Latest studies
- Active not recruitingPHASE3
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
This study is looking at a new medicine called Olezarsen for people with very high triglyceride levels. It's an ongoing study for those who have already started the treatment in previous trials, checking its long-term safety and how well it's tolerated.
Severe HypertriglyceridemiaRomania - Active not recruitingPHASE3
A Trial to Assess Efficacy and Safety of Octreotide Subcutaneous Depot in Patients With GEP-NET
This study is testing a new medicine, CAM2029, for a type of cancer called GEP-NET. It compares CAM2029 to existing treatments, octreotide LAR and lanreotide ATG, to see if it's more effective and safe for advanced GEP-NET.
Gastro-enteropancreatic Neuroendocrine TumorRomania - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis
This study is looking at a new treatment called Ocrelizumab for primary progressive multiple sclerosis (PPMS). It compares Ocrelizumab to a dummy drug (placebo) to see how safe and effective it is for adults, including those who have had PPMS for a while.
Multiple Sclerosis, Primary ProgressiveRomania - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)
This study looks at a new drug, claseprubart, for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). It aims to see if the drug helps people with CIDP and if it's safe. Some participants will receive the drug, and others a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathyRomania - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
This study is looking at a new medicine called KarXT + KarX-EC to see if it can help improve memory and thinking skills in people with Alzheimer's disease. It also checks if the medicine is safe to use. Some people will get the active medicine, others a dummy pill.
Alzheimer's DiseaseRomania - RecruitingPHASE3
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
This study looks at the long-term safety of a new medicine, ianalumab, for people with lupus. It's for those who have already been in an earlier ianalumab study and continues to check how safe and well the medicine is tolerated over time.
Systemic Lupus ErythematosusRomania - Active not recruitingPHASE3
A Study to Compare the Efficacy, Safety, Pharmacokinetics, and Immunogenicity Between SB27 and Keytruda in Subjects With Metastatic Non-squamous Non-small Cell Lung Cancer
This study compares a new drug, SB27, with an existing one, Keytruda, for advanced lung cancer. Both are given with chemotherapy. Researchers want to see if SB27 works as well as Keytruda for patients with non-small cell lung cancer that has spread.
Non-small Cell Lung Cancer Stage IVRomania - Active not recruitingPHASE1, PHASE2
A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100)
This study is testing a new medicine called sotorasib for people with specific advanced cancers carrying a KRAS p.G12C gene change. Researchers want to see if it's safe, how much to give, and if it helps shrink tumours. It's an early-stage trial looking for better cancer treatments.
KRAS p.G12C Mutant Advanced Solid TumorsRomania - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
An open label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study comparing Maribavir Tablets 200 mg, manufactured by Sun Pharmaceutical Industries Limited, India with LIVTENCITY® (Maribavir) Coated Tablets 200 mg, manufactured by: Catalent CTS, LLC Kansas City, United States of America, packed by: Takeda Ireland Limited Bray, Ireland, imported by: Takeda Pharma Ltda. Highway SP 340 S/N, km 133.5 Jaguariúna Administrative Building -SP CNPJ 60.397.775/0001-74 SAC: 0800 - 7710345, in healthy adult, human subjects under fasting condition.
This study compares a new version of the anti-viral medicine Maribavir (for adults in good health) with the original. It checks if both versions work the same way in the body when taken on an empty stomach. This helps ensure new medicines are just as effective.
Romania - Active not recruitingPHASE3
Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy
This study looks at new drug combinations for advanced liver cancer that hasn't been treated before. It compares cabozantinib with atezolizumab against a standard treatment, sorafenib, to see which works better and is safer.
Hepatocellular CarcinomaRomania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF ORAL OZANIMOD AS MAINTENANCE THERAPY FOR MODERATELY TO SEVERELY ACTIVE CROHN’S DISEASE
This study is looking into a new medication called Ozanimod for people with moderately to severely active Crohn's disease. Researchers want to see if it can help keep symptoms under control and reduce inflammation in the gut over time.
Moderately to Severely Active Crohn's DiseaseRomania - Active not recruitingPHASE3
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both
This study looks at a new medicine called CagriSema to see how well it lowers blood sugar and helps with weight loss in people with type 2 diabetes. It's compared to another medicine called tirzepatide. Participants will get one of the medicines by chance.
Diabetes Mellitus, Type 2Romania - Recruiting
CRS Questionnaire Validation Project
This study helps check if two new questionnaires accurately measure how severe and controlled chronic sinus problems (with or without nasal polyps) are, from a patient's viewpoint. Doctors across many countries are working together to validate them with 1000 patients.
Chronic Rhinosinusitis (CRS) With and Without Nasal PolypsRomania - RecruitingPHASE3
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
This study looks at a new drug, zilovertamab vedotin, combined with standard treatment for a type of blood cancer called diffuse large B-cell lymphoma (DLBCL). Researchers want to see if this new combination helps people live longer without their cancer growing or spreading, compared to standard treatment alone.
Diffuse Large B-Cell LymphomaRomania - RecruitingPHASE3
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
This study looks at a new drug, calderasib, for advanced bowel cancer with a specific genetic change (KRAS G12C). Researchers want to see if adding calderasib to standard treatments helps people live longer without their cancer growing.
Colon AdenocarcinomaRectal AdenocarcinomaRomania - RecruitingPHASE3
A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
This study is testing a new drug, Telisotuzumab Vedotin, against a standard treatment, Docetaxel, for advanced non-small cell lung cancer. It aims to see if the new drug works better and is safe for adults who have already had treatment.
Non Small Cell Lung CancerRomania - RecruitingPHASE2
A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
This study is testing a new medicine, FWY003, for an eye condition called Geographic Atrophy (GA), which is a severe form of Age-related Macular Degeneration (AMD). We want to see how well different doses of FWY003 work and if they are safe compared to a dummy medicine (placebo).
Geographic Atrophy Secondary to Age-related Macular DegenerationRomania - Active not recruitingPHASE3
A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A
This study is testing a new medicine called Mim8 for people with haemophilia A, including those with inhibitors. Mim8 aims to prevent bleeding episodes by helping blood clot. It's for people already in other Mim8 studies.
Haemophilia AHaemophilia A With InhibitorsRomania - RecruitingPHASE3
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
This study is looking at a new medicine called Elecoglipron for people with certain types of heart failure. It compares Elecoglipron to a dummy medicine (placebo) to see if it helps improve heart health outcomes for adults already taking other heart failure medications, including dapagliflozin.
Heart Failure With Preserved Ejection Fraction (HFpEF)Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)Romania - RecruitingPHASE3
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
This study is testing new treatments for a type of lung cancer called non-small cell lung cancer. Researchers want to see if a combination of two medicines, calderasib and pembrolizumab, works better than pembrolizumab with chemotherapy to slow down cancer growth.
Non-small Cell Lung CancerRomania - RecruitingPHASE3
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
This study compares two treatments for multiple myeloma that has come back or not responded to previous treatments. It looks at a new drug, mezigdomide, combined with standard medicines (bortezomib and dexamethasone), against another combination (pomalidomide, bortezomib, and dexamethasone). The aim is to see which combination is more effective and safe.
Relapsed or Refractory Multiple MyelomaRomania - RecruitingPHASE1, PHASE2
FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC
This study is testing a new drug, TUB-040, for ovarian cancer and a type of lung cancer (non-small cell lung cancer) when standard treatments haven't worked. It checks how safe it is, how it moves in the body, and if it helps shrink tumours. The study aims to find the best dose.
Ovarian CancerNon-small Cell Lung CancerRomania - RecruitingPHASE3
A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.
This study looks at a new medicine called elecoglipron for people with long-term kidney disease. We want to see if it helps improve health compared to a dummy pill (placebo). Participants will also be taking existing kidney disease treatments like dapagliflozin. It's a large study, involving many people to get clear results.
Chronic Kidney DiseaseRomania - RecruitingPHASE3
A Study of Gammagard Liquid (Immune Globulin Infusion, 10%) to Prevent Infections in Adults With Multiple Myeloma
This study looks at a medicine called IGI to see if it can help prevent infections in adults with a type of blood cancer called multiple myeloma. Participants will either get IGI for a year or only if they develop a serious infection.
Multiple MyelomaSecondary ImmunodeficiencyRomania - Active not recruitingPHASE3
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
This study investigates how a medicine called semaglutide affects eye problems in people with type 2 diabetes over five years. Participants will get either semaglutide or a dummy medicine, injected once a week, along with their usual diabetes treatments.
Diabetes Mellitus, Type 2Romania - RecruitingPHASE3
A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
This study is testing a new medicine, Molnupiravir, to see if it can stop people at high risk of severe COVID-19 from becoming very ill. It's for people who can't take other COVID-19 treatments. We want to find out if it works better than a dummy treatment.
Coronavirus Disease (COVID-19)Romania - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
This study is testing a new medication called Tulisokibart for people with moderate to severe Crohn's disease. Researchers want to see if it's safe and effective in reducing symptoms and improving the gut lining. It involves different ways of giving the medicine compared to a dummy treatment.
Crohn's DiseaseRomania - RecruitingPHASE3
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine
This study looks at a medicine called atogepant for children and teenagers aged 6 to 17 who get occasional migraines. It will check if the medicine is safe and if it helps reduce migraines, as there aren't many approved treatments for young people.
Episodic MigraineRomania - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants with Symptomatic Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (TITANIA)
This study is testing a new medicine, Tozorakimab, for people with severe COPD who often have flare-ups. We want to see if it reduces these flare-ups and is safe to use. Some people will get the new medicine, others a dummy medicine (placebo).
Chronic Obstructive Pulmonary Disease (COPD)Romania - Active not recruitingPHASE3
A Study of TAR-200 Versus Intravesical Chemotherapy in Participants With Recurrent High-Risk Non-Muscle-Invasive Bladder Cancer (HR-NMIBC) After Bacillus Calmette-Guérin (BCG)
This study compares a new treatment, TAR-200, with standard chemotherapy for a type of bladder cancer that has returned after initial treatment. It's for people who can't or won't have surgery to remove their bladder.
Non-Muscle Invasive Bladder NeoplasmsRomania - Not yet recruitingPHASE3
A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism Spectrum Disorder
This study is looking at a new medication called KarXT combined with KarX-EC to help children and teenagers with autism who experience a lot of irritability. The aim is to see if this combination can make them feel less irritable.
Irritability Associated With Autism Spectrum DisorderRomania - RecruitingPHASE3
Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation
This study compares two treatments for advanced breast cancer. It looks at lasofoxifene with abemaciclib versus fulvestrant with abemaciclib for ER+/HER2- breast cancer that has a specific gene change (ESR1 mutation) and has grown after previous treatment.
Metastatic Breast CancerRomania - Active not recruitingPHASE3
An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma
This study looks at a daily tablet called ivosidenib for adults with bile duct cancer that has come back or spread, and has been treated before. It aims to confirm if the treatment is safe and works well, and how it affects quality of life.
CholangiocarcinomaRomania - Recruiting
AutoInflammatory Disease Alliance Registry (AIDA)
This project is building a secure online registry to collect health information from people with rare inflammatory conditions. The goal is to better understand these diseases, how they affect people, and how different treatments work. Your information could help doctors improve care for others.
Hereditary Autoinflammatory DiseasesSchnitzler SyndromeBehcet SyndromePFAPA SyndromeRomania - Active not recruitingPHASE3
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
This study allows some cancer patients who are already benefiting from certain treatments in another study to continue receiving that treatment. It’s for those who wouldn't be able to get the treatment otherwise, helping them keep accessing therapies that are working for them.
CancerRomania - Not yet recruitingPHASE3
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
This study is for people who were in a previous trial for a medicine called anifrolumab (Saphnelo) and found it helpful. It lets you keep taking the medicine to see if it continues to work and monitor your safety.
Systemic Sclerosis Cutaneous Lupus E Myopathies Systemic Lupus ErythematosusRomania - Active not recruitingPHASE3
A Study of Abemaciclib (LY2835219) Combined With Fulvestrant in Women With Hormone Receptor Positive HER2 Negative Breast Cancer
This study looks at new ways to treat advanced breast cancer that is sensitive to hormones and doesn't have too much HER2 protein. It compares a new drug called abemaciclib plus fulvestrant to fulvestrant alone, to see which helps patients live longer without their cancer growing.
Breast NeoplasmsRomania - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, Open-label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of Sotorasib (AMG 510) Monotherapy in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation and Sotorasib (AMG 510) Combination Therapy in Subjects With Advanced NSCLC With KRAS p.G12C Mutation (CodeBreaK 100)
This study is testing a new medicine, Sotorasib, for people with advanced cancers that have a specific genetic change called KRAS p.G12C. Researchers want to see if it's safe and effective, both on its own and when combined with other treatments.
KRAS p.G12C Mutant Advanced Solid TumorsRomania - Active not recruitingPHASE3
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)
This study is testing new combinations of medicines for advanced kidney cancer (renal cell carcinoma). Its aim is to see if these new combinations work better and are safe compared to a standard treatment, for people who haven't had treatment for their advanced cancer before.
Carcinoma, Renal CellRomania - Active not recruitingPHASE2
A Dose-finding Trial With Lu-AG09222 in Adults With Migraine Who Have Not Been Helped by Prior Preventive Treatments
This study is looking for people with frequent migraines that haven't improved with other treatments. It's testing a new medication, Lu AG09222, to find the best dose to help prevent migraines. Volunteers will receive either the new medication or a dummy pill.
MigraineRomania - RecruitingPHASE3
A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively
This study looks at a medicine called KarXT for young people aged 5 to 17. It checks how safe and tolerable it is over a long time for schizophrenia and irritability linked to autism. It's for those who have already started treatment in previous related studies.
SchizophreniaAutism-Related IrritabilityRomania - Active not recruitingPHASE1
A PK Study to Compare GME751 (Proposed Pembrolizumab Biosimilar) and US-licensed and EU-authorized Keytruda® in Participants With Stage II and III Melanoma
This study compares a new medicine called GME751 to an existing treatment, Keytruda, for people with melanoma that has been removed by surgery. It checks if GME751 works similarly and is safe.
MelanomaRomania - Active not recruiting
Long-Term Observational Study on Effectiveness and Safety of Lecigon in Patients With Advanced Parkinson's Disease
This study looks at how a medicine called Lecigon® works and its safety for people with advanced Parkinson's disease in their everyday lives. It gathers information from around 300 patients who are already using Lecigon® to help manage their symptoms that aren't well controlled by other treatments.
Advanced Parkinson DiseaseRomania - RecruitingPHASE1, PHASE2
A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
This study is testing a new drug, BI-1206, with an existing cancer treatment, pembrolizumab, for adults with advanced solid tumours. It aims to find the safest dose and see if this combination can help people whose cancer has progressed or who haven't had previous treatment for advanced disease.
Solid Tumor, AdultRomania - Active not recruitingNA
AMEND-CRT: Mechanical Dyssynchrony as Selection Criterion for CRT
This study looks at a new way to pick patients for a heart treatment called CRT. It aims to see if checking how the heart muscles move can help more people benefit and reduce unnecessary treatments, making it safer and more efficient.
Left Ventricular DyssynchronyHeart FailureCardiomyopathy, DilatedCardiac Remodeling, VentricularRomania - Recruiting
PulseSelect™ PFA Global Registry
This study is observing how well a new treatment called PulseSelect™ PFA works for people with atrial fibrillation (an irregular heartbeat). It collects information on its safety and effectiveness in patients receiving this approved treatment as part of their routine care.
Atrial FibrillationRomania - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
An open label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study comparing Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets (Mixed Salts of Single Entity Amphetamine Product) 30 mg, manufactured by Frontida Biopharm. Inc., Philadelphia, USA with Attent 30 mg (Mixed Amphetamine Salts tablets) manufactured by Teva Israel Ltd., in healthy adult, human subjects under fasting condition.
This study compares a new 30mg ADHD medication with an existing one to ensure they work the same way in healthy adults. It's a quick, one-dose test to check if the body handles both medicines similarly, helping ensure new versions are just as effective.
ADHDRomania - RecruitingPHASE2
A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine called MORF-057 for adults with moderate to severe Crohn's disease. It compares different doses of the medicine to a dummy pill to see if it's safe and helps improve symptoms.
Inflammatory Bowel DiseasesCrohn's DiseaseRomania - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome
This study is testing a new medicine, Deucravacitinib, for adults with an active form of Sjögren's Syndrome. Researchers want to see if it's safe and effective compared to a dummy pill. It's a key step to finding better treatments for this autoimmune condition.
Sjögren's SyndromeRomania - RecruitingPHASE2
A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis
This study is looking into new medicines, Eltrekibart and Mirikizumab, for adults with moderate to severe ulcerative colitis. Researchers want to see if these medicines are safe and if they can help people feel better.
Ulcerative ColitisUlcerative Colitis ChronicRomania