe skin conditions
Acne is a common skin condition that affects confidence and well-being. This study tests whether a daily skincare routine using Eucerin products helps clear mild to severe spots. Researchers want to see how well these creams work over a year in people aged 12 to 50 across the UK and worldwide.
Subjects with acne-prone skin aged 12-50 years with Investigator's Global Assessment (IGA) grades 2-4, evaluating treatment of mild to severe acne vulgaris.Germany - RecruitingPhase III
A study of JNJ-78934804 in participants with moderately to severely active Crohn's disease
This clinical trial is testing a new combination medicine, JNJ-78934804, for moderate to severe Crohn’s disease. It combines two drugs into one injection to target gut inflammation. Researchers want to see if this two-in-one approach works better than a single medicine for people whose previous treatments have stopped working.
Crohn’s diseaseGermany - RecruitingHuman Pharmacology (Phase I)- Other
A Phase 1, Open-Label, Multicenter Study of INCB160058 in Participants With Myeloproliferative Neoplasms.
This early-stage clinical trial is testing a new experimental medicine called INCB160058 for adults with myeloproliferative neoplasms (rare blood disorders). The main aim is to find out if the drug is safe, learn how the body handles it, and see what the best dose might be for future treatment.
Myeloproliferative NeoplasmsGermany - RecruitingTherapeutic exploratory (Phase II)
C1071003 - MAGNETISMM-3, An Open-Label, Multicenter, Non-Randomized Phase 2 Study of Elranatamab (PF-06863135) Monotherapy in Participants With Multiple Myeloma Who Are Refractory to at Least One Proteasome Inhibitor, One Immunomodulatory Drug and One Anti-CD38 Antibody
This clinical trial is testing a new medicine called elranatamab for adults with multiple myeloma. It is designed for people whose cancer has returned or stopped responding after trying three standard types of treatment. The aim is to find out how well the drug works on its own.
Multiple myelomaGermany - CompletedPhase III
Prevention of complications to Improve outcome in elderly patients with acute stroke - A randomised clinical trial
This clinical trial looks at whether giving common medicines right after a stroke can prevent complications like fever, sickness, and chest infections before they start. Researchers want to see if treating older adults early with paracetamol, antibiotics, or anti-sickness medicine helps them recover better and stay independent.
Acute ischaemic stroke or intracerebral haemorrhageGermany - AuthorisedTherapeutic use (Phase IV)
Sample Collection Study to Monitor the Risk of Malignancy Due to Insertional Oncogenesis in Early Onset Patients with Metachromatic Leukodystrophy Treated with OTL-200 in the Clinical Development Program
This study monitors the long-term safety of a gene therapy called Libmeldy in adults treated for metachromatic leukodystrophy (MLD). Doctors collect blood and tissue samples to check for very rare risks, such as abnormal cell growth or cancer, helping to ensure the treatment remains safe over time.
Metachromatic leukodystrophyGermany - AuthorisedPhase II and Phase III (Integrated)
A Prospective, Randomized, Controlled, Multinational, Phase 2/3, Open-Label Trial to Evaluate the Efficacy and Safety of SIL204-SL Administered as an Integrated Therapeutic Regimen in Combination with Chemotherapy vs. Chemotherapy Treatment Alone in Participants with Locally Advanced Pancreatic Cancer
This study looks at a new drug, SIL204-SL, combined with standard chemotherapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. Researchers want to find out if adding this new treatment helps people live longer, slows tumour growth, and maintains quality of life compared to chemotherapy alone.
Non-Resectable Locally Advanced Pancreatic Cancer (LAPC)Germany - Completed
A multi-site observational study looking at the risk factors associated with tooth sensitivity, receding gums and tooth wear
This study looks into why adults develop sensitive teeth, receding gums, and worn tooth enamel. Researchers are studying how diet, brushing, and lifestyle affect oral health across Europe. Taking part is simple: it involves completing a short lifestyle survey and having a gentle mouth check-up during a single dental appointment.
Dentine hypersensitivity Tooth wear Recession Clinical loss of attachment Oral hygiene habits Dietary habitsGermany - AuthorisedTherapeutic confirmatory (Phase III)
Colchicine after Electrocardioversion for Atrial Fibrillation - The COLECTRO-AF Trial
This study looks at whether an anti-inflammatory medicine called colchicine can help keep your heartbeat regular after an electrical cardioversion. Cardioversion is a routine treatment that resets the heart's rhythm. Researchers want to see if taking colchicine daily for six months stops atrial fibrillation from returning better than a dummy pill.
Atrial FibrillationGermany - AuthorisedTherapeutic exploratory (Phase II)
A Master Protocol of a Phase II, Open-label, Multicenter, Global Platform Study to Evaluate the Safety and Efficacy of Immunotherapy With or Without Other Anticancer Drugs in Participants with Unresectable Stage III Non-small Cell Lung Cancer Planning to Undergo Concurrent Chemoradiotherapy (AQUARIUS)
This clinical study tests a new immunotherapy drug called rilvegostomig for adults with stage 3 non-small cell lung cancer that cannot be removed by surgery. Researchers want to see if adding it to standard chemotherapy and radiotherapy is safe and helps control the cancer better.
Non-small Cell Lung CancerGermany - AuthorisedTherapeutic confirmatory (Phase III)
Efficacy and safety of Dalbavancin in the treatment of infective Endocarditis caused by gram-positive cocci
This study compares a long-acting antibiotic called dalbavancin with standard antibiotic treatments for adults who have a serious heart infection called infective endocarditis. Researchers want to see if dalbavancin is just as effective and safe, potentially reducing the time patients need to spend hooked up to hospital drips.
Infectious endocarditis caused by Gram-positive cocci (staphylococci,enterococci, streptococci)Germany - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
Phase 1-2, Open-Label, Single and Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION337 in Patients with Dravet Syndrome
This early clinical trial is testing an experimental medicine called ION337 for people with Dravet syndrome. Researchers want to find out if the drug is safe, how the body handles it, and whether it can help reduce the number of major seizures patients experience.
Dravet SyndromeGermany - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3 Multicenter Double-blind Randomized Study of Taletrectinib Versus Placebo in Patients With ROS1-Fusion Positive Stage IB-IIIA Non-Small Cell Lung Cancer Who Have Undergone Complete Tumor Resection
This clinical trial looks at whether a targeted medicine called taletrectinib can stop lung cancer from returning. It is for adults who have had surgery to completely remove non-small cell lung cancer with a specific gene change known as ROS1. Participants take either taletrectinib capsules or dummy capsules.
Non Small Cell Lung Cancer (NSCLC)Germany - AuthorisedTherapeutic confirmatory (Phase III)
A Long-term Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder for Treatment of Pulmonary Hypertension Associated with Interstitial Lung Disease
This study tests an inhaled dry powder medicine called treprostinil palmitil for adults with high blood pressure in the lungs linked to lung scarring. The trial lasts up to two years to see if the medicine is safe and helps improve breathing, walking ability, and overall quality of life.
Pulmonary Hypertension Associated with Interstitial Lung DiseaseGermany - AuthorisedTherapeutic confirmatory (Phase III)
AugmENtation witH cAnnabidiol iN first episode psyChosis: a doublE blind randomised controlled trial (STEP-ENHANCE Trial)
This clinical trial looks at whether cannabidiol (CBD) can help people experiencing psychosis for the first time. Participants take either CBD liquid or a harmless dummy medicine alongside their standard care for six weeks. Researchers want to see if adding CBD helps reduce symptoms and improves overall recovery.
First Episode Psychosis (FEP)Germany - AuthorisedHuman Pharmacology (Phase I)- First administration to humans
Nasal application of Staphylococcus lugdunensis for decolonization of Staphylococcus aureus – a first-in-human proof-of-concept microbiome intervention study
This early-stage study looks at using a helpful type of bacteria in the nose to clear out a common germ called Staphylococcus aureus. Researchers want to see if this natural approach is safe and whether it can stop the germ from living inside the nose without needing standard antibiotics.
Persistent or intermitting colonization of the nose with Staphylococcus aureusGermany - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Surovatamig in Adults with Antibody-mediated Kidney Disease
This study tests a new medicine called surovatamig for adults with kidney disease caused by the immune system. Doctors want to see if it is safe and can lower protein leaking into the urine, which helps protect kidney function. Everyone in the trial receives the active study medicine.
Antibody-mediated Kidney DiseaseGermany - RecruitingTherapeutic exploratory (Phase II)
A Phase IIb, randomised, double-blind, placebo-controlled, multicentre study to evaluate the efficacy and safety of concomitant use of eplontersen and ALXN2220 compared with eplontersen and placebo in adult participants with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM).
This clinical trial looks at whether combining two medicines, eplontersen and ALXN2220, is safe and effective for adults with a heart condition called ATTR-CM. Researchers want to find out if using both treatments together helps improve breathing, exercise fitness, and overall heart health better than taking eplontersen with a dummy drug.
Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)Germany - AuthorisedTherapeutic exploratory (Phase II)
Randomized Phase II study of multi-peptide vaccination and bispecific PSMAxCD3 antibody treatment in patients with biochemical relapse of prostate cancer
This Phase II trial tests an immunotherapy combination for men whose prostate cancer might be returning. It combines a cancer vaccine with a specialised antibody. The study aims to see if training the body's immune system can safely destroy lingering prostate cancer cells and stop PSA levels from rising.
biochemical relapse of prostate cancerGermany - AuthorisedTherapeutic exploratory (Phase II)
Randomized Controlled Trial Assessing the Effectiveness and Safety of Fecal Microbiota Transfer for VRE Eradication in Immunocompromised Patients (EU CTR, Phase II) – VRE-ex
This study tests whether a treatment called gut microbiota transfer can clear a stubborn gut bug called VRE in people with weakened immune systems. Participants receive either the real treatment or a dummy medicine to see if introducing healthy gut bacteria safely removes the bug.
Intestinal colonization with vancomycin-resistant enterococci (VRE)Germany - AuthorisedTherapeutic confirmatory (Phase III)
A Phase 3b, Open-Label Study of Crinecerfont to Evaluate Androgen Reduction and Related Outcomes in Adults With Classic Congenital Adrenal Hyperplasia
This clinical trial is studying a medicine called crinecerfont for adults with classic congenital adrenal hyperplasia (CAH). CAH causes the body to make too much male hormone. Researchers want to see if this daily medicine can safely lower these hormone levels over 24 weeks without needing high steroid doses.
Classic Congenital Adrenal Hyperplasia (CAH)Germany - AuthorisedTherapeutic confirmatory (Phase III)
An Open-Label, Phase 3 Study to Evaluate the Efficacy and Safety of Salanersen (BIIB115) in Participants Aged 15-60 Years With Spinal Muscular Atrophy Who Are Either Treatment-Naïve or Have Previously Been Treated With Risdiplam
This phase 3 study tests an investigational medicine called salanersen (BIIB115) for people aged 15 to 60 with spinal muscular atrophy (SMA). Researchers want to see if it helps improve physical movement, arm strength, and walking ability over time in people new to treatment or previously treated with risdiplam.
Spinal Muscular AtrophyGermany